Different Clinical Features of Celiac Disease in Children, Adolescents, and Adults; a Cross-sectional Study

BACKGROUND Celiac disease is a common disorder but there are few studies comparing the clinical features of the disease in adults, adolescents and children. METHODS Demographic and clinical characteristics of all patients with celiac disease referred to the Celiac Clinic were evaluated and compared in different age groups. RESULTS Of 3416 participants, 473 patients were included. 302 (63.8%) were women and 171 (36.2%) were men. Overall, 325 (68.7%) and 411 (86.9%) patients had gastrointestinal (GI) and non-GI manifestations, respectively. The most common symptom in adults was psychiatric problems (66.5%), while abdominal discomfort was the most common symptom in adolescents (45.2%) and children (53.8%). According to age groups, GI manifestations were seen in 79 (66.4%), 119 (59.8%), and 127 (81.9%) children, adolescents, and adults, respectively. Adults had significantly more GI manifestations than the other groups (PR 1.167; 95% CI: 1.094- 1.244; p < 0.001). Non-GI manifestations were seen in 90 (75.6%), 174 (87.4%), and 147 (94.8%) children, adolescents, and adults, respectively. Adults had significantly more non-GI manifestations than the other groups (PR 1.112; 95% CI: 1.060-1.168; p < 0.001). CONCLUSION Our study showed that there were significant differences in the clinical features of celiac disease between the different age groups. Considering these results may help plan for future studies.

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Cataract among elderly in Sri Lanka

10.1101/540518 ◽

2019 ◽

Author(s):

A.A. Nilanga Nishad ◽

S.A. Hewage ◽

K. Arulmoly ◽

M.S. Amaratunge ◽

J de Silva ◽

...

Keyword(s):

Sri Lanka ◽

Screening Programme ◽

National Level ◽

Age Groups ◽

Cross Sectional Study ◽

Community Based ◽

Cross Sectional ◽

Future Studies ◽

Factors Associated ◽

Younger Age

AbstractOut of 39 billion people who are blind around the world, 20 billion (51.3%) is due to cataract, which is preventable. This study intended to assess the prevalence and factors associated with cataract among elderly in a divisional secretariat area in Sri Lanka. This community based cross sectional study assessed randomly selected470 adults over 60 years of age. Diagnosis of cataract was made by a slit lamp examination by medical officers, and classified according to Oxford Lens Opacity Classification system (LOCS III). Majority was between 60-69 age groups and 71% was females. The prevalence of cataract was estimated to be 80.6% including operated eye and 73.6% excluding the operated eye, with a female preponderance in lower age categories. Commonest type of cataract was the nuclear type (n=422; 44.9%), with a majority in grade 2 (218; 23.2%). The prevalence of cataract surgery in the diseased population was as low as 7%. Cataract leading to blindness is very prevalent among adults over 60 years of age in the studied area. Females tend to develop the disease at an early age than males. These findings warrant screening programme for elderly at community level, targeting females at a younger age than males. Future studies are recommended to assess the coverage and barriers for cataract surgeries at national level, which would be immensely useful in planning and improving health services.

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SPIROMETRY FINDINGS IN SUBJECTS PRESENTING WITH DYSPNEA IN BANNU DISTRICT, PAKISTAN

Gomal Journal of Medical Sciences ◽

10.46903/gjms/16.01.1890 ◽

2018 ◽

Vol 16 (1) ◽

pp. 20-23

Author(s):

Fazli Maula ◽

Nargis Noman ◽

Iftikhar Ahmad ◽

Abdul Razzaq ◽

Muhammad Adil ◽

...

Keyword(s):

Bronchial Asthma ◽

Age Groups ◽

Disease Patient ◽

Sampling Technique ◽

Acute Bronchitis ◽

Cross Sectional Study ◽

Interstitial Lung Diseases ◽

Common Symptom ◽

Lung Pathology ◽

Cross Sectional

Background: Dyspnea is a common symptom in patients presenting to emergency departments worldwide. The objective of the study was to determine the pattern of spirometry findings in subjects presenting with dyspnea in Bannu, KP, Pakistan. Materials & Methods: This descriptive cross-sectional study was conducted in Bannu Medical College, Bannu, KP, Pakistan from 1st December 2015 to 31st march 2018. Sample size was 4300 selected through convenient sampling technique. All patients with acute and chronic dyspnea were included. Any patient unable to perform spirometry, recently diagnosed smear positive pulmonary tuberculosis (PTB), recent myocardial infarction and any infectious disease patient were excluded. A self-administered proforma was used for data collection. The demographic variables were sex and age groups. The research variables were type of lung pathology, severity of obstructive lung pathology, severity of restrictive lung pathology, causes of obstructive lung pathology and causes of restrictive lung pathology. All variables being categorical were analyzed through count and percentages using spss version17. Results: Out of 4300 subjects, (55.72%) were males and (44.28%) were females. Two thousands four hundered and forty five (52.32%) had obstructive, (22.49%) restrictive, (12.9%) with mixed pattern and (4.3%) had normal spirometry. In obstructive patients bronchial asthma were (35.13%), COPD 741(30.3%) asthma-COPD overlap syndrome (ACOS) (9.48%), acute bronchitis (05.64%), bronchiectasis 173(7.07%) and unclear diagnosis (04.17%). In restrictive patients post pulmonary tuberculous fibrosis (PTB) were (33.77%), cardiovascular disorders (28.35%), interstitial lung diseases (17.79%), chest wall disorders (6.47%) and unclear diagnosis in 143(13.6%). Conclusion: Ninety five percent of individuals were having an abnormal spirometeric pattern. mostly old males were having bronchial asthma & COPD as obstructive and PTB & CVDs as restrictive lung disease.

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Can Meals Outside Homes Impact Sodium Intake?

Current Developments in Nutrition ◽

10.1093/cdn/nzaa091 ◽

2020 ◽

Vol 4 (6) ◽

Cited By ~ 1

Author(s):

Ana Maria Pita Ruiz ◽

Margareth Guimarães Lima ◽

Lhais de Paula Barbosa Medina ◽

Renata Luz Pinto ◽

Marilisa Berti de Azevedo Barros ◽

...

Keyword(s):

Salt Intake ◽

Sodium Intake ◽

Age Groups ◽

Population Based ◽

Cross Sectional Study ◽

Nutrition Survey ◽

Cross Sectional ◽

Salt Consumption ◽

Adolescents And Adults ◽

Study Participants

ABSTRACT Background The WHO currently recommends a daily sodium intake of 2 g and has established the goal of a 30% reduction in mean salt intake by 2025. Objective We sought to estimate sodium intake in study participants according to the locations of where they consumed meals and their demographic and socioeconomic characteristics and practices related to salt consumption. Methods A population-based, cross-sectional study was conducted with a sample of 2574 individuals aged ≥10 y who answered the 2015 Campinas-Brazil Nutrition Survey. Mean sodium intake was estimated using a 24-h recall log and associations with the independent variables were tested using generalized regression analysis stratified by age group. Results Sodium intake was higher in male participants as well as adolescents and adults who reported eating ≥1 meal outside the home (6.07% and 7.06% increase, respectively). Per meal, sodium was consumed more outside the home at breakfast, during an afternoon snack, and at dinner among adolescents. No significant differences were found in the analysis by type of meal among the adults and seniors. Conclusions Sodium intake exceeded the WHO recommendation in all age groups analyzed. Having ≥1 meal outside the home was associated with greater sodium intake among adolescents and adults. Measures to regulate the food industry and dietary/nutritional education strategies targeting consumers are important to reducing the sodium intake of the population.

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A Study On Clinical and Laboratory Profile of Children with COVID-19 Attending A Tertiary Care Hospital in Bangladesh

Dhaka Shishu (Children) Hospital Journal ◽

10.3329/dshj.v36i2.54386 ◽

2021 ◽

Vol 36 (2) ◽

pp. 95-100

Author(s):

Kazi Iman ◽

Sharmin Mahbuba ◽

Farhana Rahat ◽

Morsheda Khanam ◽

Azmeri Sultana ◽

...

Keyword(s):

Clinical Features ◽

Normal Limit ◽

Tertiary Care ◽

Cross Sectional Study ◽

Common Symptom ◽

Care Hospital ◽

Disease Category ◽

Cross Sectional ◽

Laboratory Profile ◽

Wbc Count

Background: An outbreak of COVID-19 caused by 2019 novel coronavirus started first in Wuhan, Hubei province of China. Thereafter it spreaded to different countries of the world. Cases among children has been increasing day by day. Despite taking all measures of prevention virus spreading is uncontrolled. Objectives: To determine the clinical features and laboratory profile of children with COVID-19. Methods: This was a cross sectional study conducted in Dr. MR Khan Shishu Hospital and Institute of Child Health, Dhaka. Clinical and laboratory profile were analyzed among the children (aged 0-16 years) admitted between 1st May 2020 to November 2020 with positive RT-PCR for COVID-19. Data were analyzed by using SPSS. Results: Total 159 cases were included in the study. The most common symptom was fever (97.5%), then the second most common was cough (80.5%), other symptoms were diarrhea (28.3%), vomiting (17%), anorexia (30.8%) and weakness (30.2%). WBC count was within normal limit, leucocytosis was found in 5% cases and leucopenia in 3% cases. Few cases were reported with neutropenia and lymphopenia. Few cases were reported as thrombocytosis. ESR and CRP were high. Chest X-ray showed opacities in 62.9% cases. In most of the cases it was bilateral, few cases showed unilateral. In 37.1% cases it was normal. The disease category of all infected children remained same all through the hospital stay and no mortality was seen. Conclusion: Children with COVID-19 had distinct clinical features. Fever and cough were the most common symptoms. WBC count was found within normal limit but ESR and CRP were high. Chest radiograph showed opacities in majority cases. The outcome of COVID-19 in children was good. DS (Child) H J 2020; 36(2): 95-100

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BMI and age associated variations in the gut microbiome: A pan India, cross sectional study

10.21203/rs.3.rs-370880/v1 ◽

2021 ◽

Author(s):

Kumaresan Nallasamy ◽

Sucheta Gokhale ◽

Anirban Bhaduri ◽

Ashok Kumar Dubey

Keyword(s):

Gut Microbiota ◽

Relative Abundance ◽

Gut Microbiome ◽

Age Groups ◽

Normal Subjects ◽

Cross Sectional Study ◽

Gut Bacteria ◽

The Other ◽

Cross Sectional ◽

Other Hand

Abstract In the current study, we aimed to investigate the association between gut microbiome composition and two physiological factors, BMI and age. We did not observe a significant relationship between occurrence of gut bacteria with BMI or age alone. On the other hand, we observed BMI and age together played an important role in impacting gut microbiota composition. Comparison of the microbiota of normal and obese subjects for the each of 20s and 50s group revealed 13 gut bacteria that show significantly different relative abundance in the two groups. We observed that certain organisms show opposite trends within the two age groups. Haemophilus parainfluenzae relative abundance was found to be increased in obese-20s group while reduced in obese-50s group. Relative abundance of organisms such as Mitsuokella jalaludini and Blautia obeum were reduced in obese-20s group while increased in obese-50s group as compared to the normal subjects of respective age group. On the other hand, a reduction in the average relative abundance of both M. jalaludini and B. obeum for obese group as compared to the normal in pan-India only BMI-based group comparison. While studying obesity-related gut microbiota changes, it is critical to consider multiple factors such as age and geography into the study design.

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Do laypersons perceive aesthetic differences between coated and uncoated orthodontic archwires?

Dental Press Journal of Orthodontics ◽

10.1590/2177-6709.24.1.062-067.oar ◽

2019 ◽

Vol 24 (1) ◽

pp. 62-67 ◽

Cited By ~ 2

Author(s):

Célia Regina Maio Pinzan-Vercelino ◽

Ricardo Gabriel Calvet Campelo ◽

Claudia Gonçalves Fahd ◽

Meire Coelho Ferreira ◽

Melissa Proença Nogueira Fialho ◽

...

Keyword(s):

Epoxy Resin ◽

Age Groups ◽

Cross Sectional Study ◽

The Other ◽

Niti Wire ◽

Cross Sectional ◽

Coated Metal ◽

Significant Difference ◽

The Aesthetic ◽

Orthodontic Archwires

ABSTRACT Introduction: Aesthetic brackets are routinely combined with metallic wires in fixed orthodontic therapy, mainly due to the disadvantages of the clinical use of aesthetic archwires. The current situation needs to be explored in the literature by considering laypersons’ perceptions. Objective: The objective of this cross-sectional study was to evaluate laypersons’ aesthetic perceptions of metal archwires with and without aesthetic coating. Three age ranges and both sexes were evaluated. Methods: A volunteer using fixed aesthetic orthodontic appliance was photographed wearing the following archwires: stainless steel, nickel-titanium (NiTi), NiTi coated with epoxy resin and NiTi coated with rhodium. Using a 100-mm visual analog scale, 90 laypersons evaluated the photographs. Sex and age ranges (18-30, 31-45, over 46 years of age) were evaluated. The comparisons between the archwires and between age ranges were made using ANOVA and Tukey’s test. Genders were compared using Mann-Whitney test. Results: The results showed that the evaluators considered the archwire coated with epoxy resin to be the most aesthetic (60.64 ± 13.04) and the NiTi wire to be the least aesthetic (30.82 ± 7.79) (p< 0.05). Only the range of 31-45 years of age considered the NiTi archwires less aesthetic, when compared with the other age groups. For the other archwires, no statistically significant difference were found between the age groups. No differences between the sexes were detected. Conclusions: The results indicated that the aesthetic coated archwires represent an improvement in the visual aspect of ceramic brackets. The epoxy-coated metal wire was considered the most aesthetic option.

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The Presentation Pattern of Celiac Disease in Central India –A Prospective Study in Children

Journal of Nepal Paediatric Society ◽

10.3126/jnps.v40i3.29509 ◽

2020 ◽

Vol 40 (3) ◽

pp. 255-260

Author(s):

Shashi Sharma ◽

. Richa ◽

Sakshee Madan ◽

Tanu Singh ◽

Bharat Bhushan Sharma

Keyword(s):

Celiac Disease ◽

Clinical Features ◽

Villous Atrophy ◽

Failure To Thrive ◽

Central India ◽

Abdominal Distension ◽

Common Symptom ◽

Laboratory Findings ◽

Cross Sectional ◽

Female Ratio

Introduction: Celiac disease is a common immune-mediated enteropathy characterised by villous atrophy. It has clinical phenotypes of classic, non-gastrointestinal and silent/subclinical or potential depending on the clinical phenotype. We intended to assess the clinical features and laboratory findings of patients with celiac disease and compare the classical celiac disease with non-gastrointestinal celiac disease. Methods: This is a two-year cross-sectional study conducted at our institute. Children from one year to 18 years diagnosed as celiac disease based on the revised ESPGHAN criteria were enrolled. They were categorised into classical celiac disease and non-gastrointestinal celiac disease (atypical) and their clinical features and laboratory findings were documented. Results: Forty patients had confirmed celiac disease. The mean age of the subjects was 6.84 ± 4.41 years, with male: female ratio of 1.85. The commonest presentations were failure to thrive (75%), anaemia (70%), associated rickets (67.5%) and 32% diarrhoea. Patients with classical features were identified at an earlier age than those with non-gastrointestinal celiac disease. Marsh grade 3a and above were more commonly seen in classical celiac disease. The most common symptom among the classical group was abdominal distension. Among the non-gastrointestinal group, the most common symptom was anaemia. Vitamin D deficiency was almost equally present in both groups. Conclusions: Non-gastrointestinal celiac disease is not uncommon among our population. Patients with clinical features of recurrent abdominal pain, vomiting, failure to thrive, or merely short stature and refractory anaemia should be worked up for celiac disease.

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Revisiting Spleen Function and Pneumococcal Risk in Children with Hemoglobin SC Disease

Blood ◽

10.1182/blood-2021-150629 ◽

2021 ◽

Vol 138 (Supplement 1) ◽

pp. 768-768

Author(s):

Charlotte Pourdieu ◽

Sara El Hoss ◽

Enora Le Roux ◽

Justine Pages ◽

Berengere Koehl ◽

...

Keyword(s):

Age Groups ◽

Pneumococcal Infection ◽

Cross Sectional Study ◽

Control Group ◽

Healthy Children ◽

Cross Sectional ◽

Splenic Function ◽

Routine Administration ◽

Adolescents And Adults ◽

Hemoglobin Sc Disease

Abstract Spleen dysfunction and susceptibility to pneumococcal infection is a well known feature in homozygous sickle cell disease (HbSS), whilst to date splenic function in hemoglobin SC disease (HbSC) has been poorly investigated. The aim of this study was to analyze spleen function in children with HbSC disease using a high-throughput validated method (1) and to examine if the current recommendations regarding pneumococcal risk are appropriate in this population. Spleen function was evaluated using a flow cytometry quantification of red blood cells (RBCs) with Howell-Jolly bodies (HJBs), in a cross-sectional study of patients at steady state during an outpatient visit in an expert center. Quantification of HJB-RBCs was performed in children with HbSC disease aged < 10 years and compared to children with HbSS disease or healthy children of the same age groups, or splenectomized children. Additional exploratory analysis was performed according to age (under or above the age of 5 years old) and treatment group (hydroxyurea). The median (Q1-Q3) HJB-RBCs count was 16 (11-28.25) /100.000 RBCs in 40 HbSC children (Figure 1). This result was not statistically different from the control group of 22 healthy children (p=0.96) nor in subgroups < or ≥ 5 years old, indicating that children with HbSC under 10 years have a preserved splenic function. Expectedly, the HJB-RBCs counts differed significantly from splenectomized children (419 (296-489)/100.000 RBCs, n=15, p<0.0001). By contrast, among the 53 HbSS children, the median HJB-RBCs count was 134 (29-216) /100.000 RBCs, differing significantly from HbSC children (p<0.0001). In HbSS children, HJB-RBCs counts increased significantly with age (r=0.30, p=0.03), showing important variability among subjects but did not reach the level found in splenectomized patients suggesting that complete loss of spleen function occurs presumably later in a majority of children in this population. Treatment with hydroxyurea did not significantly impact HJB-RBCs counts in a subgroup analysis in HbSS children. The result of this study suggests that spleen function in children under 10 years old with HbSC is not altered. The routine administration of prophylactic penicillin to young children with SC disease may therefore be questioned. Similarly, fever in children with HbSC under 3 years old may not require parenteral antibiotics as it is generally currently recommended by analogy to children with HbSS. Functional or anatomical asplenia in children with HbSC is delayed compared to those with HbSS at least after the first decade of life. Future large cohort studies using similar methodology will allow better evaluation of the pneumococcal risk in adolescents and adults with Hb SC disease. Bibliography (1) El Hoss S, Dussiot M, Renaud O, Brousse V, El Nemer W. A novel non-invasive method to measure splenic filtration function in humans. Haematologica. oct 2018;103(10):e436-9. Figure 1 Figure 1. Disclosures El Nemer: Hemanext: Consultancy.

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CLINICAL FEATURES AND COAGULATION ABNORMALITIES IN CHILDREN WITH SEPSIS AT DANANG HOSPITAL FOR WOMEN AND CHILDREN

Journal of Medicine and Pharmacy ◽

10.34071/jmp.2018.2.16 ◽

2018 ◽

pp. 97-103

Author(s):

Huu Hoi Vo ◽

Binh Bao Son Bui

Keyword(s):

Septic Shock ◽

Clinical Features ◽

Cross Sectional Study ◽

Severe Thrombocytopenia ◽

Cross Sectional ◽

Hematologic Tests ◽

Coagulation Abnormalities ◽

Women And Children ◽

Key Words Coagulation ◽

Coagulation Dysfunction

Objective: To determine the relationship between coagulation abnormalities and main clinical features, and hematologic tests. Methods: A descriptive cross-sectional study was conducted in 65 children with sepsis at the PICU, Da Nang Hospital for Women and Children from April 2012 to June 2013. Results: The frequency of internal hemorrhage in septic shock children was significantly higher than in children with sepsis (p < 0.001). The rate of thrombocytopenia was 30.8%, in which 10.8% of the children had severe thrombocytopenia (<50 x 109/l). Hypofibrinogenemia was observed in 30.8% of the patients, in which severe hypofibrinogenemia (≤ 1 g/l) was observed in 16.9% of the children. The frequency of reduced prothrombin ratio was 40%, in which 23.1% of the patients had prothrombin ratio < 50%. 35.4% of the patients had rAPTT > 1.15. Positive D-dimer and DIC were observed in 53.8% and 20% of the patients, respectively. Hemostatic changes showed the significant relationship with hemorrhage and the mortality of sepsis. Conclusion: Children with sepsis, especially septic shock were at high risk of coagulation dysfunction and coagulation abnormalities showed the correlation with hemorrhage and the mortality of sepsis. Key words: coagulation abnormalities, sepsis, children

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CONCENTRATION OF THE SERUM TGF-BETA1 IN HEALTHY ADULT PEOPLE

Journal of Medicine and Pharmacy ◽

10.34071/jmp.2014.4_5.12 ◽

2014 ◽

pp. 90-93

Author(s):

Van Tuan Nguyen ◽

Tam Vo ◽

Bui Bao Hoang

Keyword(s):

Transforming Growth Factor ◽

Healthy Adult ◽

Age Groups ◽

Elevated Serum ◽

Cross Sectional Study ◽

Healthy People ◽

Sectional Study ◽

Transforming Growth Factor Beta1 ◽

Cross Sectional ◽

And Gender

Elevated serum Transforming growth factor-beta1 (TGF-beta1) levels have been linked to tissue fibrosis including chronic kidney disease. Objectives: (1) Investigate serum TGF-beta1 levels in healthy adult people and (2) Examined the relation between serum TGF-beta1 level and gender, age, body mass index (BMI). Method: A cross-sectional study. TGF-beta1 were quantified by ELISA. Results: Levels of serum TGF-beta1 in healthy people were 13,45 ± 7,17 ng/mL mL (0,59 - 33,10 ng/mL). There are no difference of serum TGF-beta1 levels between men and women, between the age groups (<40 years, 40 to < 60 years and ≥ 60 years), between BMI groups < 23 and BMI group ≥ 23. Key words: TGF-beta1, healthy people

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