scholarly journals Antisettici e controllo della carica batterica nelle ulcere venose/Antiseptics and control of bacterial load in venous ulcers

2018 ◽  
Vol 2 (2) ◽  
Author(s):  
Giuseppe Nebbioso ◽  
Ciro Falasconi ◽  
Viviana Nebbioso ◽  
Francesco Petrella
Keyword(s):  
Tissue Repair ◽  
Chronic Wound ◽  
Early Stage ◽  
Bacterial Load ◽  
Repair Process ◽  
Local Infection ◽  
Bacterial Burden ◽  
Venous Ulcers ◽  
Systemic Antibiotic Therapy ◽  
And Control

L’insorgenza di infezione su una lesione cutanea cronica determina un arresto del processo di riparazione tessutale e impone l’instaurazione di una terapia antibiotica sistemica che, in una fase iniziale, sarà empirica e, dunque, non scevra di insuccessi. L’utilizzo di antimicrobici con ridotto potere citotossoco/istiolesivo può essere considerata, in molti casi, una valida alternativa per il controllo della carica batterica e dell’infezione locale. L’associazione di antimicrobici a base di poliesanide biguanide, betaina e cadexomero iodico, in molti casi, permette di controllare/ridurre la carica batterica e l’infezione locale fungendo da starter per la ripresa del processo di riparazione tessutale. The onset of infection on a skin ulcer (chronic wound) leads to a halt in the tissue repair process and requires a systemic antibiotic therapy which, at an early stage, will be empirical and, therefore, not free from setbacks. The use of antimicrobials with reduced cytotoxic/histiolesive power can be considered, in many cases, a valid alternative for bacterial burden and local infection control. The combination of antimicrobials based on polystyrene biguanide, betaine and iodine cadexomer, in many cases, allows to control/reduce the bacterial burden and local infection by acting as a starter for the resumption of the tissue repair process.

Avaliação do Efeito da Microcorrente na Reparação de Feridas Cutâneas em Ratos

UNICIÊNCIAS ◽  
2018 ◽  
Vol 22 (2) ◽  
pp. 62
Author(s):  
Belle Virginia Da Silva Coimbra Rodrigues ◽  
Suellen Borges de Souza ◽  
Thayanne Caroline Pereira Munhoz ◽  
Gracieli Nonato Bressanin ◽  
Alessandra Aparecida Cunha Lopes ◽  
...  
Keyword(s):  
Tissue Repair ◽  
Specific Treatment ◽  
Low Frequency ◽  
Repair Process ◽  
Skin Lesions ◽  
Treated Group ◽  
Therapeutic Modality ◽  
Cervical Region ◽  
Control Group ◽  
And Control

A bioeletricidade tem se tornado cada vez mais reconhecida no mundo científico devido a sua importante contribuição na cicatrização de feridas. Dentro desta modalidade terapêutica está inserida a terapia com microcorrente, que por ter baixa frequência e pequena intensidade é capaz de promover o restabelecimento do potencial elétrico das células. Por se tratar de uma corrente de elevado potencial, durante o processo de reparação tecidual, esta pode atuar tanto na fase inflamatória quanto na proliferativa. Dessa maneira, este estudo teve por objetivo principal avaliar a resposta cicatricial quanto ao efeito da microcorrente em lesões cutâneas em ratos. Para tanto, foram utilizados 28 ratos Wistar, divididos em dois grupos: grupo tratado (GT) e grupo controle (GC). Os animais de ambos os grupos foram submetidos a procedimento cirúrgico de lesão cutânea região cervical dorsal, seguido de tratamento com microcorrente durante 21 dias no GT, e sem tratamento específico no GC. Também foi realizada a avaliação termográfica a cada três dias de todos os animais. Após este período, foi feita eutanásia com posterior coleta de pele na região da lesão para avaliação histopatológica. Os resultados obtidos mostraram, a partir dos parâmetros analisados, a presença de um recurso capaz de incrementar a formação de novos vasos, embora não apresentasse efeito significativo em relação à proliferação de fibroblastos. Diante disso, sugere-se que a utilização da microcorrente possa ter favorecido a neovascularização nos tecidos dos animais analisados. Palavras-chave: Rato. Microcorrente. Angiogênese. Reparo tecidual. AbstractBioelectricity has become increasingly recognized in the scientific world because of its important contribution to wound healing. Within this therapeutic modality the therapy with microcurrent is inserted, which because of low frequency and small intensity is able to promote the reestablishment of the cells electric potential. Because it is a  high potential v during the tissue repair process, it can act both in the inflammatory and proliferative phases. Thus, this study had as main objective to evaluate the healing response regarding the microcurrent effect  on rats’ skin lesions. For this, 28 Wistar rats were divided into two groups: treated group (GT) and control group (CG). The animals of both groups underwent a surgical procedure of skin lesion in the dorsal cervical region, followed by treatment with microcurrent for 21 days in the GT, and without specific treatment in the CG. A thermographic evaluation was also performed every three days of all the animals. After this period, euthanasia was performed with subsequent skin collection in the lesion region for histopathological evaluation. The obtained results showed, from the analyzed parameters, the presence of a resource able to increase the  new vessels formation, although it did not present significant effect in relation to the  fibroblasts proliferation. Therefore, it is suggested that the use of microcurrent may have favored neovascularization in the tissues of the animals analyzed.Keywords: Mouse. Microcurrent. Angiogenesis. Tissue repair. 

scholarly journals Autologous and homologous skin grafts treated with platelet-rich plasma (PRP): experimental study in rabbits

2018 ◽  
Vol 38 (9) ◽  
pp. 1818-1823 ◽  
Author(s):  
Bernardo Kemper ◽  
Cláudia V.S. Brandão ◽  
Victor J.V. Rossetto ◽  
Lucas F.S. Gushiken ◽  
Carlos R. Padovani ◽  
...  
Keyword(s):  
Initial Phase ◽  
Tissue Repair ◽  
Early Stage ◽  
Platelet Rich Plasma ◽  
Repair Process ◽  
Positive Influence ◽  
Collagen Fibers ◽  
Autologous Graft ◽  
Cosmetic Appearance ◽  
Hematoxylin Eosin

ABSTRACT: The aim of the present study was to compare tissue repair of skin defects in rabbits submitted to autologous and homologous grafts treated or not with platelet-rich plasma (PRP). We selected nine rabbits and constituted four groups, designated as G1, in which were performed autologous graft treated with PRP; G2, autologous graft only; G3, homologous graft treated with PRP; and G4, homologous graft only. Macroscopic and histomorphometric evaluation was realized. The histomorphometric evaluation was performed by Hematoxylin/Eosin and Masson´s Trichrome staining with quantification of collagen fibers, macrophages, fibroblasts and vessels. The autologous graft treated with PRP showed positive influence on the early stage of the tissue repair process at the macroscopic evaluation, characterized by rosy color and cosmetic appearance. At the histomorphometric evaluation, there was no statistical difference in the number of macrophages and fibroblasts between the treated grafts or not with the PRP, as well as the quantification of vessels and collagen fibers. It can be concluded that PRP promotes a positive influence on the initial phase or “take” of the graft.

Environmental technology: Fluidised-bed steam dryers — latest developments and practical experience

2016 ◽  
pp. 86-90
Author(s):  
Gerald Caspers ◽  
Klaus Nammert ◽  
Holger Fersterra ◽  
Hartmut Hafemann
Keyword(s):  
Data Acquisition ◽  
Early Stage ◽  
Practical Experience ◽  
Great Depth ◽  
Fluidised Bed ◽  
Operating Data ◽  
Beet Pulp ◽  
Improved Design ◽  
Distribution Plate ◽  
And Control

Fluidised-bed steam dryers have been in use for industrial-scale drying of pressed beet pulp for more than 20 years. This highly energy-efficient process can be considered to be state of the art in the industry. Scientific laboratory and pilot-plant testing have provided the basis for a detailed description of the principles of fluidisation and drying in superheated water vapour. Advances in production data acquisition, in particular regarding the options for the real-time presentation and evaluation of high-resolution operating data (Industry 4.0), have opened up new potentials for optimisation of the drying process in fluidised-bed steam dryers. By analysing and interpreting sequences of events, or simultaneous events, it is now possible to analyse process behaviour in great depth. This allows malfunctions to be avoided by improved design or, assisted by suitable measuring and control systems, to be detected at an early stage. Failures can then be prevented altogether by initiating automated countermeasures. On the basis of more recent insights gained from the analysis of faults and disruptions using modern operating data acquisition, BMA’s fluidised-bed steam dryer (WVT) has been subjected to fundamental technological and technical improvements, so it now meets today’s demands for efficiency and reliability. Modifications include the product inlet, the distribution plate and several other parts, in addition to the known and patented PPS (Plug Protection System; EP 2457649 B1), and the patented rotary weir (EP 2146167 B1).

scholarly journals Interactive effects between travel behaviour and COVID-19: a questionnaire study

2021 ◽  
Author(s):  
Jinbao Zhang ◽  
Jaeyoung Lee
Keyword(s):  
Early Stage ◽  
Travel Behaviour ◽  
Interactive Effects ◽  
Factors Affecting ◽  
Individual Level ◽  
Passenger Volume ◽  
Spatial Autoregressive ◽  
Railway Passenger ◽  
The Individual ◽  
And Control

Abstract This study has two main objectives: (i) to analyse the effect of travel characteristics on the spreading of disease, and (ii) to determine the effect of COVID-19 on travel behaviour at the individual level. First, the study analyses the effect of passenger volume and the proportions of different modes of travel on the spread of COVID-19 in the early stage. The developed spatial autoregressive model shows that total passenger volume and proportions of air and railway passenger volumes are positively associated with the cumulative confirmed cases. Second, a questionnaire is analysed to determine changes in travel behaviour after COVID-19. The results indicate that the number of total trips considerably decreased. Public transport usage decreased by 20.5%, while private car usage increased by 6.4%. Then the factors affecting the changes in travel behaviour are analysed by logit models. The findings reveal significant factors, including gender, occupation and travel restriction. It is expected that the findings from this study would be helpful for management and control of traffic during a pandemic.

scholarly journals Quantitative Approach to Fragmented QRS in Arrhythmogenic Cardiomyopathy: From Disease towards Asymptomatic Carriers of Pathogenic Variants

2020 ◽  
Vol 9 (2) ◽  
pp. 545 ◽  
Author(s):  
Rob W. Roudijk ◽  
Laurens P. Bosman ◽  
Jeroen F. van der Heijden ◽  
Jacques M. T. de Bakker ◽  
Richard N. W. Hauer ◽  
...  
Keyword(s):  
Early Stage ◽  
Pathogenic Variant ◽  
Observer Agreement ◽  
Arrhythmogenic Cardiomyopathy ◽  
Fragmented Qrs ◽  
Early Disease Detection ◽  
Pathogenic Variants ◽  
Disease Penetrance ◽  
Ecg Leads ◽  
And Control

Fragmented QRS complexes (fQRS) are common in patients with arrhythmogenic cardiomyopathy (ACM). A new method of fQRS quantification may aid early disease detection in pathogenic variant carriers and assessment of prognosis in patients with early stage ACM. Patients with definite ACM (n = 221, 66%), carriers of a pathogenic ACM-associated variant without a definite ACM diagnosis (n = 57, 17%) and control subjects (n = 58, 17%) were included. Quantitative fQRS (Q-fQRS) was defined as the total amount of deflections in the QRS complex in all 12 electrocardiography (ECG) leads. Q-fQRS was scored by a single observer and reproducibility was determined by three independent observers. Q-fQRS count was feasible with acceptable intra- and inter-observer agreement. Q-fQRS count is significantly higher in patients with definite ACM (54 ± 15) and pathogenic variant carriers (55 ± 10) compared to controls (35 ± 5) (p < 0.001). In patients with ACM, Q-fQRS was not associated with sustained ventricular arrhythmia (p = 0.701) at baseline or during follow-up (p = 0.335). Both definite ACM patients and pathogenic variant carriers not fulfilling ACM diagnosis have a higher Q-fQRS than controls. This may indicate that increased Q-fQRS is an early sign of disease penetrance. In concealed and early stages of ACM the role of Q-fQRS for risk stratification is limited.

scholarly journals Topical Application of Ozonated Oils for the Treatment of MRSA Skin Infection in an Animal Model of Infected Ulcer

Biology ◽  
2021 ◽  
Vol 10 (5) ◽  
pp. 372
Author(s):  
Vanessa Silva ◽  
Cecília Peirone ◽  
Rosa Capita ◽  
Carlos Alonso-Calleja ◽  
José A Marques-Magallanes ◽  
...  
Keyword(s):  
Wound Healing ◽  
Animal Model ◽  
Topical Application ◽  
Early Stage ◽  
Bacterial Load ◽  
Ozone Treatment ◽  
Diabetic Patients ◽  
Colony Forming Units ◽  
Group 2 ◽  
Epidermal Regeneration

Diabetic foot ulcers are a common cause of morbidity in diabetic patients. One of the main pathogens found in these ulcers is methicillin-resistant Staphylococcus aureus (MRSA). MRSA often carries resistance to several classes of antibiotics and their infections are becoming harder to treat. Therefore, new alternatives are urgently needed. Thus, this study aimed to investigate the capacity of topical ozonated oil application on the treatment of early-stage skin infected with MRSA in an animal model. Ozonated oil was prepared from a mixture of oils subjected to a gas stream of O2/O3 mixture. Sixteen Wistar rats were inoculated by an intradermic injection of MRSA suspension, producing an abscess lesion. After 3 days, the skin epidermis was removed to open the wound. Group 1 received an application of oil mixture without ozone treatment and Group 2 received an application of ozonated oil. After the treatment period, skin was collected, colony-forming units (CFU) of bacteria were quantified and the histological analysis of the skin was carried out. Skin samples from the control 1 and 2 had a bacterial load was of 1.1 × 105 and 5.7 × 103 CFU/mL, respectively. Group 2 showed better wound healing from mild to moderate epidermal regeneration. Topical application of ozonated vegetable oil in MRSA-infected skin in rats showed a small reduction of the bacterial load and better wound healing.

scholarly journals Macular vessel density and foveal avascular zone parameters in patients after acute primary angle closure determined by OCT angiography

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Kangcheng Liu ◽  
Huizhuo Xu ◽  
Haibo Jiang ◽  
Hua Wang ◽  
Pingbao Wang ◽  
...  
Keyword(s):  
Early Stage ◽  
Normal Subjects ◽  
Vessel Density ◽  
Foveal Avascular Zone ◽  
Angle Closure ◽  
Acute Primary Angle Closure ◽  
Primary Angle Closure ◽  
Circularity Index ◽  
Avascular Zone ◽  
And Control

Abstract This study analyzed the optical coherence tomography angiography (OCTA) macular parameters in primary angle-closure glaucoma (PACG) patients after acute primary angle closure (APAC) episodes. Thirty-three patients with 33 APAC eyes and 33 primary angle closure suspect (PACS) eyes and 33 age-matched normal subjects (controls) were enrolled. Macular vessel density (VD) in central, inner, outer and full regions and foveal avascular zone (FAZ) parameters (area, perimeter and circularity index) were compared between APAC, PACS, and control eyes. For resolved APAC eyes, the VD in each macular region was significantly lower than that in control eyes, with less central and inner macular VD than PACS eyes. The central macular VD was significantly lower in PACS eyes than in controls. There was no difference in FAZ area and perimeter between APAC, PACS, and control eyes. FAZ circularity was highest in control eyes, followed by PACS eyes, and lowest in APAC eyes. The AUC, sensitivity and specificity of FAZ circularity were 0.944, 93.9% and 84.8%, respectively, in APAC eyes and 0.881, 84.8% and 81.8%, respectively, in PACS eyes. Therefore, FAZ circularity had the best discrimination capability for detecting both APAC and PACS eyes. Macular assessment with OCTA could provide an accurate early-stage diagnostic tool for PACG.

Supporting Co-Design of Physical and Control Architectures of Mechatronic Systems

2011 ◽  
Author(s):  
Andre´s A. Alvarez Cabrera ◽  
Hitoshi Komoto ◽  
Tetsuo Tomiyama
Keyword(s):  
Control Structure ◽  
Mutual Influence ◽  
Early Stage ◽  
Physical Structure ◽  
Mechatronic Systems ◽  
Design Problems ◽  
Software And Hardware ◽  
Design Integration ◽  
And Control ◽  
Recent Tendency

There is a rather recent tendency to define the physical structure and the control structure of a system concurrently when designing the architecture of a product, i.e., to perform codesign. We argue that co-design can only be enabled when the mutual influence between physical system and control is made evident to the designer at an early stage. Though the idea of design integration is not new, to the best of our knowledge, there is no computer tooling that explicitly supports this activity by enabling co-design as stated before. In this paper the authors propose a method for co-design of physical and control architectures as a better approach to design mechatronic systems, allowing to exploit the synergy between software and hardware and detecting certain design problems at an early stage of design. The proposed approach is supported by a set of tools and demonstrated through an example case.

scholarly journals Effectiveness Of 2% And 4% Papain Gels In The Healing Of Venous Ulcers

2015 ◽  
Vol 49 (3) ◽  
pp. 394-400 ◽  
Author(s):  
Andréa Pinto Leite Ribeiro ◽  
Beatriz Guitton Renaud Baptista de Oliveira ◽  
Marja Ferreira Soares ◽  
Bruna Maiara Ferreira Barreto ◽  
Débora Omena Futuro ◽  
...  
Keyword(s):  
Experimental Study ◽  
Teaching Hospital ◽  
Clinical Assessment ◽  
Outpatient Clinic ◽  
Tissue Repair ◽  
Average Decrease ◽  
Consecutive Sample ◽  
Venous Ulcers ◽  
Quasi Experimental ◽  
Original Size

OBJECTIVE To analyze the effectiveness of 2% and 4% papain gels in tissue repair of venous ulcers. METHOD Quasi-experimental study with consecutive sample of 16 patients with 30 venous ulcers treated at the outpatient clinic of a teaching hospital, from April to November in 2011, using a form for clinical assessment of the patient and its lesion. Variables were analyzed by Wilcoxon and McNemar test (p < 0.05). RESULTS Most participants were female; aged between 51 and 59 years; obese; with hypertension. Regarding ulcers, there was an average decrease of 7.9 cm2 (50% of its original size) in 90 days; 20% of the ulcers completely healed within 56.67 days. There was an increase in epithelialization, significant reduction in the slough and edema, improved depth, in the type and amount of exudate (p < 0.0001). CONCLUSION 2% and 4% papain gels were effective in healing venous ulcers.

Retinal Morphological Changes during the Two Years of Follow-Up in Parkinson's Disease

2020 ◽  
Author(s):  
Mahmut Atum ◽  
Bekir Enes Demiryurek
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Rating Scale ◽  
Early Stage ◽  
Morphological Changes ◽  
Fiber Layer ◽  
Significant Difference ◽  
Yahr Scale ◽  
And Control

Abstract Background: The study aims to investigate the relationship between the progression of idiopathic Parkinson's disease (IPD) and retinal morphology. Methods: The study was carried out with 23 patients diagnosed with early-stage IPD (phases 1 and 2 of the Hoehn and Yahr scale) and 30 age-matched healthy controls. All patients were followed up at least two years, with 6-month intervals (initial, 6th month, 12th month, 18th month, and 24th month), and detailed neurological and ophthalmic examinations were performed at each follow-up. Unified Parkinson's Disease Rating Scale part III (UPDRS Part III) scores, Hoehn and Yahr (H&Y) scores, best-corrected visual acuity (BCVA), intraocular pressure (IOP) measurement, central macular thickness (CMT) and retinal nerve fiber layer (RNFL) thickness were analyzed at each visit. Results: The average age of the IPD and control groups was 43.96 ± 4.88 years, 44.53 ± 0.83 years, respectively. The mean duration of the disease in the IPD group was 7.48 ± 5.10 months at the start of the study (range 0-16). There was no statistically significant difference in BCVA and IOP values between the two groups during the two-year follow-up period (p> 0.05, p> 0.05, respectively). Average and superior quadrant RNFL thicknesses were statistically different between the two groups at 24 months and there was no significant difference between other visits (p = 0.025, p=0.034, p> 0.05, respectively). There was no statistically significant difference in CMT between the two groups during the follow-up period (p> 0.05). Conclusion: Average and superior quadrant RNFL thicknesses were significantly thinning with the progression of IPD.

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