scholarly journals Comparative study of causative organism in erosive cervicitis, cervical intra epithelial neoplasia and carcinoma cervix using Pap smear

2019 ◽  
Vol 8 (3) ◽  
pp. 1186
Author(s):  
Jyoti Bindal ◽  
Deepak Paldiya
Keyword(s):  
Pap Smear ◽  
Lower Abdominal Pain ◽  
Hpv Infection ◽  
Causative Organism ◽  
Age Group ◽  
Carcinoma Cervix ◽  
Medical College ◽  
Obstetrics And Gynaecology ◽  
Contraception Use ◽  
Specific Symptoms

Background: Cervical cancer is the third largest cause of cancer mortality in India after cancers of the mouth and oropharynx, and oesophagus, accounting for nearly 10% of all cancer related deaths in the country.Methods: The present study carried out 300 patients in Gajra Raja Medical College in the Department of Obstetrics and Gynaecology, OPD and indoor admitted patients from July 2016 to December. 2016. The selected patients were examined with care to note any cervical lesion, appearance of cervix, nature of any cervical/ vaginal discharge. Then a cervical scrape was taken with an Ayre’s spatula and slide stained and then examined.Results: The maximum cases of HPV were seen in CIN, LSIL and HSIL. Maximum incidence of all cases was seen in the age group of 30-50 yrs. The women married before 18 years had the highest incidence of CIN and HPV infection. Majority of the cases of cervicitis were co-infected with H-Vaginalis and Trichomonas. Most women opted for a sterilization procedure rather than any other method of contraception. Use of no contraception puts these women at a high risk of acquiring HPV infection from infected partners.Conclusions: Occurrence of HPV infection declines with increasing grades. Most of the patients with HPV infection had presented with non-specific symptoms of discharge P/V or lower abdominal pain.

scholarly journals Diagnostic Modalities of Precancerous and Cancerous Cervical Lesions with Special Emphasis on CD31 Angiogenesis Factor as a Marker

2013 ◽  
Vol 2013 ◽  
pp. 1-5 ◽  
Author(s):  
Bandana Sharma ◽  
Neetu Singh ◽  
Neena Gupta ◽  
Pavika Lal ◽  
Shefali Pande ◽  
...  
Keyword(s):  
Statistical Analysis ◽  
Pap Smear ◽  
Histopathological Examination ◽  
Cervical Lesions ◽  
Invasive Group ◽  
Angiogenesis Factor ◽  
Medical College ◽  
Obstetrics And Gynaecology ◽  
Diagnostic Modalities

Objectives. To evaluate the role of angiogenesis tumor marker CD31 in the detection of precancerous and cancerous cervical lesions and to compare its efficacy with colposcopy and histopathology. Materials and Methods. 230 patients with a suspicious looking cervix and an abnormal Pap smear attending the Outpatient Department of Obstetrics and Gynaecology of GSVM Medical College were subjected to a colposcopic examination. 180 patients with suspected colposcopic findings were subjected to a colposcopic directed biopsy. Biopsy tissues were sent for histopathological examination out of which 50 biopsied samples were sent for immunostaining of CD-31. Statistical analysis was done. Results. Comparison of microvessel density (MVD) count by haematoxylin and eosin staining (HE) and immunostaining of CD31 in preinvasive group were and , respectively, and in invasive group were and , respectively, which showed that MVD was higher by CD31 both in preinvasive and invasive group, and it was statistically significant. Conclusion. Angiogenesis is a marker of tumor progression, and CD31 fixes up vessel better as compared to HE, so aggressiveness of the tumor can be better predicted by MVD-CD31 as compared to MVD-HE.

scholarly journals Cytologic and colposcopic evaluation of all symptomatic women at tertiary care centre

2017 ◽  
Vol 4 (3) ◽  
pp. 799
Author(s):  
Richa Garg ◽  
Ranjana Desai
Keyword(s):  
Prospective Observational Study ◽  
Pap Smear ◽  
Invasive Carcinoma ◽  
Tertiary Care ◽  
Care Centre ◽  
Carcinoma Cervix ◽  
Tertiary Care Centre ◽  
Medical College ◽  
Carcinoma Of Cervix ◽  
Malignant Lesions

Background: Cervical cancer in India ranks as the 2nd most frequent cancer among women and the 2nd most frequent cancer among women between 15 and 44 years of age. Invasive carcinoma of cervix is preventable as it is associated with pre-invasive stage which occurs 10-15 years prior to it, thus permitting early detection by screening and leading to effective treatment and thereby reducing mortality rate with greater impact on lives saved. Objectives were to correlate the findings of Pap smear with colposcopy in evaluation of all symptomatic women; and to assess the utility of colposcopy in detecting the premalignant and malignant lesions of cervix.Methods: This was a prospective observational study of 200 symptomatic women attending the Gynecology OPD of Umaid Hospital Dr. S. N. Medical College Jodhpur, Rajasthan, India from February 2015 to October 2016. Evaluation of all symptomatic women done with Pap smear, colposcopy and biopsy in selected cases and findings were noted.Results: Commonest complaint was white discharge per vaginum in 58.5% followed by pelvic pain in 24% women. 8% women had abnormal pap smear findings with 4% of women had ASCUS, 0.5% had ASC-H, 3% had LSIL and 0.5% had HSIL,73% had inflammatory and 19% with normal smear. 38.5% had abnormal colposcopy with maximum 28% women had acetowhite lesions. Sensitivity of pap smear was 44.44% while sensitivity of colposcopy was 88.88%.Conclusions: Pap smear had poor sensitivity as compared to colposcopy. Hence simultaneous use of colposcopy has shown to increase in the rate of carcinoma cervix detection in symptomatic women.

scholarly journals Pattern of Histopathologically Confirmed Uterine and Ovarian Anomeli Among 98 Hysterectomies Attending a Private Medical College Hospital, Dhaka

2017 ◽  
Vol 8 (1) ◽  
pp. 6-9
Author(s):  
Tabassum Tahmin Sajani ◽  
Tanjila Tahmin Sarnali ◽  
Md Atiqur Rahman ◽  
Shoib Ahmed
Keyword(s):  
Histopathological Examination ◽  
Developed Countries ◽  
Age Group ◽  
Pathological Findings ◽  
Carcinoma Cervix ◽  
College Hospital ◽  
Medical College ◽  
Total Hysterectomy ◽  
Gynecological Disorders ◽  
Chronic Cervicitis

Background: Endometrial diseases ranked among the most common gynecological disorders that affect women globally. This study was undertaken to identify the most common pathologies identified in hysterectomy specimens.Materials & Methods: The present study was conducted in the Department of Pathology, Anwer Khan Modern Medical College, Dhaka over a period of 6 months from July to December 2013. Ninety eight (98) hysterectomy specimens were received by the pathology department during this period. On receiving the hysterectomy specimens, the gross features were noted. A detailed microscopic examination was done to arrive at an accurate diagnosis.Result: Most of the women 54% were 40-49 years age group followed by 25% in 30-39 years age group. Chronic cervicitis and adenomyosis were the commonest pathological findings in (80.6%) and (32.7%) respectively. Other pathologies identified include Leiomyoma (23.5%), endometrial hyperplasia (17.4%), endometrial polyp (4.1%) and PID with hemorrhagic infection (1.0%). Two cases of carcinoma cervix (2.0%), two local invasion of tumors (2.0%) and one adenocarcima (1.0%) was found. Type of operation most common is total hysterectomy with oophorectomy (51.0%).Conclusion: Hysterectomy still remains the widely used treatment modality even in developed countries. The ultimate diagnosis is only on histology, so every hysterectomy specimen should be subjected to histopathological examination. Benign pathologies are more common than their malignant counterparts and the most common pathologies identified in hysterectomy specimens are chronic cervicitis, adenomyosis and leiomyoma.Anwer Khan Modern Medical College Journal Vol. 8, No. 1: Jan 2017, P 6-9

scholarly journals Analysis on the Incidence, Staging and Treatment of Carcinoma Cervix at Delta Medical College and Hospital of Bangladesh

2013 ◽  
Vol 1 (2) ◽  
pp. 31-36
Author(s):  
Parvin A Banu ◽  
Naheed Rukhsana ◽  
Jebunnessa Yasmin ◽  
Lutfun Nahar ◽  
Sadiqur R Malik
Keyword(s):  
Cervical Cancer ◽  
Screening Program ◽  
External Beam Radiotherapy ◽  
Concurrent Chemotherapy ◽  
Time Interval ◽  
Age Group ◽  
Carcinoma Cervix ◽  
Cross Sectional ◽  
Medical College ◽  
Incidence And Mortality

Background: Cervical cancer remains the most common cancer among women in this part of the world. Bangladesh has the highest level of incidence and mortality rates due to cervical cancer among women. Cervical cancer is a preventable disease by screening and treatment of pre-invasive condition. Unfortunately, there is no effective screening program in Bangladesh. Objective: The objective was to analyze the clinico-pathologic characteristics and, subsequently the therapy delivered to the patients. Materials and method: This cross sectional study was done from January to December 2011 in oncology division of Delta Medical College and Hospital, Dhaka, Bangladesh. During this period a total of 2264 female carcinoma patients were registered. Out of them 523 patients were with the diagnosis of carcinoma of cervix. Evaluation and characterization of patients with carcinoma cervix were done according to the age group, clinical stages and surgical status. External beam radiotherapy (EBRT) and doses, brachytherapy doses and fractions, time interval between EBRT and brachytherapy, neo-adjuvant and concurrent chemotherapy status were the factors taken into consideration for the analysis of treatment of these patients. Results: The study revealed that the incidence of carcinoma cervix was 23% and highest incidence was between 40-50 years of age group, most of the patients were in Stage IIB (34%) and IIIB (28%) and 31% with unknown stage. About 44% patients were referred postoperatively and most of them with unknown stage. Almost 90% patients received EBRT, 24% patients received concurrent chemo-radiation, 46% of them completed 5 cycles of concurrent chemotherapy and 8.6% patients received neo-adjuvant chemotherapy. About 69% patients received brachytherapy with HDR Co-60 sources and 23% of patients received their brachytherapy treatment after 12 weeks of completion of EBRT. Conclusion: Lack of proper clinical evaluation and documentation, delay in referral and lack of implementation of a standard protocol for the treatment of carcinoma cervix are the major obstacles in our country. DOI: http://dx.doi.org/10.3329/dmcj.v1i2.15915 Delta Med Col J. Jul 2013;1(2):31-36

scholarly journals Prospective study of colposcopic screening of unhealthy cervix

2019 ◽  
Vol 8 (4) ◽  
pp. 1467
Author(s):  
Pushpa Kannoujiya ◽  
Arpita Shrivastava ◽  
Tariq Ahmed Mala
Keyword(s):  
Selection Criteria ◽  
Analytical Study ◽  
Pap Smear ◽  
Income Group ◽  
Histopathological Analysis ◽  
Age Group ◽  
Lower Income ◽  
Lower Income Group ◽  
Obstetrics And Gynaecology ◽  
High Incidence

Background: The study was conducted to screen women who have abnormal vaginal discharge with Pap smear to do histopathological analysis of colposcopically directed biopsies.Methods: A prospective analytical study carried out in the department of obstetrics and gynaecology. The patients were randomly selected who fulfilled the selection criteria and was carried out to study the correlation of Pap smear and colposcopy in women with unhealthy cervix.   Results: Among all patients 13% were between 20-29 years, 38% were between 30- 39%, 31% belonging to 40-49 years group and 18% was between 50-59%.  Among 100 Women studied, 33% were illiterates, 55% had primary/high school education and 12% had Higher education Majority of the patients (68.7%) of CIN occurred in the age group of 30-49years, 41.7% with CIN were paragrvida 2, 43.8% with CIN were paragravida 3 and 18.6% were greater than paragravida 4 showing high incidence of CIN in multiparity.The incidence of CIN was found to be high among the lower income group 87.5%.The major presenting complains in the study patients were white discharge per vagina.Conclusions: Colposcopy was found to be useful in understanding the morphology of the cervical lesion, both of the neoplastic and nonneoplastic ones and was very helpful in planning their management. Cytology is an accepted method for screening for cervical cancer and the value of colposcopy has been recognized. Hence it may be better to utilize cervical cytology smear with colposcopy should be offered as a diagnostic method in all patients with unhealthy cervix.

EVALUATION OF THE ETIOLOGIES AND OUTCOME OF PRETERM LABOUR

2021 ◽  
pp. 13-17
Author(s):  
Rabindra Nath Behera ◽  
Sini Venugopal ◽  
Avilas Das
Keyword(s):  
Gestational Age ◽  
Neonatal Outcome ◽  
Preterm Labour ◽  
Tertiary Care ◽  
Age Group ◽  
Tertiary Care Centre ◽  
Mortality And Morbidity ◽  
Medical College ◽  
Obstetrics And Gynaecology ◽  
Covered Group

Objective : This is a Prospective cohort study carried out in department of Obstetrics and Gynaecology, Hi-Tech Medical College & Hospital, Bhubaneswar, a tertiary care centre, with the objective of knowing the etiology and outcome of preterm labour and formulate measures to prevent the onset of preterm labour and deal with complications arising from preterm labour. Materials and methods : A total of 112 patients with preterm labour were included in the study. The investigations required to identify the etiology and also other routine investigations were carried out . The study was conducted over a two year period i.e. from November 2018 to October 2020 at Hi-Tech Medical College & Hospital, Bhubaneswar. Results : Majority of the patients were in the age group of 20-24 years. Among them, majority of the patients belonged to the gestational age group of 28-34 weeks . Infection was the commonest cause of preterm labour. There is signicant improvement in neonatal outcome in steroid covered group if gestational age is less than 34 weeks . Conclusion: Preterm labour has major impact on neonatal mortality and morbidity. Hence identication of risk factors and etiologies of preterm labour and timely interventions in the form of investigations and management and preparedness to tackle the maternal and neonatal complications are vital for a good maternal and neonatal outcome.

scholarly journals Effectiveness of Mifepristone in the Treatment of Uterine Leiomyomata

2013 ◽  
Vol 8 (1) ◽  
pp. 22-25
Author(s):  
Mayurika Sinha ◽  
A Kyal ◽  
P Mukhopadhay
Keyword(s):  
Side Effects ◽  
Uterine Leiomyoma ◽  
Endometrial Hyperplasia ◽  
Lower Abdominal Pain ◽  
Simple Type ◽  
Age Group ◽  
Uterine Leiomyomata ◽  
Obstetrics And Gynaecology ◽  
Perimenopausal Women ◽  
A Prospective Study

Aims: The goal of this study was to determine the effects of mifepristone in perimenopausal women with leiomyomas, thereby to see a decrease in severity of symptoms and a decrease in size of the leiomyomas. Methods: This was a prospective study conducted at Eden HospitalMedical College and Hospital, Kolkatafrom July 2010 to June 2011. Fifty patients received 20-25mg mifepristone daily and comparison was made between pre and post treatment symptoms and leiomyoma volume. Results: All patients became amenorrhoeic after treatment, relieving heavy menstrual flow most complained of. Lower abdominal pain improved by > 80% in most patients and volume of leiomyoma decreased appreciably. The drug did not have any major side effects. Endometrial hyperplasia detected by ultrasound in 42% patients was only of simple type on biopsy. Conclusions: Mifepristone can be useful in treating symptomatic women with uterine leiomyoma in perimenopausal age group, in those awaiting surgery to stop bleeding and improve anaemia and to reduce size of tumor to make surgery technically easier, making it a cheaper alternative to GnRH agonists and without any major side effects. Nepal Journal of Obstetrics and Gynaecology / Vol 8 / No. 1 / Issue 15 / Jan- June, 2013 / 22-25 DOI: http://dx.doi.org/10.3126/njog.v8i1.8856

scholarly journals Study of diagnosis and management of ectopic pregnancy

2019 ◽  
Vol 8 (6) ◽  
pp. 2465
Author(s):  
Seema Patel ◽  
Ajesh Desai
Keyword(s):  
Abdominal Pain ◽  
Surgical Treatment ◽  
Ectopic Pregnancy ◽  
Clinical Presentation ◽  
Lower Abdominal Pain ◽  
Age Group ◽  
Obstetrics And Gynaecology ◽  
Beta Hcg ◽  
Adnexal Pathology ◽  
A Prospective Study

Background: Diagnosis of ectopic pregnancy was frequently missed. Aim of the study was to determine the clinical presentation, and treatment associated with ectopic pregnancy.Methods: This is a prospective study which was carried out at Obstetrics and Gynaecology department, GMERS SOLA civil hospital from August 2017 to October 2018. Total 416 patients were admitted during study period out of them 50 patients diagnosed with ectopic pregnancy were enrolled in the study and information was collected and analysed.Results: 80% patients were between the age group of 21-30 years. 56% patients were nulliparous. Amenorrhea (92%) with lower abdominal pain (94%) is the most common presenting symptom. 26% of patients show typical triad of amenorrhea, abdominal pain and bleeding per vagina. UPT and USG were most commonly performed investigations. 96% cases showed UPT positive. 100% USG showed adnexal pathology. Serum beta-hCG was done in 37 patients as an aid for diagnosis and to decide the line of management. Conservative medical management with Injection MTX was done in 4 patients of which 1 patients required laparotomy later on. Surgical management was done in 90% of patients. Laparoscopic management was done in 54% of cases.Conclusions: Early diagnosis and timely intervention in the form of conservative or surgical treatment will help in reducing the morbidity and mortality associated with ectopic pregnancy.

scholarly journals A correlation study of cervical cytology on Pap smear with cervical biopsy in a tertiary hospital of Eastern Nepal

2018 ◽  
Vol 8 (2) ◽  
pp. 1389-1392
Author(s):  
Nirajan Mainali ◽  
Neha Homagai ◽  
Niraj Nepal ◽  
Prabesh Choudhary
Keyword(s):  
Pap Smear ◽  
Early Stage ◽  
Tertiary Hospital ◽  
Cross Sectional Study ◽  
Correlation Study ◽  
Pap Smears ◽  
Carcinoma Cervix ◽  
Cross Sectional ◽  
Medical College ◽  
Cervical Biopsy

Background: Carcinoma cervix is among a curable cancer, if identified at an early stage. Pap smear is a simple, safe, noninvasive, outdoor and effective method for detection of lesions of the cervix but it fails to localize the lesion. Cervical biopsy, on the other hand is a gold standard but invasive technique.Materials and Methods: A prospective cross-sectional study was done in Nobel medical college from January 16, 2017 to January 15, 2018 where all pap smears received in a Department of Pathology were included in the study. However, only cases that had undergone both Pap smear and cervical biopsy were compared. Out of the 1492 pap smears, 118 cases underwent biopsy. Correlation was then done regarding cytological and histological diagnosis.Results: Majority of the cytological findings were normal. 7 patients of HSIL revealed moderate dysplasia and higher lesions in biopsy. 2 cases were that of adenocarcinoma which were diagnosed as inflammatory smear in Pap smear.Conclusion: Cervical Pap smear is reliable screening test to identify high grade squamous cell lesions and carcinoma, but it fails to localize the lesion and adenocarcinoma is hard to identify in a pap smear. Hence, cervical biopsy should be carried out to confirm the findings of Pap smear and in case of strong clinical suspicion.

scholarly journals Prospective comparative study between colposcopy and histopathology for diagnosis of CIN and carcinoma cervix

2019 ◽  
Vol 8 (9) ◽  
pp. 3661
Author(s):  
Kishorkumar Hol ◽  
Shweta S. Mishra ◽  
Sameer Darawade ◽  
Hemant Damle
Keyword(s):  
Gold Standard ◽  
Pap Smear ◽  
Precancerous Lesions ◽  
Screening Tests ◽  
Age Group ◽  
Precursor Lesions ◽  
Carcinoma Cervix ◽  
Prospective Comparative Study ◽  
A Prospective Study

Background: Cervical cancer develops from precursor lesions and detection of these lesions is of utmost importance. The detection of precancerous lesions is made with help of screening tests most important include PAP smear and colposcopy. So we conducted this study to understand the role of colposcopy in down staging of Carcinoma cervix.Methods: We performed a prospective study between Jan 2018 to Dec 2018 on 180 subjects chosen from patients who sought consultation for various gynaecological complaints between age group of 18-60 years. A Pap smear followed by a colposcopy was performed and colposcopic directed biopsies were taken and subjected to histolopathological examination.Results: Colposcopy had a sensitivity of 83.3%, specificity of 78.5%, PPV of 68.9% for CIN 1. It had a sensitivity of 90.9%, specificity of 95.2%, PPV of 83.33% for CIN 2 and 3 when co related with gold standard histopathology which is much higher as compared to Pap smear.Conclusions: Colposcopy is an effective tool in down staging of Carcinoma cervix.

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