scholarly journals Salmonella Paratyphi A in India - Changing trends in presentation and antibiotic susceptibility

2011 ◽  
Vol 2 (1) ◽  
pp. 14-17 ◽  
Author(s):  
Sanjay V Kulkarni ◽  
Arun Narayan ◽  
Vrithmani Aprameya Indumathi ◽  
Tejas Suresh Rao ◽  
Punith Kempegowda
Keyword(s):  
Enteric Fever ◽  
Antibiotic Sensitivity ◽  
Rational Approach ◽  
Common Symptom ◽  
Test Results ◽  
Medical Sciences ◽  
Presenting Symptoms ◽  
Sensitivity Pattern ◽  
The Mean ◽  
The Difference

Objective: Not only has the prevalence of enteric fever due to Salmonella paratyphi A increased over the last decade, there has also been a change in common presenting symptoms and antibiotic sensitivity pattern of these organisms. Knowledge of the existing epidemiology of the disease is essential for a rational approach to treat the same. Hence the present study was done to establish the existing epidemiology of enteric fever due to Salmonella paratyphi A-their common presenting symptoms and antibiotic sensitivity pattern- at our setting. Material & Methods: This prospective study was conducted in MS Ramaiah Hospitals, Bangalore between January 2008 and December 2008. Patients admitted to the hospital with clinical suspicion of enteric fever and whose blood culture grew paratyphi A were included in the study. Common presenting symptoms and signs were recorded in these patients and the sensitivity patterns of the causative organisms were studied. The difference in their response to Ciprofloxacin and Ceftriaxone was studied. The analysis was done using the statistical software package-SPSS Version 16. The difference in the defervescence period was calculated by 2-way Independent two-sample t-test. Results: A total 32 patients were included in the study. Fever and hepatomegaly were the most common symptom and sign among the study subjects. All isolates were susceptible to commonly used antibiotics except for Nalidixic acid. The mean defervescence period was shorter in patients treated with Ceftriaxone as compared to those treated with Ciprofloxacin (p<0.002). Conclusion: We report a change in the presentation and antibiotic sensitivity of paratyphi A infection as compared to existing literature. Ceftriaxone is a better drug as choice as it has shorter defervescence time. Key Words: Salmonella paratyphi A; Ceftriaxone; Ciprofloxacin; Defervescence DOI: 10.3126/ajms.v2i1.3546 Asian Journal of Medical Sciences 2 (2011) 14-17

scholarly journals Clinical Profile, Laboratory Profile and Current Antibiotic Sensitivity Pattern of Enteric Fever in a Teaching Hospital of Central Nepal

2020 ◽  
Vol 16 (2) ◽  
pp. 74-77
Author(s):  
Atanu Pan ◽  
Debarshi Jana
Keyword(s):  
Enteric Fever ◽  
Clinical Manifestations ◽  
Antibiotic Sensitivity ◽  
Febrile Illness ◽  
Cross Sectional Study ◽  
Medical Sciences ◽  
Cross Sectional ◽  
Paediatric Department ◽  
Sensitivity Pattern ◽  
Laboratory Profile

Background: About 26.9 million typhoid cases and more than 2 lakh deaths occur each year, with      majority of the cases reported in Asia. The incidence of typhoid varies substantially within Asia. The aim of the study is to asses study the clinical and laboratory profile, culture positive & sensitivity pattern of Salmonella Typhiand its response to antimicrobial therapy in the paediatric department of College Of Medical Sciences, Bharatpur, Nepal. Methods: A descriptive cross sectional study was conducted among 104 Children in the age group of 5 to 12 years admitted with history of fever ≥5 days duration chosen as study population Paediatric Department College Of Medical Sciences, Bharatpur, Nepal from  February 2015 to October 2019. Results: Our study found that 40(38.5) patients had pallor, 28(26.9) patients had Hepatomegaly, 19(18.3) patients had splenomegaly and 21(20.2) patients had coated tongue. It was found that 37(90.2) patients had sensitive ciprofloxacin, 37(90.2) patients had sensitive ofloxacin, 39(95.1) patients had sensitive levofloxacin and 37(90.2) patients had sensitive azithromycin. 38(92.7) patients had sensitive Cefixime, 38(92.7) patients had sensitive ceftriaxone, 39(95.1) patients had sensitive imipenam and 33(80.5) patients had sensitive cotrimoxazole ,32(78.0) patients had sensitive amoxicillin, 37(90.2) patients had sensitive cefotaxime. Conclusions: Enteric fever is an important cause of febrile illness in children. Fever with anorexia, cough, diarrhea, headache, hepatosplenomegaly were the common clinical manifestations of enteric fever. An adequate trial of first line antibiotics like oral cefexime,ofloxacin,co-trimoxazole, ampicillin can be tried before starting injectable antibiotics due to increased emergence of sensitivity to these drugs. Keywords: enteric fever; antibiotic sensitivity pattern  

scholarly journals Clinico-laboratory Profile of Enteric Fever and Antibiotic Sensitivity Pattern in Hospitalized Children

2018 ◽  
Vol 42 (2) ◽  
pp. 54-57
Author(s):  
Farhana Rahat ◽  
NK Ghosh ◽  
Kazi Iman ◽  
Morsheda Khanam ◽  
Azmeri Sultana ◽  
...  
Keyword(s):  
Enteric Fever ◽  
Tertiary Care ◽  
Antibiotic Sensitivity ◽  
Salmonella Typhi ◽  
Fourth Generation ◽  
Care Hospital ◽  
Presenting Symptoms ◽  
Culture Positivity ◽  
Sensitivity Pattern ◽  
Culture Positivity Rate

Background: Enteric fever is endemic in Bangladesh. This is an important cause of morbidity and mortality in developing countries. The aim of the study was to evaluate the clinical and laboratory profiles, culture positivity rate and sensitivity pattern of Salmonella enterica.Methodology: This was an observational study carried out in a tertiary care hospital in Dhaka, Bangladesh during the period from January to December, 2017. Total 120 children who had enteric fever diagnosed either by positive blood culture or widal test with significant titre for Salmonella Typhi or Paratyphi were enrolled in the study.Results: Fever and abdominal pain were the main presenting symptoms. Leucocyte and platelet count were normal whereas ALT and CRP found to be elevated. Culture positivity rate in our study was 43.33%. Of the culture positive isolates, 88.46% were Salmonella Typhi and 11.53% were Salmonella Paratyphi. All the isolates were sensitive to third and fourth generation cephalosporins while 79.54% showed intermediate sensitivity to ciprofloxacin.Conclusion: A good sensitivity to third and fourth generation cephalosporins against Salmonella was noted whereas ciprofloxacin found to be less sensitive. Ceftriaxone showed remarkable efficacy when used as monotherapy.Bangladesh J Child Health 2018; VOL 42(2) :54-57

scholarly journals The Role of Indomethacin in Isolated Polyhydramnios

2020 ◽  
Vol 8 (2) ◽  
pp. 52-56
Author(s):  
Greeshma Singham ◽  
Vivekanand Achanta ◽  
Satyaprabha Siripurapu ◽  
SubhaRanjan Samantaray
Keyword(s):  
Gestational Age ◽  
Test Results ◽  
Medical Sciences ◽  
End Of Treatment ◽  
Gestational Age At Delivery ◽  
The Mean ◽  
The Difference ◽  
A Prospective Study ◽  
Respiratory Embarrassment

Objective: To study the role of Indomethacin in patients with Idiopathic Polyhydramnios who were symptomatic. Methods: A prospective study was conducted in Prathima Institute of Medical Sciences, Karimnagar from September 2017 to May 2019. Eighteen patients with Idiopathic Polyhydramnios who presented with respiratory embarrassment, premature opening of os or presence of uterine activity were given Indomethacin orally at a dose of 25mg 6th hourly. The significance of changes in AFI was tested by paired t test. Results : There was significant improvement in the symptoms in all the eighteen patients. The mean age of the patients in our study was 26.4±5.5 years. The majority 14(77.7%) of women were multigravida. Mean gestational age at presentation was 30.78±1.56 weeks. Mean AFI at presentation was 31.56±3.68 cm. Indomethacin was given orally at a dose of 25mg, every 6th hourly for a mean duration of 22.5±6.38 days. Mean AFI at the end of treatment was 20.28±5.64 cm. Pregnancy was prolonged by an average of 5.5±1.89 weeks. The difference in AFI at the end of treatment was statistically significant (p<0.05). Oligohydramnios was seen in one patient. Mean gestational age at delivery was 36.28±1.41 weeks. 17(94.4%) of them had good neonatal outcome. There was one neonatal death at< 7 days of birth. Conclusion: Indomethacin significantly decreases amniotic fluid volume in patients with Idiopathic Polyhydramnios and relieves symptoms but close surveillance is necessary.

Antibiotic Sensitivity and Resistance Patterns of Salmonella Typhi in Rajshahi Medical College Hospital

2020 ◽  
Vol 33 (2) ◽  
pp. 10-14
Author(s):  
Md Azizul Haque ◽  
Laila Shamima Sharmin ◽  
KM Faisal Alam ◽  
Md Mohimanul Hoque ◽  
M Morsed Zaman Miah ◽  
...  
Keyword(s):  
Blood Culture ◽  
Enteric Fever ◽  
Antibiotic Sensitivity ◽  
Salmonella Typhi ◽  
Medical College Hospital ◽  
Personal Hygiene ◽  
Care Hospital ◽  
College Hospital ◽  
Medical College ◽  
Sensitivity Pattern

Typhoid and paratyphoid fevers, collectively known as enteric fever, is caused by Salmonella enterica subspecies serovars Typhi and Paratyphi A, B and C. Despite this declining global trend, enteric fever is still considered to be a major public health hazard in Bangladesh and other developing countries due to poor sanitation, inadequate food safety measures and poor personal hygiene. In Bangladesh, the incidence of typhoid fever was reported to be 200 episodes per 100,000 person-years during 2003–2004. Multidrug-resistant (resistance to the first-line antimicrobials ampicillin, cotrimoxazole, and chloramphenicol) strains of S. Typhi and S. Paratyphi are on the rise globally and even cases of extensively drug-resistant (XDR) typhoid cases resistant to chloramphenicol, ampicillin, trimethoprim-sulfamethoxazole, third generation cephalosporins and fluoroquinolones are being reported from many corners of the world. This descriptive, observational study was carried out in Rajshahi Medical College Hospital Hospital, Rajshahi, Bangladesh from July 2017 to June 2019. Antibiotic sensitivity pattern of total 76 cases of enteric fever due to Salmonella Typhi were studied. Blood culture was carried out by BACT ALERT-3D, Automated blood culture analyzer from BioMeriuex SA, France Patented FAN Plus method. Based on the minimum inhibitory concentration (MIC), the organism was categorized as sensitive, intermediate, and resistant against the respective antibiotics as per Clinical and Laboratory Standards Institute (CLSI) criteria. We are reporting antibiotic sensitivity and resistant patterns of S. Typhi documented in Rajshahi Medical College Hospital, a large tertiary care hospital in Northern Bangladesh. TAJ 2020; 33(2): 10-14

scholarly journals Outcome of Type 1 tympanoplasty: An experience at Biratnagar eye hospital in Eastern Nepal

2015 ◽  
Vol 7 (2) ◽  
pp. 55-60 ◽  
Author(s):  
Sanjeev Kumar Thakur ◽  
Sanjay Kumar Singh ◽  
Anwar Afaque ◽  
Nisha Ghimire
Keyword(s):  
Medical Sciences ◽  
Hearing Improvement ◽  
Hearing Outcome ◽  
Type 1 Tympanoplasty ◽  
Younger Age ◽  
History Of ◽  
The Mean ◽  
The Difference ◽  
Graft Success

Background: The history of tympanoplasty is well over a century. Type 1 tympanoplasty is an established procedure worldwide with a variation in the outcome.Aims and Objectives: To analyze the outcome of Type 1 tympanoplasty surgeries in terms of graft success and hearing improvement done at the Ear Department of Biratnagar eye hospital in eastern Nepal and discuss the various factors that might have influenced it.Materials and Methods: Retrospective analysis of records of the cases that underwent Type 1 tympanoplasty from August 2013 to January 2015 was done. The factors analysed were age, gender, the side of the affected ear and the perforation size. Appropriate Statistical test was applied and the results were discussed.Results: A total of 151 cases of type 1 Tympanoplasty were analysed were females had higher frequency than males, with higher incidence at younger age. The mean age of successful cases was 28.53. Females had a better success rate in terms of graft success compared to males. Moderate size perforations had the best outcome of graft success and least were of small size perforations. Of all cases analyzed, hearing improvement was observed in maximum cases.Conclusion: There was no significant influence of age or gender on the hearing outcome. The difference of hearing improvement according to size of perforation was also not significant.Asian Journal of Medical Sciences Vol.7(2) 2015 55-60

scholarly journals Salbutamol nebulization for management of transient tachypnea of newborn (TTN).

2021 ◽  
Vol 28 (01) ◽  
pp. 52-59
Author(s):  
Fatima Maroof ◽  
Tehmina Maqbool ◽  
Hafiz Muhammad Irfan ◽  
Beenish Bashir Mughal ◽  
Ayesha ◽  
...  
Keyword(s):  
Placebo Group ◽  
Respiratory Rate ◽  
Test Results ◽  
Demographic Information ◽  
Significant Difference ◽  
Nebulized Salbutamol ◽  
The Mean ◽  
Randomized Control ◽  
The Difference ◽  
Trial Setting

Objective: To compare the mean change in respiratory rate with salbutamol nebulization versus placebo for treatment of transient tacyopnea of newborn. Study Design: Randomized Control Trial. Setting: Department of Neonatology, Federal Government Polyclinic (PGMI), Islamabad. Period: 8th August 2017 to 7th February 2018. Material & Methods: 100 neonates fulfilling selection criteria were enrolled in the study. Informed consent was obtained from parents. Demographic information was also noted. All baseline respiratory rate were noted. Neonates were divided into two groups by lottery method. Neonates in Treatment group were nebulized with Salbutamol. Placebo group was nebulized with Normal Saline. Then neonates were followed-up in N.I.C.U after 4 hours of second nebulization. After 4 hours, respiratory rates were assessed and change in respiratory rate was noted. Both groups were compared for mean reduction in respiratory rate by using independent sample t-test. Results: In nebulized salbutamol, group, mean respiratory rate was changed from 79.62±8.18bpm to 52.06±4.96bpm. This was a significant decrease (p<0.05). In placebo group, mean respiratory rate was changed from 81.88±8.86bpm to 62.50±6.75bpm. This was significant decrease (p<0.05). The difference between both groups at baseline was insignificant while after 4 hours was significant. The mean changed in respiratory rate with nebulized salbutamol was 27.56±6.83bpm while with placebo was 19.35±9.83bpm. There was significant difference in mean reduction in respiratory rate (p<0.05). Conclusion: It has been proved that nebulized salbutamol can be helpful in reducing respiratory rate significantly in neonates with TTN as compared to placebo.

scholarly journals CLINICAL PROFILE AND ANTIBIOTIC SENSITIVITY PATTERN OF ENTERIC FEVER AMONG CHILDREN ADMITTED IN PEDIATRICS DEPARTMENT OF JLNMCH, BHAGALPUR, BIHAR

2021 ◽  
pp. 1-3
Author(s):  
Mithilesh Kumar ◽  
R. K. Sinha ◽  
Debarshi Jana
Keyword(s):  
Enteric Fever ◽  
Tertiary Care ◽  
Antibiotic Sensitivity ◽  
Urban Slum ◽  
Case Definition ◽  
Clinical Profile ◽  
Suspected Case ◽  
Care Hospital ◽  
Widal Test ◽  
Sensitivity Pattern

Objective: In this study our main aims to know the clinical profile of pediatric enteric fever and the sensitivity pattern of the disease to drugs in this region. Methodology: This prospective observational study conducted in a tertiary care hospital at Dhaka from March to December 2019 among suspected case of Enteric fever as per case definition. Among 212 suspected enteric fever 117 children were diagnosed as enteric fever by blood culture and/or Widal test. Results: During the study, Male: female were 1.3: 1. Maximum (70%) children were in age group 5 years or more. Most of the children were from urban slum area (53.6%) of Dhaka city. Cases were admitted throughout the year. Common presentation were fever (100%), anorexia (100%), pain abdomen (74.4%) and loose motions (46.1%). The common signs were hepatomegaly (41.9%), hepatosplenomegaly (5.1%) coated tongue (64.9%), pallor (74.4%). The complications rate was 35.9% and commonest being UTI and pneumonia. The overall positivity of Widal test was 89.7% and the culture positivity was 32.5%. Among isolates, 94.7%were Salmonella typhi and 5.3% Salmonella paratyphi A. Among them18.1% isolates were multi drug resistant. Conclusion: Enteric fever is most prevalent during summer & rainy session. WASA supplied water may play a role. Hepatomegaly is common. UTI and pneumonia are the commonest complication. Multidrug resistant cases are not so as high as other countries. Cefixime, Ceftriaxone. Meropenam and Ofloxacine are the drugs of choice. Ciprofloxacin is still could be chosen for the treatment of enteric fever. Higher rate of resistant to Azithromycin is alarming.

scholarly journals A study on clinical profile of typhoid fever in children

2017 ◽  
Vol 4 (3) ◽  
pp. 1067
Author(s):  
Ranganatha A. Devaranavadagi ◽  
Srinivasa S.
Keyword(s):  
Public Health ◽  
Typhoid Fever ◽  
Clinical Manifestations ◽  
Antibiotic Sensitivity ◽  
Public Health Problem ◽  
Public Health Issue ◽  
Common Symptom ◽  
Major Public Health Problem ◽  
Sensitivity Pattern ◽  
Wide Range

Background: Typhoid fever is caused by Salmonella typhi. It is a major public health problem in India. Typhoid fever is endemic in many developing countries. Wide variations in the clinical manifestations of typhoid fever make its diagnosis a challenging task. This study was conducted to understand the wide range of clinical manifestations, complications and antibiotic sensitivity patterns of typhoid fever in children.Methods:Prospectively, 113 children admitted in pediatric unit with confirmed Typhoid fever from September 2015 to December 2016 at KIMS hospital, Bangalore were included. In each case, age, sex, presenting complaint, laboratory investigations and antibiotic sensitivity pattern are collected and analysed.Results: Out of 113 cases, 72 cases (63.8.1%) were males, 41 cases (36.2%) were females. The most common age group was 5-10 years. The most common symptom was fever, seen in 100% cases, followed by anorexia (61%), vomiting (44%) and abdominal pain (18%). The most common sign observed was toxic look in 68% of the cases, followed by coated tongue in 49% and hepatomegaly in 44%. Leucocytopenia was found in 34% of cases. Eosinopenia was found in 39% of cases. Anaemia was found in 16% of cases. Thrombocytopenia was found in 15% of cases. Blood culture was positive in 20% of cases. Use of municipal water for drinking was found in 65% of cases. Outside eating was found in 40% of cases. Unhygienic practices were found in 64% of cases. Duration of hospital stay varied from 3-10 days. No mortality reported.Conclusions:Typhoid fever is most commonly observed with unhygienic practices and eating of unhealthy outside food. This major public health issue can be tackled by bringing awareness among people regarding disease transmission and its various preventive measures. 

scholarly journals Prevalence and Antibiotic Sensitivity Pattern of Asymptomatic Bacteriuria among Female Students and Staff of College of Applied Medical Sciences, Taif University.

2020 ◽  
Vol 3 (1) ◽  
pp. 862-867
Author(s):  
Taisir Saber ◽  
Nahed M. Hawsawi ◽  
Aisha hassen Alharthi ◽  
Mashael hamad Algethami ◽  
Reem Abdullah Alnefaie ◽  
...  
Keyword(s):  
Bacterial Growth ◽  
Asymptomatic Bacteriuria ◽  
Antibiotic Sensitivity ◽  
Educational Status ◽  
Medical Sciences ◽  
Cross Sectional ◽  
Sensitivity Pattern ◽  
Group A ◽  
Group B ◽  
Urine Specimens

Background: Asymptomatic bacteriuria (ASB) is a common condition where bacteria are present in a significant count in urine without symptoms. Pathogen persistence for a long period of time can cause urinary tract infection (UTI) that may lead to a serious complication. This study was carried out to assess the prevalence of ASB among female student and staff in College of Applied Medical Sciences, Taif university. Methods: This was a cross sectional study where a clean-catch midstream urine specimens were collected from 50 participant; 29 staff (group A) and 21 students (group B). The urine specimens were cultured quantitatively onto CLED agar plates and incubated at 35-37 ºC for 24- 48 hours. Bacterial growth equal to or more than 105 CFU/ml was considered significant. Bacteria that grew in significant count were identified by Gram stain, catalase test, coagulase test and novobiocin sensitivity.  Results: Out of the 50 urine specimens screened for ASB, two specimens (4 %) showed significant bacterial growth; where one specimen (3.4 %) in group A and one specimen (4.8 %) in group B showed significant bacterial growth. The rest of urine specimens showed either no or non-significant bacterial growth. Staphylococcus saprophyticus and Staphylococcus epidermidis were the isolated organisms. Conclusion: Low prevalence of asymptomatic bacteriuria was noted in this study. This may be due to the relatively small number of the students and staff investigated. Another likely explanation is that our target group has high educational status as socioeconomic marker.

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