The chemokine system and its relation to the framework of host immunological pathways
In my previous study, I summarized a framework of all host immunological pathways including eradicable immune responses and tolerable immune responses. We already know that chemokine receptor CXCR5 is related to the marker of follicular helper T cells. I am also interested in categorize the other chemokine receptors into the framework of the host immunological pathways. By literature review, I summarize the findings below: TH1 is related to CCR5, TH1-like is related CCR1/CCR2, TH2 is related to CCR4, TH9 is related CCR3, TH22 is related to CCR10, TH17 is related to CCR6, THalpha/beta(Tr1) is related to CXCR3, Treg is related to CCR8, and TH3 is related to CX3CR1. I also find out that CCR7 is related to lymph node homing, and CCR9 is related to thymus homing. CXCR1 and CXCR2 are important for chemotaxis of neutrophils and are important in innate immunity. CXCR4 is for immune cell homing to bone marrow. CXCR6 is for immune cell homing to spleen. XCR1 is expressed in dendritic cells and has important function for CD8 T cell cross presentation. These findings can help to identify biomarkers of these immune cells and provide new insight of the host immunological pathways.