scholarly journals Dissection of the mitotic and nuclear functions of Chromator, a nuclear-derived spindle matrix component in Drosophila

2008 ◽  
Author(s):  
Yun Ding
Keyword(s):  
Matrix Component ◽  
Spindle Matrix

scholarly journals Erratum: An intrinsic mechanism controls reactivation of neural stem cells by spindle matrix proteins

2017 ◽  
Vol 8 (1) ◽  
Author(s):  
Song Li ◽  
Chwee Tat Koe ◽  
Su Ting Tay ◽  
Angie Lay Keng Tan ◽  
Shenli Zhang ◽  
...  
Keyword(s):  
Stem Cells ◽  
Neural Stem Cells ◽  
Matrix Proteins ◽  
Spindle Matrix ◽  
Intrinsic Mechanism

scholarly journals Hyperglycaemia and aberrated insulin signalling stimulate tumour progression via induction of the extracellular matrix component hyaluronan

2017 ◽  
Vol 141 (4) ◽  
pp. 791-804 ◽  
Author(s):  
Sören Twarock ◽  
Christina Reichert ◽  
Ulrike Peters ◽  
Daniel J. Gorski ◽  
Katharina Röck ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Insulin Signalling ◽  
Tumour Progression ◽  
Extracellular Matrix Component ◽  
Matrix Component

scholarly journals Hyaluronan in intestinal homeostasis and inflammation: implications for fibrosis

2011 ◽  
Vol 301 (6) ◽  
pp. G945-G949 ◽  
Author(s):  
Carol A. de la Motte
Keyword(s):  
Extracellular Matrix ◽  
Wound Healing ◽  
Intestinal Inflammation ◽  
Cellular Mechanisms ◽  
Matrix Component ◽  
Matrix Deposition ◽  
Fibrotic Tissue ◽  
Myofibroblast Phenotype ◽  
Extracellular Matrix Deposition ◽  
Chronic Intestinal Inflammation

The causes of fibrosis, or the inappropriate wound healing, that follows chronic intestinal inflammation are not well defined and likely involve the contributions of multiple cellular mechanisms. As other articles in this series confirm, inflammatory cytokines clearly play a role in driving cell differentiation to the myofibroblast phenotype, promoting proliferation and extracellular matrix deposition that are characteristic of fibrotic tissue. However, controlling the balance of cytokines produced and process of myofibroblast differentiation appears to be more complex. This review considers ways in which hyaluronan, an extracellular matrix component that is remodeled during the progression of colitis, may provide indirect as well as direct cues that influence the balancing act of intestinal wound healing.

scholarly journals NRF2 Activation Inhibits Both TGF-β1- and IL-13-Mediated Periostin Expression in Fibroblasts: Benefit of Cinnamaldehyde for Antifibrotic Treatment

2018 ◽  
Vol 2018 ◽  
pp. 1-10 ◽  
Author(s):  
Yasutaka Mitamura ◽  
Mika Murai ◽  
Chikage Mitoma ◽  
Masutaka Furue
Keyword(s):  
Dermal Fibroblasts ◽  
Treatment Modalities ◽  
Oxygen Species ◽  
Extracellular Matrix Component ◽  
Fibrotic Disease ◽  
Matrix Component ◽  
Nrf2 Activation ◽  
Life Threatening ◽  
Fibrotic Diseases ◽  
Tgf Β1

Systemic fibrosing or sclerotic disorders are life-threatening, but only very limited treatment modalities are available for them. In recent years, periostin (POSTN), a major extracellular matrix component, was established by several studies as a novel key player in the progression of systemic fibrotic disease. In this research, we revealed the involvement of oxidative stress in the expression of POSTN induced by TGF-β1 and IL-13 in dermal fibroblasts. We found that the antioxidant cinnamaldehyde activated the NRF2/HMOX1 pathway. Cinnamaldehyde also alleviated TGF-β1- and IL-13-mediated production of reactive oxygen species and subsequent POSTN upregulation in dermal fibroblasts. In contrast, NRF2 silencing abolished the cinnamaldehyde-mediated downregulation of POSTN. These results suggest that cinnamaldehyde is a broad inhibitor of POSTN expression covering both TGF-β1 and IL-13 signaling. Cinnamaldehyde may thus be beneficial for the treatment of systemic fibrotic diseases.

scholarly journals Effect of Aluminum Phosphate Species as New Matrix Component on Cracking Performance of FCC Catalyst with or without ZSM-5 Additive

2016 ◽  
Vol 59 (3) ◽  
pp. 104-108 ◽  
Author(s):  
Yuji SAKA ◽  
Norihito CHIYODA ◽  
Katsuya WATANABE ◽  
Satoshi INAGAKI ◽  
Yoshihiro KUBOTA
Keyword(s):  
Aluminum Phosphate ◽  
Matrix Component ◽  
Fcc Catalyst ◽  
Cracking Performance ◽  
Phosphate Species

scholarly journals Evidence for a role of spindle matrix formation in cell cycle progression by antibody perturbation

PLoS ONE ◽  
2018 ◽  
Vol 13 (11) ◽  
pp. e0208022 ◽  
Author(s):  
Changfu Yao ◽  
Chao Wang ◽  
Yeran Li ◽  
Michael Zavortink ◽  
Vincent Archambault ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Cell Cycle Progression ◽  
Cycle Progression ◽  
Spindle Matrix

scholarly journals The spindle matrix through the cell cycle in Drosophila

Fly ◽  
2009 ◽  
Vol 3 (3) ◽  
pp. 215-222 ◽  
Author(s):  
Jorgen Johansen ◽  
Kristen M. Johansen
Keyword(s):  
Cell Cycle ◽  
Spindle Matrix

scholarly journals Eg5 is static in bipolar spindles relative to tubulin

2001 ◽  
Vol 154 (6) ◽  
pp. 1125-1134 ◽  
Author(s):  
Tarun M. Kapoor ◽  
Timothy J. Mitchison
Keyword(s):  
Motor Activity ◽  
Half Life ◽  
Microtubule Dynamics ◽  
Spindle Matrix ◽  
Spindle Poles ◽  
Kinesin Eg5 ◽  
Mitotic Kinesin Eg5 ◽  
Bipolar Spindles

We used fluorescent speckle microscopy to probe the dynamics of the mitotic kinesin Eg5 in Xenopus extract spindles, and compared them to microtubule dynamics. We found significant populations of Eg5 that were static over several seconds while microtubules flux towards spindle poles. Eg5 dynamics are frozen by adenylimidodiphosphate. Bulk turnover experiments showed that Eg5 can exchange between the spindle and the extract with a half life of <55 s. Eg5 distribution in spindles was not perturbed by inhibition of its motor activity with monastrol, but was perturbed by inhibition of dynactin with p50 dynamitin. We interpret these data as revealing the existence of a static spindle matrix that promotes Eg5 targeting to spindles, and transient immobilization of Eg5 within spindles. We discuss alternative interpretations of the Eg5 dynamics we observe, ideas for the biochemical nature of a spindle matrix, and implications for Eg5 function.

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