Use of Topical Berberine to Manage Premature Ejaculation and/or Erectile Dysfunction: Restoration of Endothelial Homeostasis.

2021 ◽  
Author(s):  
Mina Kelleni
Keyword(s):  
Erectile Dysfunction ◽  
Premature Ejaculation ◽  
Herbal Extract ◽  
Sexual Disorders ◽  
The World ◽  
Endothelial Homeostasis

Premature ejaculation and erectile dysfunction are affecting millions of patients all over the world and the quest for novel and safe drugs to manage either or both diseases is considered of great importance. Topical use of the herbal extract berberine might provide potential cure through restoration of endothelial homeostasis that is disturbed in both diseases as well as numerous other mechanisms as described in this manuscript and the author is the inventor and one of the holders of an internationally registered copyright to use berberine topically for management of sexual disorders.

scholarly journals Tactics of treatment of patients with sexual dysfunctions and intermediate disorders

2018 ◽  
Keyword(s):  
Premature Ejaculation ◽  
Rating Scale ◽  
Sexual Disorders ◽  
Study Group ◽  
Sexual Dysfunctions ◽  
Nootropic Drugs ◽  
The World ◽  
Latency Interval ◽  
Development Of Anxiety ◽  
Hamilton Rating Scale

The article gives the world views on the main types of sexual disorders among the male contingent and their interrelation with the phases of sexual reaction. The interrelation of the development of sexual dysfunctions under the influence of significant stress or psychoemotional overload or in the absence of any psychoneurological disorders, among which the leading place occupy border disorder, is shown. The necessity of therapeutic correction of affective pathology in the complex therapy of sexual dysfunctions is substantiated. The basic mechanisms of complex treatment of sexual dysfunctions and psychopathological manifestations are shown. In order to work out a more effective therapeutic complex using the Questionnaire International Erectile Function Index (IEFI), calculation of the duration of sexual intercourse (the so-called Intravaginal latency interval (ILI) and the Hamilton Rating Scale for Depression (HDRS-17) were evaluated. 83 patients with sexual dysfunctions: 52 patients (1 group) with premature ejaculation (PE); 31 patients (2 groups) with erectile dysfunction (ED) (the presence of these sexual dysfunctions led to the development of anxiety-depressive and neurosis-like disorders, which was confirmed by the Hamilton Scales) and 45 patients (3 groups) with sexual dysfunctions that developed as a result of existing initial psychopathological or boundary disorders (BD). Each study group was divided into two subgroups (a and b), each of which used different therapies from each other. With the use of one or another therapeutic scheme, patients of each group received cognitive-behavioral psychotherapeutic correction, tadalafil, nootropic drugs (noofen or glycine) and antidepressants (fluoxetine or coaxiаl). The duration of the observation was 3 months. As a result of the study, improvement of the ejaculatory function (with an increase in the ILI score) was established, which significantly increased at each control examination. In the analysis of the dynamics of the overall indicator of the MIEF questionnaire after the therapy, improvement in sexual function was observed in all groups, but the best results were obtained in the ED group. The results of the HDRS questionnaire showed that after 3 months, patients in the PE group compared with the BD group were reliably less susceptible to depressive disorder, especially of a pronounced nature.

scholarly journals Evaluation of sexual dysfunction prevalence in infertile men with non-obstructive azoospermia

2020 ◽  
Vol 91 (4) ◽  
pp. 241-244
Author(s):  
Taha Numan Yıkılmaz ◽  
Erdem Öztürk ◽  
Nurullah Hamidi ◽  
İsmail Selvi ◽  
Halil Başar ◽  
...  
Keyword(s):  
Erectile Dysfunction ◽  
Sexual Dysfunction ◽  
Premature Ejaculation ◽  
Sexual Relationship ◽  
Sexual Disorders ◽  
Obstructive Azoospermia ◽  
Male Partners ◽  
Negative Effects ◽  
Infertile Couples ◽  
Relationship Stress

Objectives: To determine the prevalence of sexual dysfunction in male partners of infertile couples and evaluate the effect of childlessness on erectile dysfunction (ED) and sexual relationship stress. Materials and methods: We collected datas of couples who attended our clinics for infertility between 2009 and 2016. Erectile dysfunction was investigated with the Questionnaires of International Index of Erectile Function-15 (IIEF-15) whereas premature ejaculation (PE) status with the Premature Ejaculation Diagnostic Tool (PEDT). The stress status of the childlessness in terms of sexual intercourse was scored by the Visual analogue scale (VAS) questionnaire. These scores were measured before and after a successful assisted reproductive treatment with the birth of the child. Results: The median age of the 193 male patients was 31 years (range 23-48). Erectile dysfunction was found in 68 (35.2%) and PE in 42 (21.7%) subjects. One hundred and forty-one couples were treated with assisted reproductive treatments. Forty eight couples had successful pregnancy. The IIEF-15 test was repeated after the birth of the child to the male partners of these couples. We observed that the IIEF-15 scores increased from 16 to 21 (p = 0.014). However there were no significant improvement on their ejaculation status (p > 0.05). The mean VAS scores of male partners was 5.2 (3-10) in the treatment period while it decreased to 4.1 (0-8) after the birth of the chils (p = 0.02). Statistically analysis showed a correlation between VAS and infertility as did IIEF-15. Conclusions: We observed that having children has a reducing effect on sexual relationship stress. Infertility is absolutely blamed on the women and men. This condition may have negative effects on male sexual performance and it is closely related with some emerging female sexual disorders. It should be taken into consideration that infertile couples may have sexual dysfunction.

Pharmacologic Treatment Strategies for Sexual Dysfunction in Patients with Epilepsy and Depression

CNS Spectrums ◽  
2006 ◽  
Vol 11 (S9) ◽  
pp. 31-37 ◽  
Author(s):  
Glen L. Stimmel ◽  
Mary A. Gutierrez
Keyword(s):  
Erectile Dysfunction ◽  
Sexual Dysfunction ◽  
Sexual Desire ◽  
Selective Serotonin Reuptake Inhibitors ◽  
Premature Ejaculation ◽  
Sexual Disorders ◽  
Comorbid Condition ◽  
Phosphodiesterase Type 5 Inhibitor ◽  
Female Orgasmic Disorder ◽  
Patients With Epilepsy

AbstractSexual dysfunction is a frequently encountered comorbid condition in patients with many medical and psychiatric conditions, such as epilepsy and depression. Most depressed patients experience some type of sexual dysfunction, decreased sexual desire being the most common. The association of sexual dysfunction with epilepsy is less clear. Changes in sex hormone levels are common in patients with epilepsy and may be attributable to the disease or to antiepileptic drugs (AEDs). Sexual dysfunction associated with depression or epilepsy is generally treated according to standard guidelines for the management of sexual disorders, since data from special populations are not available. The most common forms of female sexual dysfunction are lack of sexual desire and difficulty achieving orgasm. There are no approved pharmacotherapies for female hypoactive sexual desire disorder or female orgasmic disorder. Female sexual arousal disorder is treated with estrogen replacement therapy when indicated or vaginal lubricants. The most common male sexual dysfunction disorders are premature ejaculation and erectile dysfunction.  Phosphodiesterase type-5 inhibitor drugs are now the first-line treatment for erectile dysfunction, and selective serotonin reuptake inhibitors and topical anesthetic creams are nonapproved but effective treatments for premature ejaculation. Testosterone and aromatase inhibitors have been used investigationally to treat sexual dysfunction in men taking AEDs. Patient education and follow-up appointments are essential to ensure optimal outcomes of pharmacologic treatments for sexual dysfunction.

scholarly journals Sociodemographic and Clinical Profile of Patients Presenting With Erectile Dysfunction: Experience From a Tertiary Care Centre of North India

2021 ◽  
pp. 263183182110311
Author(s):  
Adarsh Tripathi ◽  
Dhirendra Kumar ◽  
Sujita Kumar Kar ◽  
PK Dalal ◽  
Anil Nischal
Keyword(s):  
Erectile Dysfunction ◽  
Rating Scale ◽  
Nuclear Family ◽  
Sexual Experience ◽  
Tertiary Care ◽  
Clinical Profile ◽  
Sexual Disorders ◽  
Care Hospital ◽  
Tertiary Center ◽  
Hamilton Rating Scale

Background: Erectile dysfunction (ED) is one of the most common psychosexual disorders in clinical practice, and it results in significant distress, interpersonal impairments, poor quality of life, and marital disharmony. However, there is limited research on ED in India. Therefore, this study aimed to assess the sociodemographic and clinical profile of patients presenting with ED. Method: Cross-sectional evaluation of patients with ED presenting to the psychosexual outpatient department (OPD) of psychiatry department in a tertiary care hospital was done on structured clinical pro forma, Mini-International Neuropsychiatric Interview, International Index of Erectile Function-5, Arizona Sexual Experience, Hamilton rating scale for depression, and Hamilton rating scale for anxiety. Results: The sample included 102 patients. The mean age was 33.38 years. The majority of the patients were married (81.4%), Hindu (82.4%), residing in a rural area (60.8%), and belonging to a nuclear family (62.7%). The majority of the patients had a moderate level of ED (50%) followed by mild-to-moderate ED (26.5%) and severe ED (23.5%). Premature ejaculation (46.1%) and depression (28.4%) were the most common sexual and psychiatric comorbidities. Obesity was common (62.7%), and only a minority had other metabolic dysfunction, namely dyslipidemia (7.8%), diabetes (5.9%), and hypertension (4.9%). Tobacco dependence and alcohol dependence were present in 37.3% and 6.9% cases, respectively. Conclusion: Young adults with moderate-to-severe ED were present for treatment at a tertiary center. Comorbidities of other sexual disorders, psychiatric disorders, and substance use are commonly encountered in such patients. Promotion of early help-seeking should be encouraged. Clinicians should thoroughly assess even the young patients for other sexual, psychiatric, and medical comorbidities.

scholarly journals Spermatorrhea in a Chinese patient with temporal lobe epilepsy: a case report

2021 ◽  
Vol 49 (1) ◽  
pp. 030006052098281
Author(s):  
Liang Zhang ◽  
Hao Yu ◽  
Dan Li ◽  
Hui Qian ◽  
Yuchao Chen
Keyword(s):  
Erectile Dysfunction ◽  
Case Report ◽  
Sexual Dysfunction ◽  
Temporal Lobe Epilepsy ◽  
Temporal Lobe ◽  
Neurological Disorder ◽  
Premature Ejaculation ◽  
Chinese Patient ◽  
Left Temporal Lobe ◽  
Rare Manifestation

Epilepsy is a chronic neurological disorder that is characterized by episodes of seizure. Sexual dysfunction has been reported in patients with seizure, which mostly manifests as erectile dysfunction and premature ejaculation in men. In this study, we report the case of a 65-year-old Chinese man with frequent spermatorrhea. Electroencephalography suggested local epilepsy in the left temporal lobe. After treatment with anti-epilepsy drugs, the symptoms disappeared and did not recur. To the best of our knowledge, this is the first reported case of epilepsy-induced spermatorrhea. The symptoms of spermatorrhea are probably a rare manifestation of seizure. When repetitive stereotyped symptoms occur, seizure should be considered, and tentative anti-epileptic treatment may be a good option.

scholarly journals Urinary symptoms and sexual dysfunction among Italian men: The results of the #Controllati survey

2017 ◽  
Vol 89 (1) ◽  
pp. 75
Author(s):  
Vincenzo Mirone ◽  
Roberto Carone ◽  
Giuseppe Carrieri ◽  
Elisabetta Costantini ◽  
Giuseppe Morgia ◽  
...  
Keyword(s):  
Erectile Dysfunction ◽  
Sexual Desire ◽  
Sexual And Reproductive Health ◽  
Premature Ejaculation ◽  
Urinary Symptoms ◽  
Research Approach ◽  
Sexual Disorder ◽  
Increased Risk ◽  
Large Survey

Objective: Prevention may improve the quality of life and sexual and reproductive health. To improve prevention require a comprehensive research approach that examines the frequency and risk factors for urologic conditions. In June 2016 the Italian Urologic Society coordinated a preventive initiative : the 1st Week of Male Urologic Prevention ”#Controllati”. Material and methods: During the 1st Week of Male Urologic Prevention “#Controllati”, men aged 18 years or more were invited to attend participating urologic centers for a free of charge visit for counseling about urologic or andrologic conditions. Each participating man underwent a physical examination. Further he was asked about his a medical history and about his urologic symptoms, sexual activity and possible related problems. Results: Data were collected in 81 centers: 2380 men answered the questionnaire. A total of 1226 subjects participating in the study reported one or more urinary symptom [51.5% (IC 95% 48.9%-54.5%)]. The risk of any urinary symptoms increased with age: in comparison with men aged < = 30 years or less the risk of any urinary symptoms was 2.31, 2.92, 5.12, 7.82 and 17.02 respectively in the class age 31-40, 41-50, 51-60, 61-70 and > = 71. Overweight/obese men were at increased risk of any urinary symptoms [OR1.35 (95% CI 1.12-1.64)]. 27.2% (IC 95% overall 25.2% -29.3%) of the subjects had at least a sexual disorder (erectile dysfunction, premature ejaculation, hypoactive sexual desire). The erectile dysfunction and hypoactive sexual desire increased with age, but premature ejaculation tended to be higher among younger aged men aged 40 years or more. Current any urinary symptoms [OR 1.85 (CI 1.40-2.43)], hypertension [OR 1.66 (95% CI 1.21-2.26) and diabetes (OR 2.37 (95% CI 1.45-3.88)] increased the risk of erectile dysfunction. Conclusions: This large survey gives a picture of the burden of the more frequent urologic conditions offering useful information in order to focus preventive campaign.

scholarly journals PREVALENCE OF PREMATURE EJACULATION AND ERECTILE DYSFUNCTION AND THEIR ASSOCIATED FACTORS AMONG URBAN AND RURAL POPULATION OF MALAYSIA

2017 ◽  
Vol 17 (3) ◽  
pp. 86-96 ◽  
Author(s):  
Mohd Rohaizat Hassan ◽  
Mohd Fadhli Samsuri ◽  
Shamsul Azhar Shah ◽  
Nazarudin Safian ◽  
Zulkifli Md Zainuddin ◽  
...  
Keyword(s):  
Erectile Dysfunction ◽  
Rural Areas ◽  
Rural Population ◽  
Associated Factors ◽  
Premature Ejaculation ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Factors Associated ◽  
Urban And Rural Areas

The purpose of this study was to determine the prevalence and factors associated with of Premature Ejaculation &Erectile Dysfunctionamong Malaysian men. A cross-sectional study was conducted in urban and rural areas using standardized and validated self-administered questionnaires. A total of 319 samples were recruited for PE screening. The overall prevalence of PE was 31.7% with 20.7% and 40.8% for urban and rural area respectively. Depression, anxiety and frequent masturbation were significantly associated with PE. While For ED, infrequent sexual intercourse was the sole factor significantly associated with ED.PE and ED were highly prevalent in both urban and rural areas; with several significant preventable associated factors.

scholarly journals Premature Ejaculation in Urban Malaysian Population: The Associations between Erectile Dysfunction(ED), Anxiety and Depression

2020 ◽  
Vol 15 (1) ◽  
Author(s):  
Shamini Arasalingam ◽  
Hatta Sidi ◽  
Ng Chong Guan ◽  
Srijit Das ◽  
Marhani Midin ◽  
...  
Keyword(s):  
Erectile Dysfunction ◽  
Clinical Diagnosis ◽  
Premature Ejaculation ◽  
Strong Association ◽  
Depression Scale ◽  
Anxiety And Depression ◽  
Health Issues ◽  
Dsm V ◽  
Male Patients ◽  
The Relationship

Introduction: Both premature ejaculation(PE) and erectile dysfunction(ED) are prevalent sexual health disorders that have been inadequately investigated in Malaysia, a multiethnic and conservative nation.The objective of the study was to study the relationship between PE and ED, and other common mental health issues, i.e. anxiety and depression in Malaysian urban population. Methods: The diagnosis for PE was established by clinical diagnosis using DSM-5 and ISSM definition criteria for PE, whereas a diagnosis of ED was established by the International Index of Erectile Function (IIEF) questionnaire. Anxiety and depression levels were detected from the Hospital Anxiety and Depression Scale (HADS). Results: Based on DSM-V and ISSM clinical diagnosis for PE, the prevalence of PE was found to be 25%. Erectile dysfunction (p = 0.035, OR = 3.315, 95% CI 1.088, 10.103) and severe anxiety (p = 0.020, OR = 7.656, 95% CI 1.383, 42.396) significantly predicted presence of PE. Conclusion: There was a strong association between PE and ED and between PE and anxiety. Routine examination for PE in male patients should address the issue and the management of both ED and anxiety among PE patients, especially in an urban Malaysian clinical and medical care setting.

scholarly journals SEXUAL DISORDERS AFTER HEART TRANSPLANT

2020 ◽  
Vol 73 (10) ◽  
pp. 2277-2281
Author(s):  
Kamila Fuczyło ◽  
Magdalena Piegza ◽  
Robert Pudlo
Keyword(s):  
Quality Of Life ◽  
Erectile Dysfunction ◽  
Sexual Dysfunction ◽  
Heart Transplantation ◽  
Heart Transplant ◽  
Sexual Disorders ◽  
State Of Health ◽  
Review Of The Literature ◽  
Pubmed Database

The aim: To systematize and bring the reader closer to knowledge about the occurrence of sexual disorders in people after heart transplantation based on available bibliography. Material and methods: A review of the literature on this topic from the last 30 years made with using the PubMed database, using a total of 17 articles. Conclusions: The incidence of sexual dysfunction (SD) is higher in heart recipients than in the general population and erectile dysfunction is the most common. When the symptoms of dysfunction occur before the transplant – they do not improve, rather they get worse, which reduces the improvement in the quality of life of these patients compared to patients without sexual dysfunction. Improvement in quality of life is observed in patients with SD after heart transplantation, but not as pronounced as in subjects without sexual dysfunction. Some patients notice an increase in libido, with the genital response being insufficient or completely disappearing, which results in a decrease in the quality of relationships between partners and a deterioration in the quality of life. The cause of SD in heart recipients is unclear, but it is associated with the type of immunosuppression used, the level of sexual activity and the state of health of patients prior to transplantation. Nowadays patients after ortotrophic heart transplant live longer and their quality of life improves, but not in sexual terms. The articles concerned almost exclusively men, that is why the topic requires exploration in subsequent research.

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