scholarly journals Uso do nitrato de cério associado ao colágeno e alginato de cálcio no tratamento das queimaduras: uma série de casos

2019 ◽  
Vol 78 (16) ◽  
Author(s):  
José Aldari Lima ◽  
Roberta Araújo Montana
Keyword(s):  
Rio De Janeiro ◽  
Tissue Repair ◽  
Healing Process ◽  
Clinical Signs ◽  
Repair Process ◽  
Treatment Center ◽  
Innovative Technology ◽  
Burn Treatment ◽  
Bovine Collagen ◽  
Specialized Care

Introdução: O tratamento das queimaduras é considerado um grande desafi o para os profi ssionais da área de saúde.Cada vez mais, a indústria produz e disponibiliza para o mercado novos produtos com tecnologia inovadora paratratamento de lesões, que permitem redução do número de trocas dos curativos e da dor, maior conforto e queaceleram o processo de reparo tecidual da pele. O objetivo deste estudo foi avaliar o processo de reparo tecidualde queimaduras de 2º grau superfi cial e intermediário em uso de um curativo biológico composto por nitrato decério, colágeno bovino e alginato de cálcio. Método: Trata-se de uma série de seis casos. A coleta de dados foirealizada de dezembro de 2013 a maio de 2014, por médicos e enfermeiros do Centro de Tratamento de Queimadosde um hospital municipal do Rio de Janeiro/RJ. Resultados: Em todos os casos acompanhados as queimadurasapresentaram melhora no processo de reparo tecidual e da dor e não foram evidenciados sinais clínicos de infecçãodurante as trocas de curativos. Conclusão: O uso de um curativo biológico e de alta tecnologia, aliado ao cuidadoespecializado do paciente queimado, trazem mais benefícios para o processo de cicatrização da queimadura e paraa saúde do paciente.Descritores: Queimaduras; Cicatrização; Ferimentos e Lesões. ABSTRACTIntroduction: Burns treatment is still a major challenge for health professionals. Increasingly, industry producesand provides to the market, new products with innovative technology for the treatment of lesions that enablereduction in the number of dressing changes and pain, increase comfort and accelerate the skin tissue repairprocess. The aim of this study was to evaluate the tissue repair process of superfi cial and intermediate 2nddegree burns with the use of a biological dressing composed of cerium nitrate, bovine collagen and calciumalginate. Method: This is a series of 06 cases. Data collection was conducted from December 2013 to May 2014by doctors and nurses from the Burn Treatment Center of a Rio de Janeiro Municipal Hospital. Results: In allcases followed, burns showed improvement in tissue repair process and pain and have not shown clinical signs ofinfection during dressing changes. Conclusion: We conclude that the use of a high technology biological dressingcombined with burned patients specialized care, brings greater benefi ts to the healing process of burns and alsofor patient health.Keywords: Burns; Wound Healing , Wounds and Injuries

scholarly journals Antisettici e controllo della carica batterica nelle ulcere venose/Antiseptics and control of bacterial load in venous ulcers

2018 ◽  
Vol 2 (2) ◽  
Author(s):  
Giuseppe Nebbioso ◽  
Ciro Falasconi ◽  
Viviana Nebbioso ◽  
Francesco Petrella
Keyword(s):  
Tissue Repair ◽  
Chronic Wound ◽  
Early Stage ◽  
Bacterial Load ◽  
Repair Process ◽  
Local Infection ◽  
Bacterial Burden ◽  
Venous Ulcers ◽  
Systemic Antibiotic Therapy ◽  
And Control

L’insorgenza di infezione su una lesione cutanea cronica determina un arresto del processo di riparazione tessutale e impone l’instaurazione di una terapia antibiotica sistemica che, in una fase iniziale, sarà empirica e, dunque, non scevra di insuccessi. L’utilizzo di antimicrobici con ridotto potere citotossoco/istiolesivo può essere considerata, in molti casi, una valida alternativa per il controllo della carica batterica e dell’infezione locale. L’associazione di antimicrobici a base di poliesanide biguanide, betaina e cadexomero iodico, in molti casi, permette di controllare/ridurre la carica batterica e l’infezione locale fungendo da starter per la ripresa del processo di riparazione tessutale. The onset of infection on a skin ulcer (chronic wound) leads to a halt in the tissue repair process and requires a systemic antibiotic therapy which, at an early stage, will be empirical and, therefore, not free from setbacks. The use of antimicrobials with reduced cytotoxic/histiolesive power can be considered, in many cases, a valid alternative for bacterial burden and local infection control. The combination of antimicrobials based on polystyrene biguanide, betaine and iodine cadexomer, in many cases, allows to control/reduce the bacterial burden and local infection by acting as a starter for the resumption of the tissue repair process.

Platelets in tissue repair: control of apoptosis and interactions with regenerative cells

Blood ◽  
2013 ◽  
Vol 122 (15) ◽  
pp. 2550-2554 ◽  
Author(s):  
Meinrad Gawaz ◽  
Sebastian Vogel
Keyword(s):  
Cell Survival ◽  
Tissue Repair ◽  
Molecular Mechanisms ◽  
Healing Process ◽  
Critical Role ◽  
Cellular Migration ◽  
Tissue Repair And Regeneration ◽  
Primary Hemostasis ◽  
Regenerative Cells ◽  
Insight Into

Abstract Besides mediating primary hemostasis and thrombosis, platelets play a critical role in tissue repair and regeneration. They regulate fundamental mechanisms involved in the healing process including cellular migration, proliferation, and angiogenesis. Control of apoptosis/cell survival and interaction with progenitor cells, which are clinically relevant but poorly understood aspects of platelets in tissue repair, will be highlighted in this review. Gaining deeper insight into the less well-characterized molecular mechanisms is necessary to develop new therapeutic platelet-based options.

scholarly journals Losartan no tratamento das lesões musculares

2021 ◽  
Vol 12 (2) ◽  
pp. 26-28
Author(s):  
Filipe Cabral ◽  
◽  
Pedro Barata ◽  
Keyword(s):  
Functional Capacity ◽  
Sports Medicine ◽  
Muscle Injury ◽  
Healing Process ◽  
Repair Process ◽  
Muscle Repair ◽  
Muscle Injuries ◽  
Fibrotic Scar ◽  
Tgf Β1 ◽  
Injury Recurrence

Muscle injuries are very common in sports medicine. Frequently the muscle repair process ends in the formation of a fibrotic scar, that not only limits the complete functional recovery, but also increases the likelihood of injury recurrence. TGF-β1 is the main profibrogenic factor involved in this healing process. By blocking its activity, Losartan has proven it efficacy in reducing fibrosis and increasing regenerative and functional capacity post muscle injury. Therefore, its use should be considered as an alternative therapeutic for this kind of injuries.

scholarly journals Dynamics of the Activity of MAP-Kinase Cascades in the Healing Process of Postoperative Musculocutaneous Wounds

2019 ◽  
Vol 4 (5) ◽  
pp. 55-59
Author(s):  
I. A. Shurygina ◽  
V. A. Umanets ◽  
M. G. Shurygin
Keyword(s):  
Map Kinase ◽  
Healing Process ◽  
Traumatic Injury ◽  
Repair Process ◽  
Modern Medicine ◽  
Peak Activity ◽  
Specific Staining ◽  
Mapk Cascades ◽  
Reparative Process ◽  
The Impact

Background. Management of the reparative process is an urgent task of modern medicine. In our opinion, the development of pathogenetically grounded approaches to optimizing the repair process for managing the interrelations of stromal cells is promising. One of the promising areas in this regard is the impact on the MAPK-cascades.Aim: to study the expression of MAP-kinase mechanisms in the regulation of repair by the example of a musculocutaneous wound.Methods. A linear muscular skin wound was modeled using Wistar rats weighing 220–250 g at the age of 9 months (n = 24). Immunofluorescence staining was performed to detect the activity of p38, JNK, and ERK MAPK cascades from 1 to 30 days.Results. It was established that specific staining in the area of connective tissue formation during staining with p38 MAPK and its phosphorylated form was first observed on the 3rd day, and its maximum severity occurred at the same time. On the 7th and 14th day, small zones in the area of scar formation were minimally stained. The phosphorylated part of the JNK-cascade in the zone of traumatic injury was detected starting from the 1st day after the injury. Bright color persisted on the 3rd day. On the 7th day, the color was minimal, and by the 14th day a second wave of expression was observed. ERK-staining was observed from the 1st to the 14th day with a peak activity on the 3rd day.Conclusion. Thus, we revealed the simultaneous involvement of p38, JNK-, and ERK-cascades in the regulation of the reparative process in the conditions of a musculoskeletal wound. At the same time, it is noteworthy that the peak activity of all cascades coincides and falls on the 3rd day.

scholarly journals Bee Pollen as a Promising Agent in the Burn Wounds Treatment

2016 ◽  
Vol 2016 ◽  
pp. 1-12 ◽  
Author(s):  
Paweł Olczyk ◽  
Robert Koprowski ◽  
Justyna Kaźmierczak ◽  
Lukasz Mencner ◽  
Robert Wojtyczka ◽  
...  
Keyword(s):  
Quantitative Research ◽  
Healing Process ◽  
Physiological Saline ◽  
Healing Time ◽  
Wound Healing Process ◽  
Burn Treatment ◽  
Bee Pollen ◽  
Domestic Pigs ◽  
Burn Wounds ◽  
Number Of Microorganisms

The aim of the present study was to visualize the benefits and advantages derived from preparations based on extracts of bee pollen as compared to pharmaceuticals commonly used in the treatment of burns. The bee pollen ointment was applied for the first time in topical burn treatment. Experimental burn wounds were inflicted on two white, domestic pigs. Clinical, histopathological, and microbiological assessment of specimens from burn wounds, inflicted on polish domestic pigs, treated with silver sulfadiazine or bee pollen ointment, was done. The comparative material was constituted by either tissues obtained from wounds treated with physiological saline or tissues obtained from wounds which were untreated. Clinical and histopathological evaluation showed that applied apitherapeutic agent reduces the healing time of burn wounds and positively affects the general condition of the animals. Moreover the used natural preparation proved to be highly effective antimicrobial agent, which was reflected in a reduction of the number of microorganisms in quantitative research and bactericidal activity of isolated strains. On the basis of the obtained bacteriological analysis, it may be concluded that the applied bee pollen ointment may affect the wound healing process of burn wounds, preventing infection of the newly formed tissue.

P5374Genetic deletion of IL-22 increased cardiac rupture after myocardial infarction in mice

2019 ◽  
Vol 40 (Supplement_1) ◽  
Author(s):  
M Yamamoto ◽  
H Yasukawa ◽  
J Takahashi ◽  
S Nohara ◽  
T Sasak ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Real Time ◽  
Real Time Pcr ◽  
Tissue Repair ◽  
Repair Process ◽  
Cardiac Rupture ◽  
Blue Dye ◽  
Border Area ◽  
Infarct Area

Abstract Background Interleukin-22 (IL-22) is a member of the IL-10 cytokine family, which mainly targets epithelial cells and does not target immune cells. Recently, it has been reported that IL-22 play roles in tissue repair in the skin and the liver; however, role of IL-22 in the process of tissue repair after myocardial infarction (MI) is unknown. Here, we investigated the role of IL-22 in tissue repair process after MI. Methods and results First, we examined the expression of IL-22 and its receptor IL-22RA1 in the wild type (WT) mice by real-time PCR. The expression of IL-22 and IL-22RA1 in the hearts were significantly increased 3 days after MI (p<0.05). To clarify the role of IL-22 in the heart after MI, we produced MI model in the WT mice and IL-22 knockout (KO) mice. We found that the IL-22 KO mice had significantly higher mortality than the WT mice after MI (p<0.05). Approximately 80% of the IL-22 KO mice died with cardiac rupture after MI. The infarct size which was estimated by evans blue dye and triphenyltetrazolium chloride staining at 3 days after MI was comparable between the IL-22 KO mice and the WT mice. Next, we performed real time PCR and PCR array analysis for tissue fibrosis and repair genes. We found that alpha-smooth muscle actin (aSMA), NF-kB, TNF-a and MMP13 (also known as collagenase-3) were significantly increased in the infarct area of IL-22 KO mice compared to WT mice. Immunostaining showed that the myofibroblast marker aSMA positive cells in the border area after MI were markedly higher in the IL-22 KO mice compared with the WT mice (p<0.05). Approximately 70% of cardiac rupture after MI in the IL-22 KO mice were occurred in the infarct area adjacent to the border area. Furthermore, we found aSMA positive cells and MMP13 positive cells around the ruptured site of the heart. Conclusion Thus, IL-22 KO mice exhibit high mortality and increased cardiac rupture after MI. And expression of aSMA and MMP13 were highly expressed in the ruptured site after MI in the IL-22 KO mice. These results suggest that IL-22 may play an important role in the tissue repair process after MI.

Physiology of Wound Healing and Risk Factors that Impede the Healing Process

1990 ◽  
Vol 1 (3) ◽  
pp. 545-552 ◽  
Author(s):  
Susan O’Brien Norris ◽  
Barbara Provo ◽  
Nancy A. Stotts
Keyword(s):  
Diabetes Mellitus ◽  
Wound Healing ◽  
Tissue Repair ◽  
Wound Repair ◽  
Healing Process ◽  
Critically Ill Patient ◽  
Wound Complications ◽  
Care Environment ◽  
Patient Morbidity ◽  
Illness Knowledge

In the critically ill patient, wound repair can be impeded by processes inherent to the illness, its treatment, and the critical care environment. This vulnerability to wound complications increases patient morbidity and mortality as well as length of stay, resource consumption, and hospital cost. The physiology of wound healing and factors that impede wound repair are discussed. Those factors commonly seen in critical illness include advanced age, diabetes mellitus, compromised immunocompetence, inadequate perfusion, and oxygenation, infection, malnutrition, obesity, and preoperative illness. Knowledge of management of the physiologic factors that affect wound healing enables the nurse to maximize tissue repair and prevent wound complications

Rescue of a deep burned elbow using a radial forearm pedicled flap, an original irrigation system and a specific immobilization

2020 ◽  
Author(s):  
Marie Benayoun ◽  
Marie-Charlotte Dutot ◽  
Céline Aboud ◽  
Kévin Serror ◽  
Marc Chaouat ◽  
...  
Keyword(s):  
Irrigation System ◽  
Case Reports ◽  
Donor Site ◽  
Drainage System ◽  
Complete Recovery ◽  
Pedicled Flap ◽  
Treatment Center ◽  
Burn Treatment ◽  
Efficient Treatment ◽  
Radial Forearm

Abstract Introduction Deep soft tissue defects next to the joints can rapidly lead to irreversible damages and have to be covered urgently and effectively. In severely burned patients the usual approach is to use a flap even though it has its limitations in regards to the extent of the burn and the general condition of the patient. Case report A twenty seven-year-old male was admitted at the Burn Treatment Center for a thermic burn of seventy-two percent of his body surface area. At first he has benefited from several skin grafts and later on a major open right elbow had to be treated urgently to rescue the joint. Results After the burn, a revascularization of the donor site was noticed, sufficient to use the radial forearm pedicled flap as a cover for the elbow. This case reports an innovative approach based on the use of an irrigation and drainage system placed underneath the flap. The elbow was rigidly immobilized with an external fixator in order to facilitate an optimal healing of the flap. Conclusion In this case, the choice of this flap, combined with the irrigation and drainage system and the immobilization by external fixation, provided an original and efficient treatment. Post operatively the healing of the flap and of the donor site was complete. The functional results exceeded the expectations with a complete recovery of the joint amplitude. Thus, in case of no other therapeutic options, it is probably possible to use a variety of flaps recently healed.

Keimbesiedlung von chronischen Ulcera cruris: Unterscheidet sich das diabetische vom venösen und arteriellen Geschwür?

VASA ◽  
2000 ◽  
Vol 29 (1) ◽  
pp. 62-70 ◽  
Author(s):  
Schmidt ◽  
Debus ◽  
Jeßberger ◽  
Ziegler ◽  
Thiede
Keyword(s):  
Bacterial Growth ◽  
Healing Process ◽  
Clinical Signs ◽  
The Other ◽  
Leg Ulcers ◽  
Diabetic Ulcers ◽  
Venous Ulcers ◽  
Positive Smear ◽  
Diabetic Wounds ◽  
The Impact

Background: At the Surgical Department of Surgery of the University Hospital Würzburg microbiological examinations were performed of the ulcer grounds from patients with diabetic-neuropathic, diabetic-ischemic, venous, and arterial leg ulcers. The aim of the examination was to evaluate possible differences in the healing process of these ulcers based on the knowledge of their bacterial populations. Patients and methods: In a period of four months, 63 patients were consecutively examined by taking a bacteriological swab of their ulcer area. The healing process of their wounds was followed and related to the impact of bacterial colonisation and clinical signs of infection. Results: 95% of the venous and arterial leg ulcers had a positive smear, whereas only 70% of diabetic ulcers were positive for bacterial growth. Bacterial population of the three ulcer entities, however did not differ significantly. 100% of the clinically infected venous and arterial ulcers but only 80% of the diabetic wounds revealed a positive smear. On the other hand, only 22% of the venous ulcers with a positive smear developed a clinical infection in contrast to 70% of the arterial and diabetic. Venous ulcers showed only in a few patients prolonged healing, even in cases of marked bacterial contamination. Despite of clinical signs of infection however, diabetic wounds sometimes did not reveal a positive wound smear (20%). All infected venous, but only 20% of the infected ischemic ulcers healed satisfactorily. Arterial wounds with no bacterial growth healed significantly better than contaminated wounds. This difference was not significant in the other entities. Radical removal of the infection by minor amputation increased the healing rate in diabetic ulcers over 80%, whereas ischemic wounds did not profit from this therapy. Conclusions: A positive bacterial wound smear is not inevitably correlated with a protracted leg ulcer healing. Nevertheless a fulminant infection often developed in diabetic ulcers despite the initial inability to demonstrate bacterial growth. In order to start antibiotic treatment as early as possible, a wound smear should be obtained routinely from patients with diabetic ulcers. In chronic venous ulcers, a routine swab does not appear to be indicated as it bears no clinical consequences. The same applies to patients with surgically fully treated peripheral arterial occlusive disease. As ischemia presents the limiting factor, antibiotic therapy in case of infection will not prevent imminent amputation.

scholarly journals Learning clinical skills through audiovisual aids embedded in electronic-PBL sessions in undergraduate medical curriculum: perception and performance

2019 ◽  
Vol 43 (3) ◽  
pp. 378-382
Author(s):  
Shoukat Ali Arain ◽  
Nasir Ali Afsar ◽  
Dileep Kumar Rohra ◽  
Muhammad Zafar
Keyword(s):  
Classroom Environment ◽  
Medical Curriculum ◽  
Clinical Skills ◽  
Intervention Group ◽  
Clinical Signs ◽  
Innovative Technology ◽  
Control Group ◽  
Undergraduate Medical Students ◽  
Audiovisual Aids ◽  
And Performance

Learning clinical skills in a large group of undergraduate medical students is challenging. Innovative technology-based modalities are being evaluated to complement limited hospital rotations. We determined the effectiveness of clinical skills-related audiovisual (AV) aids embedded in electronic-problem-based learning (PBL) sessions, in terms of students’ feedback and formative Objective Structured Clinical Examinations (OSCE) grades. This mixed-method study was conducted during the Cardiovascular System module in year 3 of the Bachelor of Medicine, Bachelor of Surgery program. The AV aids, mainly consisting of abnormal chest auscultation sounds, were linked to the cases for the intervention group. The control group received only a description of clinical signs. Sessions were conducted using an intranet platform. At the end of the module, feedback was obtained from intervention group students and faculty using a self-administered questionnaire. The learning was compared between intervention and control groups through an OSCE. Finally, focus group interviews were conducted to explore factors underlying deviation from the expected results. Out of 110 intervention group students, 86 (78%) responded. The students appreciated the inclusion of AV aids, as suggested by a high average satisfaction score of 4.2 (SD 0.8). They agreed that, apart from being appropriate and relevant, the aids improved the learning environment and engagement in the process. The tutors also gave a similar feedback. However, no difference in the OSCE scores was found between control and intervention groups. The study indicates that inclusion of AV aids improved students’ engagement and classroom environment in electronic-PBL sessions, but did not improve diagnostic abilities based on the learned clinical skills.

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