scholarly journals Evaluation of Antidiabetic potential and Hypolipidemic activity of Coccinia indica (leaves) in Diabetic Albino rats

2019 ◽  
Vol 10 (4) ◽  
pp. 49-54
Author(s):  
Mamata Pochhi
Keyword(s):  
Folk Medicine ◽  
Water Extract ◽  
Glucose Consumption ◽  
Diabetic Rats ◽  
Lipid Lowering ◽  
Albino Rats ◽  
Whole Plant ◽  
Coccinia Indica ◽  
Metabolizing Enzyme ◽  
Coa Reductase

Background: The whole plant of Coccinia indica is very effective in different types of diseases with fewer side effects. The leaves, roots of this plant were claimed to be useful in the treatment of diabetes mellitus based on folk medicine. The purpose of this study was to examine the antihyperglycemic effect of water extract of C. indica in alloxan diabetes rats. Aims and Objectives: The aim of this study is to find whether the conditions, hyperglyclemia and hyerlipidemia, are correlated and whether the application of the aqueous extract leads to abating these two conditions. Materials-Methods: The aqueous leaves extracts of C. indica (200 mg/kg) were administered orally for 14 days, in alloxan induced diabetic rats on Glucose, Lipid profile, Lipoproteins and Lipid metabolizing enzymes activity.   Result: The aqueous leaves extract of C. indica induced significant improvement in glucose, serum Lipids, lipoproteins and lipid metabolizing enzyme activity (HMG CoA reductase, LCAT). Conclusion: The present study indicates that the extract of Coccinia indica exhibits lipid lowering, maintaining lipoproteins concentration and also improves the activities of lipid metabolizing enzyme in hyperglycemic rats leading to an increase in peripheral glucose consumption.

scholarly journals Hypoglycemic and antihyperlipidemic effect of aqueous leaves extract of Ficus Religiosa in alloxan induced diabetic rats

2017 ◽  
Vol 8 (2) ◽  
pp. 50-55 ◽  
Author(s):  
Mamata Pochhi ◽  
MG Muddeshwar
Keyword(s):  
Medicinal Plants ◽  
Folk Medicine ◽  
Diabetic Rats ◽  
Lipid Lowering ◽  
Medical Sciences ◽  
Indigenous Plants ◽  
Metabolizing Enzymes ◽  
Ficus Religiosa ◽  
Lipid Metabolizing Enzymes ◽  
Coa Reductase

Background: Medicinal plants provide valuable therapeutic agents,with less adverse effects. A number of indigenous plants were claimed to be useful in the treatment of diabetes mellitus based on folk medicine. The purpose of this study was to examine the hypoglycemic and antihyperglycemic effect of aqueous leaves extract of F. religiosa in alloxan diabetes albino rats.Aims and Objectives: Therefore, the present thesis aim is in evaluating whether the hyperglycemic condition is related with hyperlipidemia and both these conditions could be controlled by indigenous preparations.Materials and Methods: The aqueous leaves extracts of Ficus religiosa (250 mg/kg) were administered orally for 21 days, in alloxan induced diabetic rats on Glucose, Lipid profile, Lipoproteins and Lipid metabolizing enzymes.Result: The aqueous leaves extract of F. religiosa induced signifi cant improvement in glucose, serum lipids, lipoproteins concentration and lipid metabolizing enzymes activity (Lipase, HMG CoA reductase and LCAT).Conclusion: The present study indicates that the extract of Ficus religiosa exhibits lipid lowering, maintaining lipoproteins concentration and improve the activities of lipid metabolizing enzymes in hyperglycemic rats, by initiating the release of insulin. This study confi rm the possible role of indigenous medicinal plants in the treatment of Diabetes.Asian Journal of Medical Sciences Vol.8(2) 2017 50-55

scholarly journals Effect of Ethanolic Extract ofEmbelia Ribeson Dyslipidemia in Diabetic Rats

2002 ◽  
Vol 3 (3) ◽  
pp. 159-162 ◽  
Author(s):  
Uma Bhandari ◽  
Raman Kanojia ◽  
K. K. Pillai
Keyword(s):  
Folk Medicine ◽  
Anthelmintic Activity ◽  
Ethanolic Extract ◽  
Thiobarbituric Acid ◽  
Diabetic Rats ◽  
Herbal Remedies ◽  
Lipid Lowering ◽  
Embelia Ribes ◽  
Liver And Pancreas ◽  
Tbars Values

Diabetes mellitus has been treated orally with herbal remedies based on folk medicine since ancient times.Embelia ribes burm(Myrsinaceae), known commonly as vidanga, was used in Ayurveda for its anthelmintic activity. Ayurveda describes vidanga as pungent, causes increase in digestive fire, and cures flatulence and colic. A single study reported the antihyperglycemic activity of decoction ofE. ribesin glucose-induced hyperglycemic albino rabbits. In the present study, the lipid-lowering and antioxidant potential of ethanolic extract ofE. ribes burmwas investigated in streptozotocin (40 mg/kg, IV, single injection)-induced diabetes in rats. Twenty days of orally feeding the extract (200 mg/kg) to diabetic rats resulted in significant (P< 0.01) decrease in blood glucose, serum total cholesterol, and triglycerides, and increase in HDLcholesterol levels when compared to pathogenic diabetic rats. Further, the extract also lowered the liver and pancreas thiobarbituric acid–reactive substances (TBARSs) values (P< 0.01) when compared to TBARS values of liver and pancreas of pathogenic diabetic rats. The results of test drug were comparable to gliclazide (25 mg/kg, orally), a standard antihyperglycemic agent. This is the first pilot study to provide biochemical evidence of potential ofE. ribesin diabetic dyslipidemia.

scholarly journals Comparative evaluation of anti-diabetic activity of fresh juice and ethanolic extract of Sunderban mangrove Rhizophora mucronata Lam. leaves in animal model

2017 ◽  
Vol 6 (9) ◽  
pp. 2193
Author(s):  
Anjan Adhikari ◽  
Moumita Ray ◽  
Tapas K. Sur ◽  
Sharmistha Biswas ◽  
Anup K. Das
Keyword(s):  
Comparative Analysis ◽  
Folk Medicine ◽  
Ethanolic Extract ◽  
Ethanol Extract ◽  
Diabetic Rats ◽  
Lipid Lowering ◽  
Rhizophora Mucronata ◽  
Potent Effect ◽  
Diabetic Model ◽  
Treatment Of Diabetes

Background: Mangrove flora possess compounds with potential medicinal values with unique bioactive components. Traditionally Rhizophora mucronata, a mangrove has been used extensively for the treatment of diabetes. Studies revealed that, the leaves of Rhizophora (Bhora) had promising anti-diabetic action in rat model.Methods: A comparative analysis of the anti-diabetic action of fresh juice and ethanolic extract of Rhizophora mucronata leaves was carried out in Streptozotocin induced diabetic model and the different biochemical parameters were evaluated.Results: Present research explored a comparative analysis of the anti-diabetic action of fresh juice and ethanolic extract of leaves of Rhizophora mucronata Lam. in Streptozotocin induced diabetic model. The ethanolic extract showed more potent effect in lowering the elevated blood sugar in the diabetic rats, 200mg/kg was the most effective dose for both the extracts. The ethanol extract was more beneficial having potent lipid lowering action along with anti-hyperglycemic property.Conclusions: This supports the scientific validation for using Rhizophora mucronata leaves in the treatment of diabetes as traditional folk medicine. Identification of the bioactive molecule is under process.

Hypolipidemic and Antioxidant Effects of Diallyl Disulphide and Diaceto-Dipropyl Disulphide on Renal Tissue in Alloxan Diabetic Rats - A Comparative Study

2021 ◽  
Vol 8 (32) ◽  
pp. 2999-3005
Author(s):  
Vijay Venkataiah ◽  
Divya D ◽  
Sandhya H. Puttaswamy ◽  
Kashinath R.T
Keyword(s):  
Diabetic Nephropathy ◽  
Comparative Study ◽  
Diabetic Control ◽  
Renal Tissue ◽  
Diabetic Rats ◽  
Lipid Lowering ◽  
Albino Rats ◽  
Total Lipids ◽  
Antioxidant Effects ◽  
Rat Kidneys

BACKGROUND Diabetic nephropathy (DN) is one of the commonest causes for end stage renal disease. Renal accumulation of lipids is one of the pathological finding seen in diabetic nephropathy. Diallyl disulphide (DADS), a principle component of garlic oil, is known for its hypolipidemic properties. Diaceto-dipropyl disulphide (DADPDS) is a structural analogue of DADS, and is more palatable and less toxic to diabetic rats. Hence this animal experiment study was undertaken to compare the hypolipidemic and antioxidant effects of DADS and DADPDS on diabetic rat renal tissue and to evaluate the better disulphide among the two that may be used as adjuvant drug in treating or preventing diabetic nephropathy. METHODS This was an animal experimental comparative study. 24 male albino rats were grouped (6 rats in each group) into normal, diabetic control, DADS and DADPDS treated diabetic rats. Diabetes was induced in albino rats by intraperitoneal injection of alloxan. DADS and DADPDS were fed by gastric intubation for 90 days. After stipulated time, kidneys were dissected out and its total lipids, cholesterol and phospholipid levels were estimated along with tissue thiobarbituric acid reactive substances (TBARS) levels. RESULTS Renal tissue total lipids, cholesterol and phospholipids were significantly decreased in DADS and moderately decreased in DADPDS treated diabetic kidneys, when compared to diabetic control rats. But TBARS levels were significantly decreased in DADPDS rat kidneys compared to DADS treated rat kidneys. CONCLUSIONS In this comparative study, we note that DADS has better lipid-lowering effect on renal tissue of alloxan diabetic rats compared to DADPDS. On the other hand, DADPDS has low renal toxic effects, as indicated by low TBARS levels and improvement in blood glucose levels, when compared to DADS treated diabetic rats. Hence, DADS can be used as an adjuvant drug, only in atherogenic diabetic patients without nephropathy and DADPDS can be used as an adjuvant drug in diabetic nephropathy patients. KEYWORDS Diallyl-Disulphide, Diallyl-Dipropyl Disulphide, Diabetic Nephropathy, Renal Lipids

scholarly journals Nephroprotective effect of ethanolic leaf extract of Thaumatococcus danielli (benth.) in streptozotocin induced diabetic Rats

2017 ◽  
Vol 7 (12) ◽  
pp. 923
Author(s):  
Olubukola Sinbad Olorunnisola ◽  
Adewale Adetutu ◽  
Rasaq B POPOOLA ◽  
Abiodun Olusoji Owoade ◽  
Peter Adegbola ◽  
...  
Keyword(s):  
Leaf Extract ◽  
Standard Procedure ◽  
Folk Medicine ◽  
Inflammatory Cells ◽  
Diabetic Control ◽  
Diabetic Rats ◽  
Control Group ◽  
Albino Rats ◽  
Nephroprotective Activity ◽  
Ethanolic Leaf Extract

Background: The leaves of Thaumatococcus danielli (Benth.) have been traditionally used in folk medicine to treat malaria in Nigeria. However, there is no report on whether these leaves contain Nephroprotective activity. Thus, the ethanol leaf extract was investigated for Nephron-protective activity in Streptozotocin induced diabetic rats.Methods: First, the LD50 of the leaf was determined using standard procedure. Rats were assigned to 5 groups (A-E) of five rats. Except for the control group, each group was made diabetic using Streptozotocin (65 mg/kg/b.wt. i p). The treated groups received 0.5 ml of glibenclamide (25mg/kg/b.wt, o.p), 250 and 500 mg/kg/b.wt, o.p of Thaumatococcus danielli respectively. After 14 days of treatment, animals were sacrificed under light anaesthesia. Data were expressed as Means ± S.D (n=5) and were analyzed using one-way ANOVA followed by Dunnet’s test, values were considered significant at p<0.05. Results: The plant showed a LD50 greater than 5000 mg/kg/b.wt in albino rats observed for 72 hours. A significant (p<0.05) decreased in serum Na+, Cl-, HCO-3, total protein, and an insignificant increase in K+, urea and creatinine level were observed in the diabetic group when compared with the normal group. Oral administration of plant extract and glibenclamide significantly (p<0.05) restored the electrolytes to near normal. Histological alterations such as glomerulonephritis, and tubules infiltration by inflammatory cells observed in diabetic control were also reversed.Conclusion: This study suggests renal protective ability of the plant against impairment due to hyperglycemia.Keywords: Streptozotocin, Thaumatococcus danielli, Nephroprotective, Glibenclamide, serum electrolytes.

scholarly journals Biopharmacological studies of the aqueous extract of Lepidium sativum seeds in alloxan - induced diabetes in rats

2012 ◽  
Vol 36 (0E) ◽  
pp. 158-163
Author(s):  
Shahbaa M. Al-khazraji
Keyword(s):  
Body Weight ◽  
Aqueous Extract ◽  
Folk Medicine ◽  
Diabetic Rats ◽  
Lipid Lowering ◽  
Lepidium Sativum ◽  
Hypolipidemic Effect ◽  
Reference Drug ◽  
Glucose Reabsorption ◽  
Renal Glucose Reabsorption

Garden cress (Lepidium sativum) seeds are considered extensively in the folk medicine as anantidiabetic agent in many countries. The current investigations focuses attention on theglucose and lipid lowering effect of the aqueous extract of L. sativum seeds on experimentally induced diabetes in rats. The biochemical parameters studied were plasma glucose, insulin, totalcholesterol,triglycerides,phospholipids,hemoglobin, and glycosylated hemoglobin.In addition body weight and renal glucose reabsorption were notified. Aqueous extract of L. sativum were orally administered daily for 30 days in a dose of 20 mg / kg body weight to alloxan – diabetic rats , and a significant reduction in the parameters measured was investigated compared to diabetic rats. Meanwhile, Glibinclamide was used as standard reference drug. In cznclusion , L. sativum seeds possess a hypoglycaemic with concurrent hypolipidemic effect in diabetic states , and may further suggests thatL. Sativum may be useful in the therapy andmanagements of diabetic hyperlipidemia through reducing lipids levels .

Statins and Inflammation in Cardiovascular Disease

2018 ◽  
Vol 23 (46) ◽  
pp. 7027-7039 ◽  
Author(s):  
Georgia Vogiatzi ◽  
Evangelos Oikonomou ◽  
Gerasimos Siasos ◽  
Sotiris Tsalamandris ◽  
Alexandros Briasoulis ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Lipid Lowering ◽  
Hmg Coa Reductase ◽  
Ample Evidence ◽  
Reductase Inhibitors ◽  
Immune System Activation ◽  
Hmg Coa Reductase Inhibitors ◽  
Anti Inflammatory ◽  
Artery Disease ◽  
Coa Reductase

Background: Chronic inflammation and immune system activation underlie a variety of seemingly unrelated cardiac conditions including not only atherosclerosis and the subsequent coronary artery disease but also peripheral artery disease, hypertension with target organ damage and heart failure. The beneficial effects of HMG-CoA reductase inhibitors or statins are mainly attributed to their ability to inhibit hepatic cholesterol biosynthesis. Beyond their lipid lowering activity, ample evidence exists in support of their potent anti-inflammatory properties which initiate from the inhibition of GTPase isoprenylation, activating a cataract of secondary pathways and extend to the inhibition and blocking of immune cell activation and interaction. </P><P> Objective: To summarize the anti-inflammatory mechanisms of statins in clinical and experimental settings in cardiovascular disease. </P><P> Methods: A systematic search of PubMed and the Cochrane Database was conducted in order to identify the majority of trials, studies, current guidelines and novel articles related to the subject. </P><P> Results: In vitro, statins have immuno-modulatory and anti-inflammatory effects, and they can exert antiatherosclerotic effects independently of their hypolipidemic actions. In addition, positive results have emerged from mechanistic and experimental studies on the active role of HMG-CoA reductase inhibitors in HF. By extrapolating those data in clinical setting, we further understand how HMG-CoA reductase inhibitors can beneficially affect not only systolic but also diastolic HF. </P><P> Conclusion: In this review article, we present the basic pathophysiologic data supporting the anti-inflammatory actions of statins in clinical and experimental settings and we link these mechanisms with confirmatory clinical data on the potent non lipid lowering effects of HMG-CoA reductase inhibitors.

Synergistic Antitumor Effect of 5-Fluorouracil Combined with Constituents from Pleurospermum lindleyanum in Hepatocellular carcinoma SMMC-7721 Cells

2020 ◽  
Vol 20 ◽  
Author(s):  
Xiao-Feng Zhu ◽  
Xiao-Jin Li ◽  
Zhong-Lian Cao ◽  
Xiu-Jie Liu ◽  
Ping Yang ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Treatment Effectiveness ◽  
Synergistic Effects ◽  
Folk Medicine ◽  
Inhibitory Effect ◽  
Caspase 9 ◽  
Whole Plant ◽  
Anti Cancer ◽  
Induced Apoptosis

Background: A Chinese folk medicine plant Pleurospermum lindleyanum possesses pharmacological activities of heat-clearing, detoxifying and preventing from hepatopathy, coronary heart disease, hypertension, and high altitude sickness. We isolated and characterized its constituents to investigate its synergistic effects against human hepatoma SMMC-7721 cells. Objective: The aim of this study was to explore the synergistic anti-cancer activities of isolates from P. lindleyanum with 5-FU on hepatoma SMMC-7721 cells in vitro and their primary mechanisms. Methods: Sequential chromatographic techniques were conducted for the isolation studies. The isolates structures were established by spectroscopic analysis as well as X-ray crystallographic diffraction. Growth inhibition was detected by MTT assay. The isobologram method was used to assess the effect of drug combinations. Flow cytometry and western blot were used to examine apoptosis and protein expression. Results: A new coumarin (16), along with sixteen known compounds, were isolated from the whole plant of P. lindleyanum and their structures were elucidated by spectroscopic methods. Four coumarins (2, 3, 5, and 16), two flavonoids (8 and 9) and three phytosterols and triterpenes (12-14) were found to synergistically enhance the inhibitory effect of 5-FU against SMMC-7721 cells. Among them, compounds 3 and 16 exhibited the best synergistic effects with IC50 of 5-FU reduced by 16-fold and 22-fold possessing the minimum Combination Index (CI) 0.34 and 0.27. The mechanism of action of combinations might be through synergistic arresting for the cell cycle at G1 phases and the induction of apoptosis. Moreover, western blotting and molecular docking revealed that compounds 3 or 5 might promote 5-FU-induced apoptosis by regulating the expression of Caspase 9 and PARP. Conclusion: Constituents from P. lindleyanum may improve the treatment effectiveness of 5-FU against hepatocellular carcinoma cells.

Evaluation of Glucose and Lipid Lowering Activity of Arganimide A in Normal and Streptozotocin-Induced Diabetic Rats

2019 ◽  
Vol 19 (4) ◽  
pp. 503-510 ◽  
Author(s):  
Mohamed Eddouks ◽  
Farid Khallouki ◽  
Robert W. Owen ◽  
Morad Hebi ◽  
Remy Burcelin
Keyword(s):  
Body Weight ◽  
Blood Glucose ◽  
Oral Administration ◽  
Lipid Profile ◽  
Plasma Cholesterol ◽  
Diabetic Rats ◽  
Lipid Lowering ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Lowering Activity

Aims: Arganimide A (4,4-dihydroxy-3,3-imino-di-benzoic acid) is a compound belonging to a family of aminophenolics found in fruit of Argania spinosa. The purpose of this study was to investigate the glucose and lipid lowering activity of Arganimide A (ARG A). Methods: The effect of a single dose and daily oral administration of Arganimide A (ARG A) on blood glucose levels and plasma lipid profile was tested in normal and streptozotocin (STZ) diabetic rats at a dose of 2 mg/kg body weight. Results: Single oral administration of ARG A reduced blood glucose levels from 26.50±0.61 mmol/L to 14.27±0.73 mmol/L (p<0.0001) six hours after administration in STZ diabetic rats. Furthermore, blood glucose levels were decreased from 5.35±0.30 mmol/L to 3.57±0.17 mmol/L (p<0.0001) and from 26.50±0.61 mmol/L to 3.67±0.29 mmol/L (p<0.0001) in normal and STZ diabetic rats, respectively, after seven days of treatment. Moreover, no significant changes in body weight in normal and STZ rats were shown. According to the lipid profile, the plasma triglycerides levels were decreased significantly in diabetic rats after seven days of ARG treatment (p<0.05). Moreover, seven days of ARG A treatment decreased significantly the plasma cholesterol concentrations (p<0.001). Conclusion: ARG A possesses glucose and lipid-lowering activity in diabetic rats and this natural compound may be beneficial in the treatment of diabetes.

Study of Antihyperglycemic, Antihyperlipidemic and Antioxidant Activities of Tannins Extracted from Warionia saharae Benth. & Coss

2019 ◽  
Vol 19 (2) ◽  
pp. 189-198 ◽  
Author(s):  
Mohammed Ajebli ◽  
Fadwa El Ouady ◽  
Mohamed Eddouks
Keyword(s):  
Antioxidant Activity ◽  
Antioxidant Activities ◽  
Histopathological Examination ◽  
Density Lipoprotein ◽  
Hdl Cholesterol ◽  
Diabetic Rats ◽  
Lipid Lowering ◽  
Glucose Levels ◽  
Soxhlet Apparatus

Background and Objective: Warionia saharae Benth & Coss, a plant belonging to Asteraceae family, is used for its anti-diabetic properties in Morocco. The objective of this study was to evaluate the effect of tannins extracted from Warionia saharae (W. saharae) on blood glucose levels and lipid profile in normal and streptozotocin(STZ)-induced diabetic rats. Methods: Tannins (TE) were extracted from W. saharae using Soxhlet apparatus and different organic solvents. Single and once daily repeated oral administration of TE (10 mg/kg) for 15 days were used to evaluate the glucose and lipid-lowering activity in normal and diabetic rats. Furthermore, glucose test tolerance, liver histopathological examination and in vitro antioxidant activity of TE were carried out in this study. Results: The results showed that TE was able to exert antihyperglycemic and lowering total cholesterol effects as well as improvement of the high-density lipoprotein (HDL)-cholesterol serum level after 15 days of treatment. Furthermore, TE improved glucose tolerance, histopathological status of liver in diabetic rats and demonstrated interesting antioxidant activity. Conclusion: In conclusion, the present investigation revealed that TE possesses potent antidiabetic and antihyperlipidemic activities as claimed in different ethnopharmacological practices.

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