TO THE QUESTION OF INDUSTRIAL AEROSOL CONTROL IN THE PROCESSING OF BLISTER COPPER

Author(s):  
O.G. Drugova ◽  
◽  
A.A. Fedoruk ◽  
T.N. Shtin

Abstract. Due to the predominance of PM1 particles in the air samples, the following metals were found in the aerosol: copper, zinc, silicon, iron, lead, sulfur, arsenic, aluminum, antimony, tin, magnesium, cadmium and several other metals. The content of sulfates was significantly noted. These physical and chemical properties show a considerable toxic potential of industrial aerosol. The MPC of lead, sulfur and silicon dioxides, as well as nitrogen oxides and formaldehyde were detected in the working air. Meanwhile, copper, zinc, and iron did not exceed their MPC. Moreover, an underestimation of the aerosol was observed within the framework of industrial control. It has been found that the aerosol components may have an irritating, reprotoxic, allergenic, and carcinogenic effect on the body. Further consideration of the dispersed and chemical composition of the aerosol is required to determine the concentration of identified substances in the working air and the limiting components determining its biological effect.

Nanomedicine ◽  
2019 ◽  
Vol 14 (20) ◽  
pp. 2763-2775 ◽  
Author(s):  
Fatih Zor ◽  
Fatma Nurefsan Selek ◽  
Giuseppe Orlando ◽  
David F Williams

Biocompatibility is a very common word that is used within biomaterial science and used for description of the interactions between the foreign material and the body. However, the meaning of biocompatibility as well as the mechanisms that collectively constitutes is still unclear. With the advance of nanotechnology, new concerns have been observed related to biocompatibility of these biomaterials. Due to their small size and variability of their physical and chemical properties, nanoparticles’ (NP) distribution within the body and interactions with the target cells and tissues are highly variable. Here, we tried to provide an overview about NPs, the concept of biocompatibility and biocompatibility-related issues in nanomedicine and several different NPs.


2018 ◽  
Vol 69 (11) ◽  
pp. 3106-3111 ◽  
Author(s):  
Oana Maria Muscalu (Plescan) ◽  
Valentin Nedeff ◽  
Alexandra Dana Chitimus ◽  
Ioan Gabriel Sandu ◽  
Elena Partal ◽  
...  

The purpose of this research have been to determine the influence of soil fertilizations systems (fertilization with: nitrogen, phosphorous, nitrogen and phosphorous, farmyard manure) on the physical properties (penetration hardness) and chemical properties (humidity, metals) of the soil. The experiments have been carried out in the experimental field of National Agricultural Research and Development Institute -Fundulea, Romania, for a wheat monoculture. The lowest values of the metal content in soil (nickel, copper, zinc, arsenic, lead) have been recorded for wheat experimental variant -fertilized with N90P75 kg/ha (a1b4), and the highest content have been recorded for manganese (766 mg/kg dry matter), and for the wheat experimental variant a1b4, respectively (wheat-fertilized with N90P75 kg/ha active matter), working depth 0-15 cm.


2021 ◽  
Vol 14 (4) ◽  
pp. 1983-1991
Author(s):  
Nagham Mahmood Aljamali ◽  
Sabrean Farhan Jawad

The importance of research lies in the treatment of cancerous tumors due to the spread of cancerous tumors in recent decades, so researchers have to insist on finding alternative and more treatments safe from chemotherapy and radiation, which are derivatives of some amino acids, which we attended in our current research. Also, some research showed that taking tryptophan for 3 days before exercise can improve energy and efficiency during exercise, but other preliminary research shows that taking tryptophan during exercise does not improve endurance during cycling exercises. For a few days before exercise to notice any benefit. In this research, we prepared derivatives of cyclic tryptophan and studied their efficacy as anti-tumors, and they gave good results in reducing the size of cancerous tumors and reducing their spread in the body., then sympathy all synthesized new cyclic-tryptophan compounds by numerous techniques (FT.IR ,H.NMR)–spectrophotometric, other physical and chemical properties ,with studying for one of new prepared derivatives as anti breast cancer.


2017 ◽  
Vol 2017 ◽  
pp. 1-15 ◽  
Author(s):  
Ulfuara Shefa ◽  
Seung Geun Yeo ◽  
Min-Sik Kim ◽  
In Ok Song ◽  
Junyang Jung ◽  
...  

To date, three main gasotransmitters, that is, hydrogen sulfide (H2S), carbon monoxide (CO), and nitric oxide (NO), have been discovered to play major bodily physiological roles. These gasotransmitters have multiple functional roles in the body including physiologic and pathologic functions with respect to the cellular or tissue quantities of these gases. Gasotransmitters were originally known to have only detrimental and noxious effects in the body but that notion has much changed with years; vast studies demonstrated that these gasotransmitters are precisely involved in the normal physiological functioning of the body. From neuromodulation, oxidative stress subjugation, and cardiovascular tone regulation to immunomodulation, these gases perform critical roles, which, should they deviate from the norm, can trigger the genesis of a number of neurodegenerative diseases such as Alzheimer’s disease (AD) and Parkinson’s disease (PD). The purpose of this review is to discuss at great length physical and chemical properties and physiological actions of H2S, NO, and CO as well as shedding light on recently researched molecular targets. We particularly put emphasis on the roles in neuronal inflammation and neurodegeneration and neuronal repair.


2021 ◽  
Vol 1 (2) ◽  
pp. 25-31

This study is designed to assess the concentrations of lead, copper, zinc, iron, cadmium and manganese in sediments and bivalvia (Mytilus galloprovincialis) tissues of Tobruk coast. The samples of sediments and bivalvia were collected from four sites around Tobruk city namely as Main port, Ledo, Andolus and Rasbayad (control site), during summer, 2021. The heavy metals of sediments and bivalvia tissues were determined using atomic absorption spectrometry. Also water samples were taken from four sites and physical and chemical properties of water were measured. The results of sediments showed that the Ledo site significantly recorded the higher concentrations of lead (0.624 mg/kg), zinc (73.77 mg/kg), copper (0.450mg/kg) and iron (94.38mg/kg) than those of the other sites, however, the metals of sediments collected from Rasbayad recorded the lowest concentrations. The results of bivalvia tissues revealed that Main port site recorded the greater concentration of lead (0.420 mg/l), zinc (2.185mg/l), cadmium (0.385 mg/l) and copper (3.010 mg/l) than that of other sites. Moreover, Andolus site recorded significantly the higher concentration of iron (14.135 mg/l) than that of other three sites. On the other hand, the Rasbayad recorded the lowest concentration of lead (0.070 mg/l), zinc (0.115 mg/l), cadmium (0.020 mg/l) and copper (0.030 mg/l) in bivalvia tissues. In general, the results indicated a high degree of contamination by heavy metals in sediments and bivalvia of three sites when compared with the control site (Rasbayad) and it is reflect the environmental pressure surrounding the coast of Tobruk, an urgently action is needed to reduce the causes of pollution and contamination by heavy metals.


2020 ◽  
Vol 8 (1) ◽  
pp. 67-75
Author(s):  
Vasylii Larin ◽  
Vita Datsenko ◽  
Lilya Egorova ◽  
Inna Hraivoronskaia ◽  
Tetiana Herasymchuk

This academic work is focused on the study of physical-chemical patterns of copper-zinc galvanic sludge dissolution prior to and after thermal treatment in model solutions with a given pH. They show that all types of galvanic sludge eluates prior to and after thermal treatment are characterized by rather high concentrations of Cu2+ and Zn2+ ions. In acid eluates, the contents of zinc and copper ions are comparable. In extracts of distilled water and buffer solution, Zn2+ concentrations are higher than those of Cu2+. It has been established that the thermal treatment of galvanic sludge does not contribute to the retention of heavy metal ions in the sample. The intensity of dissolution of copper and zinc from galvanic sludge after thermal treatment increases with decreasing pH. It is proved that copper-zinc galvanic sludge presents a potential water-migration hazard.


2021 ◽  
Vol 22 (1) ◽  
pp. 399
Author(s):  
Yale Yue ◽  
Xiao Zhao

Photothermal therapy (PTT) mediated by nanomaterial has become an attractive tumor treatment method due to its obvious advantages. Among various nanomaterials, melanin-like nanoparticles with nature biocompatibility and photothermal conversion properties have attracted more and more attention. Melanin is a natural biological macromolecule widely distributed in the body and displays many fascinating physicochemical properties such as excellent biocompatibility and prominent photothermal conversion ability. Due to the similar properties, Melanin-like nanoparticles have been extensively studied and become promising candidates for clinical application. In this review, we give a comprehensive introduction to the recent advancements of melanin-like nanoparticles in the field of photothermal therapy in the past decade. In this review, the synthesis pathway, internal mechanism and basic physical and chemical properties of melanin-like nanomaterials are systematically classified and evaluated. It also summarizes the application of melanin-like nanoparticles in bioimaging and tumor photothermal therapy (PTT)in detail and discussed the challenges they faced in clinical translation rationally. Overall, melanin-like nanoparticles still have significant room for development in the field of biomedicine and are expected to applied in clinical PTT in the future.


Polymers ◽  
2020 ◽  
Vol 12 (2) ◽  
pp. 408 ◽  
Author(s):  
Pei Zhang ◽  
Huixia Guo ◽  
Chenguang Liu

Micro-molecular drugs have special advantages to cope with challenging diseases, however their structure, physical and chemical properties, stability, and pharmacodynamics have more requirements for the way they are delivered into the body. Carrier-based drug delivery systems can circumvent many limited factors of drug delivery and increase their bioavailability. In this context, stable drug nanocarriers of alkaline amino acids (arginine, Arg) modified conjugated linoleic acid-carboxymethyl chitosan (CLA-CMCS) conjugate were developed, which could generate supramolecular micelles to effectively encapsulate the tyrosinase inhibitor phenylethyl resorcinol (PR). The resulting CCA-NPs were spherical nanoparticles with a mean size around 175 nm. The 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2-H-tetrazolium bromide (MTT) assay and cellular uptake investigation demonstrated that the CCA-NPs were non-cytotoxic and had excellent cell transport ability. In addition, these CCA-NPs were able to effectively deliver PR and inhibited melanin formation to reduce pigmentation by enhancing cellular uptake. In conclusion, our research indicated that nanocarriers based on self-assembly amphiphilic polymers constituted a promising and effective drug delivery system in hyperpigmentation targeting.


2021 ◽  
Vol 9 ◽  
Author(s):  
Tian-Xing Zhang ◽  
Juan-Juan Li ◽  
Hua-Bin Li ◽  
Dong-Sheng Guo

Fullerene has attracted much attention in biomedical research due to its unique physical and chemical properties. However, the hydrophobic nature of fullerene is limited to deploy in the body, given that the biofluids are mainly water. In this study, a water-soluble supramolecular nanoformulation based on a deep cavitand calixarene (SAC4A) and fullerene is developed to overcome the hydrophobicity of fullerene and is used as a potential photodynamic agent. SAC4A solubilizes fullerene very well with a simple grinding method. The significantly increased water solubility of fullerene enables efficient activation of reactive oxygen species. The host–guest strategy to solubilize fullerene can not only provide a new method to achieve water solubility but also expand the biomedical applications of fullerene.


Nano LIFE ◽  
2010 ◽  
Vol 01 (01n02) ◽  
pp. 99-108
Author(s):  
GRÉGORY COUÉ ◽  
JOHAN F. J. ENGBERSEN

The oral route is the most common and preferred route of drug delivery in view of its convenience and patient acceptance. However for oral administration of therapeutic proteins, several hurdles have to be overcome. For this purpose the use of polymers, with their ease of modification in physical and chemical properties, are attractive in protein drug carriers. They can protect their therapeutic protein loading from degradation in the gastrointestinal tract, and enhance their bioavailability at targeted sites of the body. In this review, potential and currently used polymers for fabrication of protein delivery systems and their applications for oral administration will be discussed.


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