scholarly journals Understanding the possible origin and genotyping of first Bangladeshi SARS-CoV-2 strain

2020 ◽  
Author(s):  
A. S. M. Rubayet Ul Alam ◽  
M. Rafiul Islam ◽  
M. Shaminur Rahman ◽  
Ovinu Kibria Islam ◽  
M. Anwar Hossain
Keyword(s):  
Complete Genome ◽  
Epidemiological Data ◽  
The Novel ◽  
Genome Data ◽  
The United Kingdom ◽  
Comprehensive Picture ◽  
History Of ◽  
Probable Origin ◽  
Novel Coronavirus ◽  
The Uk

The novel coronavirus, SARS-CoV-2, causes the unfathomable pandemic in the history of humankind. Bangladesh is also a victim of this critical situation. To investigate the genomic features of the pathogen, the first complete genome of the virus has very recently been published. Therefore, the long awaiting questions regarding the possible origin and typing of the strain(s) can now be answered. Here, we endeavor to mainly discuss the published reports or online-accessed data (results) regarding those issues and presented a comprehensive picture of the typing of the virus alongside the probable origin of the sub-clade containing Bangladeshi strain. Our observation suggested that this strain might have originated from the United Kingdom (UK) or other European countries epidemiologically linked to the UK. According to different genotyping classification schemes, this strain belongs to A2a clade under G major clade, is of B and/or L type, and is a SARS-CoV-2a sub-strain. The complete genome data will surely increase in the forwarding days in Bangladesh. However, a mass regional sequencing approach targeting the partial or complete genome can link the epidemiological data and may help in further clinical interventions.

scholarly journals A commentary on podiatry during the Covid-19 pandemic

2020 ◽  
Vol 13 (1) ◽  
Author(s):  
Paul Chadwick ◽  
Lawrence Ambrose ◽  
Ross Barrow ◽  
Martin Fox
Keyword(s):  
Viral Infections ◽  
The Novel ◽  
Post Discharge ◽  
Foot Health ◽  
The United Kingdom ◽  
Reduce Risk ◽  
The Many ◽  
Novel Coronavirus ◽  
The Uk

Abstract Background The arrival of the novel coronavirus (SARS-CoV-2) has impacted the many aspects of modern life, especially, in the immediate term, the delivery of healthcare. Context This commentary examines the profession of podiatry and how it has adapted and responded to the emerging crisis. It focusses on but is not exclusive to the position in the United Kingdom (UK) and the edicts and direction from the UK Government. Podiatry roles during the pandemic It describes the role of podiatry in the pandemic and highlights the deployment of podiatry resources to fight the pandemic beyond traditional podiatric practice. It also looks at the shift from conventional consultation to digital solutions for managing patients in an effort to achieve the goals of maintenance of foot health whilst reducing the spread of the virus. The commentary summarises the emerging data related to a possible foot related presentation of the coronavirus. Conclusion The podiatry profession proved its flexibility and adaptability during the pandemic, to adjust rapidly to ensure that patients were able to access treatment to reduce risk of infection, ulceration and amputation. Dermatological presentations on the feet have been associated with Covid-19 in adolescents as is often the case in viral infections. CPD webinars to support clinicians and manage and prevent the spread of Covid-19 have been widely disseminated along with algorithms to ensure that patients that need treatment are being treated appropriately. Podiatrists have embraced remote technology to ensure that patients are correctly and safely triaged and, signposted and given appropriate self-care advice. MSK podiatrists have the ability to play an intrinsic role within the post discharge rehabilitation pathway.

scholarly journals FORECASTING COVID-19 PANDEMIC: A DATA-DRIVEN ANALYSIS

2020 ◽  
Author(s):  
Khondoker Nazmoon Nabi
Keyword(s):  
United Kingdom ◽  
Rank Correlation ◽  
Trust Region ◽  
Latin Hypercube Sampling ◽  
Epidemiological Data ◽  
Transmission Dynamics ◽  
Model Parameters ◽  
The Novel ◽  
The United Kingdom ◽  
Novel Coronavirus

In this paper, a new Susceptible-Exposed-Symptomatic Infectious-Asymptomatic Infectious-Quarantined-Hospitalized-Recovered-Dead (SEIDIUQHRD) deterministic compartmental model has been proposed and calibrated for describing the transmission dynamics of the novel coronavirus disease (COVID-19). A calibration process is executed through the solution of an inverse problem with the help of a Trust-Region-Reflective algorithm, used to determine the best parameter values that would fit the model response. The purpose of this study is to give a tentative prediction of the epidemic peak for Russia, Brazil, India and Bangladesh which could become the next COVID-19 hotspots in no time. Based on the publicly available epidemiological data from late January until 10 May, it has been estimated that the number of daily new symptomatic infectious cases for the above mentioned countries could reach the peak around the beginning of June with the peak size of ≈15,774 symptomatic infectious cases in Russia, ≈26,449 cases in Brazil, ≈9,504 cases in India and ≈2,209 cases in Bangladesh. Based on our analysis, the estimated value of the basic reproduction number (R0) as of May 11, 2020 was found to be ≈4.234 in Russia, ≈5.347 in Brazil, ≈5.218 in India, ≈4.649 in the United Kingdom and ≈3.5 in Bangladesh. Moreover, with an aim to quantify the uncertainty of our model parameters, Latin hypercube sampling-partial rank correlation coefficient (LHS-PRCC) which is a global sensitivity analysis (GSA) method is applied which elucidates that, for Russia, the recovery rate of undetected asymptomatic carriers, the rate of getting home-quarantined or self-quarantined and the transition rate from quarantined class to susceptible class are the most influential parameters, whereas the rate of getting home-quarantined or self-quarantined and the inverse of the COVID-19 incubation period are highly sensitive parameters in Brazil, India, Bangladesh and the United Kingdom which could significantly affect the transmission dynamics of the novel coronavirus. Our analysis also suggests that relaxing social distancing restrictions too quickly could exacerbate the epidemic outbreak in the above mentioned countries.

scholarly journals Forecasting COVID-19 Pandemic: A Data-Driven Analysis

2020 ◽  
Author(s):  
Khondoker Nazmoon Nabi
Keyword(s):  
United Kingdom ◽  
Rank Correlation ◽  
Trust Region ◽  
Latin Hypercube Sampling ◽  
Epidemiological Data ◽  
Transmission Dynamics ◽  
The Novel ◽  
Asymptomatic Carriers ◽  
The United Kingdom ◽  
Novel Coronavirus

Abstract In this paper, a new Susceptible-Exposed-Symptomatic Infectious-Asymptomatic Infectious-Quarantined-Hospitalized-Recovered-Dead (SEIDIUQHRD) deterministic compartmental model has been proposed and calibrated for interpreting the transmission dynamics of the novel coronavirus disease (COVID-19). The purpose of this study is to give a tentative prediction of the epidemic peak for Russia, Brazil, India and Bangladesh which could become the next COVID-19 hotspots in no time by using a Trust-region-reflective (TRR) algorithm which one of the well-known real data fitting techniques. Based on the publicly available epidemiological data from late January until 10 May, it has been estimated that the number of daily new symptomatic infectious cases for the above mentioned countries could reach the peak around the beginning of June with the peak size of 15, 774 (95% CI, 13,814-17,734) symptomatic infectious cases in Russia, 26, 449 (95% CI, 23,489-29,409) cases in Brazil, 9, 504 (95% CI, 8,378-10,630) cases in India and 2,209 (95% CI, 1,878-2,540) cases in Bangladesh. As of May 11, 2020, incorporating the infectiousness capability of asymptomatic carriers, our analysis estimates the value of the basic reproduction number (R0) as of May 11, 2020 was found to be 4.234 (95% CI, 3.764-4.7) in Russia, 5.347 (95% CI, 4.737-5.95) in Brazil, 5.218 (95% CI, 4.56-5.81)in India, 4.649 (95% CI, 4.17-5.12) in the United Kingdom and 3.53 (95% CI, 3.12-3.94) in Bangladesh. Moreover, Latin hypercube sampling-partial rank correlation coeffcient (LHS-PRCC) which is a global sensitivity analysis (GSA) method is applied to quantify the uncertainty of our model mechanisms, which elucidates that for Russia, the recovery rate of undetected asymptomatic carriers, the rate of getting home-quarantined or self-quarantined and the transition rate from quarantined class to susceptible class are the most influential parameters, whereas the rate of getting home-quarantined or self-quarantined and the inverse of the COVID-19 incubation period are highly sensitive parameters in Brazil, India, Bangladesh and the United Kingdom which could signicantly affect the transmission dynamics of the novel coronavirus. Our analysis also suggests that relaxing social distancing restrictions too quickly could exacerbate the epidemic outbreak in the above-mentioned countries.

Volunteering in hospice and palliative care in the United Kingdom

2018 ◽  
Author(s):  
Ros Scott
Keyword(s):  
Palliative Care ◽  
United Kingdom ◽  
Care Services ◽  
The United Kingdom ◽  
Strategic Direction ◽  
Palliative Care Services ◽  
History Of ◽  
The Uk ◽  
Hospice And Palliative Care ◽  
Changing Role

This chapter explores the history of volunteers in the founding and development of United Kingdom (UK) hospice services. It considers the changing role and influences of volunteering on services at different stages of development. Evidence suggests that voluntary sector hospice and palliative care services are dependent on volunteers for the range and quality of services delivered. Within such services, volunteer trustees carry significant responsibility for the strategic direction of the organiszation. Others are engaged in diverse roles ranging from the direct support of patient and families to public education and fundraising. The scope of these different roles is explored before considering the range of management models and approaches to training. This chapter also considers the direct and indirect impact on volunteering of changing palliative care, societal, political, and legislative contexts. It concludes by exploring how and why the sector is changing in the UK and considering the growing autonomy of volunteers within the sector.

scholarly journals A history of high-power laser research and development in the United Kingdom

2021 ◽  
Vol 9 ◽  
Author(s):  
Colin N. Danson ◽  
Malcolm White ◽  
John R. M. Barr ◽  
Thomas Bett ◽  
Peter Blyth ◽  
...  
Keyword(s):  
Research And Development ◽  
High Power ◽  
Laser Action ◽  
Historical Review ◽  
High Power Laser ◽  
Power Laser ◽  
The United Kingdom ◽  
History Of ◽  
The Uk ◽  
Made In

Abstract The first demonstration of laser action in ruby was made in 1960 by T. H. Maiman of Hughes Research Laboratories, USA. Many laboratories worldwide began the search for lasers using different materials, operating at different wavelengths. In the UK, academia, industry and the central laboratories took up the challenge from the earliest days to develop these systems for a broad range of applications. This historical review looks at the contribution the UK has made to the advancement of the technology, the development of systems and components and their exploitation over the last 60 years.

scholarly journals Dying to Go Green: The Introduction of Resomation in the United Kingdom

Religions ◽  
2021 ◽  
Vol 12 (2) ◽  
pp. 97
Author(s):  
Georgina M. Robinson
Keyword(s):  
United Kingdom ◽  
Environmental Impact ◽  
Carbon Footprint ◽  
Human Body ◽  
Alkaline Hydrolysis ◽  
The United Kingdom ◽  
Religious Perspectives ◽  
History Of ◽  
The Uk ◽  
Hydrolysis Of

In an age where concern for the environment is paramount, individuals are continuously looking for ways to reduce their carbon footprint—does this now extend to in one’s own death? How can one reduce the environmental impact of their own death? This paper considers various methods of disposing the human body after death, with a particular focus on the environmental impact that the different disposal techniques have. The practices of ‘traditional’ burial, cremation, ‘natural’ burial, and ‘resomation’ will be discussed, with focus on the prospective introduction of the funerary innovation of the alkaline hydrolysis of human corpses, trademarked as ‘Resomation’, in the United Kingdom. The paper situates this process within the history of innovative corpse disposal in the UK in order to consider how this innovation may function within the UK funeral industry in the future, with reference made to possible religious perspectives on the process.

scholarly journals Comprehensive physiotherapy management in covid-19 – a narrative review

2020 ◽  
Vol 30 (1) ◽  
pp. 38030 ◽  
Author(s):  
Deivendran Kalirathinam ◽  
Raj Guruchandran ◽  
Prabhakar Subramani
Keyword(s):  
Narrative Review ◽  
World Health ◽  
Evidence Based ◽  
The United Kingdom ◽  
Global Pandemic ◽  
Related Quality ◽  
Health Related ◽  
Novel Coronavirus ◽  
Health Organization ◽  
The Uk

The 2019 novel coronavirus officially named as coronavirus disease 2019 (COVID-19) pandemic by the World Health Organization, has spread to more than 180 countries. The ongoing global pandemic of severe acute respiratory syndrome coronavirus, which causes COVID-19, spread to the United Kingdom (UK) in January 2020. Transmission within the UK was confirmed in February, leading to an epidemic with a rapid increase in cases in March. As on April 25- 2020, there have been 148,377 confirmed cases of COVID-19 in the UK and 20,319 people with confirmed infection have died. Survival of critically ill patients is frequently associated with significant functional impairment and reduced health-related quality of life. Early physiotherapy and community rehabilitation of COVID-19 patients has recently been identified as an essential therapeutic tool and has become a crucial evidence-based component in the management of these patients. This comprehensive narrative review aims to describe recent progress in the application of physiotherapy management in COVID 19 patients. Assessment and evidence- based treatment of these patients should include prevention, reduction of adverse consequences in immobilization, and long-term impairment sequelae. A variety of techniques and modalities of early physiotherapy in intensive care unit are suggested by clinical research. They should be applied according to the stage of the disease, comorbidities, and patient’s level of cooperation.

The pre-history of health psychology in the United Kingdom: From natural science and psychoanalysis to social science, social cognition and beyond

2017 ◽  
Vol 23 (3) ◽  
pp. 472-491 ◽  
Author(s):  
Michael Murray
Keyword(s):  
Health Psychology ◽  
United Kingdom ◽  
Social Cognition ◽  
Social Science ◽  
20Th Century ◽  
Natural Science ◽  
The United Kingdom ◽  
Theoretical Perspectives ◽  
History Of ◽  
The Uk

Health psychology formally came of age in the United Kingdom in the 1980s, but it was prefigured by much discussion about challenges to the dominance of biomedicine in healthcare and debates. This articles focuses on what could be termed the pre-history of health psychology in the UK. This was the period in the earlier 20th century when psychological approaches were dominated by psychoanalysis which was followed by behaviourism and then cognitivism. Review of this pre-history provides the backdrop for the rise of health psychology in the UK and also reveals the tensions between the different theoretical perspectives.

Transmission dynamics and mechanisms of endemicity of scrapie in the UK sheep population

2008 ◽  
Vol 137 (6) ◽  
pp. 762-774 ◽  
Author(s):  
J. E. TRUSCOTT ◽  
N. M. FERGUSON
Keyword(s):  
Structural Diversity ◽  
Epidemiological Data ◽  
Transmissible Spongiform Encephalopathies ◽  
Spongiform Encephalopathies ◽  
Sheep Population ◽  
Mean Values ◽  
The United Kingdom ◽  
The Family ◽  
The Uk

SUMMARYScrapie is a fatal neurological disease of sheep which is endemic in the United Kingdom. It is one of the family of transmissible spongiform encephalopathies (TSEs) that includes BSE. In this paper, we developed a micro-simulation model for scrapie in the UK sheep population, incorporating the genetic and structural diversity of the population and infectious contact between flocks through trading. The simulation was fitted to epidemiological data from a range of sources. We found a detection/reporting probability of 16% (95% CI 12–17) for animals dying of scrapie. Prevalence of infected animals in the population was about 0·15%. Infected individuals were found in 9% of flocks overall, rising to 60% in Shetland and 75% in Swaledale flocks. Mean values of R0 for flocks varied with breed from 2·43 (Shetland) to 0·21 (Suffolk). We also examined the possible long-term persistence of scrapie in the UK flock in the absence of any intervention.

scholarly journals Respiratory Care in Corona

2021 ◽  
Vol 58 (2) ◽  
pp. 613-620
Author(s):  
Mustafa Amdani, Dr. Swaroopa Chakole
Keyword(s):  
Severe Acute Respiratory Syndrome ◽  
Human Life ◽  
The Body ◽  
Respiratory Care ◽  
The Novel ◽  
Specific Therapy ◽  
History Of ◽  
Novel Coronavirus ◽  
Almost All ◽  
The Impact

BACKGROUND The expanse of the coronavirus disease 2019 or COVID-19 is huge. The impact is multispectral and affected almost all aspects of human life. SUMMARY Respiratory impact of the COVID-19 is the most felt and widely reported impact. As the novel coronavirus maintained its history of affecting lungs as seen previously in severe acute respiratory syndrome (SARS) outbreak. Ventilators and oxygen support system are required mostly in comorbid patients particularly amongpatientsbearing illnesses like asthma, bronchial impairment and so on. CONCLUSION More study needs to be done in order to assess the impact on the respiratory functioning of the body. Respiratory care must be including proper instruments so that more efficient result can be obtained. Research is needed to promote the invention of specific therapy for targeted action for respiratory functioning improvement.

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