scholarly journals Effectiveness of Mifepristone in the Treatment of Uterine Leiomyomata

2013 ◽  
Vol 8 (1) ◽  
pp. 22-25
Author(s):  
Mayurika Sinha ◽  
A Kyal ◽  
P Mukhopadhay
Keyword(s):  
Side Effects ◽  
Uterine Leiomyoma ◽  
Endometrial Hyperplasia ◽  
Lower Abdominal Pain ◽  
Simple Type ◽  
Age Group ◽  
Uterine Leiomyomata ◽  
Obstetrics And Gynaecology ◽  
Perimenopausal Women ◽  
A Prospective Study

Aims: The goal of this study was to determine the effects of mifepristone in perimenopausal women with leiomyomas, thereby to see a decrease in severity of symptoms and a decrease in size of the leiomyomas. Methods: This was a prospective study conducted at Eden HospitalMedical College and Hospital, Kolkatafrom July 2010 to June 2011. Fifty patients received 20-25mg mifepristone daily and comparison was made between pre and post treatment symptoms and leiomyoma volume. Results: All patients became amenorrhoeic after treatment, relieving heavy menstrual flow most complained of. Lower abdominal pain improved by > 80% in most patients and volume of leiomyoma decreased appreciably. The drug did not have any major side effects. Endometrial hyperplasia detected by ultrasound in 42% patients was only of simple type on biopsy. Conclusions: Mifepristone can be useful in treating symptomatic women with uterine leiomyoma in perimenopausal age group, in those awaiting surgery to stop bleeding and improve anaemia and to reduce size of tumor to make surgery technically easier, making it a cheaper alternative to GnRH agonists and without any major side effects. Nepal Journal of Obstetrics and Gynaecology / Vol 8 / No. 1 / Issue 15 / Jan- June, 2013 / 22-25 DOI: http://dx.doi.org/10.3126/njog.v8i1.8856

scholarly journals Study of diagnosis and management of ectopic pregnancy

2019 ◽  
Vol 8 (6) ◽  
pp. 2465
Author(s):  
Seema Patel ◽  
Ajesh Desai
Keyword(s):  
Abdominal Pain ◽  
Surgical Treatment ◽  
Ectopic Pregnancy ◽  
Clinical Presentation ◽  
Lower Abdominal Pain ◽  
Age Group ◽  
Obstetrics And Gynaecology ◽  
Beta Hcg ◽  
Adnexal Pathology ◽  
A Prospective Study

Background: Diagnosis of ectopic pregnancy was frequently missed. Aim of the study was to determine the clinical presentation, and treatment associated with ectopic pregnancy.Methods: This is a prospective study which was carried out at Obstetrics and Gynaecology department, GMERS SOLA civil hospital from August 2017 to October 2018. Total 416 patients were admitted during study period out of them 50 patients diagnosed with ectopic pregnancy were enrolled in the study and information was collected and analysed.Results: 80% patients were between the age group of 21-30 years. 56% patients were nulliparous. Amenorrhea (92%) with lower abdominal pain (94%) is the most common presenting symptom. 26% of patients show typical triad of amenorrhea, abdominal pain and bleeding per vagina. UPT and USG were most commonly performed investigations. 96% cases showed UPT positive. 100% USG showed adnexal pathology. Serum beta-hCG was done in 37 patients as an aid for diagnosis and to decide the line of management. Conservative medical management with Injection MTX was done in 4 patients of which 1 patients required laparotomy later on. Surgical management was done in 90% of patients. Laparoscopic management was done in 54% of cases.Conclusions: Early diagnosis and timely intervention in the form of conservative or surgical treatment will help in reducing the morbidity and mortality associated with ectopic pregnancy.

scholarly journals Uterine lipoleiomyoma - An unusual presentation

2021 ◽  
Vol 6 (3) ◽  
pp. 231-233
Author(s):  
Neelam Gupta ◽  
Lav Behl ◽  
Vikas Dubey ◽  
Mehak Kashyap ◽  
Nechal Kaur
Keyword(s):  
Abdominal Pain ◽  
Uterine Leiomyoma ◽  
Lower Abdominal Pain ◽  
Unusual Presentation ◽  
Benign Pathology ◽  
Perimenopausal Women

Uterine leiomyoma is one of the most common benign pathology in women and lipoleiomyoma is an extremely rare and specific type of leiomyoma. Here we are reporting and incidental of lipoleiomyoma in a 43 year old perimenopausal women presented with lower abdominal pain since 2-3 days and discharge per vaginum on and off.

STUDY TO EVALUATE EFFECTS OF MIFEPRISTONE 25mg IN MANAGEMENT OF UTERINE FIBROIDS

2021 ◽  
pp. 26-27
Author(s):  
Nidhi Johri ◽  
Priti Kumar
Keyword(s):  
Social Sciences ◽  
Side Effects ◽  
Uterine Leiomyoma ◽  
Uterine Fibroids ◽  
Cost Effective ◽  
Once Daily ◽  
Common Indication ◽  
Perimenopausal Women ◽  
Effective Option ◽  
Progesterone Antagonist

Background: In India, the uterine broid is a common indication of hysterectomy. An effective option for medical treatment may decrease the morbidity associated with hysterectomy. Objectives: We aimed to evaluate the effect of mifepristone (25 mg), progesterone antagonist, on uterine broids in perimenopausal women. Material And Methods: Fifty perimenopausal women having symptomatic uterine broids were selected from Gynaecology OPD and given 25 mg mifepristone once daily continuously for 2–4 cycles of 3 months each. Variables such as baseline broid size, position, and haemoglobin were measured and followed at 3, 6, 9, and 12 months. The data were entered in MS EXCELspreadsheet and analysis was done using Statistical Package for Social Sciences (SPSS) version 21.0. APvalue of <0.05 was considered as statistically signicant. Results: Majority were intramural broids (70%) followed by submucosal in 18%. Size of broids ranged from 7 cm; the majority of broids were in 5–7 cm size. No signicant association of location with the size of broid was found. Out of 50 cases included in the study, change in size in uterine broids was observed in 95.14% cases. There was an increase in haemoglobin, from 8.6 g% at baseline to 9.5 g% at 12 months. Conclusion: Mifepristone resulted in a reduction in uterine broids size and an increase in haemoglobin at the end of 12 months. It may be an option for uterine leiomyoma treatment, as it is given orally, cost-effective and has minimal side effects.

scholarly journals Comparative study of causative organism in erosive cervicitis, cervical intra epithelial neoplasia and carcinoma cervix using Pap smear

2019 ◽  
Vol 8 (3) ◽  
pp. 1186
Author(s):  
Jyoti Bindal ◽  
Deepak Paldiya
Keyword(s):  
Pap Smear ◽  
Lower Abdominal Pain ◽  
Hpv Infection ◽  
Causative Organism ◽  
Age Group ◽  
Carcinoma Cervix ◽  
Medical College ◽  
Obstetrics And Gynaecology ◽  
Contraception Use ◽  
Specific Symptoms

Background: Cervical cancer is the third largest cause of cancer mortality in India after cancers of the mouth and oropharynx, and oesophagus, accounting for nearly 10% of all cancer related deaths in the country.Methods: The present study carried out 300 patients in Gajra Raja Medical College in the Department of Obstetrics and Gynaecology, OPD and indoor admitted patients from July 2016 to December. 2016. The selected patients were examined with care to note any cervical lesion, appearance of cervix, nature of any cervical/ vaginal discharge. Then a cervical scrape was taken with an Ayre’s spatula and slide stained and then examined.Results: The maximum cases of HPV were seen in CIN, LSIL and HSIL. Maximum incidence of all cases was seen in the age group of 30-50 yrs. The women married before 18 years had the highest incidence of CIN and HPV infection. Majority of the cases of cervicitis were co-infected with H-Vaginalis and Trichomonas. Most women opted for a sterilization procedure rather than any other method of contraception. Use of no contraception puts these women at a high risk of acquiring HPV infection from infected partners.Conclusions: Occurrence of HPV infection declines with increasing grades. Most of the patients with HPV infection had presented with non-specific symptoms of discharge P/V or lower abdominal pain.

scholarly journals Study of endometrium by trans-vaginal sonography and it’s correlation with histopathology in perimenopausal women with abnormal uterine bleeding

2021 ◽  
Vol 10 (9) ◽  
pp. 3554
Author(s):  
Vandana R. Saravade ◽  
Shuchi Chaturvedi
Keyword(s):  
Endometrial Hyperplasia ◽  
Endometrial Thickness ◽  
Abnormal Uterine Bleeding ◽  
Uterine Bleeding ◽  
Transvaginal Sonography ◽  
Age Group ◽  
Dilation And Curettage ◽  
Perimenopausal Women ◽  
Multiparous Women ◽  
Vaginal Sonography

Background: Objectives of the study were to study the endometrial patterns in cases of abnormal uterine bleeding (AUB) and anatomical (structural) lesions of uterus using transvaginal sonography (TVS) and endometrial histopathology and to determine the efficacy of TVS.Methods: Cross-section study of 50 perimenopausal age group with AUB in TNMC BYL Nair hospital from Nov 2017 to Nov 2018.Results: AUB was seen 40 to 45 years multiparous women TVS endometrial thickness (ET) T 6-10 mm (46%), ET 11-15 (22%), ET>15 mm (14%), <5 mm in (18%), showed 21 (42%) patients with endometrial hyperplasia on TVS, 12 (24%) simple hyperplasia 4 (8%) complex hyperplasia on histopathology fibroid 8%, adenomyosis 2%. endometrial polyp 6%.Conclusions: Endometrial lining exceeds 10 mm dilation and curettage to be done r/o endometrial hyperplasia, to study the endometrial patterns in cases of abnormal uterine bleeding and anatomical (structural) lesions of uterus using transvaginal sonography and endometrial histopathology.

scholarly journals Evaluation of Norpalnt in Nepalese Women

1970 ◽  
Vol 39 (133) ◽  
pp. 154-157
Author(s):  
U Bharati ◽  
V Shrivastava
Keyword(s):  
Side Effects ◽  
Insertion Site ◽  
Age Group ◽  
Socioeconomic Group ◽  
Local Infection ◽  
Menstrual Irregularity ◽  
Low Socioeconomic ◽  
Group Number ◽  
Living Children ◽  
A Prospective Study

This was a prospective study done in Marie Stope clinic, Chabhill, Kathmandu. One hundredwomen who had Norplant insertion between May 1996 to April 1997 were followed upfor a year for its side effects. The age, ethnic group, number of living children, literacy,socioeconomic status of the women who has Norplant insertion were also analyzed. Norplantwas found to be most popular in age group of 21-30 years (68%). Maximum number ofacceptors were in Chetri community (32%). It was a popular contraceptive in women whohad two or more children and those who came from low socioeconomic group and wereilliterate. Among side effects, menstrual irregularity was commonest (67%) headachewas present in 12%, weight gain and depressive symptoms each was present in 10% ofwomen. 2% had local infection at insertion site and 1% of woman had allergic reaction.Key words: Norplant, Contraceptives, Side effects.

scholarly journals Evaluation of abnormal uterine bleeding with transvaginal sonography and hysteroscopy in perimenopausal women

2017 ◽  
Vol 6 (8) ◽  
pp. 3607 ◽  
Author(s):  
Jaya Choudhary ◽  
Veena Acharya ◽  
Monika Jain
Keyword(s):  
Endometrial Hyperplasia ◽  
Abnormal Uterine Bleeding ◽  
Uterine Bleeding ◽  
Endometrial Polyp ◽  
Transvaginal Sonography ◽  
Age Group ◽  
Perimenopausal Women ◽  
Normal Menstrual Cycle ◽  
Group A ◽  
Sensitivity Specificity

Background: Abnormal uterine bleeding is defined as any deviation from the normal menstrual cycle this include change in regularity, frequency of menses, duration or amount of bleeding during or in between periods. Objective of present study was to evaluate abnormal uterine bleeding with transvaginal sonography and hysteroscopy in perimenopausal women.Methods: This study is conducted on women presenting to the gynecological OPD with complain of abnormal uterine bleeding in perimenopausal age group. A total of 50 patients were subjected to transvaginal sonography and Diagnostic hysteroscopy.Results: On TVS, out of total 50 patients, 50% patient showed normal endometrial finding. 24% Patient showed Endometrial hyperplasia, 14% Endometrial Polyp, 8% Submucosal fibroid, 4% Adenomyosis. On TVS, out of total 50 patient, 50% patient showed normal endometrial finding. 24% Patient showed endometrial hyperplasia, 14% endometrial Polyp, 8% submucosal fibroid, 4% adenomyosis. Out of total 50 patients, 28 (56%) showed normal endometrial finding.20% cases showed endometrial Hyperplasia, 16% showed endometrial Polyp, 8% showed submucosal fibroid. Sensitivity, specificity, PPV, NPV of endometrial hyperplasia – 81.81%, 92.3%, 75%, 94.73% respectively.Conclusions: Transvaginal sonography has a moderate diagnostic accuracy in detecting endometrial hyperplasia and other intrauterine pathology. TVS is safe, acceptable and easily available & is noninvasive. It should be used as 1st line diagnostic tool in patients with AUB in perimenopausal women. Hysteroscopy has important tool in the diagnosis of various endometrial and intrauterine lesions TVS and hysteroscopy should be employed hand in hand in evaluation of AUB.

scholarly journals A Prospective Study to study the Efficacy and Side Effects of Ormeloxifene in Regression of Mastalgia and Fibroadenoma: Is It the Ideal Drug?

2016 ◽  
Vol 8 (1) ◽  
pp. 48-56
Author(s):  
Nidhi Gupta
Keyword(s):  
Side Effects ◽  
Prospective Study ◽  
Low Cost ◽  
Response To Therapy ◽  
Reproductive Age ◽  
Complete Relief ◽  
Age Group ◽  
Short Period ◽  
A Prospective Study ◽  
The Ideal

ABSTRACT Ormeloxifene (Centchroman) is a novel nonsteroidal, selective estrogen receptor modulator birth control pill which has also been used recently for the treatment of mastalgia and fibroadenoma. Fibroadenomas are the most common benign breast tumors in women but worrisome for women fearing cancer. Mastalgia whether cyclic or noncyclic may be severely incapacitating for women. This study aims to analyze the effect of this new drug on the regression of mastalgia and fibroadenoma as an alternative to presently available steroid-based drugs with significant side effects. Materials and methods This was a prospective study involving 100 women of reproductive age group (up to 35 years of age) attending the outpatient department (OPD) in Malhotra Nursing Home, Agra and Rainbow Hospital Pvt Ltd., Agra, India, from August 2011 to August 2014, complaining of mastalgia and/ or fibroadenoma and fulfilling the inclusion criteria. After informed consent, these women were divided into a mastalgia group who had mastalgia with or without nodularity and a fibroadenoma group having sizes 1.5 to 2 cm, single or multiple in one or both breasts. Ormeloxifene 30 mg on alternate days was administered for 3 months in both the groups. Patients were followed at 1, 2, 4, 8, 12 and 24 weeks to assess response to therapy. Clinical examination, change in nodularity by palpation, breast lump size by ultrasonography, change in visual analog score (VAS) and breast tenderness were monitored. Results were analyzed using ‘t’ test. Results A total of 100 patients were included in this study. Eighty percent women belonged to the age group 25 to 35 years with a mean age of 28, 31.2 and 27.2 years in groups IA, IB and group B respectively. Mean interval between drug therapy and onset of response was 6 ± 2 days in mastalgia group and 15 ± 2 days in fibroadenoma group. 97.6 to 100% of women in the mastalgia group reported complete relief at 12 weeks of therapy with a decrease in VAS score from 10 to 3 in the first week of therapy itself while 28% of fibroadenoma group reported complete relief at 12 weeks of therapy, partial relief in 31% and equivocal response in 41%. Side effects observed were allergic rash development (2%) and a delay in menstruation of 7 to 10 days (14%) during therapy. Conclusion Ormeloxifene is a novel nonsteroidal drug found to be effective in treatment of mastalgia and partially in treatment of fibroadenoma in a short period of 3 months. As compared to the drugs presently in use namely danazol and bromocriptine, ormeloxifene is safer as suggested by its side-effect profile and is cost-effective too. There is need for prospective large randomized studies to compare this low-cost drug with the standard but costly drugs being prescribed at present. How to cite this article Gupta N. A Prospective Study to Study the Efficacy and Side Effects of Ormeloxifene in Regression of Mastalgia and Fibroadenoma: Is it the Ideal Drug? J South Asian Feder Obst Gynae 2016;8(1):48-56.

scholarly journals A case of adenomyosis with leiomyoma that was effectively treated with relugolix and kamishoyosan add-on therapy

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Yukifumi Sasamori ◽  
Kohei Takehara ◽  
Tsuyoshi Terashima ◽  
Takako Onodera ◽  
Keita Yatsuki ◽  
...  
Keyword(s):  
Side Effects ◽  
Lower Abdominal Pain ◽  
Abnormal Uterine Bleeding ◽  
Resonance Imaging ◽  
Phase 3 ◽  
Case Presentation ◽  
Hot Flush ◽  
Perimenopausal Women ◽  
Gonadotropin Releasing Hormone Receptor ◽  
Uterine Volume

Abstract Background Recently, relugolix, an oral gonadotropin-releasing hormone receptor antagonist, has been considered an effective therapy for leiomyoma based on a phase 3 study in Japanese women. Leiomyoma combined with severe adenomyosis occasionally occurs in perimenopausal women; however, little information on the effectiveness of relugolix against severe adenomyosis exists. Case presentation A 49-year-old woman was referred to our hospital with acute lower abdominal pain and abnormal uterine bleeding. Magnetic resonance imaging revealed multiple leiomyomas with diffuse adenomyosis. Left hydrosalpinx was also observed. The patient refused surgical treatment and preferred oral relugolix. Since she experienced a hot flush and headache induced by relugolix, a traditional Japanese Kampo, kamishoyosan, was added to improve the side effects of relugolix. The patient was asymptomatic at the time of this report and experienced a significant shrinkage in uterine volume. Ultimately, she avoided hysterectomy as desired. Conclusions To our knowledge, this is the first report of co-occurring adenomyosis and leiomyoma, which was effectively treated with relugolix. Although the management of adverse side effects, including hot flush and headache by relugolix, has recently attracted attention and controversy, relugolix add-on therapy with kamishoyosan may help treat menopausal symptoms.

Sign in / Sign up

Export Citation Format

Share Document