Don’t Forget the Little Brain: A Framework for Incorporating the Cerebellum Into the Understanding of Cognitive Aging

2021 ◽  
Author(s):  
Jessica A. Bernard
Keyword(s):  
Older Adults ◽  
Cognitive Aging ◽  
Advanced Age ◽  
Cortical Function ◽  
Activation Patterns ◽  
Cerebellar Function ◽  
Age Related ◽  
Brain And Behavior ◽  
And Behavior

With the rapidly growing population of older adults, an improved understanding of brain and cognitive aging is critical, given the impacts on health, independence, and quality of life. To this point, we have a well-developed literature on the cortical contributions to cognition in advanced age. However, while this work has been foundational for our understanding of brain and behavior in older adults, subcortical contributions, particularly those from the cerebellum, have not been integrated into these models and frameworks. Incorporating the cerebellum into models of cognitive aging is an important step for moving the field forward. There has also been recent interest in this structure in Alzheimer’s Disease, indicating that such work may be beneficial to our understanding of neurodegenerative disease. Here, I provide an updated overview of the cerebellum in advanced age, and propose that it serves as a critical source of scaffolding or reserve for cortical function. Age-related impacts on cerebellar function further impact cortical processing, perhaps resulting in many of the activation patterns commonly seen in aging.

Activity Engagement in Cognitive Aging: A Review of the Evidence

2013 ◽  
Vol 23 (1) ◽  
pp. 1-12 ◽  
Author(s):  
Yvonne Rogalski ◽  
Muriel Quintana
Keyword(s):  
Older Adults ◽  
Cognitive Decline ◽  
Cognitive Aging ◽  
Social Activity ◽  
Current Evidence ◽  
Omega 3 ◽  
Neuroprotective Effects ◽  
Activity Engagement ◽  
Age Related ◽  
Age Related Cognitive Decline

The population of older adults is rapidly increasing, as is the number and type of products and interventions proposed to prevent or reduce the risk of age-related cognitive decline. Advocacy and prevention are part of the American Speech-Language-Hearing Association’s (ASHA’s) scope of practice documents, and speech-language pathologists must have basic awareness of the evidence contributing to healthy cognitive aging. In this article, we provide a brief overview outlining the evidence on activity engagement and its effects on cognition in older adults. We explore the current evidence around the activities of eating and drinking with a discussion on the potential benefits of omega-3 fatty acids, polyphenols, alcohol, and coffee. We investigate the evidence on the hypothesized neuroprotective effects of social activity, the evidence on computerized cognitive training, and the emerging behavioral and neuroimaging evidence on physical activity. We conclude that actively aging using a combination of several strategies may be our best line of defense against cognitive decline.

scholarly journals Electromyographic activation patterns during swallowing in older adults

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Jin Young Ko ◽  
Hayoung Kim ◽  
Joonyoung Jang ◽  
Jun Chang Lee ◽  
Ju Seok Ryu
Keyword(s):  
Older Adults ◽  
Viscous Fluid ◽  
Muscle Activation ◽  
Fatty Infiltration ◽  
Liquid Volume ◽  
Type I ◽  
Type Ii ◽  
Activation Patterns ◽  
Muscle Activation Patterns ◽  
Age Related

AbstractAge-related weakness due to atrophy and fatty infiltration in oropharyngeal muscles may be related to dysphagia in older adults. However, little is known about changes in the oropharyngeal muscle activation pattern in older adults. This was a prospective and experimental study. Forty healthy participants (20 older [> 60 years] and 20 young [< 60 years] adults) were enrolled. Six channel surface electrodes were placed over the bilateral suprahyoid (SH), bilateral retrohyoid (RH), thyrohyoid (TH), and sternothyroid (StH) muscles. Electromyography signals were then recorded twice for each patient during swallowing of 2 cc of water, 5 cc of water, and 5 cc of a highly viscous fluid. Latency, duration, and peak amplitude were measured. The activation patterns were the same, in the order of SH, TH, and StH, in both groups. The muscle activation patterns were classified as type I and II; the type I pattern was characterized by a monophasic shape, and the type II comprised a pre-reflex phase and a main phase. The oropharyngeal muscles and SH muscles were found to develop a pre-reflex phase specifically with increasing volume and viscosity of the swallowed fluid. Type I showed a different response to the highly viscous fluid in the older group compared to that in the younger group. However, type II showed concordant changes in the groups. Therefore, healthy older people were found to compensate for swallowing with a pre-reflex phase of muscle activation in response to increased liquid volume and viscosity, to adjust for age-related muscle weakness.

scholarly journals Resting‐State EEG Microstates Parallel Age‐Related Differences in Allocentric Spatial Working Memory Performance

2021 ◽  
Author(s):  
Adeline Jabès ◽  
Giuliana Klencklen ◽  
Paolo Ruggeri ◽  
Christoph M. Michel ◽  
Pamela Banta Lavenex ◽  
...  
Keyword(s):  
Older Adults ◽  
Working Memory ◽  
Resting State ◽  
Cognitive Aging ◽  
Temporal Dynamics ◽  
Spatial Working Memory ◽  
Brain Activity ◽  
Memory Performance ◽  
Brain Regions ◽  
Age Related

AbstractAlterations of resting-state EEG microstates have been associated with various neurological disorders and behavioral states. Interestingly, age-related differences in EEG microstate organization have also been reported, and it has been suggested that resting-state EEG activity may predict cognitive capacities in healthy individuals across the lifespan. In this exploratory study, we performed a microstate analysis of resting-state brain activity and tested allocentric spatial working memory performance in healthy adult individuals: twenty 25–30-year-olds and twenty-five 64–75-year-olds. We found a lower spatial working memory performance in older adults, as well as age-related differences in the five EEG microstate maps A, B, C, C′ and D, but especially in microstate maps C and C′. These two maps have been linked to neuronal activity in the frontal and parietal brain regions which are associated with working memory and attention, cognitive functions that have been shown to be sensitive to aging. Older adults exhibited lower global explained variance and occurrence of maps C and C′. Moreover, although there was a higher probability to transition from any map towards maps C, C′ and D in young and older adults, this probability was lower in older adults. Finally, although age-related differences in resting-state EEG microstates paralleled differences in allocentric spatial working memory performance, we found no evidence that any individual or combination of resting-state EEG microstate parameter(s) could reliably predict individual spatial working memory performance. Whether the temporal dynamics of EEG microstates may be used to assess healthy cognitive aging from resting-state brain activity requires further investigation.

scholarly journals Strategies and cognitive reserve to preserve lexical production in aging

GeroScience ◽  
2021 ◽  
Author(s):  
Monica Baciu ◽  
Sonja Banjac ◽  
Elise Roger ◽  
Célise Haldin ◽  
Marcela Perrone-Bertolotti ◽  
...  
Keyword(s):  
Older Adults ◽  
Cognitive Aging ◽  
Individual Variability ◽  
Future Research ◽  
Aging Effects ◽  
Main Hypothesis ◽  
Compensatory Strategies ◽  
Age Related ◽  
Complementary Domain

AbstractIn the absence of any neuropsychiatric condition, older adults may show declining performance in several cognitive processes and among them, in retrieving and producing words, reflected in slower responses and even reduced accuracy compared to younger adults. To overcome this difficulty, healthy older adults implement compensatory strategies, which are the focus of this paper. We provide a review of mainstream findings on deficient mechanisms and possible neurocognitive strategies used by older adults to overcome the deleterious effects of age on lexical production. Moreover, we present findings on genetic and lifestyle factors that might either be protective or risk factors of cognitive impairment in advanced age. We propose that “aging-modulating factors” (AMF) can be modified, offering prevention opportunities against aging effects. Based on our review and this proposition, we introduce an integrative neurocognitive model of mechanisms and compensatory strategies for lexical production in older adults (entitled Lexical Access and Retrieval in Aging, LARA). The main hypothesis defended in LARA is that cognitive aging evolves heterogeneously and involves complementary domain-general and domain-specific mechanisms, with substantial inter-individual variability, reflected at behavioral, cognitive, and brain levels. Furthermore, we argue that the ability to compensate for the effect of cognitive aging depends on the amount of reserve specific to each individual which is, in turn, modulated by the AMF. Our conclusion is that a variety of mechanisms and compensatory strategies coexist in the same individual to oppose the effect of age. The role of reserve is pivotal for a successful coping with age-related changes and future research should continue to explore the modulating role of AMF.

scholarly journals Gaming Technology to Support Leisure Activities Among Older Adults

2020 ◽  
Vol 4 (Supplement_1) ◽  
pp. 559-559
Author(s):  
Walter Boot
Keyword(s):  
Quality Of Life ◽  
Older Adults ◽  
Digital Divide ◽  
Daily Living ◽  
Leisure Activities ◽  
Well Being ◽  
Age Related ◽  
Gaming Technology ◽  
Research And Education

Abstract There has been a great deal of research on technology to support older adults in their performance of Activities and Instrumental Activities of Daily Living. There has been substantially less research, however, on exploring technology solutions that support hobbies and leisure. This is unfortunate, as quality of life and well-being are determined by more than just one’s ability to manage everyday tasks. An overview will be presented of research the Center for Research and Education on Aging and Technology Enhancement (CREATE) has conducted over two decades with the goals of understanding and supporting older adults’ performance of technology-based leisure activities. Many of these studies have involved videogaming, where there exists a substantial age-related digital divide. CREATE has evaluated older adults’ attitudes and game experiences through survey and research studies and has even recorded longitudinal gameplay. How these findings can be applied to support technology-based leisure activities will be expanded upon. Part of a symposium sponsored by Technology and Aging Interest Group.

Internet Use among Older Adults

2013 ◽  
pp. 124-141 ◽  
Author(s):  
Yiwei Chen ◽  
Bob Lee ◽  
Robert M. Kirk
Keyword(s):  
Quality Of Life ◽  
Older Adults ◽  
Internet Use ◽  
The Internet ◽  
Emotional Needs ◽  
Cognitive Limitations ◽  
Selective Optimization With Compensation ◽  
Emotional Processes ◽  
Age Related

Older adults (65 and above) are the fastest growing population to use computers and the Internet in their everyday lives. The primary purpose of this chapter is to use a Lifespan Developmental Perspective to examine both the constraints and the opportunities of Internet use among older adults. Given age-related changes in physical, cognitive, and socio-emotional processes, older adults may encounter different constraints in Internet use from younger adults. The Selective Optimization with Compensation model is used to explore opportunities for older adults in using the Internet to improve quality of life. Future product designs and training programs should take into account older adults’ physical and cognitive limitations, as well as their socio-emotional needs. It is also recommended that social policies should help older adults overcome these constraints in order to reduce age-related digital divide and promote quality of life for older adults.

scholarly journals Participatory Design

2015 ◽  
Vol 7 (3) ◽  
pp. 78-92 ◽  
Author(s):  
Lilit Hakobyan ◽  
Jo Lumsden ◽  
Dympna O'Sullivan
Keyword(s):  
Older Adults ◽  
Participatory Research ◽  
Participatory Design ◽  
Practical Experience ◽  
Age Related Macular Degeneration ◽  
Mobile Technologies ◽  
Age Related ◽  
Effective Design

Ongoing advances in mobile technologies have the potential to improve independence and quality of life of older adults by supporting the delivery of personalised and ubiquitous healthcare solutions. The authors are actively engaged in participatory, user-focused research to create a mobile assistive healthcare-related intervention for persons with age-related macular degeneration (AMD): the authors report here on our participatory research in which participatory design (PD) has been positively adopted and adapted for the design of our mobile assistive technology. The authors discuss their work as a case study in order to outline the practicalities and highlight the benefits of participatory research for the design of technology for (and importantly with) older adults. The authors argue it is largely impossible to achieve informed and effective design and development of healthcare-related technologies without employing participatory approaches, and outline recommendations for engaging in participatory design with older adults (with impairments) based on practical experience.

scholarly journals Study of adverse drug reactions and clinical profile of elderly in relation to polypharmacy

2019 ◽  
Vol 10 (6) ◽  
pp. 80-84
Author(s):  
Nagaraja BS ◽  
Keerthana Sharma
Keyword(s):  
Older Adults ◽  
Adverse Drug Reactions ◽  
The Elderly ◽  
Control Group ◽  
Case Group ◽  
Drug Reactions ◽  
Age Related ◽  
Improve Compliance ◽  
Clinical Conditions

Background: Polypharmacy is a becoming more prevalent in older adults and adverse risk increases with age-related change. Adverse drug reactions (ADRs) are common in older adults and worrisome aspect of treatment in elderly. Aims and Objective: The study aimed to identify the common clinical conditions leading to polypharmacy and to compare the adverse drug profiles of the 2 groups. Materials and Methods: This case-control study was conducted in Hospitals attached to BMCRI, where 200 patients aged 65 or more were interviewed. 100 elderly patients using 5 or more drugs were identified as cases and assessed against a control group of 100 patients. Results: Our study found that ADRs were found to be three times higher in individuals on polypharmacy compared to the control group (OR 3.4675 95% CI 1.6241 to 7.4035). The most commonly occurring ADRs were dyspepsia (OR 1.9259), drowsiness (OR 3.5926) and fatigue (OR 1.5319) with increased incidence in the case group. The most common conditions associated with polypharmacy were found to be hypertension (53%), diabetes mellitus(46%), COPD(14%) and IHD(14%). 66% of the study group had two or more of the above diseases, whereas in the control group only 32% had multiple illnesses. The most commonly prescribed medications were antihypertensives (61%), hypolipidemics (44%), antiplatelets (41%) and antibiotics(40%). Conclusion: Polypharmacy in the elderly comes with a significant increase in adverse effects. The reduced pill burden will not only decrease ADRs and improve compliance, but will also result in greater patient satisfaction and mental health, thereby improving the quality of geriatric care.

Episodic Future Thinking and Cognitive Aging

2018 ◽  
Author(s):  
Daniel L. Schacter ◽  
Aleea L. Devitt ◽  
Donna Rose Addis
Keyword(s):  
Older Adults ◽  
Problem Solving ◽  
Episodic Memory ◽  
Prospective Memory ◽  
Cognitive Aging ◽  
Episodic Future Thinking ◽  
Future Thinking ◽  
Age Related ◽  
Prosocial Intentions ◽  
Age Related Changes

Episodic future thinking refers to the ability to imagine or simulate experiences that might occur in an individual’s personal future. It has been known for decades that cognitive aging is associated with declines in episodic memory, and recent research has documented correlated age-related declines in episodic future thinking. Previous research has considered both cognitive and neural mechanisms that are responsible for age-related changes in episodic future thinking, as well as effects of aging on the functions served by episodic future thinking. Studies concerned with mechanism indicate that multiple cognitive mechanisms contribute to changes in episodic future thinking during aging, including episodic memory retrieval, narrative style, and executive processes. Recent studies using an episodic specificity induction—brief training in recollecting episodic details of a recent experience—have proven useful in separating the contributions of episodic retrieval from other non-episodic processes during future thinking tasks in both old and young adults. Neuroimaging studies provide preliminary evidence of a role for age-related changes in default and executive brain networks in episodic future thinking and autobiographical planning. Studies concerned with function have examined age-related effects on the link between episodic future thinking and a variety of processes, including everyday problem-solving, prospective memory, prosocial intentions, and intertemporal choice/delay discounting. The general finding in these studies is for age-related reductions, consistent with the work on mechanisms that consistently reveals reduced episodic detail in older adults when they imagine future events. However, several studies have revealed that episodic simulation nonetheless confers some benefits for tasks tapping adaptive functions in older adults, such as problem-solving, prospective memory, and prosocial intentions, even though age-related deficits on these tasks are not eliminated or reduced by episodic future thinking.

scholarly journals Considerations for the Development of Innovative Foods to Improve Nutrition in Older Adults

Nutrients ◽  
2019 ◽  
Vol 11 (6) ◽  
pp. 1275 ◽  
Author(s):  
Mariane Lutz ◽  
Guillermo Petzold ◽  
Cecilia Albala
Keyword(s):  
Older Adults ◽  
Functional Limitations ◽  
Chronic Illnesses ◽  
Consumer Market ◽  
Age Related ◽  
Swallowing Problems ◽  
Global Burden Of Diseases ◽  
The Impact

The population of older adults is growing globally. This increase has led to an accumulation of chronic illnesses, so-called age-related diseases. Diet and nutrition are considered the main drivers of the global burden of diseases, and this situation applies especially to this population segment. It relates directly to the development of coronary heart disease, hypertension, some types of cancer, and type 2 diabetes, among other diseases, while age-associated changes in body composition (bone and muscle mass, fat, sarcopenia) constitute risk factors for functional limitations affecting health status and the quality of life. Older adults present eating and swallowing problems, dry mouth, taste loss, and anorexia among other problems causing “anorexia of aging” that affects their nutritional status. The strategies to overcome these situations are described in this study. The impact of oral food processing on nutrition is discussed, as well as approaches to improve food acceptance through the design of innovative foods. These foods should supply a growing demand as this group represents an increasing segment of the consumer market globally, whose needs must be fulfilled.

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