scholarly journals Brain Activity Associated with Regulating Food Cravings Predicts Changes in Self-Reported Food Craving and Consumption Over Time

2020 ◽  
Author(s):  
Nicole Giuliani ◽  
Danielle Cosme ◽  
Junaid Salim Merchant ◽  
Bryce Dirks ◽  
Elliot Berkman
Keyword(s):  
Mixed Models ◽  
Brain Activity ◽  
Community Sample ◽  
A Priori ◽  
Food Craving ◽  
Healthy Foods ◽  
Related Activity ◽  
Food Cravings ◽  
Baseline Bmi

Neural patterns associated with viewing energy-dense foods can predict changes in eating-related outcomes. However, most research on this topic is limited to one follow-up time point, and single outcome measures. The present study seeks to add to that literature by employing a more refined assessment of food craving and consumption outcomes along with a more detailed neurobiological model of behavior change over several time points. Here, a community sample of 88 individuals (age: M = 39.17, SD = 3.47; baseline BMI: M = 31.5, SD = 3.9, range 24-42) with higher body mass index (BMI) performed a food craving reactivity and regulation task while undergoing functional magnetic resonance imaging. At that time—and 1 month, 3 months, and 6 months later—participants reported craving for and consumption of healthy and unhealthy foods via the Food Craving Inventory (FCI) and ASA24 (N at 6 months = 52-55 depending on the measure). A priori hypotheses that brain activity associated with both viewing and regulating personally-desired unhealthy, energy-dense foods would be associated with self-reported craving for and consumption of unhealthy foods at baseline were not supported by the data. Instead, regression models controlling for age, sex, and BMI demonstrated that brain activity across several regions measured while individuals were regulating their desires for unhealthy food was associated with the self-reported craving for and consumption of healthy food. The hypothesis that vmPFC activity would predict patterns of healthier eating was also not supported. Instead, linear mixed models controlling for baseline age and sex, as well as changes in BMI, revealed that more regulation-related activity in the dlPFC, dACC, IFG, and vmPFC at baseline predicted decreases in the craving for and consumption of healthy foods over the course of 6 months.

455 Obesity modifies the effect of 4 months of CPAP on glucose levels in adults with obstructive sleep apnea

SLEEP ◽  
2021 ◽  
Vol 44 (Supplement_2) ◽  
pp. A180-A180
Author(s):  
Victoria Pak ◽  
David Maislin ◽  
Brendan Keenan ◽  
Raymond Townsend ◽  
Bryndis Benediktsdottir ◽  
...  
Keyword(s):  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Smoking Status ◽  
A Priori ◽  
Apnea Hypopnea Index ◽  
Current Smoking Status ◽  
Glucose Levels ◽  
Obstructive Sleep ◽  
Baseline Bmi

Abstract Introduction Continuous positive airway pressure (CPAP) therapy may improve insulin sensitivity and glucose tolerance seen in individuals with obstructive sleep apnea (OSA), however there is a lack of studies on whether obesity modifies the effect. We examined the baseline and follow-up levels of insulin and glucose following 4 months of CPAP treatment among participants with body mass index (BMI) <30, 30≤ BMI<35, and BMI≥35 kg/m2. Methods We identified 221 adults (84% males) with newly diagnosed OSA in the Penn Icelandic Sleep Apnea (PISA) Study, with a mean (±SD) BMI 31.7 +- 4.2 kg/m2 and apnea-hypopnea index (AHI) of 35.7+-15.6 events/hour. Associations between changes in natural log of the biomarkers within BMI groups were explored, controlling for a priori baseline covariates of age, baseline BMI, race, sex, site, and current smoking status. Results The mean proportional change (from baseline to follow-up) in log-transformed glucose in CPAP adherent participants was significantly larger in the BMI ≥35 and 30≤ BMI<35 groups compared to BMI <30. Within the BMI ≥35 group, the baseline to follow up increase in glucose post-CPAP was 1.08 (95% CI 1.01–1.15), while there were no significant changes in the other 2 BMI groups. A mediation analysis was performed with models including BMI change, and glucose was found to be significantly different between groups. There was no statistically significant association for insulin. Conclusion Our findings show that obesity modifies the effect of four months of CPAP on glucose levels. Support (if any) 1P01-1HL094307

454 Obesity does not modify the effect of 4 months of CPAP on leptin or adiponectin

SLEEP ◽  
2021 ◽  
Vol 44 (Supplement_2) ◽  
pp. A179-A180
Author(s):  
Victoria Pak ◽  
David Maislin ◽  
Brendan Keenan ◽  
Raymond Townsend ◽  
Bryndis Benediktsdottir ◽  
...  
Keyword(s):  
Sleep Apnea ◽  
Smoking Status ◽  
A Priori ◽  
Apnea Hypopnea Index ◽  
Current Smoking Status ◽  
Cpap Treatment ◽  
Obstructive Sleep ◽  
Plasma Leptin ◽  
Baseline Bmi

Abstract Introduction Leptin and adiponectin are cytokines produced by adipocytes. Leptin is involved in the pathogenesis of obesity and adiponectin is cardioprotective. Previous studies in adults with obstructive sleep apnea (OSA) assessing the effect of continuous positive airway pressure (CPAP) on these cytokines are conflicting, and whether obesity modifies the effect remains unknown. We examined the baseline and follow up levels of changes in plasma leptin and adiponectin following 4 months of CPAP treatment among obese (BMI>30) and non-obese (BMI≤30) participants. Methods We evaluated 221 adults (84.6% males) in the Penn Icelandic Sleep Apnea (PISA) Study, with mean (±SD) body mass index (BMI) 31.7±4.9 kg/m2 and apnea-hypopnea index (AHI) 35.7±15.6 events/hour. Associations between changes in natural log of the biomarkers in obese and non-obese participants were evaluated, controlling for a priori baseline covariates of age, baseline BMI, race, sex, site, and current smoking status. Results The mean proportional change (from baseline to follow-up) in log-transformed adiponectin and leptin in CPAP adherent participants was not significantly different between BMI groups. The baseline to follow up change in leptin post-CPAP was 1.01 (95% CI 0.95–1.08) in obese participants and 1.05 (95% CI 0.96–1.14) in non-obese participants. For adiponectin, the change post-CPAP was 1.04 (95% CI 0.95–1.15) in obese participants and 1.08 (95% CI 0.96–1.22) in non-obese participants. Conclusion CPAP treatment did not have an impact on leptin or adiponectin levels. We also find no evidence for obesity modifying the effect of four months of CPAP on leptin or adiponectin. Support (if any) 1P01-1HL094307

Picture this: the role of mental imagery in induction of food craving – a theoretical framework based on the elaborated intrusion theory

2019 ◽  
Vol 37 (1) ◽  
pp. 31-42
Author(s):  
Elmira Shahriari ◽  
Ivonne M. Torres ◽  
Miguel Angel Zúñiga ◽  
Nourah Alfayez
Keyword(s):  
Mental Imagery ◽  
Food Product ◽  
Food Craving ◽  
Unhealthy Food ◽  
Healthy Foods ◽  
Food Cravings ◽  
Content Type ◽  
Future Studies ◽  
Perceived Availability

Purpose This paper aims to explore the influence of four types of imagery stimuli (i.e. visual, olfactory, gustatory and auditory) on food craving intensity based on the Elaborated Intrusion theory and the central role of mental imagery in the food craving experience. The roles of overall perception of sensory imagery attributes and perceived availability in moderating this process were also tested. The aim is to extract the positive aspects of food cravings by increasing them and shifting them toward healthy foods. Design/methodology/approach In an online experiment, 314 participants were randomly primed with each imagery condition. After being exposed to either healthy or unhealthy food pictures, participants completed a questionnaire measuring their craving state, trait food craving, imaging ability, BMI, dietary restraint, hunger and mood. At the end, the impact of food craving intensity on marketing outcomes (i.e. willingness to pay, price sensitivity and food intake) were tested. Findings As predicted, visual imagery was found to be the strongest stimulus inducing food craving followed by olfactory, gustatory and auditory stimuli. Furthermore, the results indicate that perceived availability of food is the only important variable moderating this process. Additionally, the results show that hunger makes consumers more susceptible to food cravings than mood. Moreover, food craving intensity showed significant impact on the two marketing outcomes: willingness to pay and food intake. Research limitations/implications First, the authors used a cheeseburger as unhealthy food and salad as healthy food, future studies can increase the generalizability of the findings by using other types of food. Second, physiological and psychological disorders should be considered and studied as influential factors on food cravings in future studies. Third, future studies should include some behavioral measures besides the analysis of state and trait craving. Fourth, although the main objective of this study was to compare the effect of different imagery stimuli on consumers’ food craving, there was no control (no-stimulus) condition. Practical implications Marketing strategists may benefit from the fact that encouraging consumers to visualize some specific type of food product along with informing them about its availability will elevate their craving for that food product. Hence, using this strategy in shopping environments could be beneficial. In the context of improving people’s diet, our results showed that encouraging people to visualize healthy foods (e.g. fruits and vegetables) might be more helpful than priming them with the benefits of eating healthy. Originality/value There has been a recent enthusiastic interest in identifying the role of food related mental imagery and stimuli in consumers’ decision making and their final consumption (Christian et al., 2016). Nevertheless, very few studies in marketing have paid attention to these underpinning stimuli driving food craving and the significant influence of this food craving phenomenon on marketing outcomes.

scholarly journals Brain Activity Associated With Regulating Food Cravings Predicts Changes in Self-Reported Food Craving and Consumption Over Time

2020 ◽  
Vol 14 ◽  
Author(s):  
Nicole R. Giuliani ◽  
Danielle Cosme ◽  
Junaid S. Merchant ◽  
Bryce Dirks ◽  
Elliot T. Berkman
Keyword(s):  
Brain Activity ◽  
Food Craving ◽  
Food Cravings ◽  
Over Time

scholarly journals P34 Characteristics, diagnosis and management of Cushing’s disease - A systematic review and meta-analysis

BJS Open ◽  
2021 ◽  
Vol 5 (Supplement_1) ◽  
Author(s):  
Chan Hee Koh ◽  
Danyal Z Khan ◽  
Ronneil Digpal ◽  
Hugo Layard Horsfall ◽  
Hani J Marcus ◽  
...  
Keyword(s):  
Clinical Practice ◽  
Cushing’S Disease ◽  
Meta Analysis ◽  
A Priori ◽  
Pituitary Surgery ◽  
Serum Cortisol ◽  
Cushing's Disease ◽  
Diagnosis And Management ◽  
Over Time

Abstract Introduction The clinical practice and research in the diagnosis and management of Cushing’s disease remains heterogeneous and challenging to this day. We sought to establish the characteristics of Cushing’s disease, and the trends in diagnosis, management and reporting in this field. Methods Searches of PubMed and Embase were conducted. Study protocol was registered a-priori. Random-effects analyses were conducted to establish numerical estimates. Results Our screening returned 159 papers. The average age of adult patients with Cushing’s disease was 39.3, and 13.6 for children. The male:female ratio was 1:3. 8% of patients had undergone previous transsphenoidal resection. The ratio of macroadenomas: microadenomas:imaging-undetectable adenomas was 18:53:29. The most commonly reported preoperative biochemical investigations were serum cortisol (average 26.4µg/dL) and ACTH (77.5pg/dL). Postoperative cortisol was most frequently used to define remission (74.8%), most commonly with threshold of 5µg/dL (44.8%). Average remission rates were 77.8% with recurrence rate of 13.9%. Median follow-up was 38 months. Majority of papers reported age (81.9%) and sex (79.4%). Only 56.6% reported whether their patients had previous pituitary surgery. 45.3% reported whether their adenomas were macroadenoma, microadenoma or undetectable. Only 24.1% reported preoperative cortisol, and this did not improve over time. 60.4% reported numerical thresholds for cortisol in defining remission, and this improved significantly over time (p = 0.004). Visual inspection of bubbleplots showed increasing preference for threshold of 5µg/dL. 70.4% reported the length of follow up. Conclusion We quantified the characteristics of Cushing’s disease, and analysed the trends in investigation and reporting. This review may help to inform future efforts in forming guidelines for research and clinical practice.

scholarly journals Associations of Dietary Patterns with Incident Depression: The Maastricht Study

Nutrients ◽  
2021 ◽  
Vol 13 (3) ◽  
pp. 1034
Author(s):  
Vincenza Gianfredi ◽  
Annemarie Koster ◽  
Anna Odone ◽  
Andrea Amerio ◽  
Carlo Signorelli ◽  
...  
Keyword(s):  
Depressive Symptoms ◽  
Dietary Patterns ◽  
Proportional Hazards ◽  
A Priori ◽  
Preventive Measure ◽  
Population Based ◽  
Cox Proportional Hazards ◽  
Healthy Diet ◽  
Patient Health

Our aim was to assess the association between a priori defined dietary patterns and incident depressive symptoms. We used data from The Maastricht Study, a population-based cohort study (n = 2646, mean (SD) age 59.9 (8.0) years, 49.5% women; 15,188 person-years of follow-up). Level of adherence to the Dutch Healthy Diet (DHD), Mediterranean Diet, and Dietary Approaches To Stop Hypertension (DASH) were derived from a validated Food Frequency Questionnaire. Depressive symptoms were assessed at baseline and annually over seven-year-follow-up (using the 9-item Patient Health Questionnaire). We used Cox proportional hazards regression analyses to assess the association between dietary patterns and depressive symptoms. One standard deviation (SD) higher adherence in the DHD and DASH was associated with a lower hazard ratio (HR) of depressive symptoms with HRs (95%CI) of 0.78 (0.69–0.89) and 0.87 (0.77–0.98), respectively, after adjustment for sociodemographic and cardiovascular risk factors. After further adjustment for lifestyle factors, the HR per one SD higher DHD was 0.83 (0.73–0.96), whereas adherence to Mediterranean and DASH diets was not associated with incident depressive symptoms. Higher adherence to the DHD lowered risk of incident depressive symptoms. Adherence to healthy diet could be an effective non-pharmacological preventive measure to reduce the incidence of depression.

scholarly journals Associations between perceived friends’ support of healthy eating and meal skipping in adolescence

2017 ◽  
Vol 20 (18) ◽  
pp. 3266-3274 ◽  
Author(s):  
Sharon Rosenrauch ◽  
Kylie Ball ◽  
Karen E Lamb
Keyword(s):  
Peer Influence ◽  
Healthy Eating ◽  
Eating Patterns ◽  
Healthy Foods ◽  
Cross Sectional ◽  
Friendship Groups ◽  
Friendship Group ◽  
Shared Beliefs ◽  
Meal Skipping

AbstractObjectiveMeal skipping is a relatively common behaviour during adolescence. As peer influence increases during adolescence, friendship groups may play a role in determining eating patterns such as meal skipping. The current study examined cross-sectional and longitudinal associations between perceived friends’ support of healthy eating and breakfast and lunch skipping among adolescents.DesignSurvey of intrapersonal, social and environmental factors that may influence eating patterns at baseline (2004/05) and follow-up (2006/07).SettingThirty-seven secondary schools in Victoria, Australia.SubjectsSample of 1785 students aged 12–15 years at baseline.ResultsAdolescents who reported that their friends sometimes or often ate healthy foods with them were less likely (adjusted OR; 95 % CI) to skip breakfast (sometimes: 0·71; 0·57, 0·90; often: 0·54; 0·38, 0·76) or lunch (sometimes: 0·61; 0·41, 0·89; often: 0·59; 0·37, 0·94) at baseline than those who reported their friends never or rarely displayed this behaviour. Although this variable was associated with lunch skipping at follow-up, there was no evidence of an association with breakfast skipping at follow-up. There was no evidence of an association between perceived encouragement of healthy eating, and an inconsistent relationship between perceived discouragement of junk food consumption, and meal skipping.ConclusionsFriends eating healthy foods together may serve to reduce meal skipping during early adolescence, possibly due to the influence of directly observable behaviour and shared beliefs held by those in the same friendship group. Verbal encouragement or discouragement from friends may be less impactful an influence on meal skipping (than directly observable behaviours) in adolescents.

scholarly journals Personalized Biometrics of Physical Pain Agree with Psychophysics by Participants with Sensory over Responsivity

2021 ◽  
Vol 11 (2) ◽  
pp. 93
Author(s):  
Jihye Ryu ◽  
Tami Bar-Shalita ◽  
Yelena Granovsky ◽  
Irit Weissman-Fogel ◽  
Elizabeth B. Torres
Keyword(s):  
General Population ◽  
Brain Activity ◽  
A Priori ◽  
Summary Statistics ◽  
Physical Pain ◽  
New Methods ◽  
Self Reports ◽  
Theoretical Population ◽  
The Moment ◽  
Reported Data

The study of pain requires a balance between subjective methods that rely on self-reports and complementary objective biometrics that ascertain physical signals associated with subjective accounts. There are at present no objective scales that enable the personalized assessment of pain, as most work involving electrophysiology rely on summary statistics from a priori theoretical population assumptions. Along these lines, recent work has provided evidence of differences in pain sensations between participants with Sensory Over Responsivity (SOR) and controls. While these analyses are useful to understand pain across groups, there remains a need to quantify individual differences more precisely in a personalized manner. Here we offer new methods to characterize pain using the moment-by-moment standardized fluctuations in EEG brain activity centrally reflecting the person’s experiencing temperature-based stimulation at the periphery. This type of gross data is often disregarded as noise, yet here we show its utility to characterize the lingering sensation of discomfort raising to the level of pain, individually, for each participant. We show fundamental differences between the SOR group in relation to controls and provide an objective account of pain congruent with the subjective self-reported data. This offers the potential to build a standardized scale useful to profile pain levels in a personalized manner across the general population.

scholarly journals 332 - Electroconvulsive therapy in older adults with major depression was not associated with cognitive decline during a 15-year follow-up

2020 ◽  
Vol 32 (S1) ◽  
pp. 91-91
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Major Depression ◽  
Cognitive Decline ◽  
Electroconvulsive Therapy ◽  
Antidepressant Treatment ◽  
Community Sample ◽  
Control Group

AUTHORS:Kerstin Johansson, Karolina Thömkvist, Ingmar Skoog and Sacuiu SF* (*presenter)OBJECTIVE:To determine the effects of electroconvulsive therapy (ECT) in major depression in relation to the development of dementia during long-term follow-up.METHOD:In an observational clinical prospective study of consecutive patients 70 years and older diagnosed with major depression at baseline 2000-2004 (n=1090), who were free of dementia and received antidepressant treatment, with or without ECT, we sought to determine if cognitive decline (mild cognitive impairment and dementia) during 15 -year follow-up was associated with receiving ECT at baseline. The control group was selected among the participants in the Gothenburg H70 Birth Cohort Studies matched by age group and sex 1:1.RESULTS:Among patients with affective syndromes 7% received ECT. During follow-up, 157 patients were diagnosed with dementia, equal proportions among those who received ECT (14.5%) and those who did not receive ECT (14.5%). The relation between ECT and cognitive decline remained non-significant irrespective antidepressive medication or presence of mild cognitive impairment at baseline.CONCLUSION:Preliminary results indicate that ECT was not associated with the development of cognitive decline in the long-term in a hospital-based cohort of 70+ year-olds. The results remain to verify against controls from a representative community sample.

scholarly journals Macronutrient Quality and All-Cause Mortality in the SUN Cohort

Nutrients ◽  
2021 ◽  
Vol 13 (3) ◽  
pp. 972
Author(s):  
Susana Santiago ◽  
Itziar Zazpe ◽  
Cesar I. Fernandez-Lazaro ◽  
Víctor de la de la O ◽  
Maira Bes-Rastrollo ◽  
...  
Keyword(s):  
Quality Index ◽  
Inverse Relationship ◽  
A Priori ◽  
The Sun ◽  
Significant Inverse Relationship ◽  
Carbohydrate Quality ◽  
All Cause Mortality ◽  
Middle Aged Adults ◽  
The Relationship

No previous study has assessed the relationship between overall macronutrient quality and all-cause mortality. We aimed to prospectively examine the association between a multidimensional macronutrient quality index (MQI) and all-cause mortality in the SUN (Seguimiento Universidad de Navarra) (University of Navarra Follow-Up) study, a Mediterranean cohort of middle-aged adults. Dietary intake information was obtained from a validated 136-item semi-quantitative food-frequency questionnaire. We calculated the MQI (categorized in quartiles) based on three quality indexes: the carbohydrate quality index (CQI), the fat quality index (FQI), and the healthy plate protein source quality index (HPPQI). Among 19,083 participants (mean age 38.4, 59.9% female), 440 deaths from all causes were observed during a median follow-up of 12.2 years (IQR, 8.3–14.9). No significant association was found between the MQI and mortality risk with multivariable-adjusted hazard ratio (HR) for the highest vs. the lowest quartile of 0.79 (95% CI, 0.59–1.06; Ptrend = 0.199). The CQI was the only component of the MQI associated with mortality showing a significant inverse relationship, with HR between extreme quartiles of 0.64 (95% CI, 0.45–0.90; Ptrend = 0.021). In this Mediterranean cohort, a new and multidimensional MQI defined a priori was not associated with all-cause mortality. Among its three sub-indexes, only the CQI showed a significant inverse relationship with the risk of all-cause mortality.

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