scholarly journals Comparing the structure and function of social-cognition-related brain areas in bisexual, heterosexual, and homosexual women and men

2021 ◽  
Author(s):  
Victoria Klimaj ◽  
Adam Safron ◽  
David Sylva ◽  
A.M. Rosenthal ◽  
Meng Li ◽  
...  
Keyword(s):  
Social Cognition ◽  
Large Scale ◽  
Brain Activity ◽  
Gray Matter Volume ◽  
Sex And Gender ◽  
Social Environments ◽  
Men And Women ◽  
Temporoparietal Junction ◽  
Mixed Support ◽  
The Right

A small number of studies have examined neuroanatomical differences between heterosexual and homosexual men and women. These studies have yielded mixed support for the hypothesis that homosexual individuals possess sex-atypical neural anatomy. However, in addition to differing along dimensions of sex-typicality, non-heterosexual individuals’ brains may be different in other ways, potentially as a result of differences in experience. One way in which sexual minorities may differ from others is in their social experiences. Bisexual individuals in particular may occupy unique social niches and experience complex social environments as a result of sexual and romantic interactions with both men and women, and potentially also in terms of having a less-widely-recognized sexual identity than heterosexual and homosexual individuals. Based on this idea, we hypothesized that bisexual individuals may show increased gray matter volume and activity in two social-cognition-related areas of the brain: the right temporoparietal junction (rTPJ) and the dorsomedial prefrontal cortex (dmPFC). Contrary to our hypotheses, neither brain structure nor brain activity in the rTPJ and dmPFC were significantly greater in bisexual individuals than in heterosexual and homosexual individuals. Instead, we found larger rTPJ volumes in heterosexual women than in homosexual women. We also found larger relative volumes in the dmPFC in women than in men, consistent with a recent large-scale study of sex differences, and potentially indicative of sex and gender differences in social cognition.

Emotional Reactivity to Visual Content as Revealed by ERP Component Clustering

2015 ◽  
Vol 29 (4) ◽  
pp. 135-146 ◽  
Author(s):  
Miroslaw Wyczesany ◽  
Szczepan J. Grzybowski ◽  
Jan Kaiser
Keyword(s):  
Emotional Reactivity ◽  
Brain Activity ◽  
Affective State ◽  
Occipital Lobe ◽  
Stimulus Onset ◽  
Emotional States ◽  
Neural Basis ◽  
Temporoparietal Junction ◽  
The Right ◽  
The Impact

Abstract. In the study, the neural basis of emotional reactivity was investigated. Reactivity was operationalized as the impact of emotional pictures on the self-reported ongoing affective state. It was used to divide the subjects into high- and low-responders groups. Independent sources of brain activity were identified, localized with the DIPFIT method, and clustered across subjects to analyse the visual evoked potentials to affective pictures. Four of the identified clusters revealed effects of reactivity. The earliest two started about 120 ms from the stimulus onset and were located in the occipital lobe and the right temporoparietal junction. Another two with a latency of 200 ms were found in the orbitofrontal and the right dorsolateral cortices. Additionally, differences in pre-stimulus alpha level over the visual cortex were observed between the groups. The attentional modulation of perceptual processes is proposed as an early source of emotional reactivity, which forms an automatic mechanism of affective control. The role of top-down processes in affective appraisal and, finally, the experience of ongoing emotional states is also discussed.

scholarly journals Virtual reality-based sensorimotor adaptation shapes subsequent spontaneous and naturalistic stimulus-driven brain activity

2021 ◽  
Author(s):  
Meytal Wilf ◽  
Celine Dupuis ◽  
Davide Nardo ◽  
Diana Huber ◽  
Sibilla Sander ◽  
...  
Keyword(s):  
Virtual Reality ◽  
Large Scale ◽  
Right Hemisphere ◽  
Functional Neuroimaging ◽  
Brain Activity ◽  
Visual Response ◽  
Spatial Shift ◽  
Before And After ◽  
Behavioural Tests ◽  
The Right

Our everyday life summons numerous novel sensorimotor experiences, to which our brain needs to adapt in order to function properly. However, tracking plasticity of naturalistic behaviour and associated brain modulations is challenging. Here we tackled this question implementing a prism adaptation training in virtual reality (VRPA) in combination with functional neuroimaging. Three groups of healthy participants (N=45) underwent VRPA (with a spatial shift either to the left/right side, or with no shift), and performed fMRI sessions before and after training. To capture modulations in free-flowing, task-free brain activity, the fMRI sessions included resting state and free viewing of naturalistic videos. We found significant decreases in spontaneous functional connectivity between large-scale cortical networks, namely attentional and default mode/fronto-parietal networks, only for adaptation groups. Additionally, VRPA was found to bias visual representations of naturalistic videos, as following rightward adaptation, we found upregulation of visual response in an area in the parieto-occipital sulcus (POS) in the right hemisphere. Notably, the extent of POS upregulation correlated with the size of the VRPA induced after-effect measured in behavioural tests. This study demonstrates that a brief VRPA exposure is able to change large-scale cortical connectivity and correspondingly bias the representation of naturalistic sensory inputs.

Identifying neuroanatomical signatures in insomnia and migraine comorbidity

SLEEP ◽  
2020 ◽  
Author(s):  
Kun-Hsien Chou ◽  
Pei-Lin Lee ◽  
Chih-Sung Liang ◽  
Jiunn-Tay Lee ◽  
Hung-Wen Kao ◽  
...  
Keyword(s):  
Large Scale ◽  
Gray Matter Volume ◽  
Brain Structures ◽  
Brain Network ◽  
Structural Covariance ◽  
Matter Volume ◽  
The Right ◽  
Global Brain ◽  
The Brain

Abstract Study Objectives While insomnia and migraine are often comorbid, the shared and distinct neuroanatomical substrates underlying these disorders and the brain structures associated with the comorbidity are unknown. We aimed to identify patterns of neuroanatomical substrate alterations associated with migraine and insomnia comorbidity. Methods High-resolution T1-weighted images were acquired from subjects with insomnia, migraine, and comorbid migraine and insomnia, respectively, and healthy controls (HC). Direct group comparisons with HC followed by conjunction analyses identified shared regional gray matter volume (GMV) alterations between the disorders. To further examine large-scale anatomical network changes, a seed-based structural covariance network (SCN) analysis was applied. Conjunction analyses also identified common SCN alterations in two disease groups, and we further evaluated these shared regional and global neuroanatomical signatures in the comorbid group. Results Compared with controls, patients with migraine and insomnia showed GMV changes in the cerebellum and the lingual, precentral, and postcentral gyri (PCG). The bilateral PCG were common GMV alteration sites in both groups, with decreased structural covariance integrity observed in the cerebellum. In patients with comorbid migraine and insomnia, shared regional GMV and global SCN changes were consistently observed. The GMV of the right PCG also correlated with sleep quality in these patients. Conclusion These findings highlight the specific role of the PCG in the shared pathophysiology of insomnia and migraine from a regional and global brain network perspective. These multilevel neuroanatomical changes could be used as potential image markers to decipher the comorbidity of the two disorders.

scholarly journals A Meta-analysis of Structural and Functional Brain Abnormalities in Early-Onset Schizophrenia

2020 ◽  
Vol 1 (1) ◽  
Author(s):  
Vasileios Ioakeimidis ◽  
Corinna Haenschel ◽  
Kielan Yarrow ◽  
Marinos Kyriakopoulos ◽  
Danai Dima
Keyword(s):  
Functional Mri ◽  
Early Onset ◽  
Meta Analysis ◽  
Gray Matter Volume ◽  
Anterior Cingulate ◽  
Salience Network ◽  
Early Onset Schizophrenia ◽  
Mri Findings ◽  
Temporoparietal Junction ◽  
The Right

Abstract Early-onset schizophrenia (EOS) patients demonstrate brain changes that are similar to severe cases of adult-onset schizophrenia. Neuroimaging research in EOS is limited due to the rarity of the disorder. The present meta-analysis aims to consolidate MRI and functional MRI findings in EOS. Seven voxel-based morphometry (VBM) and 8 functional MRI studies met the inclusion criteria, reporting whole-brain analyses of EOS vs healthy controls. Activation likelihood estimation (ALE) was conducted to identify aberrant anatomical or functional clusters across the included studies. Separate ALE analyses were performed, first for all task-dependent studies (Cognition ALE) and then only for working memory ones (WM ALE). The VBM ALE revealed no significant clusters for gray matter volume reductions in EOS. Significant hypoactivations peaking in the right anterior cingulate cortex (rACC) and the right temporoparietal junction (rTPJ) were detected in the Cognition ALE. In the WM ALE, consistent hypoactivations were found in the left precuneus (lPreC), the right inferior parietal lobule (rIPL) and the rTPJ. These hypoactivated areas show strong associations with language, memory, attention, spatial, and social cognition. The functional co-activated networks of each suprathreshold ALE cluster, identified using the BrainMap database, revealed a core co-activation network with similar topography to the salience network. Our results add support to posterior parietal, ACC and rTPJ dysfunction in EOS, areas implicated in the cognitive impairments characterizing EOS. The salience network lies at the core of these cognitive processes, co-activating with the hypoactivating regions, and thus highlighting the importance of salience dysfunction in EOS.

Indian Political Democracy: A Study

Ensemble ◽  
2021 ◽  
Vol 2 (2) ◽  
pp. 243-248
Author(s):  
SIDDHARTHA SANKAR MANNA ◽  
Keyword(s):  
Liberal Democracy ◽  
Large Scale ◽  
The Political ◽  
Political Democracy ◽  
Equal Rights ◽  
Men And Women ◽  
Democratic State ◽  
The Right

Democracy means the prearrangement of governance in which people can enjoy the greatest means of life. It depends on the larger participation of people regardless of caste, gender, creed, men, and women. So far, the constitution of India shaped a democratic state and ensured the right to liberty, equal rights, the notion of justice, and fraternity for all its citizens in society. The political enterprisers who uphold the various ethnoreligious characteristics, mainly the Hindu nationalist beliefs and opinions, have shaped a lot of confusion and bewilderment about the conceptual ideas of secularism. The Liberal democracy still continues as an arrangement of human governance and structure of values that keep on unwavering for millions of people. At the lower stages, the judicial organization took a large-scale initiative in some debatable and controversial occurrences.

scholarly journals Large-Scale Functional Networks, Cognition and Brain Structures Supporting Social Cognition and Theory of Mind Performance in Prodromal to Mild Alzheimer’s Disease

2021 ◽  
Vol 13 ◽  
Author(s):  
Jose Manuel Valera-Bermejo ◽  
Matteo De Marco ◽  
Micaela Mitolo ◽  
Chiara Cerami ◽  
Alessandra Dodich ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Social Cognition ◽  
Theory Of Mind ◽  
Large Scale ◽  
Grey Matter ◽  
Network Connectivity ◽  
Functional Networks ◽  
Default Mode ◽  
The Right

Impairment of social cognition (SC) skills such as recognition and attribution of intentions and affective states of others (Theory of Mind, ToM) has been evidenced in Alzheimer’s Disease (AD). This study investigated the neuropsychological, neuroanatomical and brain-functional underpinnings of SC processing to obtain an understanding of the social neurophenotype in early probable AD. Forty-six patients with mild cognitive impairment and mild probable AD underwent SC assessment including emotion recognition (Ekman-60-faces task) and cognitive and affective ToM (Reading-the-Mind-in-the-Eyes test and Story-based Empathy task). Linear models tested the association between SC scores and neuropsychological measures, grey matter maps and large-scale functional networks activity. The executive domain had the most predominant association with SC scores in the cognitive profile. Grey matter volume of the anterior cingulate, orbitofrontal, temporoparietal junction (TPJ), superior temporal, and cerebellar cortices were associated with ToM. Social cognition scores were associated with lower connectivity of the default-mode network with the prefrontal cortex. The right fronto-parietal network displayed higher inter-network connectivity in the right TPJ and insula while the salience network showed lower inter-network connectivity with the left TPJ and insula. Connectivity coupling alterations of executive-attentional networks may support default mode social-cognitive-associated decline through the recruitment of frontal executive mechanisms.

scholarly journals Distinct Contributions of Nonpredictive and Predictive Peripheral Cues to Visual Conscious Perception: an MEG study

2020 ◽  
Author(s):  
Alfredo Spagna ◽  
Dimitri J. Bayle ◽  
Zaira Romeo ◽  
Lydia Yahia-Cherif ◽  
Ana B. Chica ◽  
...  
Keyword(s):  
Visual Perception ◽  
Left Hemisphere ◽  
Visual Cues ◽  
Brain Activity ◽  
Conscious Perception ◽  
Spatial Cues ◽  
Temporoparietal Junction ◽  
Parietal Lobes ◽  
The Right ◽  
Near Threshold

AbstractDo we need attention to become aware of an external event? We used magnetoencephalography (MEG) in human participants to assess the effects of nonpredictive and predictive supra-threshold peripheral visual cues on the conscious perception of near-threshold Gabor patches. Both nonpredictive and predictive valid cues increased the number of detected targets, and shifted the response criterion towards a more liberal decision. Predictive cues unexpectedly induced a greater sensitivity (d’) for invalid trials than for valid trials. With nonpredictive cues, seen targets were associated with right-lateralized frontoparietal feed-forward and feedback sweeps. For seen targets there was increased connectivity among visual regions, and between these areas and the inferior parietal lobes and the anterior insular cortices (AIC), bilaterally. Valid predictive cues interacted with conscious target detection, with greater activation of areas mostly located in the left hemisphere, especially in the frontoparietal network and temporoparietal junction, and induced an increased connectivity between the right AIC and areas of the visual ventral stream in the seen condition only. Thus, neural activity induced by nonpredictive and predictive spatial cues can enhance conscious visual perception through distinct mechanisms, mostly relying on frontoparietal activity in the right or left hemisphere, respectively. Connectivity involving the AIC participates in shaping the interaction between attention and conscious visual perception.Significance StatementDo we need to pay attention to external objects in order to become aware of them? Characterizing the spatiotemporal dynamics of attentional effects on visual perception is critical to understand how humans process information coming from relevant aspects of their environment. Participants detected near-threshold visual targets preceded by supra-threshold spatial cues with varying degrees of predictivity, while their brain activity was recorded using magnetoencephalography. Results demonstrated that spatial cues, especially when predictive, biased participants’ conscious perception through an early recruitment of frontoparietal regions. This work highlights an interactive pattern between spatial attention and consciousness, as shown by the effects of attention-related regions on visual sensory cortices bilaterally, consistent with the hypothesis that attention is a pathway to conscious perception.

scholarly journals When differences matter: rTMS/fMRI reveals how differences in dispositional empathy translate to distinct neural underpinnings of self-other distinction in empathy

2019 ◽  
Author(s):  
Henryk Bukowski ◽  
Martin Tik ◽  
Giorgia Silani ◽  
Christian Ruff ◽  
Christian Windischberger ◽  
...  
Keyword(s):  
Individual Differences ◽  
Brain Stimulation ◽  
Brain Activity ◽  
Control Site ◽  
Temporoparietal Junction ◽  
Empathic Understanding ◽  
Affect And Cognition ◽  
Neural Underpinnings ◽  
The Right ◽  
Dispositional Empathy

Self-other distinction is crucial for empathy, since it prevents the confusion of self-experienced emotions with those of others. We aimed to extend our understanding of the neurocognitive mechanisms of self-other distinction. Thirty-one female participants underwent continuous theta burst transcranial magnetic stimulation (cTBS) targeting the right supramarginal gyrus (rSMG), a sub-region of the temporoparietal junction previously shown to be involved in self-other distinction, and the vertex, a cortical control site. Right after stimulation they completed a visuo-tactile empathy task in an MRI scanner. Self-other distinction was assessed by differences in emotion judgments, and brain activity between conditions differing in the requirement for self-other distinction. Effects of brain stimulation on self-other distinction depended on individual differences in dispositional empathic understanding: cTBS of rSMG, compared to vertex, enhanced self-other distinction in participants with lower dispositional empathic understanding, but diminished it in participants with higher empathic understanding. On the neural level, this inverse relationship between empathic disposition and self-other distinction performance was linked to a reduction of cTBS-induced rSMG activity in persons with lower dispositional empathy, and an increase in those with lower dispositional empathy. These opposite cTBS impacts were also associated with two anatomically and functionally distinct networks. These findings open up novel perspectives on the causal role of rSMG in self-other distinction and empathy. They also suggest that considering individual differences may yield novel insights into how brain stimulation affects higher-level affect and cognition, and its neural correlates.

scholarly journals Psychometric Properties of the Multifaceted Gender-Related Attributes Survey (GERAS)

2020 ◽  
Vol 36 (4) ◽  
pp. 612-623 ◽  
Author(s):  
Freya M. Gruber ◽  
Eva Distlberger ◽  
Thomas Scherndl ◽  
Tuulia M. Ortner ◽  
Belinda Pletzer
Keyword(s):  
Factor Analysis ◽  
Psychometric Properties ◽  
Gender Quotas ◽  
Sex And Gender ◽  
Social Environments ◽  
Men And Women ◽  
First Order ◽  
New Instrument ◽  
Psychometric Analyses ◽  
And Gender

Abstract. Since the 1920s, psychologists have sought to assess the sex- and gender-related attributes of men and women, including primarily aspects of personality and focusing on positive characteristics. In this paper, we introduce a new questionnaire for assessing gender-related attributes with a broader approach than provided by previous ones. Therefore, the questionnaire includes (a) not only personality traits but also cognitions and interests and (b) not only positive but also negative and neutral characteristics. Two independent datasets were acquired (Study 1: N = 1,466; Study 2: N = 471) for development and psychometric analyses. Factor analysis confirmed a hierarchical structure with two separate dimensions of masculinity and femininity overarching the multiple first-order domains of personality, cognition, and interests. Analyses of reliability and convergence with other gender identity and personality scales revealed sufficient values. The new instrument discriminated between the biological sexes and was related to the gender quotas in participants’ occupations and social environments, thus providing evidence for criterion-related validity. Therefore, we propose the Gender-Related Attributes Survey (GERAS) as a useful tool for objectively assessing gender-related attributes across multiple facets in gender and sex-difference research.

Failure to engage the temporoparietal junction/posterior superior temporal sulcus predicts impaired naturalistic social cognition in schizophrenia

Brain ◽  
2021 ◽  
Author(s):  
Gaurav H Patel ◽  
Sophie C Arkin ◽  
Daniel Ruiz-Betancourt ◽  
Fabiola I Plaza ◽  
Safia A Mirza ◽  
...  
Keyword(s):  
Social Cognition ◽  
Visual Motion ◽  
Superior Temporal Sulcus ◽  
Motion Processing ◽  
Temporoparietal Junction ◽  
Social Inference ◽  
Cortical Areas ◽  
Visual Motion Processing ◽  
The Right ◽  
Posterior Superior Temporal Sulcus

Abstract Schizophrenia is associated with marked impairments in social cognition. However, the neural correlates of these deficits remain unclear. Here we use naturalistic stimuli to examine the role of the right temporoparietal junction/posterior superior temporal sulcus (TPJ-pSTS)—an integrative hub for the cortical networks pertinent to the understanding complex social situations—in social inference, a key component of social cognition, in schizophrenia. 27 schizophrenia participants (SzP) and 21 healthy controls watched a clip of the movie “The Good, the Bad, and the Ugly” while high resolution multiband fMRI images were collected. We used inter-subject correlation (ISC) to measure the evoked activity, which we then compared to social cognition as measured by The Awareness of Social Inference Test (TASIT). We also compared between groups the TPJ-pSTS BOLD activity 1) relationship with the motion content in the movie, 2) synchronization with other cortical areas involved in the viewing of the movie, and 3) relationship with the frequency of saccades made during the movie. Activation deficits were greatest in middle TPJ (TPJm) and correlated significantly with impaired TASIT performance across groups. Follow-up analyses of the TPJ-pSTS revealed decreased synchronization with other cortical areas, decreased correlation with the motion content of the movie, and decreased correlation with the saccades made during the movie. The functional impairment of the TPJm, a hub area in the middle of the TPJ-pSTS, predicts deficits in social inference in SzP by disrupting the integration of visual motion processing into the TPJ. This disrupted integration then affects the use of the TPJ to guide saccades during the visual scanning of the movie clip. These findings suggest that the TPJ may be a treatment target for improving deficits in a key component of social cognition in SzP.

Sign in / Sign up

Export Citation Format

Share Document