scholarly journals EFEKTIFITAS HIDROGEN PEROKSIDA DALAM MEMBUNUH BAKTERI AIR ULTRA SCALER PADA DENTAL UNIT DI RSIGM SULTAN AGUNG SEMARANG

2015 ◽  
Vol 2 (1) ◽  
pp. 29
Author(s):  
Laily Maghfira Noor Ridarsyah ◽  
Djoko Priyanto ◽  
Grahita Aditya
Keyword(s):  
Hydrogen Peroxide ◽  
Infection Control ◽  
Wilcoxon Test ◽  
Back Flow ◽  
Peroxide Group ◽  
Group Iii ◽  
Ultrasonic Scaler ◽  
Group I ◽  
Before And After ◽  
Group Ii

Background: Infection control is essential in dentristry. Many studies suggested an increase of bacteria in dental unit due to back flow from ultrasonic scaler. Previous study states that hydrogen peroxidein 3% concentration may reduce the number of bacteria's colony of ultrasonic scaler water in RSIGM Sultan Agung Semarang significantly. Purpose: The aim of this study was to determine the effectiveness of hydrogen peroxide to kill bacteria of ultrasonic scaler water on dental unit in RSIGM Sultan Agung Semarang. Method: The type of research used in the study is quasy experimental with pretest-posttest design. The sample used in this study is 15 dental units which were divided into 3 groups group I 2% hydrogen peroxide, group II 4.5% hydrogen peroxide, and group III 6 % hydrogen peroxide and than flow it on ultrasonic scaler water and check the bakteria before and after experiment. Result: Based on the results of Wilcoxon test the comparison before and after at the three groups obtained the results of significance is less than 0.05. It can be concluded thathydrogen peroxide effectively kills bacteria of ultrasonic scaler water on dental unit in RSIGM Sultan Agung Semarang. Conclusion: From the results it can be concluded that the percentage of hydrogen peroxide which can cause all organisms die without disturbing the patient's health is at 4.5% and 6% concentration.

Endothelin effects in isolated, perfused lamb lungs: role of cyclooxygenase inhibition and vasomotor tone

1991 ◽  
Vol 261 (2) ◽  
pp. H443-H450 ◽  
Author(s):  
H. Toga ◽  
J. Usha Raj ◽  
R. Hillyard ◽  
B. Ku ◽  
J. Anderson
Keyword(s):  
Vasomotor Tone ◽  
Cyclooxygenase Inhibition ◽  
Group Iii ◽  
Group I ◽  
Before And After ◽  
Pulmonary Arterial ◽  
Group Ii ◽  
Sites Of Action ◽  
Arteries And Veins

We have determined the sites of action of endothelin-1 (ET) in the lamb pulmonary circulation. The influence of cyclooxygenase inhibition and baseline vasomotor tone on ET effects was also studied. Lungs of 14 lambs (6-9 wk of age, 12.1 +/- 0.6 kg body wt) were isolated and perfused with blood. Group I lungs (n = 5) were untreated, group II lungs (n = 5) were treated with indomethacin to inhibit cyclooxygenase, and group III lungs (n = 4) were treated with indomethacin and a thromboxane A2 analogue, U-46619, to elevate vasomotor tone. All lungs were perfused with constant flow in zone 3, with left atrial and airway pressures being 8 and 6 cmH2O, respectively. We measured pulmonary arterial pressure and, by the micropuncture servo-null method, pressures in 20- to 50-microns diameter subpleural venules, both before and after each dose of ET was infused (50, 100, 250, and 500 ng/kg). Group I lungs, with high baseline vasomotor tone, exhibited a biphasic response to ET; 50-100 ng/kg of ET dilated both arteries and veins, whereas 500 ng/kg of ET constricted both arteries and veins. In group II lungs with low vasomotor tone, all doses of ET caused constriction of arteries only. In group III lungs (indomethacin treated with elevated vasomotor tone), 50-100 ng/kg of ET caused dilation of arteries and veins, whereas 500 ng/kg of ET induced constriction, this time only in arteries. We conclude that ET has both dilator and constrictor effects in arteries and veins of isolated, perfused lamb lungs. ET-induced arterial and venous dilation is dependent on initial vasomotor tone but not on cyclooxygenase metabolites.(ABSTRACT TRUNCATED AT 250 WORDS)

scholarly journals Different Bleeding Patterns with the Use of Levonorgestrel Intrauterine System: Are They Associated with Changes in Uterine Artery Blood Flow?

2014 ◽  
Vol 2014 ◽  
pp. 1-6 ◽  
Author(s):  
Carlo Bastianelli ◽  
Manuela Farris ◽  
Stefania Rapiti ◽  
Roberta Bruno Vecchio ◽  
Giuseppe Benagiano
Keyword(s):  
Blood Flow ◽  
Uterine Artery ◽  
Endometrial Thickness ◽  
Power Doppler ◽  
Artery Blood Flow ◽  
Group Iii ◽  
Group I ◽  
Significant Difference ◽  
Before And After ◽  
Group Ii

Objective. Evaluate if different bleeding patterns associated with the use of the levonorgestrel intrauterine system (LNG-IUS) are associated with different uterine and endometrial vascularization patterns, as evidenced by ultrasound power Doppler analysis.Methodology. A longitudinal study, with each subject acting as its own control was conducted between January 2010 and December 2012. Healthy volunteers with a history of heavy but cyclic and regular menstrual cycles were enrolled in the study. Ultrasonographic examination was performed before and after six months of LNG-IUS placement: uterine volume, endometrial thickness, and subendometrial and myometrial Doppler blood flow patterns have been evaluated.Results. A total of 32 women were enrolled out of 186 initially screened. At six months of follow-up, all subjects showed a reduction in menstrual blood loss; for analysis, they were retrospectively divided into 3 groups: normal cycling women (Group I), amenorrheic women (Group II), and women with prolonged bleedings (Group III). Intergroup analysis documented a statistically significant difference in endometrial thickness among the three groups; in addition, mean pulsatility index (PI) and resistance index (RI) in the spiral arteries were significantly lower in Group I and Group III compared to Group II. This difference persisted also when comparing—within subjects of Group III—mean PI and RI mean values before and after insertion.Conclusions. The LNG-IUS not only altered endometrial thickness, but—in women with prolonged bleedings—also significantly changed uterine artery blood flow. Further studies are needed to confirm these results and enable gynecologists to properly counsel women, improving initial continuation rates.

scholarly journals Efficacy of hyaluronic acid in the treatment of chronic gingivitis in children

2011 ◽  
Vol 68 (12) ◽  
pp. 1021-1025
Author(s):  
Marija Igic ◽  
Dragan Mihailovic ◽  
Ljiljana Kesic ◽  
Mirjana Apostolovic ◽  
Ljiljana Kostadinovic ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
Control Group ◽  
Treatment Needs ◽  
Group Iii ◽  
Group I ◽  
Periodontal Index ◽  
Before And After ◽  
Community Periodontal Index ◽  
Group Ii ◽  
Basic Treatment

Introduction/Aim. Gingivitis is a common occurrence in children and may well be thought as a risk factor for the appearance and progression of the diseases of parodontal tissues. It is thus necessary to react in a timely and adequate fashion to prevent the disease to become serious and produce parodontopathy. The aim of the study was to establish the efficacy of hyaluronic acid in the treatment of chronic gingivitis in children. Methods. The study enrolled 130 children with permanent dentition. All of the examinees were divided into three groups: group I - 50 patients with chronic gingivitis in which only the basic treatment was applied; group II - 50 patients with chronic gingivitis in which hyaluronic acid was applied in addition to basic treatment; group III - 30 examinees with healthy gingiva (control group). Assessment of oral hygiene and status of the gingiva and parodontium was done using the appropriate indexes before and after the treatment. Inflammation of the gingiva was monitored by way of cytomorphometric studies. Results. The pretreatment values of the plaque index (PI) were high: in the group I PI was 1.94; in the group II PI was 1.68. After the treatment, the PI value was reduced to null in both groups (PI = 0). In the group III PI was 0.17. The bleeding index (BI) in the group I was 2.02 before and 0.32 after the treatment; the BI value in the group II was 1.74 before and 0.16 after the treatment. In the group III BI was 0. In the group I, the Community Periodontal Index of Treatment Needs (CPITN) was 1.66 before and 0.32 after the treatment; in the group II, the CPITN value was 1.5 before and 0.24 after the treatment. In the group III, the CPITN value was 0. In the group I, the size of the nuclei of the stratified squamous epithelium of the gingiva was reduced, although not so much as the nuclear size in the group II of examinees. Conclusion. Basic treatment is able to successfully treat chronic gingivitis in children. The use of hyaluronic acid together with the basic treatment can markedly improve the treatment effect.

Source of ethane in expirate of rats ventilated with 100% oxygen

1989 ◽  
Vol 66 (3) ◽  
pp. 1268-1272 ◽  
Author(s):  
M. P. Habib ◽  
M. A. Katz
Keyword(s):  
Group Iv ◽  
Sprague Dawley ◽  
Group V ◽  
Group Iii ◽  
Group I ◽  
Free Air ◽  
Sprague Dawley Rats ◽  
Ethane Production ◽  
Before And After ◽  
Group Ii

Ethane in alveolar expirate may have its source in organs other than the lung and be transported to the lung for elimination. We determined ethane production rates in rats (group I) ventilated with hydrocarbon-free air (HFA) before and after exsanguination. To determine whether the lung is the source of increased ethane production during exposure to 100% O2, we measured ethane in the expirate of nine exsanguinated, Sprague-Dawley rats (group II) mechanically ventilated with HFA and then with 100% O2. In all nine animals, ethane elimination rates on 100% O2 increased compared with HFA values. In five of the nine rats, HFA ventilation was reinstated after O2 (group III). In all five, ethane elimination fell with HFA ventilation compared with the value on 100%. Six rats with circulation intact were ventilated with HFA and then 100% O2 (group IV). Ethane production rate for group IV animals breathing HFA was not significantly different from the exsanguinated animals in group II while ventilated with HFA. The mean increase in ethane production for the group II animals was not significantly different from the group IV animals. Lung slices from four other rats (group V) were incubated in saline at 37 degrees C with FeCl2 (10 mg) added to enhance free radical formation. Paired lung samples from the same rat were incubated with either HFA or 100% O2. Headspace gas was analyzed chromatographically for ethane at 120 min. Mean ethane in the O2 samples was higher than for HFA. Rat lung tissue is the main source of increased ethane production during 100% O2 exposure.

scholarly journals COMPARISON BAY LEAF (SYZYGIUM POLYANTHUM (WIGHT) WALP) EXTRACT WITH 400 MG AND 600MG DOSE ON NITRIT OXIDE CONCENTRATION IN DYSLIPIDEMIC PATIENTS

2020 ◽  
Vol 7 (10) ◽  
pp. 24-28
Keyword(s):  
Nitric Oxide ◽  
Blood Vessels ◽  
Leaf Extract ◽  
Wilcoxon Test ◽  
Clinical Trial Research ◽  
Group I ◽  
600Mg Dose ◽  
Significant Difference ◽  
Before And After ◽  
Group Ii

Introduction: Dyslipidemia is a risk factor for cardiovascular disease. Dyslipidemia is known to trigger damage to endothelial blood vessels so that the disruption of nitric oxide production. Nitric oxide in blood vessels acts as an antiaterosclerotic agent, vasodilator, and prevents platelet aggression. Bay leaf extract is reported to be efficacious in reducing cholesterol, triglyceride levels and can increase levels of nitric oxide. This study aims to compare the effects of bay leaf extract at a dose of 400 mg and 600 mg on nitric oxide levels in dyslipidemic patients. Method: Clinical trial research with a prospective design. The first group (n = 15) was given therapy with dose of 400mg and the second group (n = 15) was given 600mg which was chosen randomly selected randomly in double disguised. Before and after 30 days of treatment, lipid profile and nitric oxide were examined. Data were analyzed by T-dependent statistical test and Wilcoxon test using SPSS. Significant difference when p <0.05. Result: Nitric oxide levels before drug administration compared with after treatment. The results of the study found a decrease in group I (41.71 vs 46.62) mmol / L; p = 0.233) and group II ((39.89 vs 52.62) mmol / L; p = 0.006), statistically significant in group II. Increased levels of nitric oxide in group II were greater than group I (∆4.91 vs ∆12.73), and statistically significant; p = 0.001). Conclusion: The used of bay leaf extract (Syzygium polyanthum) 600 mg for 30 days increases nitric oxide levels greater than 400 mg, and is statistically significant.

scholarly journals Efektivitas Desensitizing Agent dengan dan tanpa Fluor pada Metode in Office Bleaching terhadap Kandungan Mineral Gigi (Kajian In Vitro)

2015 ◽  
Vol 21 (2) ◽  
pp. 136
Author(s):  
Yulita Kristanti ◽  
Widya Asmara ◽  
Siti Sunarintyas ◽  
Juni Handajani
Keyword(s):  
Hydrogen Peroxide ◽  
Mineral Content ◽  
Group Iv ◽  
X Ray Diffraction ◽  
Application Process ◽  
Tooth Sensitivity ◽  
Group Iii ◽  
Group I ◽  
Before And After

In office bleaching menggunakan hidrogen peroksida 40% sering memberikan efek samping berupa linu baik selama maupun setelah perawatan tersebut dilakukan. Penelitian ini dilakukan dengan tujuan untuk mengetahui pengaruh waktu aplikasi dan kandungan fluor desensitizing agent pada metode in office bleaching terhadap kandungan mineral gigi. Delapan gigi masing-masing dipotong menjadi 4 bagian, 6 potong digunakan untuk pemeriksaan XRD awal. Gigi dikeringkan dalam oven suhu 50° selama 30 menit diserbuk, diambil 1 mg untuk diperiksa kandungan mineralnya dengan goniometer. Dua puluh empat potong yang lain dibagi dalam 4 kelompok perlakuan. Kelompok I: gigi diaplikasi bahan bleaching 0,5-1 mm hidrogen peroksida 40% selama 1 jam, dicuci, dikeringkan, diikuti aplikasi 0,1 ml desensitizing agent tanpa fluor (CPP-ACP) selama 30 menit, dicuci, dikeringkan. Kelompok II : gigi diaplikasi CPP-ACP 30 menit, dicuci, dikeringkan, dibleaching menggunakan hidrogen peroksida 40% selama 1 jam. Selanjutnya gigi diaplikasi CPP-ACP 30 menit lagi, dicuci, dikeringkan. Kelompok III gigi dibleaching menggunakan hidrogen peroksida 40% selama 1 jam, dicuci, dikeringkan, diikuti aplikasi desensitizing agent yang mengandung fluor (CPP-ACFP) selama 30 menit, dicuci, dikeringkan. Kelompok IV: gigi diaplikasi CPP-ACFP 30 menit, dicuci, dikeringkan, dibleaching menggunakan hidrogen peroksida 40% selama 1 jam. Selanjutnya gigi diaplikasi CPP-ACFP selama 30 menit, dicuci dikeringkan. Sesudah perlakuan, semua gigi dilakukan pemeriksaan kandungan mineral gigi dengan prosedur yang sama. Uji Mann Whitney menunjukkan penurunan mineral paling sedikit terjadi pada kelompok IV (4500). Desensitizing agent mengandung F sebelum dan sesudah perlakuan in office bleaching menunjukkan penurunan mineral paling kecil. The Effectiveness of Desensitizing Agent with and without Fluorine in Office Bleaching Method to Tooth Mineral content. Tooth sensitivity arises during or after an in-office bleaching was performed is usually overcome by using desensitizing agent with or without fluor. So far, desensitizing method applied only reduces tooth sensitivity but it had not overcome demineralization problem yet. This study was aimed to determine the influence of an application process and fluoride containing desensitizing agent in tooth mineral lossEight teeth were divided into four parts. Six specimens were smoothened using agate mortar. One mg of powder was inserted into the sample holder and mounted on goniometer heads to examine mineral content before treatment using X-Ray Diffraction (XRD). Twenty-four specimens were classified into four groups. In group I, 0,1 ml desensitizing agent without fluoride (CPP-ACP) was applied for 30 minutes after an in-office bleaching using 40% Hydrogen Peroxide was performed, while in group II, CPP-ACP was applied before and after an in-office bleaching was performed. In group III 0,1 ml fluoride containing desensitizing agent (CPP-ACFP) was applied for 30 minutes after in-office bleaching using 40% Hydrogen Peroxide was performed, while in group IV fluoride containing desensitizing agent was applied before and after an in-office bleaching was performed. Finally, all of the specimens were measured in their after-treatment mineral contain. Mann Whitney test showed that the lowest mineral lost was detected in group IV (4500). Fluoride containing desensitizing agent applied before and after an in-office bleaching effectively reduced mineral loss.

scholarly journals Simulation of endothelium-dependent vasodilation in young male persons based on the parameters of body weight components

2021 ◽  
Vol 23 (6) ◽  
pp. 784-790
Author(s):  
O. P. Kentesh ◽  
M. I. Nemesh ◽  
O. S. Palamarchuk ◽  
Yu. M. Savka ◽  
Ya. I. Slyvka ◽  
...  
Keyword(s):  
Body Weight ◽  
Brachial Artery ◽  
Young Male ◽  
Group Iii ◽  
Occlusion Test ◽  
Group I ◽  
Before And After ◽  
Group Ii ◽  
Total Fat ◽  
Total Body

The aim of the work. To analyze the results of endothelium-dependent vasodilation of the brachial artery in persons with different content of body weight components and to develop models for predicting the response of endothelium-dependent vasodilation based on the parameters of body weight components. Materials and methods. In total, 31 young men were examined and divided into three groups depending on the total body fat value: 16 people (51.6 %) – group I, 11 people (35.5 %) – group II and 4 people (12.9 %) – group III. Determination of such parameters as body mass index (BMI, kg/m2), the percentage of total fat (TFP, %), the visceral fat content (VFC, units) and the content of free-fat mass (FFM,%) was performed using a bioimpedance analyzer TANITA BC-601. Endothelial regulation was assessed on the basis of vasomotor dilation of the brachial artery activity before and after the occlusion test using a four-channel rheograph ReoCom (XAI-MEDICA). Results. During the occlusion test, three types of endothelium-dependent vasodilation (EDVD) were identified in individuals exa­mined. 62.50 % of men in group I had a normoergic reaction of the brachial artery, 31.25 % had a hyperergic and 6.25 % had a hypoergic reaction. Among group II persons, a normoergic type of post-occlusive reaction was in 45.4 %, hyperergic – in 36.4 %, and hypoergic type – in 18.2 %. Regarding group III, 75 % of individuals had the hyperergic type of endothelium-dependent vasodilation, 25 % had the normoergic type, and no hypoergic type of reaction was observed at all. To determine the endothelial vasoregulatory function on the basis of correlation-regression analysis, models were constructed with coefficients of determination R2 of 0.277 (BMI), 0.126 (TFP), 0.189 (VFC) and 0.146 (FFM). The models themselves had the following form: between EDVD and BMI – y = -4.5297 + 0.865x; TFP – y = 10.7389 + 0.4x; VFC – y =13.8119 + 1.0041x; FFM – y = 52.7904 – 0.4464x. In addition, statistically significant correlations were found between them – from r = +0.335 to r = +0.526. Conclusions. The data obtained allow us to note that the functional state of the endothelium and its activity depends on the content of body weight components in the organism.

Adrenocortical Insufficiency and Relapsing in the Idiopathic Nephrotic Syndrome of Childhood

PEDIATRICS ◽  
1977 ◽  
Vol 60 (3) ◽  
pp. 334-342
Author(s):  
Seppo Leisti ◽  
Jussi Vilska ◽  
Niilo Hallman
Keyword(s):  
Nephrotic Syndrome ◽  
Idiopathic Nephrotic Syndrome ◽  
Adrenocortical Function ◽  
Group Iii ◽  
Group I ◽  
Before And After ◽  
Basal Plasma ◽  
Consistent Change ◽  
Insulin Test ◽  
Group Ii

Twenty-five children with "minimal change" idiopathic nephrotic syndrome (INS) were given ACTH tests before, during, and after prednisone medication (total of 55 medication episodes). Most had insulin tests, too. Continuous medication caused a significant decrease in the responses of all children. A significant recovery was universally evident already at the end of intermittent medication. No further consistent change was observed during remission six months later. Both before and at the end of the medication, one third of the children had subnormal responses. The children were grouped according to the length of the ensuing remission: group I, &lt; 0.5 year; group II, 0.5 to 1.0 year; group III, &gt; 1.0 year. Both before and after medication the basal plasma cortisol concentration and the responses to ACTH and insulin were significantly higher in group III than in group I. At the end of the medication the responses were also significantly higher in group II than in group I. A normal response predicted a &gt; 0.5-year remission and a subnormal response a &lt; 0.5-year remission. This was true for 20 of 27 responses to ACTH before medication, and for 23 of 27 responses at the end of the medication. For the insulin test, only the response at the end of the medication was significantly predictive (16 of 18). An analysis with the ACTH test of two to six consecutive relapses in 14 children confirmed the value of the adrenocortical state in predicting the length of remission. The postmedication tests were superior to the premedication tests in predictive value. Children with postmedication adrenocortical suppression should be detected and given an appropriate cortisol substitution until their adrenocortical function has normalized. Other schedules of glucocorticoid medication of INS should be evaluated for lesser adrenocortical suppression.

Prolactin dynamics in patients with non-secreting tumours of the hypothalamic-pituitary region

1985 ◽  
Vol 110 (1) ◽  
pp. 10-16 ◽  
Author(s):  
Antonino Barbarino ◽  
Laura De Marinis ◽  
Antonio Mancini ◽  
Edoardo Menini ◽  
Colomba D'Amico ◽  
...  
Keyword(s):  
Surgical Treatment ◽  
Positive Response ◽  
Dynamic Tests ◽  
Group Iii ◽  
Reliable Tool ◽  
Group I ◽  
Before And After ◽  
Tumour Group ◽  
Group Ii ◽  
Plasma Prl

Abstract. Twenty-four patients with non-secreting tumours of the hypothalamic-pituitary region, diagnosed by radiographic procedures and confirmed at surgery, were examined before and after the surgical treatment to establish a correlation between Prl responsiveness to dynamic tests and the location of pathological tissue. Three groups of patients were identified. In 10 patients with an intrasellar tumour (group I), Prl had a positive response to TRH, metoclopramide (MCP), and nomifensine (NOM), both pre- and postoperatively. In 4 patients with tumours located entirely in the hypothalamus (group II), Prl responded to TRH, but remained unresponsive to MCP and NOM. Only a partial normalization of the Prl responses was obtained after surgery. Finally, 10 patients had an intra- and extrasellar tumour (group III). In 8 of them Prl responded to TRH, but the increment was lesser than that observed in hypothalmic tumours. Prl did not respond to MCP and NOM. After surgery, Prl responsiveness reappeared in some patients (6 after TRH, 4 after MCP, 3 after NOM). In 2 patients with extensive pituitary damage, Prl did not respond to all dynamic tests pre- or postoperatively. In conclusion, Prl dynamic tests are a reliable tool for studying the altered control of Prl secretion in these patients, since plasma Prl stems from only normal lactotropes surrounding the tumoural tissue. The location of the tumour has a key role in influencing the pattern of Prl response to direct and indirect dynamic tests.

scholarly journals THE EFFECT OF VARIOUS DESENSITIZING AGENT APPLICATION ON IN-OFFICE BLEACHING ON THE NUMBER OF FIBROBLASTS

2021 ◽  
Vol 8 (1) ◽  
pp. 132
Author(s):  
Nunik Rahayu Apriliyani ◽  
Ema Mulyawati ◽  
Yulita Kristanti
Keyword(s):  
Hydrogen Peroxide ◽  
Control Group ◽  
Dentinal Tubule ◽  
Group Iii ◽  
Group I ◽  
Before And After ◽  
Maxillary Molar ◽  
Molar Teeth ◽  
Mean Differences ◽  
Almost All

Background: Reactive Oxygen Species (ROS) released from hydrogen peroxide causes inflammation of the pulp. Remineralization action by fluoride-containing desensitizing agent (Casein Phosphopeptides-Amorphous Calcium Fluoride Phosphate/CPP-ACFP) occluding dentinal tubule, thereby minimizing the penetration of hydrogen peroxide into the pulp and affect the number of fibroblasts. The aim of this study was to determine the effect of fluoride-containing desensitizing agent (CPP-ACFP) application: before, after, and before-after in-office bleaching techniques using 40% hydrogen peroxide on the number of fibroblasts.Method: Twenty-eight maxillary molar teeth were divided into 4 groups, Control Group (bleaching treatment), Group I (CPP-ACFP application before bleaching), Group II (CPP-ACFP application after bleaching), and Group III (CPP-ACFP application before and after bleaching). Rats were sacrificed 5 days after and histological preparations were stained with HE. Fibroblasts counting was performed using a 1000x magnification light microscope.Result: ANOVA test showed that there were significant mean differences in the number of fibroblasts among the groups. The LSD test showed that there were statistically significant differences in almost all of the compared groups except between the Control Group and Group II.Conclusion: The number of fibroblasts in the pulp of rats applied CPP-ACFP before and after in-office bleaching was less than applied CPP-ACFP before or after in-office bleaching.

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