scholarly journals Cadmium induced histopathological changes in the stomach and small intestine of Swiss albino mice Mus musculus

2009 ◽  
Vol 1 (2) ◽  
pp. 253-257
Author(s):  
Animesh K. Mohapatra ◽  
Poonam Kumari ◽  
Shivika Datta
Keyword(s):  
Small Intestine ◽  
Histopathological Changes ◽  
Nuclear Fragmentation ◽  
Swiss Albino Mice ◽  
Cytoplasmic Vacuolization ◽  
Mucosal Tissues ◽  
Significant Damage ◽  
Albino Mice ◽  
Histopathological Effects ◽  
Marked Atrophy

The results on the effect of oral administration of cadmium chloride on the histomorphology of the stomach and small intestine of Swiss albino mice revealed severe histopathological effects in the tissues of both stomach and small intestine. There is marked atrophy of musculature, and disintegration of sub-mucosal and mucosal tissues, distortion of villi with disintegration of mucosal epithelial cells characterized by cytoplasmic vacuolization, nuclear pycnosis and nuclear fragmentation. A significant damage in the Brunner’s gland and crypts of Liberkuhn has been observed.

scholarly journals Arsenic induced genotoxic and histopathological changes in male Swiss albino mice, Mus musculus

2011 ◽  
Vol 3 (2) ◽  
pp. 329-339
Author(s):  
Animesh K. Mohapatra ◽  
Deepika Rai ◽  
Anika Tyagi
Keyword(s):  
Arsenic Trioxide ◽  
Mus Musculus ◽  
Seminiferous Tubules ◽  
Histopathological Changes ◽  
Histological Changes ◽  
Hydropic Degeneration ◽  
Swiss Albino Mice ◽  
Cytoplasmic Vacuolization ◽  
Liver And Kidney ◽  
Albino Mice

The present study was carried out to investigate the effect of arsenic trioxide on the DNA and histomorphology of testis, liver and kidney of Swiss albino mice, Mus musculus. Oral administration of arsenic trioxide induced DNA damage in the testis, liver and kidney marked by light pink staining of nuclei after Feulgen’s reaction with reduced fine chromatin. Simultaneously severe histological changes were noted like distortion of seminiferous tubules, disorganization of spermatogonia, spermatocytes and spermatids with cytoplasmic vacuolization and nuclear pycnosis in testis. There was almost disappearance of sinusoids due to disruption of hepatic plates, inflammatory cellular infiltration around central veins and cytoplasmic vacuolization in hepatocytes with large irregular nuclei in liver of treated mice. Disorganized glomeruli with distorted Bowman’s capsules and mild to severe multifocal cloudy and hydropic degeneration with necrosis of tubules were observed in the kidney of treated mice. Inference drawn from the study indicated that arsenic induced both genotoxic histotoxic lesions.

scholarly journals Effect of Manganese Chloride in Histological of Ovaries in Albino mice

2011 ◽  
Vol 8 (1) ◽  
pp. 235-243
Author(s):  
Baghdad Science Journal
Keyword(s):  
Heavy Metals ◽  
Blood Vessels ◽  
Manganese Chloride ◽  
Toxic Effects ◽  
Histopathological Changes ◽  
High Toxicity ◽  
Swiss Albino Mice ◽  
Albino Mice ◽  
Different Tissues ◽  
Acute Toxic

Manganese is considered as one of heavy metals with high toxicity .This element has been used widely in various industries and it is spread with huge quantities in polluted industries areas. As a result the concentrations of this element in the environment have increased and consequently producing acute toxic effects in different tissues and organs of all organisms. A study has been conducted on (30) female of Swiss albino mice, to find out the effect of manganese chloride in histopathological changes of ovaries. The study includes, giving the manganese chloride with concentrations (150, 200 and 250 mg/kg) for (15, 30 and 45 day) for each concentration. The study has reported the existence of histopathological changes in the ovaries including congestion, reddening with emergence of blood vessels. In addition to that there is decrease in their weights and their sizes get smaller. Also there is degeneration in cells of the corpus lutum, and decrease in number of these bodies in the ovaries, with increase in atretic follicles, especially within the concentration (250 mgkg) for (45 day).

scholarly journals Effect of saponin on mortality and histopathological changes in mice

2000 ◽  
Vol 6 (2-3) ◽  
pp. 345-351
Author(s):  
F. H. Diwan ◽  
I. A. Abdel Hassan ◽  
S. T. Mohammed
Keyword(s):  
Small Intestine ◽  
Acute Toxicity ◽  
Large Intestine ◽  
Lethal Dose ◽  
Renal Tubules ◽  
Histopathological Changes ◽  
Citrullus Colocynthis ◽  
Histological Changes ◽  
Liver And Kidney ◽  
Histopathological Effects

We evaluated the acute toxicity and histopathological effects of saponin [extracted from the plant Citrullus colocynthis] on mice in order to assess its safety. The median lethal dose [LD50]of the saponin was 200 mg/kg. The histological changes were confined to the small intestine, liver and kidney, whereas the stomach, large intestine and heart appeared normal. The changes in the small intestine included haemorrhage and erosion of the mucosa. In addition, hepatorenal damage resulted from necrosis of liver cells and renal tubules

scholarly journals Effect of hot aqueous extract of seeds and leaves of fenugreek (Trigonella foenum-graecum) on embryonic development in swiss albino mice

2017 ◽  
Vol 14 (1) ◽  
pp. 11-21
Author(s):  
Baghdad Science Journal
Keyword(s):  
Body Weight ◽  
Embryonic Development ◽  
Aqueous Extract ◽  
Pregnant Female ◽  
Histopathological Changes ◽  
Swiss Albino Mice ◽  
Trigonella Foenum Graecum ◽  
Normal Period ◽  
Pregnant Mice ◽  
Albino Mice

The present study has conducted to investigate the effect of hot aqueous extract of seeds and leaves of fenugreek (Trigonella foenum-graecum) on embryonic development in Swiss albino mice morphologically , the results is showed throught dosage pregnant female orally after period 4, 8, 12days at the beginning of pregnancy by doses 100 , 200 , 300 mg/kg of body weight , the results showed normal period of pregnancy 21 days and abortion did not occur when the pregnant mice take the hot aqueous extract of leaves of fenugreek, but the pregnant mice that take the hot aqueous extract of seeds of fenugreek occurred abortion of embryos and showed some histopathological changes in ovaries and uterus such as congestion, hemorrhage, necrosis, odema, no morphological malformations observed in embryos.

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