scholarly journals The Presentation Pattern of Celiac Disease in Central India –A Prospective Study in Children

2020 ◽  
Vol 40 (3) ◽  
pp. 255-260
Author(s):  
Shashi Sharma ◽  
. Richa ◽  
Sakshee Madan ◽  
Tanu Singh ◽  
Bharat Bhushan Sharma
Keyword(s):  
Celiac Disease ◽  
Clinical Features ◽  
Villous Atrophy ◽  
Failure To Thrive ◽  
Central India ◽  
Abdominal Distension ◽  
Common Symptom ◽  
Laboratory Findings ◽  
Cross Sectional ◽  
Female Ratio

Introduction: Celiac disease is a common immune-mediated enteropathy characterised by villous atrophy. It has clinical phenotypes of classic, non-gastrointestinal and silent/subclinical or potential depending on the clinical phenotype. We intended to assess the clinical features and laboratory findings of patients with celiac disease and compare the classical celiac disease with non-gastrointestinal celiac disease. Methods: This is a two-year cross-sectional study conducted at our institute. Children from one year to 18 years diagnosed as celiac disease based on the revised ESPGHAN criteria were enrolled. They were categorised into classical celiac disease and non-gastrointestinal celiac disease (atypical) and their clinical features and laboratory findings were documented. Results: Forty patients had confirmed celiac disease. The mean age of the subjects was 6.84 ± 4.41 years, with male: female ratio of 1.85. The commonest presentations were failure to thrive (75%), anaemia (70%), associated rickets (67.5%) and 32% diarrhoea. Patients with classical features were identified at an earlier age than those with non-gastrointestinal celiac disease. Marsh grade 3a and above were more commonly seen in classical celiac disease. The most common symptom among the classical group was abdominal distension. Among the non-gastrointestinal group, the most common symptom was anaemia. Vitamin D deficiency was almost equally present in both groups. Conclusions: Non-gastrointestinal celiac disease is not uncommon among our population. Patients with clinical features of recurrent abdominal pain, vomiting, failure to thrive, or merely short stature and refractory anaemia should be worked up for celiac disease.

scholarly journals Different Clinical Features of Celiac Disease in Children, Adolescents, and Adults; a Cross-sectional Study

2021 ◽  
Vol 13 (2) ◽  
pp. 121-130
Author(s):  
Ramin Niknam ◽  
Alireza Salehi ◽  
Hossein Molavi Vardanjani ◽  
Mohammad Reza Fattahi ◽  
Seyed-Mohsen Dehghani ◽  
...  
Keyword(s):  
Celiac Disease ◽  
Clinical Features ◽  
Age Groups ◽  
Cross Sectional Study ◽  
The Other ◽  
Common Symptom ◽  
Cross Sectional ◽  
Future Studies ◽  
Adolescents And Adults ◽  
Psychiatric Problems

BACKGROUND Celiac disease is a common disorder but there are few studies comparing the clinical features of the disease in adults, adolescents and children. METHODS Demographic and clinical characteristics of all patients with celiac disease referred to the Celiac Clinic were evaluated and compared in different age groups. RESULTS Of 3416 participants, 473 patients were included. 302 (63.8%) were women and 171 (36.2%) were men. Overall, 325 (68.7%) and 411 (86.9%) patients had gastrointestinal (GI) and non-GI manifestations, respectively. The most common symptom in adults was psychiatric problems (66.5%), while abdominal discomfort was the most common symptom in adolescents (45.2%) and children (53.8%). According to age groups, GI manifestations were seen in 79 (66.4%), 119 (59.8%), and 127 (81.9%) children, adolescents, and adults, respectively. Adults had significantly more GI manifestations than the other groups (PR 1.167; 95% CI: 1.094- 1.244; p < 0.001). Non-GI manifestations were seen in 90 (75.6%), 174 (87.4%), and 147 (94.8%) children, adolescents, and adults, respectively. Adults had significantly more non-GI manifestations than the other groups (PR 1.112; 95% CI: 1.060-1.168; p < 0.001). CONCLUSION Our study showed that there were significant differences in the clinical features of celiac disease between the different age groups. Considering these results may help plan for future studies.

scholarly journals Prevalence, knowledge, attitude and practice regarding self-medication among medical, dental and paramedical students in a tertiary care hospital

2018 ◽  
Vol 7 (9) ◽  
pp. 1822
Author(s):  
Madhulika Johnson ◽  
Dinesh Kumar Badyal
Keyword(s):  
Medical Students ◽  
Information Source ◽  
Tertiary Care ◽  
Common Symptom ◽  
Care Hospital ◽  
Self Medication ◽  
Cross Sectional ◽  
Female Ratio ◽  
Group A ◽  
Group B

Background: Self-medication is practiced universally. Having medical knowledge plays a vital role in its prevalence. It is more prevalent in higher education course students especially medical students. However, it is increasing in dental and paramedical students. Hence, this study was conducted to evaluate self-medication among medical, dental and para-medical students in a tertiary care hospital.Methods: A cross sectional questionnaire based study was conducted among 449 undergraduate students. They were divided into three groups. A questionnaire was developed based on literature. The questionnaire was validated and finalised. The paper questionnaire was administered to students. The data collected from questionnaires was analysed. The results were expressed as percentages and frequencies.Results: The male female ratio of students who filled questionnaire was 65:35. All the students (100%) reported that they practice self-medication. The most common reason for self-medication was prior experience (36%) in group A as well as in group B (46%), but in group C, 39% mentioned no serious problem. Main information source was family members in all the groups (A 57%, B 53%, C 29%) followed by advice from senior/friends. Fever was most common symptom reported (29%) by group A followed headache (28%) in group C and cough and cold (23%) in group B. The commonest group of drugs used is cough syrups (25%) in group B, followed by analgesics (23%) in group C and antipyretics (21%) in group A.Conclusions: Self-medication is growing among dental and paramedical students too. It is necessary to educate them about self-medication to prevent future disastrous consequences as well as to make them aware of appropriate use of self-medication.

scholarly journals Rotavirus gastroenteritis as a precipitating factor of celiac crisis in infancy - case reports and review of literature

2020 ◽  
pp. 101-101
Author(s):  
Zoran Lekovic ◽  
Vladimir Radlovic ◽  
Nevena Jovicic ◽  
Goran Djuricic ◽  
Marija Mladenovic ◽  
...  
Keyword(s):  
Celiac Disease ◽  
Villous Atrophy ◽  
Case Reports ◽  
Failure To Thrive ◽  
Complete Recovery ◽  
Latex Agglutination ◽  
Watery Diarrhea ◽  
Rapid Improvement ◽  
Rotavirus Gastroenteritis ◽  
Celiac Crisis

Introduction. Celiac crisis is a rare and life-threatening complication of celiac disease. Although it occurs in all ages, the most common affects children within the first two years. Outline of cases. We report three infants (two female, one male, age range 9-12) with celiac crises as an initial presentation of celiac disease precipitated with rotavirus gastroenteritis. Celiac crisis was preceded by failure to thrive caused by anorexia, occasional vomiting and frequent abundant stools for 4-8 weeks, and 1-2 days before admission with fever, frequent vomiting and profuse watery diarrhea. They were admitted in a very severe general condition, severely dehydrated, markedly malnourished, with an enormously distended abdomen, edema of the lower legs and feet, and perianal erythema. After correction of dehydration and hypoalbuminemia, they were placed on a gluten- and disaccharide-free diet and within the first 2 weeks on additional parenteral nutrition. The applied therapeutic measures resulted in stabilization and further rapid improvement of the patient's condition. In all three patients the latex agglutination test for rotavirus was positive, IgA anti-TTG antibodies elevated (58.6 to 78 U/ml) and all three were homozygous carriers of the HLA DQ2 gene. Enterobiopsy was performed two weeks after admission and total villous atrophy (Marsh IIIc) was registered in all three patients. In the further course, on a strict gluten-free diet, the complete recovery of the patient followed. Conclusion. Our experience indicates that rotavirus gastroenteritis in timely unrecognized classical celiac disease in infants can lead to celiac crisis.

scholarly journals ACUTE BRONCHIOLITIS IN CHILDREN;

2013 ◽  
Vol 20 (05) ◽  
pp. 707-712
Author(s):  
SHAKIL AHMAD ◽  
SADIDA AAMIR ◽  
SHAHBAZ AHMAD
Keyword(s):  
Socioeconomic Status ◽  
Clinical Features ◽  
Cross Sectional Study ◽  
Oral Feeding ◽  
University Hospital ◽  
Acute Bronchiolitis ◽  
Cross Sectional ◽  
Female Ratio ◽  
Male Predominance ◽  
Clinical Variables

Objectives: To study the epidemiological and clinical features of acute bronchiolitis in children <2 years of age with mild tomoderate acute bronchiolitis. Study design: Descriptive, cross sectional study. Place and duration of study: Outpatient department ofDepartment of Pediatrics, independent university hospital, Faisalabad, Pakistan, from October 2010 to March 2011. Methodology: 200children diagnosed clinically with mild or moderate acute bronchiolitis were included in the study using convenient sampling technique.Epidemiologic variables of interest included age, gestational age at birth, sex, weight, breastfed or not, parental or caregiver tobaccosmoking and socioeconomic status. Clinical variables of interest included cough, fever, breathlessness, wheeze, Rhonchi, feeding andsleep pattern and severity of disease. Results: Predominant age group was between 2 to 12 months (76.5%) with mean age of 7.6±4.7.95.5% of children were full term at birth. Male predominance with male to female ratio of 1.4:1 was noted. Mean weight was 7.2±1.8 kg.Predominantly mixed feeding pattern (45%) was observed. Most of the parents/caregivers (70%) were nonsmokers. Majority of children(81.5%) belonged to families with poor socioeconomic status. Results of clinical variables revealed Cough (100%), breathlessness(69.5%), audible wheeze (59.5%) and rhonchi on chest auscultation (100%), disturbed sleep (80%) and decreased oral feeding (78%).Majority of children (79.5%) were afebrile. Mild acute bronchiolitis (73.5%) was predominant as compared to moderate acutebronchiolitis (26.5%). Conclusions: Acute bronchiolitis is more prevalent in children <1 year of age with male predominance and inchildren from families with poor socioeconomic status. Mild form of acute bronchiolitis is more common. A relative lack of fever alongwith cough, breathlessness, wheeze and/or rhonchi are major presenting clinical features of acute bronchiolitis.

scholarly journals Knowledge, attitude and practice regarding tuberculosis among the patients attending a tertiary care hospital in Maharashtra, India: a cross sectional study

2019 ◽  
Vol 6 (2) ◽  
pp. 371
Author(s):  
Nilesh S. Sonawane ◽  
Chaitanya R. Patil
Keyword(s):  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Cross Sectional Study ◽  
Common Symptom ◽  
Care Hospital ◽  
Sectional Study ◽  
Cross Sectional ◽  
Female Ratio ◽  
Attitude And Practice ◽  
Knowledge Attitude And Practice

Background: Tuberculosis is major public health problem especially in the low and middle income countries like India. We conducted a study to assess the knowledge, attitude and practice related to tuberculosis among the patients attending our tertiary care institute.Methods: A cross sectional study was conducted in a tertiary care hospital on the patients attending OPD of tertiary care hospital in Maharashtra. The patients with debilitating illness or bed bound patients and those diagnosed and cured of tuberculosis or were on treatment of tuberculosis were excluded from the study. A pretested and designed questionnaire was used to assess the knowledge, attitude and practice about the cause, clinical features and treatment of tuberculosis.Results: The mean age of the study subjects was 43.34±11.23 years with male: female ratio of 1.45. About 16.67% of the subjects stated that cause of TB is bacteria, 51.33% reported that cough was the most common symptom, 58.67% believed that it spreads from person to person and among the people who said it spreads 58.67% said that it can be preventable.Conclusions: About 1/5th of the study subjects expressed the cause of TB is bacteria or germs, and more than ½ believed that TB spreads from person to person. About 2/3rd of the patients felt that TB was a very serious disease; more than ½ of them expressed fear if they were diagnosed with TB but more than ½ of them also expressed rejection if they have a TB patient as a closed one.

scholarly journals A Study On Clinical and Laboratory Profile of Children with COVID-19 Attending A Tertiary Care Hospital in Bangladesh

2021 ◽  
Vol 36 (2) ◽  
pp. 95-100
Author(s):  
Kazi Iman ◽  
Sharmin Mahbuba ◽  
Farhana Rahat ◽  
Morsheda Khanam ◽  
Azmeri Sultana ◽  
...  
Keyword(s):  
Clinical Features ◽  
Normal Limit ◽  
Tertiary Care ◽  
Cross Sectional Study ◽  
Common Symptom ◽  
Care Hospital ◽  
Disease Category ◽  
Cross Sectional ◽  
Laboratory Profile ◽  
Wbc Count

Background: An outbreak of COVID-19 caused by 2019 novel coronavirus started first in Wuhan, Hubei province of China. Thereafter it spreaded to different countries of the world. Cases among children has been increasing day by day. Despite taking all measures of prevention virus spreading is uncontrolled. Objectives: To determine the clinical features and laboratory profile of children with COVID-19. Methods: This was a cross sectional study conducted in Dr. MR Khan Shishu Hospital and Institute of Child Health, Dhaka. Clinical and laboratory profile were analyzed among the children (aged 0-16 years) admitted between 1st May 2020 to November 2020 with positive RT-PCR for COVID-19. Data were analyzed by using SPSS. Results: Total 159 cases were included in the study. The most common symptom was fever (97.5%), then the second most common was cough (80.5%), other symptoms were diarrhea (28.3%), vomiting (17%), anorexia (30.8%) and weakness (30.2%). WBC count was within normal limit, leucocytosis was found in 5% cases and leucopenia in 3% cases. Few cases were reported with neutropenia and lymphopenia. Few cases were reported as thrombocytosis. ESR and CRP were high. Chest X-ray showed opacities in 62.9% cases. In most of the cases it was bilateral, few cases showed unilateral. In 37.1% cases it was normal. The disease category of all infected children remained same all through the hospital stay and no mortality was seen. Conclusion: Children with COVID-19 had distinct clinical features. Fever and cough were the most common symptoms. WBC count was found within normal limit but ESR and CRP were high. Chest radiograph showed opacities in majority cases. The outcome of COVID-19 in children was good. DS (Child) H J 2020; 36(2): 95-100

scholarly journals Epidemiological Features and Clinical Study of Kawasaki Disease in Iran

2021 ◽  
Author(s):  
Parvin Akbariasbagh ◽  
Saharnaz Talebiyan ◽  
Yahya Aghighi ◽  
Reza Raeeskarai ◽  
Amirhosein Seyedhoseinpour ◽  
...  
Keyword(s):  
Coronary Artery ◽  
Kawasaki Disease ◽  
Clinical Features ◽  
Systemic Vasculitis ◽  
Febrile Illness ◽  
Developed Countries ◽  
Response To Treatment ◽  
Unknown Etiology ◽  
Laboratory Findings ◽  
Female Ratio

Kawasaki disease (KD) is an acute febrile systemic vasculitis of unknown etiology and the major cause of pediatric acquired cardiac disease worldwide, particularly in developed countries. This study characterizes the epidemiologic and clinical features of KD in the Pediatric Rheumatology Department service in a general hospital. 120 patients with the diagnosis of KD between 1990 and 2009 were enrolled. We investigated the epidemiologic and clinical features of coronary artery involvement of the patients. Frequency of many parameters including age, sex, season, clinical and laboratory findings, response to treatment, and complications of the patients determined. During the 20-year study period, 120 patients <15 years of age were admitted for KD. Among them, 39.2% were at the extremes of the age spectrum, with 2.5% <6 months and 36.7% >5 years of age, male to female ratio of 1.3:1 and the classic KD to incomplete KD ratio of 3.1:1. KD recurred in 5% of all cases. It occurred most frequently in the winter and least frequently in the summer. The occurrence of coronary artery abnormalities (CAA) was 4.2%. Kawasaki disease should be considered in any pediatric patients with a prolonged refractory febrile illness in order to prevent CAA formation.

scholarly journals Clinico-demographic profile of deceased patients with coronavirus disease in a tertiary care centre of central India

2021 ◽  
Vol 8 (5) ◽  
pp. 2474
Author(s):  
Rupali A. Patle ◽  
Ashok R. Jadhao ◽  
Priya B. Dhengre ◽  
Manjusha A. Dhoble
Keyword(s):  
Clinical Characteristics ◽  
Tertiary Care ◽  
Case Fatality ◽  
Central India ◽  
Cross Sectional Study ◽  
Common Symptom ◽  
Care Hospital ◽  
Tertiary Care Centre ◽  
Cross Sectional ◽  
The Difference

Background: The covid pandemic started from Hubei, Wuhan in December 2020 then covered many other countries including India. Understanding the demographic and clinical characteristics of deceased COVID-19 patients could inform public health interventions focusing on preventing mortality due to COVID-19. The present study was done with the objective of studying the socio-demographic and clinical profile of deceased patients with coronavirus disease.Methods: This is a hospital based cross-sectional study on 1190 deceased patients of coronavirus disease in a tertiary care hospital of central India which is a dedicated covid hospital from 11 March 2020 to 28 February 2021. Socio-demographic and clinical characteristics of deceased patients were recorded.Results: Overall case fatality rate was 13.24%. Maximum number of deaths occurred in the month of August 2020 and September 2020 were 372 (31.26%) and 477 (40.08%). It was higher in the males 791 (66.47%) as compared to females 399 (33.53%), but the difference was not significant. The most common symptom was fever on hospitalization 924 (77.65%), followed by generalized weakness 771 (64.79%). 352 (29.58%) patients died within 24 hours of the admission to hospital. Hypertension and type 2 diabetes mellitus were the most prevalent morbidity in 557 (46.80%) and 357 (30.00%). It was found that 232 (19.50%) deceased patients had oxygen saturation less than 50% on admission.Conclusions: Higher age and presence of co-morbidities at the time of admission were significantly associated with mortality.

scholarly journals GGLUTEN-SENSITIVE ENTEROPATHY - NEW VIEW ON PROBLEM

2021 ◽  
Author(s):  
Tsitsi Parulava ◽  
David Pruidze ◽  
Maia Chkhaidze ◽  
Tamar Gotua ◽  
Irma Mandjavidze
Keyword(s):  
Celiac Disease ◽  
Tissue Transglutaminase ◽  
Age Groups ◽  
Failure To Thrive ◽  
Elimination Diet ◽  
Epidemiologic Studies ◽  
Intestinal Biopsy ◽  
Common Symptom ◽  
Small Intestinal Biopsy ◽  
Gluten Sensitive Enteropathy

Gluten sensitive enteropathy-celiac disease is an immune-mediated disorder caused by permanent sensitivity to gluten in genetically susceptible individuals. Epidemiologic studies of last years suggest that it is common and may occur in 0,5-1% of the general population. The bowel inflammatory and immunologic response results in atrophy and damage in the small bowel and secondary malabsorbtion. The mode of presentation can be quite variable. Celiac disease is generally defined as chronic diarrea and failure to thrive in infants and toddlers, diarrhea is still the most common symptom, but disease may occure in different age groups and with exstraintestinal, sometimes monosymptomic clinic. Clinical forms of celiac disease are: classic, atypical, silent, latent and potential. Definitive diagnose of Celiac disease requires serrologic screening, small intestinal biopsy and effectiveness of elimination diet. Anti-tissue transglutaminase antybody test (TTG IgA and TTG IgG) is highly sensitive, specific and less expensive, thus is recommended for general practice. None of serologic tests are 100% reliable. Definitive diagnosis requires characteristic histologic changes in intestine mucus. Tissue for investigation may be taken from duodenum during gastro endoscopy. Diagnosing only by results of gluten-free diet is not correct. The only treatment for celiac disease is lifelong exclusion of gluten. Early diagnosis and strict dietary restrictions appear to be the only possibility of prevention risk for failure to thrive, delay of sexual maturity, autoimmune disorders, adenocarcinoma of gastrointestinal tract and lymphoma.

scholarly journals Patterns of Conversion Disorder cases reported at neurological outpatient clinic.

2020 ◽  
Vol 27 (12) ◽  
pp. 2662-2668
Author(s):  
Muslim Ali Lakhiar ◽  
Abdul Hafeez Bughio ◽  
Muhammad Raza
Keyword(s):  
Sample Size ◽  
Formal Education ◽  
Sampling Technique ◽  
Conversion Disorder ◽  
University Hospital ◽  
Common Symptom ◽  
Cross Sectional ◽  
Female Ratio ◽  
Presenting Symptoms ◽  
Conversion Disorders

Objectives: This study was carried out to see the commonest presenting symptoms of conversion disorder attending Neurology Department Liaquat University of Medical & Health Sciences Jamshoro/Hyderabad. Study Design: Cross-sectional study. Setting: Department of Neurology Outpatient at Liaquat University Hospital, Hyderabad, Pakistan. Period: September 2017 to August 2019. Material & Methods: Sample size of 111 was estimated using Open epi online sample size calculator by taking statistics of conversion disorder as 63%, margin of error as 9% and 95% confidence level. All patients of age more than 9 years of either gender diagnosed as conversion disorder were included in the study using non-probability consecutive sampling technique. Results: A total of 111 patients were registered. 33 (29.7%) were male and 78 (70.3%) were females with male to female ratio of 0.4. The age ranged from 10 years to 30 years and the mean age was 23.30 ± 9.94. Out of 111 patients 47 (42.3%) were married and 64 (57.7%) were unmarried. On the other hand majority of patients having conversion disorders 51 (45.9%) had no formal education or educated up to primary 28 (25.2%). Most common symptom was episodic loss of consciousness 24 (21.6%) followed by seizure like activity 23 (20.7%), aphonia 9 (8.1%) & headache 7 (6.3%). Conclusion: The results from our study showed conversion disorders with unexplained symptoms are relatively common in outpatient neurology clinics.

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