scholarly journals Unraveling the genetic and environmental relationship between well-being and depressive symptoms throughout the lifespan

2018 ◽  
Author(s):  
Bart Baselmans ◽  
Yayouk Willems ◽  
Toos van Beijsterveldt ◽  
Lannie Ligthart ◽  
Gonneke WIllemsen ◽  
...  
Keyword(s):  
Depressive Symptoms ◽  
Genetic Predisposition ◽  
Genetic Correlations ◽  
Well Being ◽  
Phenotypic Correlation ◽  
Substantial Part ◽  
Phenotypic Variance ◽  
Environmental Correlations ◽  
The Relationship ◽  
Two Sides

Whether well-being and depressive symptoms can be considered as two sides of the same coin is widely debated. The aim of this study was to gain insight into the etiology of the association between well-being and depressive symptoms across the lifespan. In a cohort-sequential design, including data from 43,427 twins between age 7 and 99, we estimated the association between well-being and depressive symptoms throughout the lifespan and assessed genetic and environmental contributions to the observed overlap. For both well-being (range 31% –45%) and depressive symptoms (range 50%-61%), genetic factors explained a substantial part of the phenotypic variance across the lifespan. Correlations between well-being and depressive symptoms across ages ranged from -.34 in childhood to -.49 in adulthood. In children and adults (aged >27), environmental effects explained 51% to 59% of the phenotypic correlation, while for adolescents and young adults strong genetic influences (60%-77%) on the association were observed. Moderate to high genetic correlations (ranging from 0.60 to 0.70) were observed in adolescence and adulthood, while in childhood environmental correlations were substantial but genetic correlations small. These results suggest that environmental factors are important in explaining the relationship between well-being and depressive symptoms in childhood, while from adolescence onwards a genetic predisposition for higher well-being is indicative for a genetic predisposition for lower depressive symptoms, and vice versa. These results provided more insights into the etiological underpinnings of well-being and depressive symptoms, possibly allowing to articulate better strategies for health promotion and resource allocation in the future.

scholarly journals Genetic Influences on the Covariance and Genetic Correlations in a Bivariate Twin Model: An Application to Well-Being

2021 ◽  
Author(s):  
Lianne P. de Vries ◽  
Toos C. E. M. van Beijsterveldt ◽  
Hermine Maes ◽  
Lucía Colodro-Conde ◽  
Meike Bartels
Keyword(s):  
Complex Traits ◽  
Educational Achievement ◽  
Genetic Correlations ◽  
Well Being ◽  
Genetic Influences ◽  
Phenotypic Correlation ◽  
Twin Model ◽  
Twin Models ◽  
Adolescent Twins ◽  
Depressed Symptoms

AbstractThe distinction between genetic influences on the covariance (or bivariate heritability) and genetic correlations in bivariate twin models is often not well-understood or only one is reported while the results show distinctive information about the relation between traits. We applied bivariate twin models in a large sample of adolescent twins, to disentangle the association between well-being (WB) and four complex traits (optimism, anxious-depressed symptoms (AD), aggressive behaviour (AGG), and educational achievement (EA)). Optimism and AD showed respectively a strong positive and negative phenotypic correlation with WB, the negative correlation of WB and AGG is lower and the correlation with EA is nearly zero. All four traits showed a large genetic contribution to the covariance with well-being. The genetic correlations of well-being with optimism and AD are strong and smaller for AGG and EA. We used the results of the models to explain what information is retrieved based on the bivariate heritability versus the genetic correlations and the (clinical) implications.

scholarly journals Satisfaction with Life: Mediating Role in the Relationship between Depressive Symptoms and Coping Mechanisms

Healthcare ◽  
2021 ◽  
Vol 9 (7) ◽  
pp. 787
Author(s):  
Daniela Almeida ◽  
Diogo Monteiro ◽  
Filipe Rodrigues
Keyword(s):  
Life Satisfaction ◽  
Depressive Symptoms ◽  
Coping Strategies ◽  
Satisfaction With Life ◽  
Well Being ◽  
Coping Mechanisms ◽  
Significant Positive Association ◽  
Mediating Role ◽  
The Relationship

The purpose of this study was to analyze the mediating role of life satisfaction in the relationship between fourteen coping strategies and depressive symptoms in the Portuguese population. To undertake this work, 313 Portuguese adults aged 18 to 70 years (M = 30.73; SD = 10.79) were invited to participate in this study. Their participation was completely voluntary, and participants granted and signed informed consent previously to the filling of the validated Portuguese questionnaires. These questionnaires measured depressive symptoms, coping, and life satisfaction. The results revealed that life satisfaction displayed a mediating role in the relationship between adaptive coping mechanisms, specifically between active coping, planning, reinterpretation, and acceptance and depressive symptoms, showing a negative and significant indirect effect. Maladaptive coping mechanisms of self-blame, denial, self-distraction, disengagement, and substance use had a significant positive association with depressive symptoms, considering the mediating role of satisfaction with life. Current investigation provides initial evidence of how each coping mechanism is associated with satisfaction with life and depressive symptoms. This study clearly demonstrates that not all coping strategies are capable of influencing well-being indicators and that health professionals should focus on endorsing those that are significantly associated with lowering depressive symptoms and increasing overall satisfaction with life.

scholarly journals Shame Mediates the Relationship Between Pain Invalidation and Depression

2021 ◽  
Vol 12 ◽  
Author(s):  
Brandon L. Boring ◽  
Kaitlyn T. Walsh ◽  
Namrata Nanavaty ◽  
Vani A. Mathur
Keyword(s):  
Mental Health ◽  
Depressive Symptoms ◽  
Social Withdrawal ◽  
Well Being ◽  
Poor Mental Health ◽  
Future Research ◽  
Internalized Shame ◽  
Self Worth ◽  
The Impact ◽  
The Relationship

The experience of pain is subjective, yet many people have their pain invalidated or not believed. Pain invalidation is associated with poor mental health, including depression and lower well-being. Qualitative investigations of invalidating experiences identify themes of depression, but also social withdrawal, self-criticism, and lower self-worth, all of which are core components of shame. Despite this, no studies have quantitatively assessed the interrelationship between pain invalidation, shame, and depression. To explore this relationship, participants recounted the frequency of experienced pain invalidation from family, friends, and medical professionals, as well as their feelings of internalized shame and depressive symptoms. As shame has been shown to be a precursor for depression, we further explored the role of shame as a mediator between pain invalidation and depressive symptoms. All sources of pain invalidation were positively associated with shame and depressive symptoms, and shame fully mediated the relationship between each source of pain invalidation and depression. Relative to other sources, pain invalidation from family was most closely tied to shame and depression. Overall, findings indicate that one mechanism by which pain invalidation may facilitate depression is via the experience of shame. Future research may explore shame as a potential upstream precursor to depression in the context of pain. Findings provide more insight into the harmful influence of pain invalidation on mental health and highlight the impact of interpersonal treatment on the experiences of people in pain.

scholarly journals Polygenic Architecture of Human Neuroanatomical Diversity

2020 ◽  
Vol 30 (4) ◽  
pp. 2307-2320
Author(s):  
Anne Biton ◽  
Nicolas Traut ◽  
Jean-Baptiste Poline ◽  
Benjamin S Aribisala ◽  
Mark E Bastin ◽  
...  
Keyword(s):  
Genetic Variance ◽  
Meta Analysis ◽  
Genetic Correlations ◽  
Global Scale ◽  
Phenotypic Variance ◽  
Environmental Correlations ◽  
Genomic Architecture ◽  
Snp Data ◽  
Environmental Causes ◽  
The Uk

Abstract We analyzed the genomic architecture of neuroanatomical diversity using magnetic resonance imaging and single nucleotide polymorphism (SNP) data from >26 000 individuals from the UK Biobank project and 5 other projects that had previously participated in the ENIGMA (Enhancing NeuroImaging Genetics through Meta-Analysis) consortium. Our results confirm the polygenic architecture of neuroanatomical diversity, with SNPs capturing from 40% to 54% of regional brain volume variance. Chromosomal length correlated with the amount of phenotypic variance captured, r ~ 0.64 on average, suggesting that at a global scale causal variants are homogeneously distributed across the genome. At a local scale, SNPs within genes (~51%) captured ~1.5 times more genetic variance than the rest, and SNPs with low minor allele frequency (MAF) captured less variance than the rest: the 40% of SNPs with MAF <5% captured <one fourth of the genetic variance. We also observed extensive pleiotropy across regions, with an average genetic correlation of rG ~ 0.45. Genetic correlations were similar to phenotypic and environmental correlations; however, genetic correlations were often larger than phenotypic correlations for the left/right volumes of the same region. The heritability of differences in left/right volumes was generally not statistically significant, suggesting an important influence of environmental causes in the variability of brain asymmetry. Our code is available athttps://github.com/neuroanatomy/genomic-architecture.

scholarly journals Identity Denied: Comparing American or White Identity Denial and Psychological Health Outcomes Among Bicultural and Biracial People

2018 ◽  
Vol 45 (3) ◽  
pp. 416-430 ◽  
Author(s):  
Analia F. Albuja ◽  
Diana T. Sanchez ◽  
Sarah E. Gaither
Keyword(s):  
Depressive Symptoms ◽  
Health Outcomes ◽  
Psychological Health ◽  
Well Being ◽  
White Identity ◽  
Significant Variance ◽  
Dual Identity ◽  
Stress Study ◽  
Social Belonging ◽  
The Relationship

Because bicultural and biracial people have two identities within one social domain (culture or race), their identification is often challenged by others. Although it is established that identity denial is associated with poor psychological health, the processes through which this occurs are less understood. Across two high-powered studies, we tested identity autonomy, the perceived compatibility of identities, and social belonging as mediators of the relationship between identity denial and well-being among bicultural and biracial individuals. Bicultural and biracial participants who experienced challenges to their American or White identities felt less freedom in choosing an identity and perceived their identities as less compatible, which was ultimately associated with greater reports of depressive symptoms and stress. Study 2 replicated these results and measured social belonging, which also accounted for significant variance in well-being. The results suggest the processes were similar across populations, highlighting important implications for the generalizability to other dual-identity populations.

scholarly journals 1089 Water Intake Moderates the Relationship Between Sleep Quality and Depressive Symptoms: The Latino Health and Well-Being Study

SLEEP ◽  
2020 ◽  
Vol 43 (Supplement_1) ◽  
pp. A414-A415
Author(s):  
J Blanc ◽  
N Williams ◽  
G Jean-Louis ◽  
S Lemon ◽  
M Rosal
Keyword(s):  
Depressive Symptoms ◽  
Sleep Quality ◽  
Water Intake ◽  
Depression Scale ◽  
Well Being ◽  
Epidemiologic Studies ◽  
Community Based ◽  
Latino Adults ◽  
The Relationship ◽  
Health And Well Being

Abstract Introduction This study examined the relationships between sleep quality and depressive symptoms, and whether this relationship is moderated by frequency of water intake in a sample of Latino adults. Methods Participants in this community-based study were 574 Latino adults from Lawrence, Massachusetts. Assessments included surveys and anthropological measures. Variables in this study included sleep quality (Pittsburgh Sleep Quality Index- PSQI), depressive symptoms (Center for Epidemiologic Studies Depression Scale -CES-D) and frequency of water intake in the previous three months (investigator-developed question). Covariates included demographics, stress (Perceived Stress Scale-PSS), and body mass index (BMI). Multiple linear regression analyses were conducted to explore associations between sleep and depressive symptoms. Potential moderating effect of frequency of water intake was assessed using hierarchical, moderated, multiple regression analysis. Results The sample was 51.2% female, with a mean age of 46.6 years (SD=15.4) and mean BMI of 29.6 (SD=5.9); 31% of the sample had CES-D scores > 22 (cut off for elevated depressive symptoms), the mean PSQI score was 13.11(SD=3.4) and 92% reported water intake two or more times daily. Sleep quality correlated positively with depression (r=.558; p=.000). After adjusting for covariates, sleep quality was strongly associated with depression (B = .417; SE=13; p =.000). The relationship between sleep quality and depressive symptoms was moderated by frequency of water intake (B= -.186, SE =1.107; p= 0.11). Conclusion This study is among the first to examine the association between sleep quality and depressive symptoms among Latino adults, and to show that frequency of water intake may moderate this association in this population. Support This study was supported by funding from the NIH: R01 MH085653; 1U48DP006381; and T32HL129953.

scholarly journals Genetic parameters, phenotypic, genotypic and environmental correlations and genetic variability on sunflower in the Brazilian Savannah

2017 ◽  
Vol 47 (8) ◽  
Author(s):  
Ellen Grippi Lira ◽  
Renato Fernando Amabile ◽  
Marcelo Fagioli ◽  
Ana Paula Leite Montalvão
Keyword(s):  
Genetic Variability ◽  
Genetic Parameters ◽  
Environmental Control ◽  
Genetic Correlations ◽  
Phenotypic Selection ◽  
Phenotypic Variance ◽  
Environmental Correlations ◽  
High Genetic Variability ◽  
Brazilian Savannah ◽  
Main Component

ABSTRACT: Sunflower (Helianthus annuus L.) is an annual crop that stands out for its production of high quality oil and for an efficient selection, being necessary to estimate the components of genetic and phenotypic variance. This study aimed to estimate genetic parameters, phenotypic, genotypic and environmental correlations and genetic variability on sunflower in the Brazilian Savannah, evaluating the characters grain yield (YIELD), days to start flowering (DFL) based on flowering date in R5, chapter length (CL), weight of a thousand achenes (WTA), plant height (H) and oil content (OilC) of 16 sunflower genotypes. The experiment was conducted at Embrapa Cerrados, Planaltina, DF, situated at 15º 35’ 30”S latitude, 47º 42’ 30”W longitude and 1.007m above sea level, in soil classified as dystroferric Oxisol. The experimental design used was a complete randomized block with four replicates. The nature for the effects of genotypes and blocks was fixed. Except for the character chapter length, genetic variance was the main component of the phenotypic variance among the genotypes, indicating high genetic variability and experimental efficiency with proper environmental control. In absolute terms, the genetic correlations were superior to phenotypic and environmental. The high values reported for heritability and selective accuracy indicated efficiency of phenotypic selection. Results showed high genetic variability among genotypes, which may contribute to the genetic improvement of sunflower.

Hope and Depression

2017 ◽  
Author(s):  
Lorie A. Ritschel ◽  
Christopher S. Sheppard
Keyword(s):  
Major Depressive Disorder ◽  
Depressive Symptoms ◽  
Problem Solving ◽  
Depressive Disorder ◽  
Well Being ◽  
Major Depressive ◽  
Future Directions ◽  
Psychological Correlates ◽  
Self Talk ◽  
The Relationship

This chapter examines the relationship between hopeful thinking and major depressive disorder. Hope is a positive psychology construct that comprises goals, agency thinking, and pathways thinking and has been associated with psychological and physical well-being and psychosocial outcomes. Depression is inversely correlated with hope and is characterized by a host of symptoms and psychological correlates, including feelings of sadness, negative self-talk, amotivation, and difficulties in problem-solving and concentrating. This chapter explores the empirical evidence regarding the relationship between hope and depression, including the relationship between the subcomponents of hope (i.e., pathways and agency thinking) and the biological (e.g., neural reward systems) and cognitive (e.g., executive functioning) correlates of depression. In addition, the evidence for hope as a viable route for remediating depressive symptoms is reviewed, and future directions are proposed.

Meaning in Life as Mediator of Family Allocentrism and Depressive Symptoms Among Chinese and Italian Early Adolescents

2020 ◽  
pp. 0044118X2092163 ◽  
Author(s):  
Alessandro Germani ◽  
Delvecchio Elisa ◽  
Li Jian-Bin ◽  
Lis Adriana ◽  
Mazzeschi Claudia
Keyword(s):  
Depressive Symptoms ◽  
Adolescent Development ◽  
Meaning In Life ◽  
Protective Factor ◽  
Early Adolescents ◽  
Well Being ◽  
Mediation Effect ◽  
Early Adolescent ◽  
Presence Of Meaning ◽  
The Relationship

Establishing a coherent meaning in life has long been considered to be a protective factor of well-being, but this construct has been understudied in early adolescent development. The current study investigated the relationships between family allocentrism and depressive symptoms as well as the mediation effect of meaning in life in 214 Chinese and 201 Italian early adolescents. Although family allocentrism was higher in Chinese than Italian participants, it was significantly associated to lower depressive symptoms in both countries. Moderated mediational analyses showed that in both countries: (a) family allocentrism was positively related with presence of meaning; (b) family allocentrism and presence of meaning were negatively related to depressive symptoms; and (c) presence of meaning mediated the relationship between family allocentrism and depressive symptoms. In conclusion, family allocentrism and presence of meaning in life are important preventive factors of early adolescents’ depressive symptoms in both collectivistic and in individualistic countries.

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