Profile of Skin Biopsies and Patterns of Granulomatous Skin Diseases in a Tertiary Care Center of Western Nepal

Background: Granulomatous skin diseases are one of the leading causes of morbidity in tropical countries like Nepal. These granulomatous skin lesions often pose diagnostic challenge to clinicians as well as to dermatopathologists. Histopathologic examination of a biopsy specimen represents one of the most informative and cost-effective procedure and may help to avoid other, costlier and invasive diagnostic workup. Materials and Methods: This cross-sectional observational study from October 2018 to October 2019, at department of dermatology, enrolled 142 cases of skin biopsies. Correlation between clinical impression and histopathological findings was evaluated. Results: Out of 13940 dermatology visits/ consultations, 142 (1.01%) skin biopsies were performed. Head, neck and face were the commonest sites of biopsies (29.6%). The most common biopsy technique was incisional type in 70 (50.4%). Histopathology showed granulomatous features in 49 (34.8%) cases, out of which tuberculoid type was the commonest, in 29 (58.0%). Positive clinicopathological correlation was seen in 117/142 (82.4%) for all biopsies and 41/49 (85%) for granulomaous skin lesions. Conclusion: Tuberculoid type was the most common cutaneous granuloma. High clinicopathological correlation in our study supports histopathology as an important tool for diagnosis of granulomatous as well overall skin disorders.

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Histopathological Study of Skin Lesions in a Tertiary Care Hospital: A Descriptive Cross-sectional Study

Journal of Nepal Medical Association ◽

10.31729/jnma.4799 ◽

2020 ◽

Vol 58 (224) ◽

Author(s):

Sanat Chalise ◽

Ramesh Dhakhwa ◽

Sailesh Bahadur Pradhan

Keyword(s):

Binary Data ◽

Skin Diseases ◽

Tertiary Care ◽

Skin Lesions ◽

Cross Sectional Study ◽

Point Estimate ◽

Care Hospital ◽

Sectional Study ◽

Cross Sectional ◽

Skin Biopsies

Introduction: Skin diseases are much common in developing countries. The spectrum varies accordingto geographic distribution, gender, age, and coexisting disorder. We conducted this study to find outthe prevalence of different skin lesions and to evaluate their frequency and site of distribution. Methods: A descriptive cross-sectional study was done in the pathology department of KathmanduMedical college from June 2019 to November 2019 after ethical clearance. The skin biopsies wereprocessed, sectioned and stained with Haematoxylin and eosin and evaluated. A conveniencesampling method was used. Data was collected and entry was done in Statistical Packages for SocialServices version 20.0, point estimate at 95% Confidence Interval was calculated along with frequencyand proportion for binary data. Results: Among 133 skin biopsies examined, noninfectious vesicobullous and vesicopustulardisease were found in 42 (46.6%) cases followed by microbial disease in 22 (24.5%) and noninfectiouserythematous papular and squamous disease in 21 (23.4%) cases. Spongiotic dermatitis was themost common vesicobullous disease seen in 26 (28.9%) cases. Leprosy was the commonest microbialdisease found in 7 (7.8%) cases. The commonest noninfectious erythematous papular and squamousdisease was erythema dyschromicum perstans seen in 7 (7.8%) cases. The commonest neoplasticlesion was keratinocytic tumor seen in 12 (32.5%) cases. The commonest tumor of the skin wasintradermal nevus seen in 6 (16.3%) cases. Conclusions: Spongiotic dermatitis is a predominating non-neoplastic and overall skin lesion whichwas similar to the other studies done. Histopathological examination is the gold standard for theproper diagnosis as histomorphological features distinguish various skin lesions.

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Prevalence of non-infectious dermatoses in patients attending a tertiary care center in Rajasthan

International Journal of Research in Dermatology ◽

10.18203/issn.2455-4529.intjresdermatol20190244 ◽

2019 ◽

Vol 5 (1) ◽

pp. 192

Author(s):

Bhagirath Singh ◽

Indira Subhadarshini Paul

Keyword(s):

Clinical Evidence ◽

Clinical Presentation ◽

Skin Diseases ◽

Genetic Disorders ◽

Care Center ◽

Tertiary Care ◽

Tertiary Care Centre ◽

Cross Sectional ◽

Pigmentary Disorders ◽

Protozoal Infection

Background: Pediatric dermatoses require a separate view from adult dermatoses as there are important differences in clinical presentation, treatment and prognosis. There is very little epidemiological study available on non-infectious childhood dermatoses in India. The aims of the study were to find the prevalence, clinical profile and various etiological factors associated with childhood non-infectious dermatoses and to determine the prevalence of most common non-infectious childhood dermatoses.Methods: This cross-sectional observational study conducted at tertiary care centre in Rajasthan, India. Children with age 13 years and below with clinical evidence of cutaneous disorders were studied. Parents who have not given consent for the study, acutely ill children, Children having infectious dermatoses (bacterial, fungal, viral, arthropods, parasitic and protozoal infection) were excluded from the study.Results: A total of 232 cases were studied which showed a female preponderance of 55.60%. Most of the skin diseases were seen in the 5 to 13 years (school children) age group. The most common dermatoses was eczematous (36.63%), among eczema atopic diathesis was the commonest (17;20%) followed by hypersensitivity dermatoses (21.12%), genetic disorders (13.36%), disorders of genetic disorders (7.4%), sweat gland disorders (8.18%), pigmentary disorders (4.31%), papulo squamous disorders (4.74%), Nevi (6.46%).Conclusions: Eczematous dermatoses were the most commonly noted in the study, followed by hypersensitivity dermatoses. Atopic diathesis was the commonest endogenous eczemas. Acne, insect bite reaction and miliaria were the other common dermatoses. There was no significant association of various dermatoses with systemic diseases in the study.

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Clinicopathological correlation in the diagnosis of granulomatous cutaneous disorders: a retrospective study

International Journal of Research in Dermatology ◽

10.18203/issn.2455-4529.intjresdermatol20212549 ◽

2021 ◽

Vol 7 (4) ◽

pp. 538

Author(s):

Manisha Nijhawan ◽

Divya Yadav ◽

Shivi Nijhawan ◽

Damini Shaktawat

Keyword(s):

Retrospective Study ◽

Care Center ◽

Tertiary Care ◽

Common Type ◽

Accurate Diagnosis ◽

Tertiary Care Center ◽

Clinicopathological Correlation ◽

Cutaneous Tuberculosis ◽

Skin Biopsies ◽

Granulomatous Disorder

Background: To ascertain the various cutaneous granulomatous disorders and clinicopathological concordance in skin biopsies.Methods: The study included the patients with skin biopsy showing granulomatous infiltrate in a tertiary care center. The cases were categorized according to level of concordance into consistent, corroborative and inconsistent based on the concurrence between clinical and histological diagnosis.Results: Of the total 155 granulomatous disorder, 75.48% showed clinicopathological concordance, 19.35% showed corroborative diagnosis while 5.16% were inconsistent. The maximum number of biopsies performed were in the group of young adult (19-49 years, 57.41%). The most common type of granuloma found was of tuberculoid type and disorders were Hansen’s disease, fungal infection and cutaneous tuberculosis.Conclusions: Our study showed that the coordination of dermatologist and pathologist plays a pivotal role in making accurate diagnosis of granulomatous cutaneous dermatoses.

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A Cross Sectional Study to Evaluate Cutaneous Manifestations in Diabetic Patients and their Correlation with Sugar Control at Tertiary Care Center in Western Maharashtra

VIMS Health Science Journal ◽

10.46858/vimshsj.8304 ◽

2021 ◽

Vol 8 (3) ◽

pp. 104-108

Author(s):

Dr. Ashutosh Chate ◽

Dr. Amrut Swami ◽

Ms. Sakshi Rane ◽

Dr. Ramesh Gosavi

Keyword(s):

Skin Diseases ◽

Care Center ◽

Tertiary Care ◽

Diabetic Patients ◽

Age Group ◽

Cross Sectional ◽

Cutaneous Manifestations ◽

Skin Manifestations ◽

Significant Difference ◽

Study Participants

Introduction: Diabetes is a leading chronic disease in world and number of cases are significantly increasing each year in India also. Out of many associated conditions, skin involvement in diabetes also needs to be evaluated. We conducted this study to study relation between the sugar control and skin manifestations in diabetic patients. Methodology: We studied total 100 diabetic patients visiting our dermatology OPD over a period of 1 year from January to December 2020. All skin diseases in diabetic patients were studied. We studied association of these diseases with sugar control in our study participants. Results: Mean age of our study participants was 63.48 ± 18.12 years, Majority of the males were from the age group of 61 and above, 34 (62.96%) while majority of the females were from the age group of 41-60 years 25 (54.35%). Majority of the patients had diabetes for 5-10 years (52%) followed by more than 10 years (36%) and less than 5 years in 24% cases. Out of 100 participants, 44% had controlled diabetes while rest 56% had uncontrolled diabetes with HbA1c > 6. We observed a significant difference in skin manifestations of controlled and uncontrolled sugars in diabetic patients. (p = 0.007). Conclusion: From this study, we conclude that the skin is involved in diabetes quite often. Early diagnosis and treatment of skin manifestations in diabetic patients is important to reduce unwanted morbidity and further complications in the diabetic patients.

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Granulomatous lesions of the skin

Journal of Pathology of Nepal ◽

10.3126/jpn.v1i2.5397 ◽

1970 ◽

Vol 1 (2) ◽

pp. 81-86 ◽

Cited By ~ 3

Author(s):

K Gautam ◽

RR Pai ◽

S Bhat

Keyword(s):

Skin Diseases ◽

Histopathological Examination ◽

Skin Lesions ◽

Diagnostic Challenge ◽

Modes Of Presentation ◽

Supportive Role ◽

Granulomatous Lesions ◽

Granulomatous Dermatitis ◽

Skin Biopsies

Background: Granulomatous skin lesions often present as a diagnostic challenge to dermatopathologists due to various modes of presentation and identical histological picture produced by several causes. The aim of the study was to study different granulomatous skin lesions and to determine the relative frequency, the level of clinicopathologic concordance and to compare our results with those of other workers. Materials and Methods: A retrospective analysis of skin biopsies received over a period of two years from January 2007 to December 2008; was performed, and cases of granulomatous dermatitis reported on histopathological examination were reviewed along with special stains. Results: Out of a total of 1590 skin biopsies 106 (6.67%) cases were found to have a granulomatous reaction. It was common in males (63.21%) with most occurring in the fourth to fifth decades. Majority of cases (79 cases, 74.5%) were categorized as infectious granulomatous lesions with predominance of leprosy (63 cases, 79.7%) followed by tuberculosis (6 cases, 7.6%). An overall clinicopathologic concordance was seen in 97% of cases of leprosy. Conclusion: In this study leprosy is the most common cause of granulomatous skin lesions. It can be concluded that histopathology plays an important role in classification of leprosy, and in diagnosis and management of a variety of granulomatous skin diseases. Special stains play a supportive role in infectious granulomas. Keywords: Granulomatous skin lesion; Leprosy; Skin biopsy DOI: http://dx.doi.org/10.3126/jpn.v1i2.5397 JPN 2011; 1(2): 81-86

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Prevalence of dermatoses in adult migrant workers attending dermatology OPD in a tertiary care centre in Puducherry

International Journal of Research in Dermatology ◽

10.18203/issn.2455-4529.intjresdermatol20211401 ◽

2021 ◽

Author(s):

Bhavana Sampadarao ◽

Govardhan J. Kumar ◽

Damayandhi Kaliaperumal ◽

Jude E. Dileep ◽

Sucharita Sekar ◽

...

Keyword(s):

Migrant Workers ◽

Skin Diseases ◽

Fungal Infections ◽

Tertiary Care ◽

Epidemiological Data ◽

Skin Lesions ◽

Cross Sectional Study ◽

Tertiary Care Centre ◽

Cross Sectional ◽

Medical College

Background: Migrant workers are exposed to dangerous and unhygienic work environments, which puts them at risk of developing skin diseases. This study aims to assess the prevalence of skin diseases and provide epidemiological data regarding various dermatoses among migrant workers in Puducherry.Methods: This is a hospital-based, cross-sectional study conducted in Aarupadai Veedu Medical College and Hospital from August 2019 to February 2021. 350 migrant workers were randomly selected and examined for the prevalence of infective and non-infective dermatoses. The observations were documented and data were analyzed using statistical package for the social sciences (SPSS) version 22.Results: A total of 350 migrant workers were included in the study. Of most migrants, 90.9% (n=318) were males, while the remaining 9.1% (n=32) were females. The prevalence of infective dermatoses was found to be 76% (n=266) and the prevalence of non-infective dermatoses was 43.10% (n=151) in this study. Fungal infections are the most common infective dermatoses affecting 51.5% of the workers, followed by bacterial skin lesions in 27.4%.Conclusions: This study reveals a high prevalence of infective and non-infective dermatoses among migrant workers, with fungal infections being the most commonly occurring infective skin disease. Eczema was the commonly occurring non-infective dermatoses, according to this study.

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Clinico-Pathological Profile of Cutaneous Lupus Erythematosus Patients: A Report from A Tertiary Care Center of Chattogram

Chattagram Maa-O-Shishu Hospital Medical College Journal ◽

10.3329/cmoshmcj.v20i2.56480 ◽

2021 ◽

Vol 20 (2) ◽

pp. 79-84

Author(s):

Mohammad Rafiqul Mowla ◽

Deva Pratim Barua ◽

Shakila Zaman ◽

Mohammad Ismail Hossain Chowdhury ◽

Papri Dutta ◽

...

Keyword(s):

Lupus Erythematosus ◽

Care Center ◽

Correct Diagnosis ◽

Tertiary Care ◽

Cutaneous Lupus Erythematosus ◽

Skin Lesions ◽

College Hospital ◽

Cross Sectional ◽

Common Manifestation ◽

Cutaneous Lupus

Background : Nearly all epidemiologic studies have involved patients with Systemic Lupus Erythematosus (SLE). Few authors have investigated the characteristics of patients with Cutaneous Lupus Erythematosus (CLE). We aim to describe the epidemiologic, clinical, and immunologic characteristics of a series of patients diagnosed with CLE. Materials and methods : This is a descriptive retrospective cross-sectional study carried out using the register records of total 218 patients attending the ‘Lupus Clinic’ in Chittagong Medical College Hospital during the period 2010 and 2020. The disease activity and damage of CLE were assessed according to the Cutaneous Lupus Erythematosus Disease Area and Severity Index (CLASI). Results : There were 187 females (86%) and 31 males (14%) with the female: male ratio being 6.1:1. The mean age was 28 ± 10.06 (mean ± SD) ranging between 11 and 65 years. The Chronic Cutaneous Lupus Erythematosus (CCLE) patients accounted 154 (71%) followed by Acute Cutaneous Lupus Erythematosus (ACLE) 46 (21%) and Subacute Cutaneous Lupus Erythematosus (SCLE) 18 (8%). On the basis of CLASI score, 91 (42%) patients were in mild form, 85 (39%) in moderate form and 42 (19%) in severe state. In LE specific skin lesions, common manifestation was photosensitivity 198 (91%) followed by discoid rash 154 (71%) and maculo-papular lupus rash 55 (25%). Oral ulcer was seen in 49 (22%) patients and malar rash in 46 (21%) patients. Other observed LE specific skin manifestations were papulo squamous rash 11 (5%), Toxic epidermal necrolysis like lesions 7 (3%) and lichenoid lesions 6 (3%). Among LE nonspecific skin lesions, common manifestation was nonscarring alopecia 123 (56%) followed by Raynaud’s phenomenon 17 (8%) livedo reticularis 17 (8%) Vasculitis 15 (7%) Periungual telangiectasia 7 (3%) erythema multiforme 6 (3%) and leg Ulcer 5 (2%). Antinuclear Antibody (ANA) 132 (61%) was the most common autoantibody followed by anti-ds DNA 91 (42%) anti-Sm antibody 2 (1%) anti-phospholipid antibodies 9 (4%) and anti-RNP 3 (1%). Hematological manifestations were seen in 161 (73.85%) where erythrocyte sedimentation rate was the most common hematological abnormality 161(73.85%) followed by lymphopenia 126 (57.80%) leucopenia 113 (51.80%) thrombocytopenia 107 (49.10%) anemia 92 (42%) monocytopenia 37 (16.97%). Conclusions: CCLE was the most common subtypes of CLE. Patients with different subtypes of CLE have distinct clinical and pathological characteristics. The onset or concurrence of SLE mandates the involvement of other disciplines depending on organ involvement. In the absence of consensus on a definition that makes it possible to differentiate cutaneous forms of LE from SLE, the dermatologist’s role in the correct diagnosis and classification of such patients is fundamental. Chatt Maa Shi Hosp Med Coll J; Vol.20 (2); July 2021; Page 79-84

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Study of paediatric skin lesions in a tertiary care hospital

Medpusle International Journal of Medicine ◽

10.26611/10211129 ◽

2021 ◽

Vol 11 (2) ◽

pp. 105-107

Author(s):

P Ravindra Kumar ◽

Keyword(s):

Skin Diseases ◽

Tertiary Care Hospital ◽

Economic Status ◽

Tertiary Care ◽

Paediatric Population ◽

Skin Lesions ◽

Care Hospital ◽

Care Provision ◽

Cross Sectional ◽

The World

Background: Children below 14 years of age are vulnerable to many skin diseases mainly due to malnutrition, poor hygiene, less medical care provision, low socio-economic status, etc. The incidence and the spectrum of paediatric dermatological diseases vary from one part of the world to another depending on various factors. This study was aimed to study skin problems in children below 14 years age. Material and Methods: This was a cross-sectional, observational study done with children of age below 14 years attended skin outpatient department (OPD) with skin problems. Results: During study period 310 patients were included in the study of which 178 (57.26%) were male and 132 (42.74%) were female. The ratio of male: female was 1.34:1 in our study. Infectious skin lesions were seen in 163 (52.5%) children, while non-infectious skin lesions were seen in 157 (50.6 %) children. Conclusion: Infections and infestations are commonly noted in our paediatric population. Application of preventable measures by community, early diagnosis and proper counseling by pediatrician or dermatologist is needed to prevent further morbidity of skin lesions.

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Histopathological pattern of cutaneous disorders in tertiary care center in Shahjahanpur district of India

International Journal of Research in Medical Sciences ◽

10.18203/2320-6012.ijrms20202890 ◽

2020 ◽

Vol 8 (7) ◽

pp. 2531

Author(s):

Amar Singh ◽

Astha Pant

Keyword(s):

Histopathological Examination ◽

Care Center ◽

Health Centre ◽

Tertiary Care ◽

Skin Lesions ◽

Cutaneous Tuberculosis ◽

Younger Age ◽

Common Group ◽

Skin Biopsies ◽

Patient Presentation

Background: Histopathological examination is most commonly needed and used investigation in dermatology. The main objective of this study is to share our experience with skin lesions from a tertiary health Centre by describing the histopathological patterns of 675 consecutive cases.Methods: The study was retrospective and was conducted in those patients who attended the OPD. A total of 675 cases were sent for histopathological examination. Further they were classified into various histological categories based on the site and pattern of involvement. Inclusion criteria involves all skin biopsies sent for histopathology examination, exclusion criteria was none.Results: Most common histopathological entity was infectious disease with 22.52% cases leading in this study. Out of which Hansen disease is on top with 16.29% which was followed by cutaneous tuberculosis with 3.70% (25) cases. Second most common group was of psoriasiform reactions with 9.77% cases. In this group most common disorder was psoriasis vulgaris with 5.92% (40) cases. Third and fourth most common group were spongiotic dermatitis and lichenoid dermatitis which presented with 9.18% and 9.03% cases with a minimal difference of 1 case.Conclusions: A huge diversity in skin lesions was noticed in our study ranging from nonspecific dermatitis to malignant melanoma conditions. There was a younger age predominance regarding the patient presentation. Hansen’s disease still remains a single entity in India for which skin biopsy are required.

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Study to assess the knowledge, attitude and practice of Kangaroo mother care among post-natal mothers in a tertiary care centre of Mangalore, Karnataka, India

International Journal of Contemporary Pediatrics ◽

10.18203/2349-3291.ijcp20191042 ◽

2019 ◽

Vol 6 (3) ◽

pp. 999

Author(s):

Paras Gulati ◽

Sinchana Bhat ◽

Roshan Maben ◽

Santhosh T. Soans

Keyword(s):

Low Cost ◽

Care Center ◽

Tertiary Care ◽

Cost Effective ◽

Kangaroo Mother Care ◽

Maternal Knowledge ◽

Tertiary Care Centre ◽

Cross Sectional ◽

Attitude And Practice ◽

Knowledge Attitude And Practice

Background: Kangaroo mother care (KMC) is a practical low-cost intervention which is very cost effective in developing countries for babies weighing less than 2500g. This study aimed to evaluate the knowledge, attitude and practice of post-natal mothers of LBW babies after giving a teaching session by trained personnel in a tertiary care center in Karnataka.Methods: A cross sectional descriptive study of 90 mothers whose neonates were weighing less than 2.5kg from May to October 2018.Mothers were interviewed at enrolment and were assessed about their knowledge and were oriented on its practice.Results: At recruitment (95.5%) mothers did not know about KMC.80% of mothers followed in first sitting and 86.6% of the mothers felt photo exhibition was better than verbal.96.6% of mothers thought KMC is beneficial and it was believed that other family members can even provide KMC.Conclusions: Maternal knowledge was low before now they are happily practicing KMC in hospital and thereafter at home.

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