scholarly journals Bacteriological Profile and Antimicrobial Resistance Pattern in Surgical Site Infection in a Tertiary Care Hospital, Central Nepal

2021 ◽  
Vol 20 (2) ◽  
pp. 110-115
Author(s):  
Beena Jha ◽  
Saroj Gautam ◽  
Jyotshna Sharma ◽  
Manisha Sharma
Keyword(s):  
Antimicrobial Resistance ◽  
Tertiary Care ◽  
Surgical Site Infections ◽  
Resistance Pattern ◽  
Care Hospital ◽  
Related Factors ◽  
Cross Sectional ◽  
Staph Aureus ◽  
Gram Staining ◽  
One Year

Introduction: Surgical site wound infections (SSI) are the third most commonly reported nosocomial infection and they account for approximately a quarter of all nosocomial infections. Apart from bacterial contamination of wound, various patient and environment related factors play a role in development and outcome of SSI. The present study is undertaken to study the frequency of SSI and the antimicrobial resistance pattern of the causative organisms isolated. Methods: This cross-sectional prospective study was carried out over a period of one year. A total of 245 pus samples from suspected cases of surgical site infections were processed for gram staining, culture, biochemical identification tests and antimicrobial susceptibility testing using standard microbiological protocol. Data was analysed using software word version SPSS 19. Results: The overall frequency of SSI was 13.87%. Most common isolates were staphylococcus aureus and Escherichia coli. All four staph aureus strains were resistant to penicillin and cefixime but were 100% sensitive to vancomycin and cloxacillin. Two out of four stains were methicillin resistant Staph. aureus (MRSA). Another concern in recent time is the isolation of acinetobacter from surgical wounds. Conclusions: Preoperative antibiotics, reduced hospital stay and proper control of co-morbidities decrease the incidence of post-operative infections. Marked resistance of isolates to commonly used antibiotics signifies the need for judicious and rational use of these drugs to prevent the emergence of antibiotic resistant strains.

scholarly journals Bacterial profile and their antimicrobial resistance pattern in an intensive care unit of a tertiary care hospital of Dhaka

1970 ◽  
Vol 4 (2) ◽  
pp. 66-69 ◽  
Author(s):  
Lovely Barai ◽  
Kaniz Fatema ◽  
J Ashraful Haq ◽  
Mohammad Omar Faruq ◽  
ASM Areef Ahsan ◽  
...  
Keyword(s):  
Intensive Care ◽  
Antimicrobial Resistance ◽  
Intensive Care Units ◽  
Tertiary Care ◽  
Generation Cephalosporin ◽  
Resistance Pattern ◽  
Care Hospital ◽  
Candida Sp ◽  
Treatment Regimens ◽  
One Year

Critically ill patients admitted in intensive care units (ICU) are always at a higher risk of developing infections with various antibiotic resistant organisms. The objective of this study was to know the antibiotic resistance pattern of the common isolates from blood, urine, respiratory secretions and pus/wound swab of patients admitted in ICU at BIRDEM (Bangladesh Institute of Research and Rehabilitation in Diabetes, Endocrine and Metabolic Disorder) hospital, during a one year period from March 2006 to February 2007. A total of 1660 samples were analyzed. Growth was obtained in 34% of the samples yielding 632 organisms. The major organism isolated were Pseudomonas sp. (29.1%), Acinetobacter sp. (27.5%), Candida sp. (12.8%), Escherichia coli (10.3%) and Klebsiella sp. (9.7%). Staphylococcus aureus, Enterobacter sp, Citrobacter sp, Enterococcus sp, Providencia sp and Serratia sp accounted for 10.6% of the isolates. All the isolates were highly resistant (>80%) to cephalosporins and fluoroquinolones. The frequency of third generation cephalosporin resistant E. coli, Klebsiella and imipenem resistant Pseudomonas and Acinetobacter were >50%. Acinetobacter was remarkably resistant to most antibiotics including imipenem (>70% resistant), but most of the members of the Enterobacteriacae group showed maximum sensitivity to imipenem (50%-94%). The findings of this study might help clinicians to formulate their first line empirical antibiotic treatment regimens for the patients admitted in ICUs. Key words: Intensive care units; antimicrobial resistance pattern; bacterial profile. DOI: 10.3329/imcj.v4i2.6499Ibrahim Med. Coll. J. 2010; 4(2): 66-69

scholarly journals Antimicrobial Susceptibility and Resistance Patterns in Urine Cultures - A Single-Center Experience

2020 ◽  
pp. 74-79
Author(s):  
Naureen Chaudhri ◽  
Mariam Masud ◽  
Mirza Naveed Shehzad ◽  
Jais Kumar ◽  
Mamoon Akbar Qureshi ◽  
...  
Keyword(s):  
Antimicrobial Resistance ◽  
Tertiary Care ◽  
Resistance Pattern ◽  
Care Hospital ◽  
Pathology Laboratory ◽  
Cross Sectional ◽  
Economic Implications ◽  
Tract Infections ◽  
Healthcare Associated ◽  
Klebsiella Spp

Background: Antimicrobial resistance is a threatening global medical challenge. Its prevalence is on the rise, more so in developing countries like Pakistan. It is pivotal to know and follow the local drug sensitivity and resistance pattern for effective empirical treatment of urinary tract infections. Objectives: To evaluate antibiotic susceptibility and resistant patterns of different urinary pathogens in cultures among patients presented in a tertiary care hospital. Materials and Methods: A Descriptive Cross-sectional study was carried out at the Department of Nephrology and Microbiology Holy Family Hospital, Rawalpindi Medical University from January 2018 to July 2018. All the samples from patients suspected to be suffering from UTI that were ordered a urine culture by attending doctors were recruited for the study and were sent to the central pathology laboratory of the hospital. All urine cultures performed in HFH were recruited for the study including both inpatient and outpatient departments. Data were collected in a structured performa and were entered and analyzed in SPSS version 21.0. Results: 402/1216 (33.0 %) urine samples had positive bacterial growths. Females accounted for the majority of 61.6% of cases. E.coli was the most common isolate 42.7%, followed by Klebsiella spp. 17.5%. E.coli exhibited high antimicrobial resistance, with the least resistance to fosfomycin 13.6%. E.coli, Klebsiella spp. and pseudomonas showed significant coresistance to Ceftazidime and ciprofloxacin. Conclusion: Emergence of high AMR in a developing country like Pakistan can have grave clinical and economic implications. It adversely impacts all aspects of patient care. It limits therapeutic options and leads to treatment failure. Keywords: Antimicrobial resistance, Healthcare-associated UTI, healthcare-associated infections, uropathogenic E. coli, extended-spectrum beta-lactamases, multidrug-resistant.

scholarly journals Awareness and acceptance of contraceptives among the mothers of infants attending an immunization session at a field practices area of a tertiary care hospital

2018 ◽  
Vol 6 (1) ◽  
pp. 374
Author(s):  
S. B. Gupta ◽  
Meenakshi Singh ◽  
Atul Kr. Singh ◽  
Huma Khan ◽  
Alpana Saxena
Keyword(s):  
Health Workers ◽  
Tertiary Care ◽  
Care Hospital ◽  
Medical Sciences ◽  
Postpartum Contraception ◽  
Cross Sectional ◽  
Factors Affecting ◽  
Contraceptive Measure ◽  
One Year ◽  
Type Of Delivery

Background: India was the first country in the world to have launched a National Programme for Family Planning.Methods: A cross-sectional descriptive study was carried out in the in Vaccination unit of rural field practice area of Shri Ram Murti Smarak institute of Medical Sciences (SRMSIMS) Bareilly (U.P). Objective of the study was to assess knowledge and practice of postpartum contraception and factors affecting the usage of contraceptives in Rural area. All females who delivered within last one year were included in the study. A pre-structured questionnaire was used. A total of 98 females were included. The appropriate statistical analysis was done to present the results.Results: 28.57% females had adopted one or the other postpartum contraceptive measure. Condom was the most common method used. Usage of postpartum contraception was significantly associated with women’s and husband’s education, type of delivery and availing of antenatal and postnatal visits.Conclusions: Overall usage of postpartum contraception was low there is need to focus at every step to contact of these women with health facility or health workers.

scholarly journals Paradigm Shift in Antimicrobial Resistance Pattern of Bacterial Isolates during the COVID-19 Pandemic

Antibiotics ◽  
2021 ◽  
Vol 10 (8) ◽  
pp. 954
Author(s):  
Vikas Saini ◽  
Charu Jain ◽  
Narendra Pal Singh ◽  
Ahmad Alsulimani ◽  
Chhavi Gupta ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Antimicrobial Resistance ◽  
Tertiary Care ◽  
Public Health Problem ◽  
Resistance Pattern ◽  
Coagulase Negative Staphylococcus ◽  
Care Hospital ◽  
Bacterial Isolates ◽  
Hospital Infection Control ◽  
And Staphylococcus Aureus

Antimicrobial resistance (AMR) is an emerging public health problem in modern times and the current COVID-19 pandemic has further exaggerated this problem. Due to bacterial co-infection in COVID-19 cases, an irrational consumption of antibiotics has occurred during the pandemic. This study aimed to observe the COVID-19 patients hospitalized from 1 March 2019 to 31 December 2020 and to evaluate the AMR pattern of bacterial agents isolated. This was a single-center study comprising 494 bacterial isolates (blood and urine) that were obtained from patients with SARS-CoV-2 admitted to the ICU and investigated in the Department of Microbiology of a tertiary care hospital in Delhi, India. Out of the total bacterial isolates, 55.46% were gram negative and 44.53% were gram positive pathogens. Of the blood samples processed, the most common isolates were CoNS (Coagulase Negative Staphylococcus) and Staphylococcus aureus. Amongst the urinary isolates, most common pathogens were Escherichia coli and Staphylococcus aureus. A total of 60% MRSA was observed in urine and blood isolates. Up to 40% increase in AMR was observed amongst these isolates obtained during COVID-19 period compared to pre-COVID-19 times. The overuse of antibiotics gave abundant opportunity for the bacterial pathogens to gradually develop mechanisms and to acquire resistance. Since the dynamics of SARS-COV-2 are unpredictable, a compromise on hospital antibiotic policy may ultimately escalate the burden of drug resistant pathogens in hospitals. A shortage of trained staff during COVID-19 pandemic renders it impossible to maintain these records in places where the entire hospital staff is struggling to save lives. This study highlights the extensive rise in the use of antibiotics for respiratory illness due to COVID-19 compared to antibiotic use prior to COVID-19 in ICUs. The regular prescription audit followed by a constant surveillance of hospital infection control practices by the dedicated teams and training of clinicians can improve the quality of medications in the long run and help to fight the menace of AMR.

scholarly journals Solitary thyroid nodule: an overview of one year study at a tertiary care hospital

2019 ◽  
Vol 6 (9) ◽  
pp. 3117
Author(s):  
Shyam Sundar Tandri ◽  
Ayathu V. S. Sai Mahesh
Keyword(s):  
Thyroid Nodule ◽  
Tertiary Care Hospital ◽  
Demographic Data ◽  
Tertiary Care ◽  
Common Finding ◽  
Clinical Approach ◽  
Care Hospital ◽  
Cross Sectional ◽  
Solitary Thyroid Nodule ◽  
One Year

Background: Thyroid nodules are a common finding in general practice. These nodules are either solitary or multinodular. In the present study thorough evaluation of all the cases presenting with a solitary thyroid nodule (STN) is done. The clear overview of prevalence of STN, associated risk factors, its distribution and its percentage of malignancy, clinic-pathological correlation and findings on ultra-sonogram.Methods: A one year cross sectional study at a tertiary care hospital was done after ethical committee approval. All cases of thyroid with solitary thyroid nodule were included and socio demographic data, clinical examination and USG data was noted. Thyroid hormone profile, FNAC and HPE was performed for every case enrolled and data was noted. The data was analyzed using SPSS version 22.Results: 350 cases were enrolled with 44.42% prevalence and 61.43% were females. Maximum age group was 31-40 years with swelling as the most common sign. 81.14% were euthyroid, 6.3% of cases had lymph node involvement. Micro calcification in 69.7% of nodules and 78.65 were solid. 40.3% of the STN were of colloid on FNAC and 6% were malignant. Malignancy on HPE was 14.6% and papillary carcinoma was the most commonest and follicular least.Conclusions: All cases of STN require a thorough clinical approach supported by ultra-sonogram, FNAC and detailed HPE after surgery for evaluation of benign and malignant lesions. Fine needle aspiration cytology has become an invaluable, minimally invasive and reliable tool in the preoperative assessment of patients with suspicion of malignancy.

scholarly journals Antimicrobial Resistance Patterns in Clinically Significant Isolates from Medical Wards of a Tertiary Care Hospital in North India

2020 ◽  
Vol 12 (03) ◽  
pp. 196-202
Author(s):  
Venkatesh Sudharsan Vaithiyam ◽  
Neha Rastogi ◽  
Piyush Ranjan ◽  
Niranjan Mahishi ◽  
Arti Kapil ◽  
...  
Keyword(s):  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
North India ◽  
Resistance Pattern ◽  
Resistant Organism ◽  
Care Hospital ◽  
Cross Sectional ◽  
Drug Resistance Pattern ◽  
Clinically Significant ◽  
Medical Wards

Abstract Background The global burden of infections due to multidrug-resistant organism (MDRO) has a significant impact on patients’ morbidity and mortality along with increased healthcare expenditure. Aim This article estimates the prevalence of MDRO and the spectrum of clinical infectious syndromes caused by these organisms in medical wards of a tertiary care hospital in India. Design and Methods A cross-sectional observational study was performed among patients admitted in medicine wards diagnosed with the various infectious syndromes and one or more clinically significant positive culture at a tertiary care hospital in North India over a period of 18 months. Results Out of 323 clinically significant microbiological culture isolates from 229 patients included in the study, 86 (27%) isolates showed multidrug resistance (MDR) pattern, 197 (61%) isolates showed possible extremely drug-resistance pattern, and only 40 (12%) isolates showed nonmultidrug-resistance pattern of antibiogram. Conclusion The prevalence of MRDOs is high in clinically significant culture isolates from medicine wards in India. This emphasizes the importance of appropriate antibiotic usage and implementation of antibiotic stewardship programs in this part of the world.

scholarly journals A study on the bacterial isolates from blood cultures of a tertiary care hospital

2021 ◽  
Vol 7 (3) ◽  
pp. 171-174
Author(s):  
KMS Mohamed Ali ◽  
K Girija
Keyword(s):  
Tertiary Care ◽  
Bloodstream Infections ◽  
Diffusion Method ◽  
Resistance Pattern ◽  
Care Hospital ◽  
Bacterial Isolates ◽  
Tertiary Care Centre ◽  
Sensitivity Testing ◽  
Cross Sectional ◽  
Blood Samples

Blood stream infections are the most important and common cause of morbidity and mortality in tertiary care hospitals. Since the results are usually not available promptly a knowledge of epidemiologic and antimicrobial susceptibility pattern of blood pathogens is life saving and very useful for early treatment and recovery of patients. The aim of this study is to describe the epidemiological, bacterial profile and antimicrobial resistance pattern of bloodstream infections in a tertiary care centre.A prospective cross-sectional study was done on seven hundred and eight blood samples collected over a period of six months in the Microbiology laboratory. Blood samples collected under aseptic conditions were cultured by aerobic culture method. Identification of bacterial isolates were done using standard bacteriologic and biochemical testing methods and antibiotic sensitivity testing done by Kirby - Bauer disc diffusion method.Bacteria was isolated in 201 (28.3%) samples with highest rates among newborns 84(41.8%). The most frequent isolates were 111 (55.2%) followed by 49 (24.4%). Results showed high susceptibilities of CoNS 111 (100%) to Vancomycin, Linezolid and 51 (98%) to Meropenem. This study highlights the common prevalent bacteriological agents in bacteremia, their antibiotic susceptibility & resistance patterns. and multi drug resistant were the leading causes of septicaemia in our hospital with Vancomycin, Linezolid and Carbapenems the effective antibiotics against these pathogens respectively.

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