scholarly journals Improved Application of the Control-of-Variables Strategy as a Collateral Benefit of Inquiry-Based Physics Education in Elementary School

2017 ◽  
Author(s):  
Lennart Schalk ◽  
Peter Adriaan Edelsbrunner
Keyword(s):  
Elementary School ◽  
Physics Education ◽  
High Dose ◽  
Physics Instruction ◽  
Control Of Variables ◽  
Control Of Variables Strategy ◽  
Quasi Experimental ◽  
Physics Knowledge ◽  
Physics Curriculum ◽  
To Receive

In a quasi-experimental classroom study, we longitudinally investigated whether inquiry-based, content-focused physics instruction improves students’ ability to apply the control-of-variables strategy, a domain-general experimentation skill. Twelve third grade elementary school classes (Mdnage = 9 years, N = 189) were randomly assigned to receive either four different physics curriculum units (intervention) or traditional instruction (control). Experiments were frequent elements in the physics units; however, there was no explicit instruction of the control-of-variables strategy or other experimentation skills. As intended, students in the intervention classes strongly increased their conceptual physics knowledge. More importantly, students in the intervention classes also showed stronger gains in their ability to apply the control-of-variables strategy correctly in novel situations compared to students in the control classes. Thus, a high dose of experimentation had the collateral benefit of improving the transfer of the control-of-variables strategy. The study complements lab-based studies with convergent findings obtained in real classrooms.

scholarly journals Improved application of the control-of-variables strategy as a collateral benefit of inquiry-based physics education in elementary school

2019 ◽  
Vol 59 ◽  
pp. 34-45 ◽  
Author(s):  
Lennart Schalk ◽  
Peter A. Edelsbrunner ◽  
Anne Deiglmayr ◽  
Ralph Schumacher ◽  
Elsbeth Stern
Keyword(s):  
Elementary School ◽  
Physics Education ◽  
Control Of Variables ◽  
Control Of Variables Strategy

scholarly journals The relation between the control-of-variables strategy and content knowledge in physics in secondary school

2020 ◽  
Author(s):  
Peter Adriaan Edelsbrunner ◽  
Christopher Osterhaus ◽  
Martin Schwichow
Keyword(s):  
Secondary School ◽  
Content Knowledge ◽  
Physics Education ◽  
Latent Profile Analysis ◽  
Lower Grade ◽  
Science Content ◽  
Science Content Knowledge ◽  
Control Of Variables ◽  
Control Of Variables Strategy ◽  
The Impact

The control-of-variables strategy (CVS) is considered a hallmark in the development of scientific reasoning. It holds that informative experiments need to be contrastive and controlled. Prior evidence suggests that CVS is connected to the acquisition of science content knowledge. In a cross-sectional study involving 1,283 high school students (grades 5 - 13), we investigate whether students’ mastery of CVS is related to their science content knowledge in physics. A latent variable model indicates that CVS is substantially associated with students’ science content knowledge, even when controlling for common effects of general reasoning abilities. Substantial differences in students’ CVS skills and their science content knowledge exist between the lower grade levels in secondary school when students receive physics education. A latent profile analysis shows that the most difficult aspect of CVS is understanding the impact of confounding. This sub-skill emerges in late secondary school and it requires that students master more procedural sub-skills of CVS. These findings indicate that CVS and science content knowledge are closely related within secondary school science contexts. In addition, the findings emphasize that students show various distinct patterns of CVS skills. The identified skill patterns can inform researchers and science educators about the CVS skills that students typically show and thus can be utilized in inquiry activities in different school grades, while the CVS skills students are lacking might be trained in focused interventions.

Pseudo-Parkinson Disease Secondary to Ritonavir–Buspirone Interaction

2003 ◽  
Vol 37 (2) ◽  
pp. 202-205 ◽  
Author(s):  
Patrick G Clay ◽  
Molly M Adams
Keyword(s):  
Drug Interaction ◽  
Inhibitory Effect ◽  
Hiv Positive ◽  
High Dose ◽  
Resting Tremor ◽  
Case Summary ◽  
History Of ◽  
Drug Drug Interaction ◽  
To Receive

OBJECTIVE: To report a case of Parkinson-like symptoms appearing in a patient after introduction of ritonavir to buspirone therapy. CASE SUMMARY: A 54-year-old HIV-positive white man presented to the clinic with a 2-week history of ataxia, shuffling gait, cogwheel rigidity, resting tremor, and sad affect with masked features. This patient had been receiving high-dose buspirone (40 mg every morning and 30 mg every evening) for 2 years prior to the introduction of ritonavir/indinavir combination therapy (400 mg/400 mg twice daily) 6 weeks prior to initiation of the above symptoms. Buspirone was decreased to 15 mg 3 times daily, ritonavir/indinavir was discontinued, and amprenavir 1200 mg twice daily was added. The patient's symptoms began to subside after 1 week, with complete resolution after about 2 weeks. The patient continued to receive buspirone for an additional 12 months without recurrence of symptoms. DISCUSSION: This is the first reported interaction of buspirone and antiretrovirals. Buspirone, extensively metabolized by CYP3A4, was likely at supratherapeutic levels due to the inhibitory effect of ritonavir and, secondarily, indinavir. The Parkinson-like symptoms developed rapidly and severely, impacted this patient's quality of life, and necessitated significant clinic expenditures to identify this drug–drug interaction. CONCLUSIONS: This case demonstrates a severe drug–drug interaction between buspirone and ritonavir and further demonstrates the need for awareness of the metabolic profile for all agents an HIV-infected patient is receiving.

The impact of sub-skills and item content on students’ skills with regard to the control-of-variables strategy

2016 ◽  
Vol 38 (2) ◽  
pp. 216-237 ◽  
Author(s):  
Martin Schwichow ◽  
Simon Christoph ◽  
William J. Boone ◽  
Hendrik Härtig
Keyword(s):  
Control Of Variables ◽  
Control Of Variables Strategy ◽  
Item Content ◽  
The Impact

scholarly journals Phase 1 Study of the Safety, Tolerability, and Pharmacokinetics of the β-Lactamase Inhibitor Vaborbactam (RPX7009) in Healthy Adult Subjects

2016 ◽  
Vol 60 (10) ◽  
pp. 6326-6332 ◽  
Author(s):  
David C. Griffith ◽  
Jeffery S. Loutit ◽  
Elizabeth E. Morgan ◽  
Stephanie Durso ◽  
Michael N. Dudley
Keyword(s):  
Plasma Clearance ◽  
Healthy Adult ◽  
Phase 1 ◽  
High Dose ◽  
Double Blind ◽  
Time Curve ◽  
Content Type ◽  
Multiple Doses ◽  
To Receive ◽  
Lactamase Inhibitor

ABSTRACTVaborbactam (formerly RPX7009) is a member of a new class of β-lactamase inhibitor with pharmacokinetic properties similar to those of many β-lactams, including carbapenems. The pharmacokinetics and safety of vaborbactam were evaluated in 80 healthy adult subjects in a first-in-human randomized, placebo-controlled, double-blind, sequential single- and multiple-ascending-dose study. A total of 10 dose cohorts were enrolled in the study, with 6 subjects randomized to receive 250 to 2,000 mg of vaborbactam and 2 subjects randomized to receive placebo in each cohort. Maximum concentrations for vaborbactam were achieved at the end of the 3-h infusion. Vaborbactam exposure (Cmaxand area under the concentration-time curve [AUC]) increased in a dose-proportional manner following multiple doses. There was no evidence of accumulation with multiple doses, consistent with the terminal half-life of ∼2 h. Both the volume of distribution (Vss) and plasma clearance were independent of dose. For the 2,000-mg dose, the plasma clearance was 0.17 ± 0.03 liters/h, the AUC from 0 h to infinity (AUC0–∞) was 144.00 ± 13.90 mg · h/liter, and theVsswas 21.80 ± 2.26 mg · h/liter. Urinary recovery was 80% or greater over 48 h across all dose groups. No subjects discontinued the study due to adverse events (AEs), and no serious AEs (SAEs) were observed. All AEs were mild to moderate and similar among the vaborbactam- and placebo-treated subjects, with mild lethargy as the only unique AE reported with the high dose of vaborbactam. Overall, this study revealed the safety, tolerability, and pharmacokinetic profile of vaborbactam and formed the basis for advancement into patient studies in combination with meropenem, including treatment of patients with carbapenem-resistantEnterobacteriaceae(CRE) infections. (This study is registered at ClinicalTrials.gov under identifier NCT01751269.)

Solumedrol Treatment for Severe Sepsis in Humans with a Blunted Adrenocorticotropic Hormone-Cortisol Response: A Prospective Randomized Double-Blind Placebo-Controlled Pilot Clinical Trial

2021 ◽  
pp. 088506662110388
Author(s):  
Divya Birudaraju ◽  
Sajad Hamal ◽  
John A. Tayek
Keyword(s):  
Blood Pressure ◽  
Clinical Trial ◽  
Adrenocorticotropic Hormone ◽  
Serum Cortisol ◽  
High Dose ◽  
Cortisol Response ◽  
Acth Stimulation ◽  
Double Blind ◽  
Significant Difference ◽  
To Receive

Purpose To test the benefits of Solumedrol treatment in sepsis patients with a blunted adrenocorticotropic hormone (ACTH)-cortisol response (delta <13 µg/dL) with regard to the number of days on ventilator, days on intravenous blood pressure support, length of time in an intensive care unit (ICU), 14-day mortality, and 28-day mortality. The trial was prospective, randomized, and double-blind. As part of a larger sepsis trial, 54 patients with sepsis had an intravenous ACTH stimulation test using 250 µg of ACTH, and serum cortisol was measured at times 0, 30, and 60 min. Eleven patients failed to increase their cortisol concentration above 19.9 µg/dL and were excluded from the clinical trial as they were considered to have adrenal insufficiency. The remaining 43 patients had a baseline cortisol of 32 ± 1 µg/dL increased to 38 ± 3 µg/dL at 30 min and 40 ± 3 at 60 min. All cortisol responses were <12.9 µg/dL between time 0 and time 60, which is defined as a blunted cortisol response to intravenous ACTH administration. Twenty-one were randomized to receive 20 mg of intravenous Solumedrol and 22 were randomized to receive a matching placebo every 8 h for 7-days. There was no significant difference between the two randomized groups. Data analysis was carried out bya two-tailed test and P < .05 as significant. Results Results: The mean age was 51 ± 2 (mean ± SEM) with 61% female. Groups were well matched with regard to APACHE III score in Solumedrol versus placebo (59 ± 6 vs 59 ± 6), white blood cell count (18.8 ± 2.2 vs 18.6 ± 2.6), and incidence of bacteremia (29 vs 39%). The 28-day mortality rate was reduced in the Solumedrol treated arm (43 ± 11 vs 73 ± 10%; P < .05). There was no change in days in ICU, days on blood pressure agents, or days on ventilator. Seven days of high-dose intravenous Solumedrol treatment (20 mg every 8 h) in patients with a blunted cortisol response to ACTH was associated with an improved 28-day survival. This small study suggests that an inability to increase endogenous cortisol production in patients with sepsis who are then provided steroid treatment could improve survival.

Effect of a musical instrument performance program on emotional intelligence, anxiety, and aggression in Korean elementary school children

2017 ◽  
Vol 46 (3) ◽  
pp. 440-453 ◽  
Author(s):  
Hyun-Sil Kim ◽  
Hun-Soo Kim
Keyword(s):  
Elementary School ◽  
Emotional Intelligence ◽  
School Children ◽  
Elementary School Children ◽  
Musical Instrument ◽  
School Curriculum ◽  
Control Group ◽  
Instrument Performance ◽  
Quasi Experimental ◽  
Music Class

The purpose of this study was to determine the effects of a musical instrument performance program on emotional intelligence, anxiety, and aggression in Korean elementary school children. A quasi-experimental study design was employed, in which the experimental group ( n = 30) received a weekly group musical instrument performance class with a regular music class, and the control group ( n = 30) received only a regular music class that is part of the elementary school curriculum. We measured emotional intelligence, anxiety, and aggression at the beginning and end of the 24-week intervention using the Emotional Intelligence Scale, the Trait Anxiety Inventory, and the Aggression Scale. The musical instrument performance program improved the ability to perceive emotions, and reduced physical and verbal aggression, but had no statistically significant effect on the level of total emotional intelligence, anxiety, or aggression.

scholarly journals PENGARUH PENDEKATAN VALUE CLARIFICATION TECHNIQUE (VCT) METODE PERCONTOHAN TERHADAP HASIL BELAJAR PKn SISWA SD

2019 ◽  
Author(s):  
Reinita
Keyword(s):  
Elementary School ◽  
Civic Education ◽  
Learning Outcome ◽  
Modeling Method ◽  
T Test ◽  
Control Group ◽  
Homogeneity Test ◽  
Significance Level ◽  
Quasi Experimental ◽  
Equivalent Control

This study aims to determine the effect of Value Clarification Technique (VCT) modeling method on the studnts’ learning outcome in civic education. This study is a quasi-experimental design with a non-equivalent control group. The research was conducted in elementary school Number 13 Cingkariang Banuhampu Sub-district of Agam District with class VA as the experimental class and Class VB as the control class. Both classes have twenty five students. The data analysis technique employed was the normality test and homogeneity test, which was then followed by a t-test to see the effect of VCT. The results show that the average pretest score is 38,768 for the experimental class and 41,488 for the control class. The average posstest score is 90,68 for the experimental class and 86,32 for the control class. The result of the t-test shows that the tcount is 1,73 and the ttable on the significance level of 0,05 is 1,6772, which means that tcount&gt;ttable. Therefore, it is concluded that the Value Clarification Technique modeling method affects the students’ learning outcome in civic education in Elementary School Number 13 Cingkariang

scholarly journals THE EFFECT OF COOPERATIVE LEARNING MODEL OF THINK PAIR SHARE BASED ON CONCEPT MAPPING TOWARDS CIVICS ACHIEVEMENT

2018 ◽  
Vol 2 (2) ◽  
pp. 51
Author(s):  
Ni Wayan Suyatni ◽  
Ndara Tanggu Rendra ◽  
Ni Wayan Rati
Keyword(s):  
Elementary School ◽  
Concept Mapping ◽  
Learning Model ◽  
Fifth Grade ◽  
Control Group ◽  
Control Group Design ◽  
Model Based ◽  
Fifth Grade Students ◽  
Significant Difference ◽  
Quasi Experimental

This study is aimed at investigating the difference of students’ civics achievement between those who are taught by Think Pair Share model based on concept mapping and those who are taught by conventional learning model of the fifth grade students in Elementary School of Cluster I in Petang District. It is a quasi-experimental research using non-equivalent post-test only control group design. The population of this research is 102 students in grade V in Elementary School of Cluster I Petang District. The samples of this research are fifth grade students of SD Negeri 3 Carangsari as experimental group and fifth grade students of SD Negeri 1 Carangsari as control group. The data of civics achievement were collected by using multiple choice tests. The data obtained were analyzed using descriptive statistics and inferential statistical analysis (t-test). The result showed that tcount= 3,83 and ttable = 2,03 (tcount>ttable) which can be concluded that there are significant difference between the students’ civics achievement between those who were taught by Think Pair Share learning model based on concept mapping and those who were taught by the conventional learning model in grade V in Elementary School of Cluster I Petang District of Badung Regency in academic year 2017/2018.

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