scholarly journals Clinicohistopathological Correlation in Leprosy

2012 ◽  
Vol 9 (4) ◽  
pp. 248-251 ◽  
Author(s):  
M C Mathur ◽  
R B K Ghimire ◽  
P Shrestha ◽  
S K Kedia
Keyword(s):  
Infectious Disease ◽  
Clinical Diagnosis ◽  
Histopathological Examination ◽  
Mycobacterium Leprae ◽  
P Value ◽  
Histopathological Diagnosis ◽  
Common Infectious Disease ◽  
Clinical Diagnoses ◽  
Leprosy Patients ◽  
Skin Biopsies

Background Leprosy is a chronic, infectious disease caused by Mycobacterium leprae. It is classified into five groups based on clinical, histological, microbiological and immunological criteria (Ridley & Jopling Classification). However, a great variation has been observed in the interpretation of histopathological examination ok skin biopsies and clinical presentation of the disease. Objective To correlate clinical diagnosis with histopathological diagnosis of leprosy patients in Nepal. Methods A retrospective hospital-based study was conducted among patients with all clinical types of leprosy, classified as per the Ridley-Jopling classification. Skin biopsies were taken from active lesions in all patients and were stained with Hematoxylin & Eosin stain and modified Fite-Ferraco stain for identification of Mycobacterium leprae. The histopathological findings were compared with clinical diagnoses. Results A total 156 patients were studied, out of which 84 (53.8%) males and 72 (46.1%) females between 8 and 86 years of age. The majority of patients 33 (23.57%) were in the age group of 21-30 years and least affected was children below 10 years 1(0.007%).Overall coincidence of clinical and histopathological diagnoses of classification was seen in 115 cases (80.4%). The maximum correlation (95.2%) was noted in LL patients (p value 0.000049) followed by BT(89.74%), TT (73.2%), BL(72.4%), BB(64.7%). Conclusion Leprosy still continues to be one of the common infectious disease in Nepal and skin biopsy is a useful tool in confirming the clinical diagnosis of leprosy as well as for the therapeutic guide. DOI: http://dx.doi.org/10.3126/kumj.v9i4.6338 Kathmandu Univ Med J 2011;9(4):248-51

Recent Advancement in the Diagnosis and Treatment of Leprosy

2018 ◽  
Vol 18 (18) ◽  
pp. 1550-1558
Author(s):  
Muhammad Aamir ◽  
Asma Sadaf ◽  
Sehroon Khan ◽  
Shagufta Perveen ◽  
Afsar Khan
Keyword(s):  
Vitamin D ◽  
Drug Treatment ◽  
Mycobacterium Leprae ◽  
Neglected Diseases ◽  
Specific Drug ◽  
Genetic Studies ◽  
Vitamin D Receptors ◽  
Micro Rnas ◽  
Leprosy Patients ◽  
Skin Biopsies

Background: Many of the tropical diseases are neglected by the researchers and medicinal companies due to lack of profit and other interests. The Drugs for Neglected Diseases initiative (DNDi) is established to overcome the problems associated with these neglected diseases. According to a report published by the WHO, leprosy (Hansen's disease) is also a neglected infectious disease. Methods: A negligible amount of advancements has been made in last few decades which includes the tools of diagnosis, causes, treatment, and genetic studies of the bacterium (Mycobacterium leprae) that causes leprosy. The diagnosis of leprosy at earlier stages is important for its effective treatment. Recent studies on vitamin D and its receptors make leprosy diagnosis easier at earlier stages. Skin biopsies and qPCR are the other tools to identify the disease at its initial stages. Results: Until now a specific drug for the treatment of leprosy is not available, therefore, Multi-Drug Therapy (MDT) is used, which is hazardous to health. Besides Mycobacterium leprae, recently a new bacterium Mycobacterium lepromatosis was also identified as a cause of leprosy. During the last few years the genetic studies of Mycobacterium leprae, the role of vitamin D and vitamin D receptors (VDR), and the skin biopsies made the treatment and diagnosis of leprosy easier at early stages. The studies of micro RNAs (miRNAs) made it easy to differentiate leprosy from other diseases especially from tuberculosis. Conclusion: Leprosy can be distinguished from sarcoidosis by quantitative study of reticulin fibers present in skin. The treatment used until now for leprosy is multi-drug treatment. The complete genome identification of Mycobacterium leprae makes the research easy to develop target specified drugs for leprosy. Rifampicin, identified as a potent drug, along with other drugs in uniform multi-drug treatment, has a significant effect when given to leprosy patients at initial stages. These are effective treatments but a specific drug for leprosy is still needed to be identified. The current review highlights the use of modern methods for the identification of leprosy at its earlier stages and the effective use of drugs alone as well as in combination.

scholarly journals Evaluation of agreement between clinical and histopathological diagnosis of subtype of leprosy by skin punch biopsy

2020 ◽  
Vol 13 (1) ◽  
pp. 4-8
Author(s):  
Suman Poudel ◽  
Sunita Ranabhat ◽  
Gita Pun
Keyword(s):  
Mycobacterium Leprae ◽  
Punch Biopsy ◽  
Lepromatous Leprosy ◽  
P Value ◽  
Histopathological Diagnosis ◽  
Cross Sectional ◽  
Moderate Agreement ◽  
Skin Punch Biopsy ◽  
Tuberculoid Leprosy ◽  
Granulomatous Diseases

Introduction: Leprosy is chronic granulomatous disease caused by Mycobacterium leprae. Clinically diagnosed cases of leprosy can be evaluated by punch biopsy. It can be classified according to Ridley and Jopling Classification. Objective: To study the different spectrum of leprosy and its Bacillary Index (BI), evaluate the agreement between clinical and histopathological diagnosis. Materials and Methods: This is a hospital based cross sectional retrospective study done for the period of 6 months from January to June 2019. The data were subjected to kappa analysis by using SPSS version 24 to see the agreement between clinical and histopathological diagnosis. Results: Out of 62 cases of clinically diagnosed cases of leprosy three (4.83%) cases turned out to be other granulomatous diseases. According to Ridley and Jopling classification, clinical and histopathological agreement was seen in 38 (61.29%) cases. Agreement of 100% was seen in Indeterminate leprosy (IL) and Borderline tuberculoid leprosy (BT). The BI was more in Lepromatous leprosy (LL), Borderline lepromatous (BL) whereas IL, BT and Tuberculoid leprosy (TT) showed less BI. Overall there was moderate agreement between clinical and histopathological diagnosis (kappa- 0.505) which was statistically significant (p value <0.05). Conclusion: There was moderate agreement between the clinical and histopathological diagnosis of subtype of leprosy. The Bacillary load was high in LL whereas least in TT and is determined by immune system.

scholarly journals A retrospective clinico-pathological study of hysterectomy cases in a tertiary care hospital in India – a review of 950 cases.

2018 ◽  
Vol 17 (1) ◽  
pp. 88-92
Author(s):  
Pal Subrata ◽  
Chakrabarti Srabani ◽  
Sinha Anuradha ◽  
Phukan Jyoti Prakash ◽  
Bose Kingshuk ◽  
...  
Keyword(s):  
Clinical Diagnosis ◽  
Histopathological Examination ◽  
Tertiary Care ◽  
Medical Science ◽  
Abdominal Hysterectomy ◽  
Uterine Bleeding ◽  
Histopathological Diagnosis ◽  
Care Hospital ◽  
Dysfunctional Uterine Bleeding ◽  
Common Indication

Introduction: Hysterectomy is the most commonly performed gynaecological surgery in India as well as in abroad. It is frequently done in myometrial and endometrial pathologies and rarely for other causes. Hysterectomy is definitive management for diseases like fibroid, adenomyosis, dysfunctional bleeding, prolapsed uterus and malignant lesions of uterus and adenexa. We aimed our study to observe incidence of different pathologies of uterus and other reproductive organs in hysterectomy specimens and retrospective correlation between clinical diagnosis and histopathological finding of hysterectomy cases.Materials and Methods: Retrospective data were collected from our routine histopathological laboratory. Detailed history, clinical examination and operative findings and provisional diagnosis of all 950 hysterectomy cases were recorded during study period of 2 years. Histopathological diagnosis was correlated with clinical and preoperative diagnosis.Observations: Abdominal hysterectomy (734 cases, 77.26%) was the most common route of approach during surgery. Common pre-operative diagnoses were fibroid uterus (32%), dysfunctional uterine bleeding (28.95%), uterine prolapsed (22.74%). Other causes included uterine polyps (1.6%), complications of pregnancy (2.74%), ovarian tumours (8.42%), cervical carcinomas (2.97%) etc. Common pathologies on histology were leiomyoma (32%), adenomyosis (20.32%), atrophic endometrium (17.26%) and endometrial pathology (8.95%).Discussion: Our study has been correlated with other studies of India and other south Asian countries. Most common indication of hysterectomy in our study is dysfunctional uterine bleeding (32%) but Gupta et al and Jha R et al found utero-vaginal prolapse as most common indication. Leiomyoma was the most common histology diagnosed in the present series. Clinical diagnosis was possible in 67.57% cases in our study similar to Khan et al (70.51%).Conclusions: Histopathological examination of hysterectomy specimens helps to detect the exact causes and underlined pathology.Bangladesh Journal of Medical Science Vol.17(1) 2018 p.88-92

scholarly journals The accuracy value of the dentist’s clinical diagnosis in oral lesions performed on biopsy

2013 ◽  
Vol 25 (2) ◽  
Author(s):  
Galih Fata Anadza ◽  
Endang Syamsudin ◽  
Abel Tasman Yuza
Keyword(s):  
General Hospital ◽  
Clinical Diagnosis ◽  
Clinical Examination ◽  
Oral Surgery ◽  
Histopathological Examination ◽  
Maxillofacial Surgery ◽  
Oral And Maxillofacial Surgery ◽  
Histopathological Diagnosis ◽  
Oral Lesions ◽  
The Difference

Introduction: The diagnosis of a pathological disorder can be made in various stages, namely history taking, clinical examination and supporting examination. Clinical diagnosis is a diagnosis obtained from anamnesis and the results of clinical examination. Histopathological diagnosis is a diagnosis obtained from a microscopic examination of tissue. Clinical diagnosis and histopathological examination results may differ. The aim of the study was to obtain the accuracy value of the dentist’s clinical diagnosis by calculating the number of differences between the clinical diagnosis and the results of the histopathological examination of patients who were biopsied in the Department of Oral Surgery of General Hospital Dr. Hasan Sadikin Bandung. Methods: A retrospective descriptive study of cases of pathological abnormalities biopsied in the Department of Oral and Maxillofacial Surgery of General Hospital Dr Hasan Sadikin Bandung. The total number of study samples was 109 medical records of patients with biopsy. Results: The accuracy value of the clinical diagnosis of dentists was 76%, where the difference between the clinical diagnosis and the histopathological examination was 24%. The most common type of disorder with the greatest difference in diagnosis is ameloblastoma followed by papilloma and mucocele. Conclusion: The accuracy value of the clinical diagnosis of dentists in oral lesions performed biopsy is 76%.

scholarly journals Study of glottic lesions in patients undergoing microlaryngeal surgery

2020 ◽  
Vol 6 (2) ◽  
pp. 277
Author(s):  
Vikrant Mittal ◽  
Manish Munjal ◽  
Rohit Verma ◽  
Parth Chopra ◽  
Hemant Chopra
Keyword(s):  
Clinical Diagnosis ◽  
Histopathological Examination ◽  
Detailed Examination ◽  
Histopathological Diagnosis ◽  
Female Ratio ◽  
Histopathological Correlation ◽  
Male Female Ratio ◽  
Male Preponderance ◽  
Vocal Nodules ◽  
Microlaryngeal Surgery

<p class="abstract"><strong>Background:</strong> Vocal cords are the most common site of laryngeal pathologies. Hoarseness is the sentinel symptom for lesions affecting the glottis. The aim of this study was to categorize various types of lesions affecting the glottis in patients undergoing microlaryngeal surgery. Patients’ demographic profile, gender, occupational factors were studied. Clinical, microlaryngeal and histopathological correlation of the lesions was done.</p><p class="abstract"><strong>Methods:</strong> 50 patients with glottic pathologies undergoing microlaryngeal surgery were included. Patients underwent detailed examination including indirect laryngoscopy, flexible fibreoptic laryngoscopy, followed by microscopic laryngeal examination under general anaesthesia. The lesions were excised using standard microlaryngeal instruments and the specimens were subjected to histopathological examination. The data was analysed.  </p><p class="abstract"><strong>Results:</strong> There was male preponderance (male: female ratio of 1.27:1). Housewives formed the largest group (28%). Commonest pathologies were vocal nodules (34%), vocal polyps (22%) and carcinoma (22%). Microlaryngoscopy was found to be the best means of visualizing the lesions and reaching a clinical diagnosis. In 10 (20%) patients, the final histopathological diagnosis was different from clinical diagnosis.</p><p class="abstract"><strong>Conclusions:</strong> In this study, vocal nodules were the commonest lesions to affect the glottis. Microlaryngoscopy proved to be the best method for examination. Also, there was discrepancy in the clinical and histopathological diagnosis in 20% cases.</p>

scholarly journals HUBUNGAN TINGKAT KECEMASAN DENGAN MORBUS HANSEN DAN FAKTOR – FAKTOR YANG MEMPENGARUHINYA DI BAGIAN KULIT DAN KELAMIN BLU RSUP PROF. DR. R. D. KANDOU MANADO PERIODE NOVEMBER – DESEMBER 2012

e-CliniC ◽  
2013 ◽  
Vol 1 (2) ◽  
Author(s):  
Shinta Purnama Hardy ◽  
Anita E. Dundu ◽  
Theresia M.D. Kaunang
Keyword(s):  
Infectious Disease ◽  
General Hospital ◽  
Sex Education ◽  
Mycobacterium Leprae ◽  
Health Department ◽  
Chi Square ◽  
Cross Sectional ◽  
Leprosy Patients ◽  
Chi Square Test ◽  
Education And Employment

Abstract : Relationship between Anxiety Level and Morbus Hansen and the Influencing Factors in Dermatologic Division Prof. Dr. R. D. Kandou General Hospital Manado period of November – December 2012. Introduction : anxiety is defined as a emotional tension that often accompained by physical, sweating, increase of pulse rate. Morbus Hansen (hanseniasis), or well known as leprosy, is a chronic infectious disease caused by Mycobacterium Leprae. In Indonesia leprosy are endemic disease, the number of leprosy patients estimated to be greater than that recorded in the health department, because of the high leprofobi and stigma againstleprosy. Method : this study is analytical, with a cross sectional approach. Result : based of the chi square test the results are no significant association (p>0,05) between anxiety and age, sex, education, and employment. Conclusion : There is no significant association between anxiety and Morbus Hansen.Keyword: Anxiety, HRS-A, Leprosy.  Abstrak : Hubungan tingkat kecemasan dengan morbus hansen dan faktor – faktor yang mempengaruhinya di Bagian Kulit dan Kelamin BLU RSUP Prof. DR. R. D. Kandou Manado periode November – Desember 2012. Pendahulan : kecemasan didefinisikansebagai suatu keadaan ketegangan emosional yang sering disertai dengan gejala fisik, seperti ketegangan, tremor, palpitasi, berkeringat dan peningkatan denyut nadi. Penyakit Morbus Hansen (hanseniasis), atau yang lebih dikenal dengan penyakit lepra atau kusta, merupakan penyakit infeksi kronis yang disebabkan oleh Mycobacterium Leprae. Di Indonesia penyakit kusta bersifat endemis, jumlah penyakit kusta diperkirakan lebih besar daripada yang tercatat di Departemen Kesehatan, karena adanya leprofobi dan stigma yang tinggi terhadap kusta. Metode : penelitian ini  bersifat analitik, dengan pendekatan cross sectional. Hasil : berdasarkan hasil uji chi square di dapatkan tidak ada hubungan yang bermakna (p>0,05) antara kecemasan dengan umur, jenis kelamin, pendidikan  dan pekerjaan. Kesimpulan : Tidak ada hubungan yang bermakna antara kecemasan dengan Morbus Hansen. Kata kunci: HRS-A, Kecemasan, Kusta.

scholarly journals Different Faces of Sinonasal Mass Lesions

2021 ◽  
Vol 28 (3) ◽  
pp. 193-197
Author(s):  
Devika T ◽  
Shubha P Bhat ◽  
Vadisha Srinivas Bhat ◽  
Rajeshwary Aroor ◽  
Satheesh Kumar Bhandary B ◽  
...  
Keyword(s):  
Nasal Cavity ◽  
Clinical Diagnosis ◽  
Clinical Features ◽  
Histopathological Examination ◽  
Nasal Discharge ◽  
Histopathological Diagnosis ◽  
Appropriate Treatment ◽  
Sinonasal Mass ◽  
Wide Range ◽  
Neoplastic Lesions

Introduction Mass in the nasal cavity presents with a wide range of symptoms, when a presumptive diagnosis is often made with the help of imaging and endoscopy. This study focussed on correlating clinical diagnosis with the histopathological diagnosis so that appropriate treatment can be offered to improve the quality of life of the patient. Materials and Methods The study included 120 cases who presented with symptoms and signs of mass in the nasal cavity, undergoing surgery or diagnostic biopsy. They were evaluated with a detailed history and clinical examination, diagnostic nasal endoscopy, and relevant radiological investigations. Histopathological examination of the biopsy of the excised specimen was performed by Haematoxylin and Eosin stain. Special stains and Immunohistochemistry (IHC) were performed whenever indicated. The clinical diagnosis was correlated with histopathological diagnosis. Results Nasal obstruction was the most frequent symptom followed by nasal discharge. Non-neoplastic lesions made up 85% of cases, while16% of cases were proved as neoplastic lesions. Among neoplastic lesions, 7% were benign, and 9% were malignant.  The inflammatory polyp was the most common non-neoplastic lesion. Fischer's exact test showed a correlation between clinical diagnosis and histopathological diagnosis. Non-neoplastic lesions were common in the 4th decade of life; benign lesions were common in the 3rd decade of life, while malignant lesions were common in the 5th decade of life. Conclusion Sinonasal masses present with overlapping clinical features, and sometimes the definite diagnosis is possible only by histopathological examination of the specimen. However, in the presence of characteristic clinical features, accurate clinical diagnosis is possible in most cases, and appropriate treatment can be performed without delay, pending histopathological examination.

Premalignant and Malignant Changes in Symptomatic Endometrial Polyps in Women Aged 20-70 years

2018 ◽  
Vol 9 (4) ◽  
Author(s):  
Susan Abed Zaidan ◽  
Alaa Abdulqader Abdulrazaq ◽  
Eaman Marouf Muhammed
Keyword(s):  
Histopathological Examination ◽  
Abnormal Uterine Bleeding ◽  
Common Finding ◽  
P Value ◽  
Histopathological Diagnosis ◽  
Age Group ◽  
Endometrial Polyps ◽  
Malignant Changes ◽  
Post Menopausal ◽  
Malignant Polyps

Background: endometrial polyps are localized over growth of endometrium including glandular and stromal tissue with prominent angiogenesis regulated by growth factors. Polyps occur in different age group and could be asymptomatic and discovered incidentally or it cause abnormal premenopausal and postmenopausal bleeding. Most endometrial polyps are benign but premalignant and malignant changes also occur frequently. Objective: this study was carried out to identify the age-group in which endomaterial polyps are encountered in routine surgical pathology practice, to document the agegroup in which these polyps underwent malignant changes and to identify the histological subtype of endometrial polyps according to age group. Patients and methods: This prospective study conducted to demonstrate the premalignant and malignant changes in symptomatic endometrial polyps in relation to patients age group ranging from 20-70 years with abnormal uterine bleeding examined in gynecology and obstetric department in Al-Ramadi and Al-Yarmouk Teaching Hospital during the period from January 2017 to May 2018. The endometrial samples were obtained either by D and C, hysteroscopy or the polyps were demonstrated after surgical hysterectomy. All endometrial samples were fixed in 10% formalin solution and sent to the private histopathology laboratory in Baghdad for histopathological diagnosis. Results: The total number of examined women were 150. The most common recorded age was 20-70 years. 74.6% were premenopausal and 25.4% of patients were post-menopausal at the time of diagnosis. Most of patients presented with symptomatic polyps in this study were in age group 41-50 years (36.6%) in which most of the polyps were benign, while premalignant and malignant changes were more common in women between 51-60 years. The final pathological diagnoses showed benign endometrial polyps (49.3%), (48.6%) were pre-malignant polyps and (2 %) were malignant polyps. From benign lesions secretary endometrium was the most common finding in 43 cases (58.1%), while simple endometrial hyperplasia without atypia was the most common finding in the pre-malignant group 40 cases (54.7%). The distribution of histopathological changes in each age group were significant with a P value equal to 0.02. Conclusion: all endometrial polyps in pre- and post-menopausal women should be removed and submitted for histopathological examination as some of them even though there are benign but could carry areas of cellular atypia or malignant transformation.

A STUDY OF CONCORDANCE BETWEEN CLINICAL AND HISTOPATHOLOGICAL DIAGNOSIS IN CASES OF LEPROSY WITH RELEVANCE TO THERAPY

2021 ◽  
pp. 52-55
Author(s):  
Anuradha De (Pati) ◽  
Roopsa Chakraborty ◽  
Saswati Halder
Keyword(s):  
Clinical Diagnosis ◽  
Global Strategy ◽  
Histopathological Diagnosis ◽  
Borderline Cases ◽  
Proper Diagnosis ◽  
Skin Biopsies ◽  
Epidermal Atrophy ◽  
Treatment Prognosis ◽  
Prompt Diagnosis

AIMS AND OBJECTIVES:To achieve the goal of WHO new global strategy of 2016-20 to decrease the case load, early and proper diagnosis for treatment and avoiding disability. Examination of a biopsy specimen of skin or nerve biopsies for histopathology can be a valuable aid for reaching conrmatory diagnosis of leprosy and its subtypes, differential diagnosis, prognosis of the disease and assessment or regression of the disease in patient under treatment and also for research, especially in early and borderline cases. The aim of this study was to correlate histopathological diagnosis of skin biopsies with clinical diagnosis of leprosy. This study was conducted to seek out and highlight the efcacy of the test and therefore its importance in current diagnostic scenario. MATERIALS AND METHODS: The retrospective study was carried out on the skin biopsies from untreated cases of leprosy seen in the Department of Dermatology and reported in the histopathology section of the Department of Pathology, School of Tropical Medicine, Calcutta between August 2016 to June 2019. HE sections of skin biopsies of all the cases of leprosy were examined for Epidermal atrophy, epithelioid granulomas, number & distribution of lymphocytes, histiocytes & foam cells; Inltration of nerves, blood vessels and adnexa; Grenz zone. Sections stained with ZN were examined for lepra bacilli in all cases. Histopathological ndings were graded into (TT), (BT), (BB), (BL) and (LL) according to Ridley and Jopling scale. Clinical diagnosis of the leprosy cases (as provided by department of Dermatology) using Ridley & Jopling scale was correlated with the results of histopathologic examinaton of their respective biopsies. RESULTS: Out of total cases in the OPD over Aug 2016 to June 2019,115 were sent for biopsy with conclusive clinical diagnosis of Leprosy out of which 45 cases came with the positive diagnosis of leprosy out of which TT(12) , BT(12), BB(3), BL(2),LL(8), Histoid(8). In 2016-17 the accuracy of clinichistopathological correlation was 35.4% ,41.3%in 2018 ,36.36% till mid 2019 . The discrepancy with the HPE refuting clinical diagnosis was 48.38% in 2017 ,58.62% in 2018 ,63.63% in mid 2019}. Histoid leprosy and ENL were 10 out of 31 cases in 2018-19 while 2cases were histopathologically diagnosed as leprosy despite having Sarcoidosis / Gr. Annulare clinically. Although the clinico- CONCLUSION: histopathological agreement in this study leaves much to be desired for prompt diagnosis, the disparity in correlation does decrease the chances of false positives and helps in better nalising the diagnosis for better treatment, Prognosis, follow-up and monitoring of the diseases are also aided by correct histopathological diagnosis especially in case of early and borderline cases of leprosy

scholarly journals Hubungan Pengetahuan dan Dukungan Keluarga terhadap Perawatan Diri Penderita Kusta di RSUP Dr. Sitanala Kota Tangerang

2021 ◽  
Vol 13 (3) ◽  
pp. 113-120
Author(s):  
Ainun Wulandari ◽  
Maisya Rivita
Keyword(s):  
Drug Therapy ◽  
Family Support ◽  
Self Care ◽  
Mycobacterium Leprae ◽  
Cross Sectional Study ◽  
P Value ◽  
Cross Sectional ◽  
Permanent Disability ◽  
Exact Test ◽  
Leprosy Patients

Abstrak Latar belakang: Kusta atau lepra disebabkan oleh Mycobacterium leprae dan dikategorikan sebagai penyakit menular. Kusta termasuk salah satu masalah kesehatan di beberapa negara. Disabilitas permanen dan gangguan kualitas hidup merupakan ancaman kesehatan bagi penderitanya jika tidak ditangani. Selain pengobatan dengan Multi Drug Therapy (MDT), penderita kusta perlu memperhatikan perawatan diri secara kontinyu seumur hidupnya. Perawatan diri ini dapat mencegah disabilitas dan juga memburuknya disabiltas pada penderita kusta. Studi ini ditujukan untuk mengetahui hubungan pengetahuan dan dukungan keluarga terhadap perawatan diri penderita kusta di RSUP Dr. Sitanala Kota Tangerang. Metode: Penelitian cross sectional ini dilakukan pada Juli 2020 melalui wawancara menggunakan kuesioner. Penelitian ini dilakukan di Poli Kusta RSUP Dr. Sitanala Kota Tangerang dengan responden sebanyak 83 orang dan dianalisis menggunakan uji Fisher’s Exact. Hasil: Berdasarkan hasil penelitian diketahui bahwa pengetahuan tidak memiliki hubungan terhadap perawatan diri penderita kusta di RSUP Dr. Sitanala Kota Tangerang (p-value=0,069) dan terdapat hubungan antara dukungan keluarga terhadap perawatan diri penderita kusta rawat di RSUP Dr. Sitanala Kota Tangerang (p-value = 0,003). Kesimpulan: Hasil penelitian menunjukkan bahwa penderita kusta yang memiliki pengetahuan baik ataupun kurang baik melakukan perawatan diri yang sama. Dukungan keluarga memiliki peranan penting dalam memotivasi penderita kusta untuk melakukan perawatan diri yang baik. Kata kunci: Kusta, Pengetahuan, Dukungan Keluarga, Perawatan Diri.   Abstract Background: Leprosy or leprosy is caused by Mycobacterium leprae and is categorized as an infectious disease. Leprosy is one of the health problems in several countries. Permanent disability and disruption quality of life are a health threat to sufferers if not treated. In addition to treatment with Multi Drug Therapy (MDT), selfocare must be carried out by leprosy patients continuously throughout their lives. This self-care can prevent disability and also a worsening of disability in patients with leprosy. This study was conducted to determine the relationship between knowledge and family support for self-care of leprosy patients at RSUP Dr. Sitanala, Tangerang City. Methods: A cross sectional study was performed during July 2020 by interview using questionnaires. This research was conducted at the Leprosy Poly Dr. Sitanala Central Hospital Tangerang City with 83 respondents and were analyzed using the Fisher’s Exact test. Result: The result showed that knowledge had no relationship with self-care of leprosy patients at Dr. Sitanala Hospital, Tangerang City (p-value = 0.069), while there was a relationship between family support for self-care of leprosy patients at Dr. Sitanala Hospital, Tangerang City (p-value = 0.006). Conclusion: The results showed that leprosy patients who had good or poor knowledge did the same self-care. Family support has an important role in motivating good self-care of leprosy patients. Key Words: Leprosy, Knowledge, Family Support, Self-Care.

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