scholarly journals Pericardial eff usion as a new specifi c symptom of SARS-CoV-2

2021 ◽  
Vol 99 (3) ◽  
pp. 192-197
Author(s):  
Z. N. Sukmarova ◽  
V. B. Simonenko ◽  
F. M. Ibragimova ◽  
A. V. Demyanenko
Keyword(s):  
High Frequency ◽  
Clinical Symptoms ◽  
Main Group ◽  
Cardiac Conduction ◽  
Control Group ◽  
Clear Understanding ◽  
Outpatient Basis ◽  
Antibody Testing ◽  
Comparable Group ◽  
Gender And Age

Being a consequence of COVID-19, cardiovascular disorders are now at the forefront of the infection’s after-eff ects. Researchers note the involvement of heart muscle, vascular endothelium, cardiac conduction system into the infectious infl ammation even if a person has oligosymptomatic SARS-CoV-2. On the other hand, we still do not have a clear understanding of the genesis of the long-standing persistent hyperthermia, reduced stamina and atypical cardialgia.Objective. The study demonstrates the high frequency of pericardial eff usion among patients who recovered from COVID-19. The study describes clinical symptoms of the COVID-19-induced pericarditis.Materials and methods. To compare the frequency of pericardial eff usion (based on TTE data) among a sample of patients who recovered from COVID-19 and in the control group of patients who were examined before the pandemic, the study was conducted in accordance with STROBE design. The main group, studied on a prospective basis, included patients who recovered from COVID-19 1 or 2 months ago. The control group was made up retrospectively from the database of the Functional Diagnostics Department for January–February 2019, matching the main group in terms of gender and age. The groups had no diff erence in terms of high blood pressure, ischemic heart disease, Index of Mass Corporal. Hence, 110 pairs of patients were selected from the two groups, where we analyzed TTE results following the event-control protocol.Results. The cohort of patients who recovered from COVID-19 consisted of 51 men and 59 women, with the average age of 67 ± 9 years old. 30 patients had moderate and severe forms of COVID-19 and were hospitalized. 80 ones had a mild form of COVID-19 confi rmed with PCR test or COVID-19 antibody testing and were monitored on the outpatient basis. The average time of the study spans 5 ± 1 weeks after the fi rst symptoms onset. The control group comprised 110 patients aged 67 ± 5 years. Signs of pericardial eff usion were recorded as part of TTE in 47 (43%) patients from the main group, with 5 of them (11%) having chronic causes for the eff usion. In the control group, the hydropericardium was detected in 4 (3%) patients. The rate ratio is 19,8 (95 OR 18.2–21.6). The frequency of hydropericardium symptoms did not depend on the age, principal cardiovascular diseases and the severity of COVID-19. Pericardial eff usion of the COVID-19 origin had some diff erence in ultrasound imaging as compared to pericardial eff usion of non-COVID-19 origin. The additional anti-infl ammatory therapy was prescribed for such patients.Conclusions. The hydropericardium should be viewed as a specifi c manifestation of SARSCoV-2 and taken into account when assessing the post-COVID-19 symptoms. Pericardial eff usion is found after COVID-19 12 times as frequent as in the demographically comparable group without the pandemic. Despite the severity of COVID-19, the high frequency of pericardial eff usion necessitates TTE assessment in dynamics throughout at least 2 months after the infection.

scholarly journals Evaluation of the effectiveness of ARVI treatment regimen including etiotropic (enisamium iodide) and symptomatic treatment

2020 ◽  
Vol 92 (3) ◽  
pp. 50-55
Author(s):  
D. A. Lioznov ◽  
E. J. Karnaukhova ◽  
T. G. Zubkova ◽  
E. V. Shakhlanskaya
Keyword(s):  
Influenza A ◽  
Viral Infections ◽  
Clinical Symptoms ◽  
Randomized Study ◽  
Antiviral Drug ◽  
Main Group ◽  
Average Score ◽  
Control Group ◽  
Symptomatic Therapy ◽  
Respiratory Viral Infections

Aim. To assess the effectiveness of the use of the antiviral drug enisamium iodide in the complex treatment of acute respiratory viral infections (ARVI) caused by various pathogens in routine clinical practice. Materials and methods. А prospective randomized study included 134 patients who were treated in the epidemic season of influenza and ARVI in 20182019. All patients were examined for the presence of influenza A and B viruses, respiratory syncytial virus, human metapneumovirus, parainfluenza virus, coronaviruses, rhinoviruses, adenoviruses in nasopharyngeal swabs by PCR. Patients of the main group received enisamium iodide along with symptomatic therapy, the control group received only symptomatic therapy. The primary parameter of the effectiveness of therapy was evaluated on the scale of the general severity of the manifestations of ARVI (Total Symptom Score TSS) from the 2nd to the 4th day and by the secondary criteria of effectiveness: assessment of the duration of ARVI, the severity of fever, the proportion of patients with normal body temperature, the duration of the main clinical symptoms of acute respiratory viral infections, the proportion of patients in whom complications requiring antibiotics were noted, the dynamics of interferon status on the 6th day. To conduct a statistical analysis, depending on the efficiency parameter, the ANCOVA method with a fixed group factor and an initial score on the TSS severity scale was used as covariates, a criterion for comparing quantitative indicators in two independent groups. Results. According to the results of the analysis of the primary efficacy parameter, the median (interquartile range) of the average score on the scale of the general severity of ARVI manifestations in the main group was 4.33 (3.675.83), in the comparison group 6.00 (4.677.25; p0.001). The duration of systemic and local manifestations of acute respiratory viral infections was statistically significantly less in the main group (p=0.002 and p=0.019, respectively). Prescription of additional therapy was required in 2 (2.9%) patients of the main group (patients taking enisamium iodide), compared with 8 (11.9%) patients in the control group. Serum levels of interferon  and interferon  on the last day of treatment were statistically significantly higher in patients of the main group compared with the control group (p0.001). Treatment (excellent) was evaluated by 42 (62.7%) patients, while in the control group only 17 (25.8%) patients gave similar ratings. Both patients (p0.001) and doctors (p0.002) rated therapy tolerance better in the study group. Conclusion. The results confirmed the safety and effectiveness of enisamium iodide as a treatment for ARVI and influenza. The antiviral, interferonogenic and anti-inflammatory properties of the drug are involved in the formation of an antiviral response and reduce the risk of complications, which makes it possible to reduce the number of symptomatic agents used.

scholarly journals Optimization of rehabilitation measures after artificial abortion as the result of immunomodulator aminodihydrophthalasindione sodium apply in comprehensive therapy

2019 ◽  
pp. 156-161
Author(s):  
E. A. Voroshilova
Keyword(s):  
Marked Reduction ◽  
Clinical Effect ◽  
Comparison Group ◽  
Clinical Symptoms ◽  
Randomized Study ◽  
Main Group ◽  
Control Group ◽  
Comprehensive Therapy ◽  
Effect Of Treatment ◽  
Artificial Abortion

The article presents the results of a comparative randomized study, the purpose of which was to evaluate the effectiveness of the use of aminodihydrophthalasindione sodium (Galavit, LLC SELVIM, Russia) in the treatment of patients undergoing an abortion. Included in the study, 48 women were divided into two groups, 24 patients of the main group in addition to the standard rehabilitation were treated with aminodihydrophthalasindione sodium in the comparison group – 24 patients underwent only standard rehabilitation. In this study, all patients (100%) of the main group who were treated with aminodihydrophthalasindione sodium in addition to the standard therapy marked reduction of the clinical symptoms of the disease and positive dynamics was observed at ultrasound. In the control group, the full clinical effect of treatment was observed only in 10 patients (52.6%). 9 women (47,4%) required repeated therapy. Ultrasound studies in 12 patients (63.2%) showed changes equivalent to endometritis.

Role of the fetal pancreas size in prediction of early neonatal hypoglycemia in maternal diabetes mellitus

2021 ◽  
pp. 62-70
Author(s):  
С.Н. Лысенко ◽  
М.А. Чечнева ◽  
Ф.Ф. Бурумкулова ◽  
В.А. Петрухин ◽  
Т.С. Будыкина
Keyword(s):  
Diabetes Mellitus ◽  
Pregnant Women ◽  
Premature Infants ◽  
Linear Correlation ◽  
Clinical Symptoms ◽  
Maternal Diabetes ◽  
Main Group ◽  
Control Group ◽  
Neonatal Hypoglycemia ◽  
Fetal Pancreas

Введение. Поджелудочная железа (ПЖ) плода играет роль в регуляции гликемии как у плода, так и у матери. Гипергликемия матери, независимо от типа сахарного диабета (CД) сопровождается гипергликемией у плода. Напряжение функции ПЖ плода обусловливает компенсаторное увеличение eё размеров, формирование фетальной гиперинсулинемии и развитие в первые часы жизни неонатальной гипогликемии. Клинические симптомы гипогликемии присутствуют в 25-33% случаев, частота лабораторной гипогликемии - в 21-60%. Цель - оценка прогностического значения увеличения размеров ПЖ плода накануне родов в качестве предиктора неонатальной гипогликемии при CД у матери. Методика. Проведена ультразвуковая морфометрия ПЖ у 241 беременной c CД (основная группа) и у 427 здоровых беременных (контрольная группа). В основной группе у 141 (58,5%) беременной родились дети c признаками диабетической фетопатии (ДФ). Оценивались размеры ПЖ плода. У новорождённых оценивалась гликемия в динамике в 1-e и 3-и сут жизни. Проведён ретроспективный корреляционный анализ размеров поджелудочной железы плода и характер гликемии новорожденных в 1-e и 3-и cут жизни. Результаты. Выявлена отрицательная корреляция толщины ПЖ и гипогликемии новорождённого в 1-e сут жизни c линейным коэффициентом корреляции (R) минус 0,66. В 1-e сут жизни у 87,5 % этих детей возникает гипогликемия, более выраженная у недоношенных, у 50% из них, сохраняющаяся к 3-м сут жизни. Заключение. Толщина ПЖ плода более информативный и воспроизводимый показатель, чем её длина, статистически значимый как в группе ДФ, так и без неё. Неудовлетворительный контроль за течением CД у матерей увеличивает риск гипогликемии новорождённого до 100%. Более выраженная гипогликемия выявляется у недоношенных детей, у половины которых гипогликемия сохраняется к 3-м сут жизни. Background. The fetal pancreas is involved in regulation of glucose levels in both fetal and maternal plasma. Maternal hyperglycemia, regardless of the type of diabetes mellitus (DM), is accompanied by fetal hyperglycemia. This stress of the fetal pancreatic function causes a compensatory increase in the pancreas size, the development of fetal hyperinsulinemia and of neonatal hypoglycemia in the first hours of life. The frequency of laboratory hypoglycemia varies 21-60%, while its clinical symptoms are present in 25-33% of cases. Aim. To assess the prognostic value of the increase in fetal pancreas size on the eve of delivery as a predictor of neonatal hypoglycemia in maternal DM. Methods. Ultrasound of the fetal pancreas was performed in 241 pregnant women with DM (main group) and in 427 healthy pregnant women (control group). In the main group, 141 (58.5%) pregnant women had children with signs of diabetic fetopathy (DF). The size of the fetal pancreas was estimated. In newborns, glycemia was measured on the 1st and 3rd days of life. A retrospective correlation analysis of the fetal pancreas size and the neonatal glycemia was performed on the 1st and the 3rd days of life. Results. A negative linear correlation was found between the pancreas thickness and neonatal hypoglycemia on the 1st day of life (linear correlation coefficient, R, -0.66). On the 1st day of life in 87.5-100% of these newborns, hypoglycemia is observed, which is more pronounced in premature infants and which remains through the 3rd day of life in 50% of them. Conclusion. The thickness of the fetal pancreas is a more informative and reproducible indicator than its length, which was statistically significant in groups both with and without DF. Poor glycemic control in mothers increases the risk of neonatal hypoglycemia up to 100%. More pronounced hypoglycemia is observed in premature infants and persists through the 3rd day of life in half of them.

scholarly journals Evaluation of the effectiveness of the use of osteоpathic methods of treatment of patients with chronic stone-free cholecystitis

2020 ◽  
Vol 19 (2) ◽  
pp. 101-106
Author(s):  
O. A. Pankov ◽  
V. V. Matvienko ◽  
V. K. Frolkov ◽  
V. A. Zhernov ◽  
M. M. Zubarkina
Keyword(s):  
Clinical Symptoms ◽  
Main Group ◽  
Point Of View ◽  
Control Group ◽  
Complex Therapy ◽  
Osteopathic Treatment ◽  
The Subject ◽  
Somatic Diseases ◽  
Based Medicine ◽  
Methods Of Treatment

Background. Osteopathic methods are used in practical medicine, but there is little scientific research in this area, especially in the treatment of somatic diseases. The purpose of the research is to evaluate the effectiveness of osteopathy in the complex therapy of patients with chronic stone-free cholecystitis from the point of view of evidence-based medicine. Methods. The study involved 114 patients who were divided into two groups, the control group and the main group, in which osteopathic procedures were applied. The functions of the gallbladder, bile and blood biochemistry, and cholecystokinin secretion were analyzed. Results. It was found that osteopathic methods significantly increased the effectiveness of standard therapy both in terms of regression of clinical symptoms of the disease and in the functioning of the gallbladder. It is proved that the main group of patients significantly increases the secretion of cholecystokinin, which correlates with an improvement in the biochemistry of bile and its allocation. It was found that the effectiveness of osteopathic treatment methods does not depend on the gender of patients. Conclusion. The results of the study indicate a fairly pronounced therapeutic effect of osteopathic procedures in the complex therapy of patients with chronic stone-free cholecystitis. The increase in the secretion of cholecystokinin is difficult to explain from the point of view of correction of functional blocks, and this problem remains the subject of further research.

scholarly journals Influence of low-frequency ultrasonic cavitation on the severity Of clinical symptoms in complex therapy of exacerbations Of chronic rhinosinusitis

2020 ◽  
Vol 19 (4) ◽  
pp. 39-47
Author(s):  
M. Yu. Korkmazov ◽  
◽  
A. M. Korkmazov ◽  
I. D. Dubinets ◽  
A. A. Smirnov ◽  
...  
Keyword(s):  
Chronic Rhinosinusitis ◽  
Clinical Symptoms ◽  
Low Frequency ◽  
Clinical Effectiveness ◽  
Disease Recurrence ◽  
Main Group ◽  
Ultrasonic Cavitation ◽  
Control Group ◽  
Recurrence Rates ◽  
Group A

The variability of clinical course and frequent exacerbations of chronic rhinosinusitis make it necessary to improve conservative therapy. According to current literature and EPOS 2020 data the main trends are aimed to improve drug treatment, while physiotherapy is rarely applied. The aim of the study was to increase clinical effectiveness of chronic rhinosinusitis exacerbations treatment by using low-frequency ultrasonic cavitation. Clinical examination and treatment of 57 patients with exacerbation of chronic rhinosinusitis and formation of two groups was carried out. The main group (34 patients), in addition to the conventional treatment, received a course of low-frequency ultrasonic cavitation irrigation of the nasal cavity (frequency – 29 kHz, amplitude – 25 µm), and the control group (23 patients) received a course of standard therapy in accordance with clinical recommendations. The treatment resulted in improvement of clinical symptoms and reduced disease recurrence rates in 31 (91,2%) patients in the main group and 16 (69,4%) patients in the control group. A satisfactory result was obtained in 3 (8,8%) patients in the main group and 6 (27,6%) in the control group. An unsatisfactory result was noted in one case in the control group.

scholarly journals Study of the FUT2 gene association with infection and clinical manifestations of Helicobacter pylori infection

2021 ◽  
pp. 27-32
Author(s):  
A. S. Klimova ◽  
E. V. Shrayner ◽  
A. I. Khavkin ◽  
N. V. Kokh ◽  
G. I. Lifshits ◽  
...  
Keyword(s):  
Clinical Symptoms ◽  
Polymorphic Locus ◽  
Clinical Manifestations ◽  
Main Group ◽  
Control Group ◽  
Significant Difference ◽  
Taqman Pcr ◽  
Pcr Method ◽  
H Pylori ◽  
Fut2 Gene

The aim of the pilot study of a group of adolescents with H. pylori infection was to study the preliminary data obtained on the rs602662 locus of the FUT2 gene and to establish its role in the realization of clinical manifestations of chronic gastritis, gastric ulcer and duodenal ulcer associated with H. pylori.Methods: The study included 91 patients. The study for the presence of the polymorphic locus rs602662 of the FUT2 gene was carried out by the standard TaqMan PCR method on a Real-Time CFX96 Touch amplifier. The duration of the study was 6 months.Results: The main group included 25 adolescents aged 16 to 17 years 11 months, the control group included 20 patients. Patients infected with H. pylori more often noticed symptoms of dyspepsia - in 36%, compared with the control group - 9.7%. The presence of a family history in the main group for associated diseases had a significant difference, χ2 = 4.97, p <0.05.To assess the contribution of the genotype of the rs602662 locus of the FUT2 gene to the risk of clinical manifestations in H. pylori infection, the main group was divided into subgroups. In the distribution of alleles in these groups, statistically significant differences were revealed.Allele “A” has a protective effect against the onset of clinical symptoms of dyspepsia. The odds ratio (OR) with the carriage of allele “A” (genotypes A / A and G / A versus G / G) to have clinical symptoms with a positive H. pylori status was 0.175 (CI = [0.049-0.625] chi2 = 7.79 p = 0.0053).Conclusion. As a result of the study, we were unable to identify a significant association of alleles and genotypes of the rs602662 locus of the FUT2 gene with clinical manifestations of H. pylori infection. At the same time, carriers of the A allele have a pronounced association with the absence of clinical symptoms in patients with a positive H. pylori infection status of 0.175 (C.I. = [0.049-0.625] chi2 = 7.79 p = 0.0053).

scholarly journals Effect of dynamic electroneurostimulation in treatment of community-acquired pneumonia in preschool children

2014 ◽  
Vol 95 (3) ◽  
pp. 370-374
Author(s):  
Zh R Ibragimova ◽  
O I Pikuza ◽  
Kh M Vahitov
Keyword(s):  
Preschool Children ◽  
Clinical Symptoms ◽  
Day Treatment ◽  
White Blood Cells ◽  
Community Acquired Pneumonia ◽  
Main Group ◽  
Control Group ◽  
Complex Treatment ◽  
X Ray ◽  
Inflammatory Changes

Aim. To assess the effect of dynamic electroneurostimulation in treatment of community-acquired pneumonia in preschool children. Methods. The main group consisted of 45 preschool children with community-acquired pneumonia, in whom 7-day treatment course of dynamic electroneurostimulation was included as the component of the complex treatment. The control group included 55 children in whom conventional tactics was applied. Results. General intoxication syndrome was resolved at 3.2±1.1 day in children of the main group compared to 7.7±1.4 day in the control group. The use of dynamic electroneurostimulation reduced the duration of respiratory distress by more than 1.5 times (6.8±1.3 day), regression of physical lung changes was observed at 10.3±1.4 on average, compared to the end of the second week at the control group. Resolving of the clinical symptoms in children of the main group was accompanied by statistically significant (p 0.05) reduction of basic parameters of systemic inflammation (increased white blood cells count, high neutrophil count, left shift) by 7th day of treatment. The level of C-reactive protein reduced by 7 times in children of the main group, compared to 2.3 times in comparison group (p 0.05). Chest X-ray on the 7th day showed complete resolving of inflammatory changes in 20 (44.4%) patients of the main group, while no such cases were observed in control group (p 0.001). At the same time, no positive change of X-ray picture was revealed in 25 (45.5%) children of the control group, while there were no such cases in the main group (p 0.001). On the 11th day of treatment complete resolving of inflammatory changes was found in 43 (95.6%) children of the main group, compared to 34 (61.8%) children of the control group (p 0.05). Conclusion. Including of dynamic electroneurostimulation in complex treatment of community-acquired pneumonia in children reduces the recovery time, hospital stay and treatment cost.

Sanatory therapy of chronic prostatitis with the use of physiobalneotherapy

2021 ◽  
pp. 64-69
Author(s):  
Bulat Rashitovich Gilmutdinov ◽  
Ildar Nailevich Daminov ◽  
Aydar Rashitovich Gilmutdinov ◽  
Rozaliya Amirovna Garifyanova
Keyword(s):  
Treatment Effect ◽  
Chronic Prostatitis ◽  
Magnetic Stimulation ◽  
Clinical Symptoms ◽  
Clinical Effectiveness ◽  
Main Group ◽  
Control Group ◽  
Treatment Results ◽  
Study Evaluation ◽  
Peloid Therapy

The purpose of the study. Evaluation of the effectiveness of sanatory therapy in patients with chronic prostatitis using peloid therapy and extracorporeal magnetic stimulation. Materials and methods. The efficiency of sanatory therapy was studied in 86 patients with chronic prostatitis without exacerbation; the control group received a basic sanatory complex; the main group was additionally prescribed procedures for applying pelloids and extracorporeal magnetic stimulation. Results. In most patients of the main group, it was revealed that the course of sanatory therapy can reduce the severity of the clinical symptoms of chronic prostatitis against the background of improved bacteriological, immunological, and ultrasound indicators with the preservation of treatment results over 12 months, in contrast to the control group against the background of basic sanatory treatment, where the treatment effect remained up to 6 months. Conclusions. Sanatory therapy of patients with chronic prostatitis with the inclusion of peloid therapy and extracorporeal magnetic stimulation procedures has a high clinical effectiveness with the preservation of the results for a year.

Some aspects of application glucocorticoid drugs in the complex treatment of new coronaviral infection

MedAlliance ◽  
2021 ◽  
Vol 9 (1) ◽  
pp. 43-51
Keyword(s):  
Oxygen Saturation ◽  
Acute Phase ◽  
Clinical Symptoms ◽  
Interleukin 1 ◽  
Total Duration ◽  
Interleukin 10 ◽  
Main Group ◽  
Control Group ◽  
Complex Treatment ◽  
Duration Of Treatment

The aim of the study was to evaluate the clinical and lab- oratory parameters of the effectiveness of low-dose glu- cocorticoid therapy in the complex treatment of patients with lung disease caused by a new coronavirus infection (COVID-19). Methods. The study included 40 hospitalized patients aged 37 to 68 years (mean age 52.2 years) with a confirmed diagnosis of medium severe to severe COVID- 19 pneumonia and CT-2 or CT-3 lung tissue involvement. All patients received standard therapy. Patients were randomized into two groups: the main group (n=20) and the control group (n=20). The main group additionally received MPS, according to the protocol: 4 mg tablets, 7 tablets per day, divided into 2 doses (4 tablets in the morning and 3 at lunchtime) in the course of 10 days. On admission to hospital, all patients demonstrated clinical symptoms of the disease, fever and decline in oxygen saturation. Based on the dynamics of clinical, radiological, and la boratory parameters, the additional effectiveness of oral glucocorticoids in the pathogenetic therapy of COVID-19 in comparison with control group was assessed. Results. According to laboratory test re- sults, the screened patients on hospital admission had an increased level of acute phase indicators and proin- flammatory cytokines. Correlation analysis revealed the credible link between the vo lume of lung involvement (based on CT-scans), oxygen sa turation, body mass index (BMI), and interleukin-10 levels (anti-inflammatory cy- tokine activation marker). Credible correlation between concentration of acute-phase parameters and proinflam- matory cytokines (IL-1, IL-6) in blood was detected. The use of methylprednisolone in the comprehensive treat- ment of patients with severe pneumonia associated with COVID-19 has been accompanied by reliable increase in ferritin, C-reactive protein, and interleukin-1, interleu- kin-6, interleukin-10. Less time was needed for symptom resolution and recovery of oxygen saturation in patients who took methylprednisolone. Meanwhile, a timeframe for reaching positive CT dynamics and the total duration of treatment hadn’t changed significantly. Conclusion. Prescribing cycles of oral glucocorticoid therapy helps to reduce proinflammatory cytokines in blood and accel- erate oxygen saturation recovery, however, it does not influence the duration of hospitalization and the time frame of resolution of inflammatory changes in lungs du ring the period of hospitalization.

Experience of low-intensity LED radiation (LILEDR) in combination treatment of radiation-induced rectal injuries.

2021 ◽  
Vol 39 (15_suppl) ◽  
pp. e17514-e17514
Author(s):  
Olga G. Rodionova ◽  
Vitaliy I. Voshedskiy ◽  
Pavel G. Sakun ◽  
Elena A. Sheiko ◽  
Marina A. Gusareva ◽  
...  
Keyword(s):  
Exposure Time ◽  
Combination Treatment ◽  
Conservative Therapy ◽  
Radiation Treatment ◽  
Clinical Symptoms ◽  
Clinical Manifestations ◽  
Main Group ◽  
Control Group ◽  
Rehabilitation Period ◽  
Radiation Induced

e17514 Background: Malignant pelvic tumors account for more than 25% of cancer incidence in Russia. Radiation therapy is the most common treatment for such patients; however, 10-15% of patients develop radiation-induced complications of the pelvic organs, and more effective treatments are required to manage these complications. Methods: The study included 30 patients with cervical cancer T3NхM0 after combination treatment. 7-10 months after combined radiation treatment (total radiation dose to the primary focus 80 Gy), patients developed erosive ulcerative radiation rectitis (RTOG grade 1 and 2). Patients were divided into 2 groups: main group (n = 15) – conservative treatment combined with LILEDR. Each course included 10 LILEDR sessions, the red spectrum λ = 640 nm on the cubital vein projection (exposure time 5 minutes, dose 6.86 J/cm2) and locally on the ulcerated zones (exposure time 3 minutes, dose 3.96 J/cm2). Patients received 2 LILEDR courses with a 1-month interval. The control group received only conservative therapy. Results: Main clinical manifestations of rectitis (tenesmus, bloody mucous discharge) disappeared in the main group already on the 3-4th day of the first course, epithelialization of ulcerative defects occurred in a shorter period of 7-10 days. Soft superficial scars not causing rectal stenosis formed at the site of the ulcer by the end of LILEDR courses. The control group showed long periods of the ulcer epithelialization up to 30 days, late remission and a lingering recurrent character of the disease. Conclusions: LILEDR in combination with the main conservative therapy allows rapid managing with the clinical symptoms of radiation rectitis and regression of disorders developed after the complex treatment, which improves the quality of life of patients and shortens the rehabilitation period.

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