scholarly journals Clinical Profile of Thyroid Disorders – A retrospective study at BPKIHS

2018 ◽  
Vol 2 (2) ◽  
pp. 19-25
Author(s):  
Anuskha Agrawal ◽  
Nidhi Rani ◽  
Robin Maskey

Background: The thyroid gland produces two key metabolic hormones which regulate metabolic rate, growth and development. They play vital roles in digestion, heart and muscle function, brain development and maintenance of bones. People suffering from thyroid disorders may have autoimmune disease, ranging from primary hypothyroidism, Hashimoto’s thyroiditis, to hyperthyroidism caused by Graves’ disease. Objectives: To study clinical profile of thyroid disorders in endocrinology clinic of BPKIHS, Nepal. Methods: This is a hospital based retrospective study of past five years (2012 – 2017) done in department of internal medicine at B.P. Koirala Institute of Health Sciences, in which thyroid disorder patient records from the endocrinology clinic will be compiled together will be analyzed after classifying them according to the guidelines of the American Thyroid Association (ATA). Results: Among 584 thyroid disorder cases that were sampled, higher prevalence of thyroid disorders was seen in females, and the Male: Female ratio was 1:4.13. Most common type of thyroid disorder was Hypothyroidism (29.6%) followed by Subclinical hypothyroidism (28.3%). Conclusions: Thyroid disorders are more common in females than males and hypothyroidism being commonest thyroid disorder in our setup. Subclinical hypothyroidism is second commonest followed by hyperthyroidism. In Subclinical hypothyroidism Anti TPO antibody is most commonly found to be positive.

2018 ◽  
Vol 5 (1) ◽  
pp. 68
Author(s):  
Rakesh B. Bilagi ◽  
Hafiz Deshmukh

Background: Tuberculosis is one of the most important cause of most of the respiratory diseases. It is estimated that about one-third of the world's population is infected with mycobacterium tuberculosis. It is important to know about the clinical profile of these patients. There are many studies which are done among OPD patients but fewer among indoor patients hence, the current study was planned.Methods: Retrospective study of the patients admitted in the inpatient department of the study area were taken as the sample size from May 2016 to April 2017, who were diagnosed as TB patients.Results: a retrospective study was conducted among admitted patients, which included data of one year. There was male predominance with male: female ratio of 2.89. major cause of admission was extrapulmonary causes. The HIV patients were more predisposed to extrapulmonary and diabetes than pulmonary tuberculosis.Conclusions: There is male predominance for admission cases. There is also increased cases of extrapulmonary TB admitted than pulmonary cases.


1970 ◽  
Vol 16 (1) ◽  
pp. 3-8
Author(s):  
Delwar Hossain ◽  
Mosleh Uddin ◽  
Ahmmad Taous ◽  
Kazi Shameemus Salam ◽  
Rafiqul Islam

Canal wall window (CWW) tympanomastoidectomy is a modified form of attico-antrostomywhich can be a substituted for canal wall down procedure. A retrospective study of 84 casesof CWW tympanomastoidectomy were collected from department of otolaryngology and Headnecksurgery, BSMMU and ENT Foundation Hospital, Dhaka from June 2005 to July 2009.In this study majority of the patients were 16 to 48 years 57(67.86%). Male female ratio was3:1. Most of the patients were found cholesteatoma 27 (32.14%), granulation tissue 25(29.76%),retraction pocket 22(26.19%),Postoperative hearing gain (mean three frequency pure tone air bone gap) assessed 3 monthsafter primary surgery, most of the patients 34(40.48%) had gain 20dB+, 26 patients (30.95%)had gain 10dB+,18 patients (2143%) had gain 30dB+.Materials used in tympano-ossiculoplasty were chonchal cartilage, sculptured incus, PORPand TORP. Most of the patients we used incus reposition 36(42.86%), cartilage ossiculoplasty28(33.33%), PORP 12(14.29%) and TORP 8 (9.52%).Post operative followup of the patient was done in 1 month, 3 month and 6 month intervals andcondition of external auditory canal assessed. Dry ear were found 70 patients (83.33%), moistear were found 8 patients (9.52%) and 6 patients (7.14%) were found purulent dischargingears and later canal wall down mastoidectomy done .Key words: Canal wall window; Tympanomastoidectomy.DOI: 10.3329/bjo.v16i1.5774Bangladesh J Otorhinolaryngol 2010; 16(1): 3-8


Author(s):  
Durgavathi Kothapalli ◽  
Kamesari Kolluru

Background: Menstrual irregularities are common with thyroid disorders. It has been reported that hyperthyroidism the most common manifestation is simple oligomenorrhea and hypothyroidism usually is associated with polymenorrhea. Present study has been designed to evaluate the menstrual and endometrial patterns in women with thyroid disorders in costal Andhra Pradesh.Methods: During the study period of two years and ten months we have enrolled 110 patients with clinical presentation of thyroid disorder with menstrual irregularities as per our study criteria. Based on report patients were divided in to three groups, hyperthyroid, hypothyroid and subclinical hypothyroidism. Based on abnormal menstrual pattern patients were divided in to menorrhagia, oligomenorrhea, polymenorrhea, and amenorrhea groups. Endometrial biopsy was taken from women in perimenopausal age group and histopathological examination was done to know the pattern of endometrium.Results: Subclinical hypothyroidism was present in 24 (21.81%) patients, hypothyroidism was present in 52 (47.27%) patients and hyperthyroidism was present in 34 (30.90%) patients. amenorrhea was present in 26 (23.63%) patients, oligomenorrhea was present in 12 (10.90%) patients, Intermenstrual bleeding was present in 2 (1.81%) patients, Menorrhagia was present in 44 (40%) patients which was most common type of menstrual disorder and Polymenorrhagia was present in 26 (23.63%) patients.Conclusions: Hypothyroidism is most common thyroid disorder followed by hyperthyroidism and subclinical hypothyroidism is least common. We have found that menstrual irregularities are more common in hypothyroid patients than hyperthyroid. Menorrhagia and Polymenorrhagia is more common than amenorrhoea and oligomenorrhea in hypothyroid patients. 


2021 ◽  
Vol 9 ◽  
Author(s):  
Min Da ◽  
Bo Qian ◽  
Xuming Mo ◽  
Cheng Xu ◽  
Haiyan Wu ◽  
...  

Background: Inflammatory myofibroblastic tumor (IMFT) is a rare neoplasm mainly affecting children and young adults. We conducted a retrospective study to evaluate the clinical features and treatment alternatives of childhood inflammatory myofibroblastic tumors.Methods: A total of 19 patients who were pathologically diagnosed with IMT between December 2008 and October 2018 were included. Collected data were demographic information, main complaints, tumor characteristics, treatment, pathological results, immunohistochemical analysis, and prognosis.Results: The male/female ratio was 13:6. The mean age at disease onset was 44.9 ± 33.9 months (range 4 to 111 months). The mean tumor size was 6.5 ± 4.0 cm (range 1.2 to 17.0 cm). The most common site was the abdomen (13/19). The most commonly used detection tool was CT. Eleven patients (57.9%) had aggressive tumor growth, including eight receiving extensive resection and three receiving palliative resection due to high local invasiveness and postoperative chemotherapy. Eight cases whose tumors were completely enveloped received complete resection. Immunohistochemistry was performed for 17 patients and ALK positivity was found in 11 patients. Despite three children lost to follow-up, sixteen patients were followed up for 6 to 132 months (average 63.9 months, median 66 months). Of which, twelve children survived with no evidence of IMT, and four cases (21%) showed local recurrences (two of them died). No distant metastasis was detected.Conclusions: IMT is rare in children with various locations, mostly appearing in the abdomen. Whether the tumor could be completely removed, the location and the invasiveness of surrounding tissues might be highly prognosis-related.


Author(s):  
Dada Mobolaji Usman ◽  
Okewole Adeniran Olubunmi ◽  
Raji Ayanjide Lukman

Aims: To obtain sociodemographic and clinical profile of patients receiving Electroconvulsive therapy in a Nigerian psychiatric hospital. Study Design: A retrospective study. Place and duration: The study was carried out at the Federal Neuropsychiatric Hospital Yaba, Lagos, Nigeria over a period of 3 months. Methodology: An extensive review of the hospital records of patients receiving the modified form of electroconvulsive therapy for the first time over a period of eight years was done.  The demographic information, clinical diagnosis and indication for electroconvulsive therapy were retrieved and analysis was done using SPSS 19. Results: There were a total of 222 cases, ranging from 45 in 2000 to 21 in 2007. Mean age was 31.7 ± 9.65. Male: female ratio was 1:2. Almost 60% of them were single and unemployed. Clinical diagnosis using ICD 10 ranged from schizophrenia (44.8%), severe depression (27.8%), bipolar disorder (15.5%) to puerperal psychosis (8.2%). Indications for electroconvulsive therapy included psychosis (41.6%), severe depressive episode (25.8%), catatonia (23.7%) and manic episode (7.4%). Conclusion: This study has shown that the use of ECT has declined in the facility over the study periods.  Also, females were twice as likely to receive electroconvulsive therapy compared to males and schizophrenia still remains the most common diagnosis among the patients.


2015 ◽  
Vol 22 (06) ◽  
pp. 798-803
Author(s):  
Mariam Arif

Introduction: There are three types of compression of neck which are of primeforensic importance – (1) Manual strangulation (2) Hanging (3) Ligature strangulation. Ligaturemark is found in the latter two types.1 Ligature mark is a pressure mark on the neck underneaththe ligature. Initially it appears as a pale groove which on drying becomes yellowish brownparchment like.2,5 Objective: The aim is to study the information provided by a ligature markin ligature asphyxial deaths. Methodology: Study Design: A retrospective study on ligatureasphyxial deaths. Setting: Forensic Medicine and Toxicology Departments of King EdwardMedical University, Lahore and Nishtar Medical College, Multan. Period: January, 2012 toDecember, 2013. Results: The incidence of violent ligature asphyxial deaths was 4.21% of thetotal medicolegal deaths autopsied. Age group 21 to 30 years accounted for the maximumcases (37.6%). Male: female ratio was 1.02. Nylon rope (44.7%) was the most common ligaturematerial used. Ligature mark was single in all cases and was situated above thyroid cartilage in82.92% cases of hanging. In ligature strangulation deaths, mark was one in number in 93.18%cases and was below thyroid cartilage in 97.72% cases. The manner of death in hangingwas mostly suicidal (90.24%) as compared to homicidal in all cases of ligature strangulation.Ligature mark was incompletely encircling the neck in 85.36% cases and obliquely present in100% cases of hanging. In all deaths due to ligature strangulation, it was completely encirclingand transversely present around the neck. Underlying soft tissues of neck were glisteningwhite in all hanging deaths while it showed extravasations of blood in all ligature strangulationcases. Conclusions: A meticulous examination of the ligature mark during autopsy, though notconclusive, can give valuable information that can be very helpful in diagnosing deaths due tohanging and ligature strangulation.


2021 ◽  
pp. 20-25
Author(s):  
Ajit Kumar Nayak ◽  
Manorama Swain ◽  
Sujata Misra ◽  
Manju Kumari Jain

Thyroid disorder is a very common endocrine problem encountered by pregnant women. Maternal thyroid dysfunction is associated with adverse outcome both in mother and fetus. The aim of the study: to find out the prevalence of various thyroid disorders in pregnant women attending antenatal clinic. Materials and methods. This prospective cross-sectional study was carried out in the Department of Obstetrics and Gynecology, F.M. Medical College & Hospital, Balasore, Odisha from June 2020 to May 2021. 220 women with uncomplicated singleton pregnancy were included. Serum Thyroid-stimulating hormone (TSH), free T4 (FT4) and free T3 (FT3) were estimated by using electro-chemiluminescence immunoassay technique. Results. Out of 220 pregnant women screened for thyroid dysfunction, 68 were found to have thyroid disorders. 27.3 % of pregnant women had subclinical hypothyroidism, 1.4 % had overt hypothyroidism, 1.8 % had subclinical hyperthyroidism and 0.5 % had overt hyperthyroidism. Prevalence of subclinical hypothyroidism was 6.36 % when the upper reference limit of TSH level taken as 4 mIU/L. Prevalence of thyroid disorder among pregnant women in the age groups 18–25 years, 26–30 years and 31–40 years were 28.9 %, 32.1 % and 38.9 % respectively. There were 35.5 %, 28 % and 26 % pregnant women with thyroid disorders in the first, second and third trimester respectively. Prevalence of both subclinical and overt hypothyroidism were more in multigravida compared to primigravida. Conclusion. Our study revealed high prevalence of thyroid disorders in pregnant women and maternal subclinical hypothyroidism was the most common pattern.


2021 ◽  
Vol 8 (2) ◽  
pp. 976-980
Author(s):  
Radhika R ◽  
◽  
Pushpa Latha M ◽  

Introduction: To describe socio - demographic and clinical profile of patients with vernal keratoconjunctivitis (VKC) and to assess the compliance of patients to the treatment of vernal keratoconjunctivitis. Materials and methods: Prospective study of 100 patients with VKC was done. Purposive sampling of 100 Patients with signs and symptoms of VKC were taken, who satisfy inclusion and exclusion criteria. Treatment was given depending on grade of disease. Results: Out of 100 patients 66 were Males and 33 were Females. Mean age at presentation was 9.4 years and 2 patients presented at the age of 28 and 30 year and 60% patients from rural area, 40% from urban. Family history of allergies was noted in 7% patient. History of chronic perennial disease was seen in 57% patients. Mixed form of VKC was seen in 66%, limbal form in 18% and palpebral form in 16%. 47% had mild and 10% had severe disease. Conclusion: VKC is a bilateral disease affects most commonly young males between ages of 6 to 10 years. Male: female ratio of 2:1. Association of family history of allergic disorders are less. For persistent severe disease needs frequent follow-up. KEY WORDS: Allergy, Compliance, Papillae, and Vernal Keratoconjunctivitis.


Author(s):  
Aditi Rai ◽  
Sapna Raina

Background: Abnormal uterine bleeding (AUB) is one of the most frequent presentation to gynecology OPD. AUB is a common but complicated clinical presentation and occurs in 15-20% of women between menarche to menopause and significantly affects the women’s health. Thyroid disorders are more common in women than in men and cause abnormal sexual development, menstrual irregularity, infertility and premature menopause. Objective of this study was to estimate the prevalence of thyroid disorders in women in reproductive age group with AUB.Methods: A hospital based prospective cross sectional observational study was carried out in department of obstetrics and gynecology, Mazumdar-Shaw Cancer and Medical Center and Narayana Hrudayalaya Hospital at Narayana Health City, Bangalore with abnormal uterine bleeding during the period of 2 years (December 2015 to November 2017), total 153 patients were included in the study. All women with AUB in reproductive age group were included. Diagnosed cases of ovarian cyst, uterine fibroid, polyp, adenomyosis, endometriosis and malignant (endometrial and cervical) tumors were excluded. Women who are on drugs or hormone therapy (for past 3 months. IUCD users/oral contraceptives pill user. Patients with known case of thyroid disorder, carcinoma thyroid patients with history of coagulation disorder, liver disorder, renal disorder, tuberculosis.Results: A total N=115 (75.2%) of patients who took part in this study had euthyroid status. The estimated prevalence of thyroid dysfunction was 24.9%. Out of which n=22 (14.4%) had subclinical hypothyroidism, n=14 (9.2%) had overt hypothyroidism, n=2 (1.3%) had hyperthyroidism. The most common thyroid dysfunction amongst the study group was noted to be subclinical hypothyroidism (14.4%).Conclusions: There is a high prevalence of thyroid disorders in cases which are clinically diagnosed as AUB. TSH is most sensitive test in detecting thyroid dysfunction. Subclinical cases need to be treated. Hence thyroid function evaluation should be made mandatory in cases of AUB to detect thyroid dysfunction.


2021 ◽  
Vol 11 (3) ◽  
pp. 494-504
Author(s):  
Saif Aboud M. Alqahtani

The thyroid gland plays a significant role in the metabolism and proliferation of blood cells; hematological disorders are frequently observed in patients with thyroid disorders, and the most frequent problem is anemia. The main objective of this research work is to evaluate the prevalence and types of thyroid dysfunction and their association with anemia in different gender stratified by age in the Asir region of Saudi Arabia. Four years of data from July 2016 to July 2020 for 9992 study subjects were collected. Statistical analysis was performed based on thyroid disorder and anemia stratified by gender and age subgroup. The mean age of the study subject was 43.4 ± 15.8 years, and females constituted 61.7% of cases. Thyroid dysfunction was observed in 49.76% (4973), and subclinical hypothyroidism was the most prevalent type (3922/9992), followed by primary hypothyroidism (530/9992). Females have a significantly higher overall prevalence of thyroid dysfunction than males (p < 0.05). Anemia was detected in 1344 females and 465 males with a thyroid disorder, and also, the prevalence was significantly higher (p < 0.05), compared to the normal thyroid group. Thyroid disorders are a common problem in our population, more prevalent in females than males, with the peak age of above 30 years, and are associated with an increased prevalence of anemia.


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