Assessment of occupational risk of dust lung diseases using biological markers

: Biological markers (biomarkers) play a key role in drug development, regulatory approval and clinical care of patients and are linked to clinical and surrogate outcomes. : Both acromegaly and Growth Hormone Deficiency (GHD) are pathological conditions related to important comorbidities that, in addition to having stringent diagnostic criteria, require valid markers for the definition of treatment, treatment monitoring and follow-up. GH and insulin-like growth factor-I (IGF-I) are the main biomarkers of GH action in children and adults while, in acromegaly, both GH and IGF-I are established biomarkers of disease activity. : However, although GH and IGF-I are widely validated biomarkers of GHD and acromegaly, their role is not completely exhaustive or suitable for clinical classification and follow-up. Therefore, new biological markers for acromegaly and GH replacement therapy are strongly needed. : The aim of this paper is to review and summarize the current state in the field pointing out new potential biomarkers for acromegaly and GH use/abuse.

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Working conditions and occupational morbidity as a basis for risk management

10.33920/pro-4-2103-06 ◽

2021 ◽

pp. 36-50

Author(s):

N.A. Kostenko

Keyword(s):

Risk Management ◽

Working Conditions ◽

Russian Federation ◽

Occupational Diseases ◽

Legal Status ◽

Occupational Risk ◽

Work Related ◽

The Russian Federation

The results of studies are presented, they allow to formulate recommendations on principal problems of unification in the field of statistics of occupational diseases. There are several definitions of occupational diseases in Russia, but they are outdated and do not correspond to the concept of occupational risk recognized in the Labour Code of the Russian Federation. It is proposed to adopt the WHO concept of work-related illnesses and give it a legal status.

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Definition of non-responders: biological markers

Neurological Sciences ◽

10.1007/s10072-008-0940-3 ◽

2008 ◽

Vol 29 (S2) ◽

pp. 214-215 ◽

Cited By ~ 4

Author(s):

Roberto Furlan

Keyword(s):

Biological Markers ◽

Definition Of

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Questions of ethical regulation of immunobiological therapy of some occupational lung diseases

Perm Medical Journal ◽

10.17816/pmj383131-140 ◽

2021 ◽

Vol 38 (3) ◽

pp. 131-140

Author(s):

L. A. Shpagina ◽

L. A. Panacheva ◽

E. V. Zolotukhina

Keyword(s):

Lung Diseases ◽

Occupational Diseases ◽

Legal Regulation ◽

Interstitial Lung Diseases ◽

Production Factors ◽

High Prevalence ◽

Medical Documents ◽

Occupational Lung Diseases ◽

Medical Examinations

Objective. Taking into account a high prevalence of occupational pathology associated with the exposure of industrial aerosols, to analyze the principles of therapy used for patients with these diseases. Materials and methods. The regulating medical documents, the data of preventive medical examinations as well as the principles of therapy applied for patients with occupational diseases, which are presented in scientific literarure, are analyzed. Results. The role of harmful production factors in the formation of pneumoconiosis and alveolitis, which join the group of interstitial lung diseases (ILD), has been proved. The outcome of these occupational diseases is fibrosing alveolitis with the development of diffuse pulmonary fibrosis. In the treatment of ILD, immunobiological drugs (IBD) are used to suppress the immune processes selectively affecting the monoclonal antibodies, blocking of which interrupts inflammation and in 90 % of cases stops the further development of the disease. Conclusions. The use of immunobiological drugs in clinical practice should be carried out within the framework of ethical and legal regulation between the patient and the doctor.

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Definition of progressive fibrosing interstitial lung diseases and approach to the patientPosition paper of Czech Respiratory Society

10.1183/13993003.congress-2021.pa2378 ◽

2021 ◽

Author(s):

Martina Šterclová ◽

Martina Doubkova ◽

Renata Kralova ◽

Petr Pohunek ◽

Vladimir Bartos ◽

...

Keyword(s):

Lung Diseases ◽

Interstitial Lung Diseases ◽

Definition Of

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Occupational morbidity in the Samara Region and its dynamics in the context of the pandemic of the novel coronavirus infection COVID-19

Terapevt (General Physician) ◽

10.33920/med-12-2102-01 ◽

2021 ◽

pp. 7-11

Author(s):

S.A. Babanov

Keyword(s):

Hearing Loss ◽

Infectious Diseases ◽

Sensorineural Hearing Loss ◽

Lung Diseases ◽

Occupational Diseases ◽

The Novel ◽

Occupational Infectious Diseases ◽

Coronavirus Infection ◽

Novel Coronavirus ◽

Occupational Allergies

The indicators of occupational morbidity in the Samara Region and its dynamics in the context of the pandemic of the novel coronavirus infection COVID-19 are presented. In 2020, out of 127 acute and chronic occupational diseases diagnosed in 11 months, 22.05 % (28 cases) were diagnosed with professional sensorineural hearing loss, 5.51 % (7 cases) with dust lung diseases, 5.51 % (7 cases) — atrophic rhinopharyngolaryngitis, in 3.94 % (5 cases) — occupational allergies in the form of occupational bronchial asthma and eczema, in 3.94 % (5 cases) — vibration disease, in 1.57 % (2 cases) — chronic occupational radiculopathy, in 0.79 % (1 case) — oncological occupational pathology (dermatosarcoma of the hand), in 3.14 % (4 cases) — occupational infectious diseases (except for COVID-19).

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Obsessive-compulsive disorder and Tourette Syndrome: is there a relationship?

Sao Paulo Medical Journal ◽

10.1590/s1516-31801997000200008 ◽

1997 ◽

Vol 115 (2) ◽

pp. 1410-1411 ◽

Cited By ~ 3

Author(s):

Maria Conceição do Rosário ◽

Eurípedes Constantino Miguel Filho

Keyword(s):

Obsessive Compulsive Disorder ◽

Tourette Syndrome ◽

Biological Markers ◽

Scientific Evidence ◽

Psychiatric Disease ◽

Obsessive Compulsive ◽

Clinical Genetic ◽

Compulsive Disorder ◽

Neuroimaging Data ◽

Definition Of

The authors describe the main characteristics of Obsessive-Compulsive Disorder, the fourth most frequent psychiatric disease, and Tourette Syndrome. Considered completely separate disorders, there is growing scientific evidence that there is a connection between them. The authors present clinical, genetic and neuroimaging data reinforcing this idea, and call attention to the importance of research in this area, as they believe that the definition of more homogenous subgroups will facilitate the identification of biological markers and predictors of treatment response.

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Reliability in headache diagnosis

Cephalalgia ◽

10.1177/0333102493013s1207 ◽

1993 ◽

Vol 13 (12_suppl) ◽

pp. 29-33 ◽

Cited By ~ 32

Author(s):

Richard B Lipton ◽

Walter F Stewart ◽

Kathleen Ries Merikangas

Keyword(s):

Risk Factors ◽

Diagnostic Criteria ◽

Biological Markers ◽

Psychiatric Diagnosis ◽

International Headache Society ◽

Clinical Information ◽

Diagnostic Methods ◽

Diagnostic Instruments ◽

Headache Diagnosis ◽

Definition Of

The reliability of headache diagnosis using the criteria of the International Headache Society (IHS) has not been well studied. One definition of reliability refers to the reproducibility of diagnoses assigned to the same individual at different times. Reproducibility of diagnosis should be assessed using different clinicians at different times, with or without specific diagnostic instruments. A diagnosis may be unreliable because of variability in diagnostic criteria, in the clinical information used to assign diagnoses, or in the interpretation and application of clinical information to a given set of diagnostic criteria. Reliable diagnostic methods are essential to the development of valid diagnostic methods, as well as for the identification of headache risk factors, biological markers, and effective treatments. An approach to studying the reliability of the International Headache Society criteria is outlined, modeled after the extensive studies conducted in the area of psychiatric diagnosis.

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EXPRESS: IMPACT OF THE NEW DEFINITION FOR PULMONARY HYPERTENSION IN PATIENTS WITH LUNG DISEASE: AN ANALYSIS OF THE UNOS DATABASE

Pulmonary Circulation ◽

10.1177/2045894021999960 ◽

2021 ◽

pp. 204589402199996

Author(s):

Christopher King ◽

Steven Nathan ◽

Scott Barnett ◽

Steeve Provencher ◽

Joan Albert BarberÃ ◽

...

Keyword(s):

Pulmonary Hypertension ◽

Lung Disease ◽

Lung Diseases ◽

Right Heart Catheterization ◽

Recent Change ◽

Heart Catheterization ◽

Copd Patients ◽

Previous Definition ◽

Definition Of ◽

United Network

The implications of the recent change in the definition of pulmonary hypertension (PH) on epidemiology and outcomes are not known. We sought to determine the percentage of patients with the two most common lung diseases that would be reclassified regarding the presence/absence of PH with the revised definition. A query of the United Network for Organ Sharing database was performed. The percentage of patients meeting the current and previous definition of PH were described. Outcomes of patients stratified by the current and previous definitions were compared. There were 15,563 patients with right heart catheterization data analyzed. PH was more prevalent in both COPD and IPF under the new definition at 52.4% versus 82.4%, and 47.6% versus 73.6%, respectively. âPre-capillaryâ PH by the new definition was lower at 28.1% for COPD and 36.8% for IPF. Of the patients with PH by the old definition, 23.9% of COPD patients and 18.7% of IPF patients were not classified as PH by the new definition. Conversely, 15.9% of COPD patients and 15.1% of IPF patients who did not meet diagnostic criteria for PH by the old definition, did have PH by the new definition. Patients in both disease categories had shorter transplant-free waitlist survival in the presence of PH by both the new and old definitions. There was a trend toward the new definition of pre-capillary PH better discerning outcomes compared to the old definition of PH in IPF patients. Most patients with advanced lung disease who are listed for lung transplantation have PH, but fewer have pre-capillary PH than PH by the old definition. Both the old and new definition of precapillary PH appear to discern outcomes among the two groups of lung disease analyzed, with some evidence to suggest that the new definition performs slightly better in the IPF population.

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