Individual concerns modulate Pavlovian-instrumental transfer for sexual outcomes
Pavlovian and instrumental conditioning are fundamental processes helping organisms learn about stimuli that predict rewards in the environment and actions that lead to their obtainment. The interplay between these two forms of learning notably exerts a strong impact on reward-seeking behaviors. However, mechanisms modulating this impact are not well elucidated. Here, we examined whether the influence of Pavlovian cues on instrumental action for sexual rewards is determined by their relevance to the individual’s sexual concerns in humans. In two experiments, we manipulated the relevance of sexual outcomes in a Pavlovian-instrumental transfer paradigm by recruiting heterosexual and homosexual men and selecting sexual stimuli for each sexual orientation. Results showed that Pavlovian-instrumental transfer effects were enhanced in response to the cue that was associated with the most relevant sexual outcome to participants’ sexual orientation compared to the cue associated with the less relevant sexual outcome, thereby reflecting that inter-individual differences in sexual concerns modulated these effects. These findings suggest that motivational control of reward-related instrumental action triggered by Pavlovian stimuli in humans relies on inter-individual differences in current concerns and can extend beyond homeostatic needs such as hunger or thirst. This fosters further insight into the mechanisms underlying human reward-seeking behaviors.