scholarly journals A study on clinical profile of typhoid fever in children

2017 ◽  
Vol 4 (3) ◽  
pp. 1067
Author(s):  
Ranganatha A. Devaranavadagi ◽  
Srinivasa S.
Keyword(s):  
Public Health ◽  
Typhoid Fever ◽  
Clinical Manifestations ◽  
Antibiotic Sensitivity ◽  
Public Health Problem ◽  
Public Health Issue ◽  
Common Symptom ◽  
Major Public Health Problem ◽  
Sensitivity Pattern ◽  
Wide Range

Background: Typhoid fever is caused by Salmonella typhi. It is a major public health problem in India. Typhoid fever is endemic in many developing countries. Wide variations in the clinical manifestations of typhoid fever make its diagnosis a challenging task. This study was conducted to understand the wide range of clinical manifestations, complications and antibiotic sensitivity patterns of typhoid fever in children.Methods:Prospectively, 113 children admitted in pediatric unit with confirmed Typhoid fever from September 2015 to December 2016 at KIMS hospital, Bangalore were included. In each case, age, sex, presenting complaint, laboratory investigations and antibiotic sensitivity pattern are collected and analysed.Results: Out of 113 cases, 72 cases (63.8.1%) were males, 41 cases (36.2%) were females. The most common age group was 5-10 years. The most common symptom was fever, seen in 100% cases, followed by anorexia (61%), vomiting (44%) and abdominal pain (18%). The most common sign observed was toxic look in 68% of the cases, followed by coated tongue in 49% and hepatomegaly in 44%. Leucocytopenia was found in 34% of cases. Eosinopenia was found in 39% of cases. Anaemia was found in 16% of cases. Thrombocytopenia was found in 15% of cases. Blood culture was positive in 20% of cases. Use of municipal water for drinking was found in 65% of cases. Outside eating was found in 40% of cases. Unhygienic practices were found in 64% of cases. Duration of hospital stay varied from 3-10 days. No mortality reported.Conclusions:Typhoid fever is most commonly observed with unhygienic practices and eating of unhealthy outside food. This major public health issue can be tackled by bringing awareness among people regarding disease transmission and its various preventive measures. 

scholarly journals Antimicrobial susceptibility of Salmonella Typhi in India

2009 ◽  
Vol 4 (02) ◽  
pp. 070-073 ◽  
Author(s):  
Kavita Nagshetty ◽  
Shivannavar T. Channappa ◽  
Subhashchandra M. Gaddad
Keyword(s):  
Public Health ◽  
Typhoid Fever ◽  
Antimicrobial Susceptibility ◽  
Enteric Fever ◽  
Public Health Problem ◽  
Salmonella Typhi ◽  
Personal Hygiene ◽  
Public Health Issue ◽  
Dilution Method ◽  
Major Public Health Problem

Background: Typhoid fever continues to remain a major public health problem, especially in regions such as Gulbarga, due to poor sanitation and personal hygiene. Gulbarga region is often prone to enteric fever outbreaks and is an endemic region of typhoid fever. Enteric fever caused by Salmonella Typhi has not been adequately explored in this region. Methodology: A total of 95 isolates of S. Typhi collected from different clinical and environmental sources were tested for antimicrobial susceptibility according to the CLSI guidelines. MIC of resistant isolates to various antibiotics was performed by agar dilution method. Results: Of the total isolates studied, 10% were found to be multidrug resistant (MDR) (defined as resistance to ampicillin, chloramphenicol and co-trimoxazole). There was a decrease in the susceptibility to ciprofloxacin of S. Typhi with MIC showing an upward trend (0.125-4µg/mL). Concurrently, there has been an increase in the number of isolates sensitive to all antibiotics except nalidixic acid. Conclusion: MDR S. Typhi continues to be an important public health issue in Gulbarga. Presence of quinolone resistance and associated low-level ciprofloxacin resistance is a concern and requires further study.

scholarly journals Multidrug-resistant typhoid fever: a review

2011 ◽  
Vol 5 (05) ◽  
pp. 324-337 ◽  
Author(s):  
Syed Ahmed Zaki ◽  
Sunil Karande
Keyword(s):  
Public Health ◽  
Typhoid Fever ◽  
English Language ◽  
Public Health Problem ◽  
Public Health Education ◽  
Abdominal Distension ◽  
Clinical Results ◽  
Multidrug Resistant ◽  
Major Public Health Problem ◽  
Handling Practices

Introduction: Multidrug-resistant typhoid fever (MDRTF) is defined as typhoid fever caused by Salmonella enterica serovar Typhi strains (S. Typhi), which are resistant to the first-line recommended drugs for treatment such as chloramphenicol, ampicillin and trimethoprim-sulfamethoxazole. Since the mid-1980s, MDRTF has caused outbreaks in several countries in the developing world, resulting in increased morbidity and mortality, especially in affected children below five years of age and those who are malnourished. Methodology: Two methods were used to gather the information presented in this article. First PubMed was searched for English language references to published relevant articles. Secondly, chapters on typhoid fever in standard textbooks of paediatric infectious diseases and preventive and social medicine were reviewed. Results: Although there are no pathognomonic clinical features of MDRTF at the onset of the illness, high fever ( > 104°F), toxaemia, abdominal distension, abdominal tenderness, hepatomegaly and splenomegaly are often reported. The gold standard for the diagnosis of MDRTF is bacterial isolation of the organism in blood cultures. Ciprofloxacin and ceftriaxone are the drugs most commonly used for treatment of MDRTF and produce good clinical results. Conclusion: MDRTF remains a major public health problem, particularly in developing countries. Mass immunization in endemic areas with either the oral live attenuated Typhi 21a or the injectable unconjugated Vi typhoid vaccine, rational use of antibiotics, improvement in public sanitation facilities, availability of clean drinking water, promotion of safe food handling practices and public health education are vital in the prevention of MDRTF. 

scholarly journals Clinical profile and antibiotic sensitivity pattern of typhoid fever in children: a hospital based prospective study from a tertiary care center

2020 ◽  
Vol 7 (4) ◽  
pp. 901
Author(s):  
Shekar V. ◽  
Chapay Soren ◽  
Lakshmi Aparnadevi V. V. ◽  
Umadevi M. ◽  
Malathi Vanka
Keyword(s):  
Typhoid Fever ◽  
Clinical Presentation ◽  
Tap Water ◽  
Tertiary Care ◽  
Antibiotic Sensitivity ◽  
Public Health Problem ◽  
Clinical Profile ◽  
Drinking Water Source ◽  
Chloramphenicol Resistance ◽  
Sensitivity Pattern

Background: Typhoid fever is a serious public-health problem in many developing countries including India. There is a wide spectrum of clinical presentation and with the emergence of multidrug resistant typhoid now a days, the treatment has become still more complex. The present study authors describe the clinical profile and antibiotic sensitivity pattern of typhoid fever in children from a tertiary care in Mahabubnagar, Telangana, South India.Methods: This hospital based prospective observational study was done in Department of Pediatrics, SVS Medical College, Mahabubnagar, Telangana over a period of 3-year period from January 2017 to December 2019. The study was approved by institutional ethics committee. Written informed consent was obtained from children’s parents. All pediatric patients diagnosed as typhoid fever if presented with fever (temperature >38ºC) for at least 3 days with positive blood culture for S. typhi or paratyphi were included in the study. The demographic profile and clinical data were recorded and tests including antibiotic sensitivity and resistance were done.Results: A total of 136 patients were included in the study. Majority of the children were between 8 to 12-year age group (38.2%). Out of 136 children, 78 were males and 58 were females. Majority of the cases were from rural areas accounting for 69%. Drinking water source was tap water in 63% cases and bore well water in 37% cases. Majority (65%) belonged to lower socioeconomic class and 68% were during rainy seasons. The clinical findings observed were fever (100%), vomiting (98, 72%), diarrhea (55.8%), headache (45.5%), and splenomegaly (42.6%). Other clinical features found were coated tongue, abdominal pain, hepatomegaly, constipation, and dehydration. Six children had complications, 3 had enteric hepatitis, 2 had shock, and 1 had encephalopathy. Ampicillin, amoxicillin and chloramphenicol resistance was observed in 76%, 71% and 22% of patients with typhoid fever respectively. Maximum sensitivity was observed with ceftriaxone (95%), followed by aztreonam (92%), ciprofloxacin (84.5%), and azithromycin (77%).Conclusions: Clinical presentation in the study subjects was similar to available reports from literature. Increasing resistance of salmonella to Ampicillin and amoxicillin were observed.

The Epidemiology of Māori Suicide in Aotearoa/New Zealand

2000 ◽  
Vol 12 ◽  
pp. 1-12
Author(s):  
Nicole M. Coupe
Keyword(s):  
Public Health ◽  
New Zealand ◽  
Suicide Rate ◽  
Age Groups ◽  
Public Health Problem ◽  
Epidemiological Data ◽  
Public Health Issue ◽  
Major Public Health Problem ◽  
Age Group ◽  
Aotearoa New Zealand

AbstractSuicide is a Māori Public Health Issue. Suicide rates in Aotearoa/New Zealand are amongst the highest in OECD countries in the 15-24 year age group and second only to Hungary in other age groups (WHO, 1996; Disley & Coggan, 1996). Suicide is the leading cause of death for young people under the age of 25 years in Aotearoa/New Zealand and a major public health problem (Coggan, 1997). Approximatel, 540 New Zealanders kill themselves each year (Rose, Hatcher, & Koelmeyer, 1999). The total Māori suicide rate (per 100 000) increased to 17.5 in 1997, compared to non-Māori (13.1), and the Māori youth suicide rate (33.9) far exceeded the equivalent non-Māori rate (24.3), reflecting the disparity between Māori and non-Māori (Ministry of Health, 1997). This paper aims to present epidemiological data on Māori suicide and then use the existing literature to discuss possible reasons for the high Māori rate.

scholarly journals Assessing the Impact of Drug Resistance on the Transmission Dynamics of Typhoid Fever

2013 ◽  
Vol 2013 ◽  
pp. 1-13 ◽  
Author(s):  
S. Mushayabasa ◽  
C. P. Bhunu ◽  
E. T. Ngarakana-Gwasira
Keyword(s):  
Public Health ◽  
Mathematical Model ◽  
Drug Resistance ◽  
Typhoid Fever ◽  
Public Health Problem ◽  
Transmission Dynamics ◽  
Reproductive Number ◽  
Major Public Health Problem ◽  
Drug Resistant ◽  
The Impact

Typhoid fever continues to be a major public health problem in the developing world. Antibiotic therapy has been the main stay of treating typhoid fever for decades. The emergence of drug-resistant typhoid strain in the last two decades has been a major problem in tackling this scourge. A mathematical model for investigating the impact of drug resistance on the transmission dynamics of typhoid fever is developed. The reproductive number for the model has been computed. Numerical results in this study suggest that when a typhoid outbreak occurs with more drug-sensitive cases than drug-resistant cases, then it may take 10–15 months for symptomatic drug-resistant cases to outnumber all typhoid cases, and it may take an average of 15–20 months for nonsymptomatic drug-resistant cases to outnumber all drug-sensitive cases.

scholarly journals Pattern of Anti-microbial Drug Resistance in Childhood Typhoid Fever in a Selected Hospital in Karachi, Pakistan

2019 ◽  
pp. 1-9
Author(s):  
Hiba Siddiqui ◽  
Firdous Jahan ◽  
Muhammad A. Siddiqui
Keyword(s):  
Drug Resistance ◽  
Typhoid Fever ◽  
Clinical Manifestations ◽  
Salmonella Typhi ◽  
Resistance Pattern ◽  
Public Health Issue ◽  
High Grade Fever ◽  
Antimicrobial Drug Resistance ◽  
Microbial Drug Resistance ◽  
Sensitivity Pattern

Introduction: Typhoid fever is a major public health issue in Pakistan. Variations in clinical manifestations make diagnosis a challenging task. Over use of antibiotics make the organism resistant. Antibiotic resistance is currently the most threatening issue as regards to infection control and our study would be helpful in the understanding of this feature of the microbes. The main purpose of this study was to determine the antimicrobial drug resistance and sensitivity pattern in Salmonella typhi and S. paratyphi. Methods: This is a descriptive study carried out in a private hospital in Karachi, Pakistan. One hundred consecutive patients, children from age one day till 12 years admitted in the hospital with the history of fever and had positive blood culture for Salmonella typhi and S.paratyphi were included, 9 antimicrobial drugs were taken into account to check their sensitivity.  Statistical analysis was performed using SPSS (IBM SPSS Statistics 20.0). Data was expressed in frequencies and percentages. Results: Most of the children belong to middle class 58% with 62% male and common age group (40%) was 1 day to 4 years. Nearly half of them drinking un-boiled water and had ladder pattern of high grade fever. Most pronounced symptoms were abdominal pain, nausea and anorexia. Resistance pattern was ciprofloxacin 100%, chloramphenicol 89.1%, Ampicillin 87.1% Ceftriaxone 76.2%, Cefixime 75.2%, Amoxicillin 65.3%. Conclusion: Typhoid fever is most commonly observed with unhygienic practices, eating of unhealthy outside food and contaminated water. Pattern of anti microbial resistance gives us a little choice to select antibiotic for typhoid fever. Typhoid fever still remains the commonest bacteraemic illness in Pakistan with children being especially susceptible. Antimicrobial non-susceptibility continues to complicate management.

Japanese Encephalitis (JE); The Fatal Public Health Issue In Uttar Pradesh, India : A Review

2015 ◽  
Vol 7 (1) ◽  
Author(s):  
Purnima Srivastava ◽  
Manindra Kumar Srivastava
Keyword(s):  
Public Health ◽  
Japanese Encephalitis ◽  
Health Problem ◽  
East Asian ◽  
Uttar Pradesh ◽  
Public Health Problem ◽  
Public Health Issue ◽  
Major Public Health Problem ◽  
Viral Origin ◽  
Important Disease

Japanese Encephalitis (JE) an important disease of viral origin has attracted the attention of public health specialists in South East Asian Regions especially in the BBIN (Bangladesh, Bhutan, India & Nepal) countries due to its endemicity, high CFR and residual problems among survivors. JE has been occurring in the endemic form since long back particularly in northern states of India. Eastern parts of U.P. particularly Gorakhpur division is the worst hit division of Uttar Pradesh (UP) in India. U.P. alone is reporting nearly half of the cases found in whole India. Innocent children are the most common victims. This paper attempts to review the problem & emphasizes the need of identifying auxiliary feasible factors rather than concentrating on unfeasible, as despite of best efforts of state the disease is still a major public health problem.

scholarly journals Neurocysticercosis

2013 ◽  
Vol 71 (9B) ◽  
pp. 710-713 ◽  
Author(s):  
Osvaldo M. Takayanagui
Keyword(s):  
Public Health ◽  
Endemic Area ◽  
Clinical Manifestations ◽  
Public Health Problem ◽  
Controlled Trials ◽  
Parasitic Diseases ◽  
Major Public Health Problem ◽  
Prevention Strategies ◽  
Resonance Imaging ◽  
Randomized Controlled

Cysticercosis is one of the most common parasitic diseases of the nervous system in humans, and constitutes a major public health problem for most of the developing world. The clinical manifestations of neurocysticercosis (NCC) largely depend on the the host immune response against the parasite. NCC diagnosis is based upon neuroimaging studies (computerized tomography, magnetic resonance imaging) and antibody/antigen detection in the serum and the cerebrospinal fluid. Anticysticercal therapy has been marked by an intense controversy. Randomized controlled trials evaluating the clinical benefit of treatment have yield conflicting data with some studies indicating a benefit and others failing to show a difference. Prevention strategies must rely on multiple approaches, tailoring each to the special features of the particular endemic area.

scholarly journals Evaluation of Pathogens Causing Urinary Tract Infection and Their Sensitivity Pattern

2022 ◽  
Vol 8 (1) ◽  
pp. 31-37
Author(s):  
Vijay Kumar ◽  
Swayambhu Shubham ◽  
Satyendra Narayan Singh
Keyword(s):  
Tract Infection ◽  
Antibiotic Sensitivity ◽  
Public Health Problem ◽  
Diffusion Method ◽  
Major Public Health Problem ◽  
Sensitivity Testing ◽  
Antimicrobial Susceptibility Pattern ◽  
Antimicrobial Sensitivity ◽  
Sensitivity Pattern ◽  
Improper Use

Background: UTI constitute a major public health problem in India accounting 2nd most common infection next to respiratory tract infection. They are responsible for increasing treatment cost and significant morbidity.Aim:-To determine the incidence of UTI, evaluation of pathogens responsible and their antimicrobial susceptibility pattern in the population.Methods:Urine samples were collected from 300 patients attending the OPD Patna medical college, Patna during the period of 18 months (January 2017 to June 2018) Antimicrobial sensitivity testing was done for the bacterial isolates present in the sample by Kirby- Bauer disc diffusion method. Only those samples were taken into consideration which develops count equal to or greater than 1*105CFU/ml as indicated by Kass.Results:Out of 300 samples collected 146 (48.66%)) yielded bacterial growth. Out of 146 culture isolates E.Coli was the most common pathogen followed by klebsiella, CoNS and staphylococcus. Antibiotic sensitivity was performed on all the isolates. It was observed that highest sensitivity was 49.31% to amikacin, gentamycin (45.89%), nitrofurantoin (38.35%) meropenem (27.39%).Conclusions:It was observed that high grade of resistance to ampicillin, cotrimoxazole, ciprofloxacin, cefuroxime, chloramphenicol, cefotaxime, cefazolin, amoxicillin + clavulanic acid and gentamycin is present as a result of misuse or improper use of antibiotic in the community. Hence urine culture is necessary for the diagnostic screening of UTI before the treatment.

scholarly journals Scrub septicemia progressing to polyneuropathy: a case report

2021 ◽  
Vol 8 (1) ◽  
pp. 64-67
Author(s):  
Dr. Pradeep Kumar Jena ◽  
◽  
Dr. Swasthi Kabi Satapathy ◽  
Dr. Alok Satya Prakash Nayak ◽  
Dr. Sarthak NaIik ◽  
...  
Keyword(s):  
Public Health ◽  
Case Report ◽  
Health Problem ◽  
Scrub Typhus ◽  
Wide Spectrum ◽  
Clinical Manifestations ◽  
Public Health Problem ◽  
Major Public Health Problem ◽  
Endemic Areas ◽  
Gi Bleed

Scrub typhus is a major public health problem in India with a wide spectrum of clinicalmanifestations and a low index of suspicion is low endemic areas which in turn can increasemorbidity and mortality. The clinical manifestations of scrub typhus can range from mild non-specificfebrile illness or constitutional symptoms such as fever, rash, myalgia, headache to various organdysfunction such as AKI, myocarditis, pneumonia, meningitis, encephalitis, GI bleed, hepatitis. Herewe report a case of a 9-year-old girl who presented with scrub septicemia and progressed to developcritical illness myopathy, which is very unusual.

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