scholarly journals Vitamin P – Do Certain Polyphenolic IMPS Have a Vital Function?

2020 ◽  
Author(s):  
Guido Pauli
Keyword(s):  
Vitamin C ◽  
Plant Extracts ◽  
Mode Of Action ◽  
Essential Role ◽  
Meta Analysis ◽  
Vital Function ◽  
Synthetic Vitamin ◽  
Dietary Nutrient ◽  
Plant Constituents ◽  
Single Compound

In the 1930s, it was discovered that the ability of synthetic Vitamin C to treat scurvy was inferior to plant extracts containing Vitamin C. This observation led to the proposal of Vitamin P (permeability), as an essential phytochemical dietary nutrient. Subsequent attempts to isolate and characterize Vitamin P led to confusing and sometimes irreproducible results. Over the years several flavonoids and coumarins have been identified as having Vitamin P-like activity. Essentially all of these Vitamin P candidates were recently identified as IMPs (Invalid/Improbable/Interfering Metabolic Panaceas) in a NAPRALERT meta analysis. While the historic inability to define a single compound and specific mode of action led to general skepticism about the Vitamin P proposition, the more logical conclusion is that several abundant and metabolically labile plant constituents fill this essential role in human nutrition. This review of 100+ years of multilingual Vitamin P and C literature provides the rationales for this conclusion.

scholarly journals Do Certain Flavonoid IMPS Have a Vital Function?

2021 ◽  
Vol 8 ◽  
Author(s):  
David S. Seigler ◽  
J. Brent Friesen ◽  
Jonathan Bisson ◽  
James G. Graham ◽  
Ana Bedran-Russo ◽  
...  
Keyword(s):  
Vitamin C ◽  
Meta Analysis ◽  
Vascular Plant ◽  
Future Research ◽  
Synthetic Vitamin ◽  
Nutrition Research ◽  
Plant Constituents ◽  
Single Compound ◽  
Residual Complexity ◽  
Metabolic Interconversion

Flavonoids are a vast group of metabolites that are essential for vascular plant physiology and, thus, occur ubiquitously in plant-based/-derived foods. The solitary designation of thousands of known flavonoids hides the fact that their metabolomes are structurally highly diverse, consist of disparate subgroups, yet undergo a certain degree of metabolic interconversion. Unsurprisingly, flavonoids have been an important theme in nutrition research. Already in the 1930s, it was discovered that the ability of synthetic Vitamin C to treat scurvy was inferior to that of plant extracts containing Vitamin C. Subsequent experimental evidence led to the proposal of Vitamin P (permeability) as an essential phytochemical nutrient. However, attempts to isolate and characterize Vitamin P gave confusing and sometimes irreproducible results, which today can be interpreted as rooted in the unrecognized (residual) complexity of the intervention materials. Over the years, primarily flavonoids (and some coumarins) were known as having Vitamin P-like activity. More recently, in a NAPRALERT meta-analysis, essentially all of these Vitamin P candidates were identified as IMPs (Invalid/Improbable/Interfering Metabolic Panaceas). While the historic inability to define a single compound and specific mode of action led to general skepticism about the Vitamin P proposition for “bioflavonoids,” the more logical conclusion is that several abundant and metabolically labile plant constituents fill this essential role in human nutrition at the interface of vitamins, cofactors, and micronutrients. Reviewing 100+ years of the multilingual Vitamin P and C literature provides the rationales for this conclusion and new perspectives for future research.

scholarly journals Correction: Hill, A.; et al. Effects of Vitamin C on Organ Function in Cardiac Surgery Patients: A Systematic Review and Meta-Analysis. Nutrients 2019, 11, 2103

Nutrients ◽  
2020 ◽  
Vol 12 (12) ◽  
pp. 3910
Author(s):  
Aileen Hill ◽  
Kai Clasen ◽  
Sebastian Wendt ◽  
Ádám Majoros ◽  
Christian Stoppe ◽  
...  
Keyword(s):  
Systematic Review ◽  
Cardiac Surgery ◽  
Vitamin C ◽  
Meta Analysis ◽  
Organ Function

The authors thank the readers for pointing out the issues [...]

scholarly journals The effectiveness of Bacopa monnieri (Linn.) Wettst. as a nootropic, neuroprotective, or antidepressant supplement: analysis of the available clinical data

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
James M. Brimson ◽  
Sirikalaya Brimson ◽  
Mani Iyer Prasanth ◽  
Premrutai Thitilertdecha ◽  
Dicson Sheeja Malar ◽  
...  
Keyword(s):  
Plant Extracts ◽  
Neurological Diseases ◽  
Digit Span ◽  
Meta Analysis ◽  
Statistical Significance ◽  
Verbal Learning ◽  
Memory Loss ◽  
Learning Task ◽  
Inspection Time ◽  
Neuroprotective Effects

AbstractBacopamonnieri (Linn.) Wettst. has been used in traditional medicine as a drug to enhance and improve memory. In this regard, this study aims to provide B. monnieri's efficacy as a neuroprotective drug and as a nootropic against various neurological diseases. Literatures were collected, following Prisma guidelines, from databases, including Scopus, PubMed, Google Scholar, and Science Direct and were scrutinized using a quality scoring system. Means, standard deviations and ‘n’ numbers were extracted from the metrics and analyzed. Jamovi computer software for Mac was used to carry out the meta-analysis. The selected studies suggested that the plant extracts were able to show some improvements in healthy subjects which were determined in Auditory Verbal Learning Task, digit span-reverse test, inspection time task and working memory, even though it was not significant, as no two studies found statistically significant changes in the same two tests. B. monnieri was able to express modest improvements in subjects with memory loss, wherein only a few of the neuropsychological tests showed statistical significance. B. monnieri in a cocktail with other plant extracts were able to significantly reduce the effects of Alzheimer’s disease, and depression which cannot be solely credited as the effect of B. monnieri. Although in one study B. monnieri was able to potentiate the beneficial effects of citalopram; on the whole, currently, there are only limited studies to establish the memory-enhancing and neuroprotective effects of B. monnieri. More studies have to be done in the future by comparing the effect with standard drugs, in order to establish these effects clinically in the plant and corroborate the preclinical data.

scholarly journals Dietary and circulating vitamin C, vitamin E, β-carotene and risk of total cardiovascular mortality: a systematic review and dose–response meta-analysis of prospective observational studies

2019 ◽  
Vol 22 (10) ◽  
pp. 1872-1887 ◽  
Author(s):  
Ahmad Jayedi ◽  
Ali Rashidy-Pour ◽  
Mohammad Parohan ◽  
Mahdieh Sadat Zargar ◽  
Sakineh Shab-Bidar
Keyword(s):  
Systematic Review ◽  
Vitamin E ◽  
Vitamin C ◽  
Dose Response ◽  
Observational Studies ◽  
Meta Analysis ◽  
Dietary Intakes ◽  
Relative Risks ◽  
Β Carotene ◽  
Cvd Mortality

AbstractObjectiveThe present review aimed to quantify the association of dietary intake and circulating concentration of major dietary antioxidants with risk of total CVD mortality.DesignSystematic review and meta-analysis.SettingSystematic search in PubMed and Scopus, up to October 2017.ParticipantsProspective observational studies reporting risk estimates of CVD mortality across three or more categories of dietary intakes and/or circulating concentrations of vitamin C, vitamin E and β-carotene were included. A random-effects meta-analysis was conducted.ResultsA total of fifteen prospective cohort studies and three prospective evaluations within interventional studies (320 548 participants and 16 974 cases) were analysed. The relative risks of CVD mortality for the highest v. the lowest category of antioxidant intakes were as follows: vitamin C, 0·79 (95 % CI 0·68, 0·89; I2=46 %, n 10); vitamin E, 0·91 (95 % CI 0·79, 1·03; I2=51 %, n 8); β-carotene, 0·89 (95 % CI 0·73, 1·05; I2=34 %, n 4). The relative risks for circulating concentrations were: vitamin C, 0·60 (95 % CI 0·42, 0·78; I2=65 %, n 6); α-tocopherol, 0·82 (95 % CI 0·76, 0·88; I2=0 %, n 5); β-carotene, 0·68 (95 % CI 0·52, 0·83; I2=50 %, n 6). Dose–response meta-analyses demonstrated that the circulating biomarkers of antioxidants were more strongly associated with risk of CVD mortality than dietary intakes.ConclusionsThe present meta-analysis demonstrates that higher vitamin C intake and higher circulating concentrations of vitamin C, vitamin E and β-carotene are associated with a lower risk of CVD mortality.

scholarly journals Association of vitamin C, vitamin D, vitamin E and risk of bladder cancer: a dose-response meta-analysis

2015 ◽  
Vol 5 (1) ◽  
Author(s):  
Fuqiang Chen ◽  
Qingshu Li ◽  
Yang Yu ◽  
Wenrong Yang ◽  
Fei Shi ◽  
...  
Keyword(s):  
Vitamin D ◽  
Bladder Cancer ◽  
Vitamin E ◽  
Vitamin C ◽  
Dose Response ◽  
Meta Analysis

Strategies Preventing Contrast-Induced Nephropathy After Coronary Angiography: A Comprehensive Meta-Analysis and Systematic Review of 125 Randomized Controlled Trials

Angiology ◽  
2016 ◽  
Vol 68 (5) ◽  
pp. 389-413 ◽  
Author(s):  
Sadegh Ali-Hassan-Sayegh ◽  
Seyed Jalil Mirhosseini ◽  
Zahra Ghodratipour ◽  
Zahra Sarrafan-Chaharsoughi ◽  
Elham Rahimizadeh ◽  
...  
Keyword(s):  
Systematic Review ◽  
Coronary Angiography ◽  
Vitamin C ◽  
Enzyme Inhibitors ◽  
Meta Analysis ◽  
Angiotensin Converting Enzyme Inhibitors ◽  
Pooled Analysis ◽  
Loop Diuretics ◽  
Contrast Induced Nephropathy ◽  
Converting Enzyme Inhibitors

This systematic review with meta-analysis sought to determine the strength of evidence for the effects of hydration (sodium bicarbonate [SB] and normal saline [NS]), supplementations ( N-acetylcysteine [NAC] and vitamin C), and some common drugs (adenosine antagonists [AAs], statins, loop diuretics, and angiotensin-converting enzyme inhibitors [ACEIs]) on the incidence of contrast-induced nephropathy (CIN) and requirement for hemodialysis after coronary angiography. After screening, a total of 125 trials that reported outcomes were identified. Pooled analysis indicated beneficial effects of SB versus NS (odds ratio [OR] = 0.73; 95% confidence interval [CI]: 0.56-0.94; P = .01), NAC (OR = 0.79; 95% CI: 0.70-0.88; P = .001), vitamin C (OR = 0.64; 95% CI: 0.45-0.89; P = .01), statins (OR = 0.45; 95% CI: 0.35-0.57; P = .001), AA (OR = 0.28; 95% CI: 0.14-0.47; P = .001), loop diuretics (OR = 0.97; 95% CI: 0.33-2.85; P = .9), and ACEI (OR = 1.06; 95% CI: 0.69-1.61; P = .8). Overall, hydration with SB, use of supplements, such as NAC and vitamin C, and administration of statins and AA should always be considered for the prevention of CIN after coronary angiography.

DENTAL IMPLANTS IN MEDICALLY COMPROMISED PATIENTS

2021 ◽  
pp. 64-65
Author(s):  
A.Bhagya Mathivanan ◽  
Balakrishnan Balakrishnan
Keyword(s):  
Literature Review ◽  
Dental Implants ◽  
Clinical Studies ◽  
Meta Analysis ◽  
Endocrine Disorders ◽  
Oral Bisphosphonates ◽  
Inclusion Criteria ◽  
Vital Function ◽  
The Status ◽  
Compromised Patients

The present study was carried out with an aim and interest to evaluate the status of implant, its function, and durability which are placed in the medically compromised patient .The literature review was done in order to identify the medically compromised patients with implants and were on medication with oral bisphosphonates for the ossication to be formed around dental implants for its vital function. The articles published between the years2001 to 2010 were included in the study. The articles of clinical studies in which 7-8 patients were treated, consensus articles,review articles and meta analysis were included. The total of 34 articles was found in which 26 articles met the inclusion criteria. The systematic diseases/ medically compromised are those patients with cardiac, diabetic,endocrine disorders and who are also seems to treated with dental implant and its outcomes.

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