Exploring the Relationship between Demographic Isolation and Professional Experiences of Black and Latinx Teachers

2021 ◽  
Author(s):  
Susan Kemper Patrick ◽  
Francisco Arturo Santelli
Keyword(s):  
Small Sample Size ◽  
The United States ◽  
Black Teachers ◽  
Small Sample ◽  
Continuous Measure ◽  
Professional Experiences ◽  
Workplace Experiences ◽  
Perceived Satisfaction ◽  
Ordinal Measure ◽  
Qualitative Work

Educational leaders throughout the United States have repeatedly emphasized the importance of increasing the number of Black and Latinx teachers in American schools. Prior qualitative work suggests that Black and Latinx teachers who are demographically isolated in their schools often report negative experiences. Drawing on theories of proportional representation in organizations, we use Tennessee statewide survey and administrative data to examine whether self-reported professional experiences of Black and Latinx teachers are different when they are demographically isolated. We estimate models using two measures of demographic isolation: a continuous measure and a theoretically generated ordinal measure. We find that, for Black teachers, the percentage of Black teachers in the school is positively associated with teachers’ perceived satisfaction and support and with the frequency of collaboration. There is also some evidence of threshold effects of demographic isolation for Black teachers, as Black teachers in schools in which at least 60% of fellow teachers are Black report significantly higher satisfaction and support than other Black teachers. Our models do not find any associations between isolation and professional experience for Latinx teachers, but a small sample size and lack of variation in demographic isolation among Latinx teachers makes it difficult to estimate these associations. Our findings suggest that both ordinal and continuous measures of demographic isolation may be useful when examining relationships between demographic isolation and workplace experiences. Because we study factors linked to turnover in prior research, these analyses can contribute to the broader discussion about the retention of Black and Latinx teachers.

Trends in glassy cell cervical cancer in the United States from 1973-2015: Analysis based on SEER database.

2021 ◽  
Vol 39 (15_suppl) ◽  
pp. e17502-e17502
Author(s):  
Anahat Kaur ◽  
Shuai Wang ◽  
Tarek N. Elrafei ◽  
Lewis Steinberg ◽  
Abhishek Kumar
Keyword(s):  
United States ◽  
Cervical Cancer ◽  
Overall Survival ◽  
Cell Carcinoma ◽  
Small Sample Size ◽  
Black Population ◽  
The United States ◽  
Small Sample ◽  
Cervix Uteri ◽  
Kaplan Meier

e17502 Background: Glassy cell carcinoma of cervix (GCCC) is a rare histological subtype of cervical cancer which has historically been associated with rapidly progressive disease, early development of metastases and overall poor prognosis. We attempt to define real-world trends in GCCC in the United States based on data from SEER (Surveillance, Epidemiology and End Results) database. Methods: We extracted data from the US National Cancer Institute's SEER 2018 dataset using ICD-O code for ‘Cervix Uteri Glassy Cell Carcinoma’. All patients who were diagnosed between 1973-2015 were included. Statistical analysis was done using SPSS 26. Kaplan Meier curve was used for survival analysis. Results: Data for a total of 57 patients with GCCC was available from 1975 to 2017. Median age at diagnosis was 38 years (range 30.5-44.5). Increased frequency of cases was noted in white females (77.2%) as compared to black population (22.2%). Most cases initially presented with localized or regional spread (47.4% and 40.4% respectively) with distant metastasis seen in only 10.5% patients. Data analysis revealed that 63.2% patients had Grade III poorly differentiated carcinoma, 66.7% received radiation therapy, 57.9% underwent chemotherapy and 59.6% had cancer direceted surgery performed. Calculated mean overall survival was 121.9 months. We were unable to calculate 5 year and 10 year median overall survival due to small sample size and censored data. Conclusions: GCCC is a rare histologic type of cervical cancer that presents at a younger age, is more frequently seen in white females and is commonly associated with localized or regional spread at time of initial presentation.[Table: see text]

Impact of race on biomarker testing among HER2- advanced breast cancer (ABC) patients (pts) in the United States: Results from a real-world study.

2021 ◽  
Vol 39 (15_suppl) ◽  
pp. 10598-10598
Author(s):  
Reshma L. Mahtani ◽  
Alexander Niyazov ◽  
Katie Lewis ◽  
Lucy Massey ◽  
Alex Rider ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Targeted Therapies ◽  
Small Sample Size ◽  
The United States ◽  
Small Sample ◽  
Access To Treatment ◽  
History Of ◽  
Biomarker Testing ◽  
Abstract Data ◽  
The Impact

10598 Background: African Americans (AA) have the highest breast cancer (BC) mortality rate. Access to treatment is a known contributing factor. In the past 4 years, several targeted therapies for HER2- BC have become available which require testing for specific biomarkers. This study assessed the impact of race on biomarker testing rates in HER2- ABC pts receiving treatment in the US. Methods: Oncologists were recruited to abstract data from medical charts for the next 8-10 pts receiving treatment with HER2- ABC during Sept 2019-Apr 2020. Pts records were stratified by race and categorized into 3 mutually exclusive cohorts [White/Caucasian (White), AA, Other]. The other race cohort was excluded from this analysis due to small sample size. Differences in pt demographics/clinical characteristics were analyzed via Fisher’s exact tests. Testing rates for actionable biomarkers (i.e. BRCA1/2, PIK3CA, PD-L1) were compared between White and AA pts utilizing logistic regressions controlling for age, known family history of a BRCA-related cancer, hormone receptor (HR) status and practice setting (academic vs. community). Further analyses by age will be presented. Results: This analysis included 378 pts records, provided by 40 oncologists. Mean age was 64 years; 77% had HR+/HER2- ABC; 20% had advanced triple negative breast cancer (TNBC), 3% had ABC with an unknown HR status. Compared to White pts, AA pts were significantly more likely to have advanced TNBC (27% vs. 18%, p<0.05). Compared to White pts, AA pts had significantly lower BRCA1/2 mutation (mut) testing rates (Table). Numerically lower rates of PIK3CAmut and PD-L1 testing were observed among AA pts (Table). BRCA1/2mut positivity rate (germline [g] and/or somatic [s]) was higher among AA vs. White pts (30% vs. 22%). Positivity rate for PIK3CAmut was lower for AA vs. White pts (8% vs. 11%). Conclusions: A higher than expected BRCA1/2mut positivity rate was observed than previously reported in the literature. This is likely because this analysis included s BRCA1/2mut and represented a high risk pt population. Across all biomarkers assessed, AA pts had lower testing rates than White pts. This suggests racial disparities in testing rates of actionable biomarkers. Consistent with guidelines, and with the increased availability of targeted therapies, focused efforts should be developed to increase biomarker testing in AA pts. Funding: Pfizer Biomarker Testing Rates by Race.[Table: see text]

ID: 76: AVOIDING TRANSTHORACIC ECHOCARDIOGRAPHY (TTE) AND TRANSESOPHAGEAL ECHOCARDIOGRAPHY (TEE) FOR PATIENTS WITH VARIABLE BODY MASS INDEXES (BMI) IN INFECTIVE ENDOCARDITIS

2016 ◽  
Vol 64 (4) ◽  
pp. 916.3-917
Author(s):  
R Sogomonian ◽  
H Alkhawam ◽  
N Vyas ◽  
J Jolly ◽  
A Ashraf ◽  
...  
Keyword(s):  
Infective Endocarditis ◽  
Transesophageal Echocardiography ◽  
Body Mass ◽  
Sensitivity And Specificity ◽  
Transthoracic Echocardiography ◽  
Small Sample Size ◽  
The United States ◽  
Small Sample ◽  
Blood Cultures ◽  
True Negative

BackgroundEchocardiography has been a popular modality used to aid in the diagnosis of infective endocarditis (IE) with the modified Dukes' criteria. We evaluated the necessity between the uses of either a transthoracic echocardiography (TTE) or transesophageal echocardiography (TEE) in patients with a body mass index (BMI) greater than or equal to 25 kg/m2 and less than 25.MethodsA single-centered, retrospective study of 198 patients between the years of 2005 and 2012 diagnosed with IE based on modified Dukes' criteria. Patients were required to be above the age of 18, undergone an echocardiogram study and had blood cultures to be included in the study.This study was conducted at a major hospital in one of the most diverse communities in the United States, providing a cultural and epidemiologically significant advantage. An approved chart analysis using QuadraMed Computerized Patient Record (QCPR) was retrospectively accessed with data-input and calculations formulated in computerized software.ResultsAmong 198 patients, two echocardiographic groups were evaluated as 158 patients obtained a TTE, 143 obtained a TEE, and 103 overlapped with TEE and TTE. 167 patients were included in the study as 109 (65%) were discovered to have native valve vegetations on TEE and 58 (35%) with TTE. TTE findings were compared to TEE results for true negative and positives to isolate valvular vegetations Overall sensitivity of TTE was calculated to be 67% with a specificity of 93%. Patients were further divided into two groups with the first group having a BMI less than or equal to 25 kg/m2 and the subsequent group with a BMI<25. Patients with a BMI less than or equal to 25 that underwent a TTE study had a sensitivity and specificity of 54% and 92, respectively. On the contrary, patients with a BMI<25 had a TTE sensitivity and specificity of 78% and 95, respectively. Furthermore, we obtained the sensitivities of specific valves diseased from vegetations, visualized by TTE (figure 1). Lastly, we were able to demonstrate a correlation between the different modalities of echocardiography used to the specific organism identified on blood cultures (figure 2).ConclusionCalculating a BMI in patients with suspicion for IE may provide benefit in reducing further diagnostic imaging. Our study demonstrated that patients having a BMI <25 kg/m2 with a negative TTE should refrain from further diagnostic studies with TEE, given the findings of increased sensitivities (figure 3). Patients with a BMI less than or equal to 25 may proceed directly to a TEE, possibly avoiding an additional study with a TTE given the low sensitivities identified in this population. Clinicians should be aware that this study has several limitations, one of which a small sample size that may be increased with a multi-centered study. Further investigations with a larger population may improve and possibly provide similar findings, reinforcing the study.

Subgroup analysis of patients enrolled in the United States in the CORRECT phase 3 trial of the multikinase inhibitor regorafenib (REG) in metastatic colorectal cancer (mCRC).

2015 ◽  
Vol 33 (3_suppl) ◽  
pp. 767-767
Author(s):  
Heinz-Josef Lenz ◽  
Eric Van Cutsem ◽  
Udit N. Verma ◽  
Marc Saltzman ◽  
Jyotsna Fuloria ◽  
...  
Keyword(s):  
Subgroup Analysis ◽  
Small Sample Size ◽  
The United States ◽  
Small Sample ◽  
Wild Type ◽  
Correct Trial ◽  
Multikinase Inhibitor ◽  
Kras Status ◽  
The Us ◽  
Dose Modifications

767 Background: The CORRECT trial (NCT01103323) showed that REG improves overall survival (OS) vs placebo (PBO) in patients with mCRC who failed approved therapies (OS HR 0.77; 1-sided p=0.0052; Grothey 2013). A total of 760 patients were randomized to REG (n=505) or PBO (n=255) in more than 100 centers across North America, Europe, Asia, and Australia. We conducted a post-hoc exploratory subgroup analysis of the 83 (11%) patients from 18 US centers. Methods: Eligible patients had an ECOG PS ≤1 and had received approved therapies, including a fluoropyrimidine, oxaliplatin, irinotecan, and bevacizumab, and if KRAS wild-type cetuximab and/or panitumumab. Data from the overall cohort, including US patients, are provided for perspective. Descriptive statistics are shown. Results: Of the 83 US patients, 36 (43%) were randomized to PBO and 47 (57%) to REG. Baseline characteristics of the US group were consistent with the overall cohort: median age in the US was 58 yr (range, 34 – 85) vs 61 (22 – 85) overall, 49% of US patients were ECOG PS1 (vs 46%), and 46% received ≤ 3 treatments for mCRC (vs 52%). KRAS status mutant/wild-type was 57%/34% in the US vs 57%/39% overall. All patients in the trial had prior bevacizumab and 57% of US patients also had prior cetuximab and/or panitumumab (vs 51% overall). However, higher proportion of patients in the US were Black (11% vs 2%), KRAS status unknown (10% vs 4%), and had colon as the primary disease site (82% vs 65%). Mean percentages of planned REG dose were similar (76% US vs 79% overall) and mean REG treatment duration was 3.1 mos in US vs 2.8 mos overall. Rates of dose modifications REG/PBO were 87%/47% in the US vs 76%/38% overall and grade ≥3 adverse events REG/PBO were 74%/64% vs 78%/49%, respectively. Based on 44 total death events, the HR for OS in the US subgroup was 0.46 (95%CI 0.25 – 0.84) favoring REG; median OS was 4.7 mos for PBO, but could not be estimated for REG due to censored data. However, this analysis was based on a relatively small sample size and event count. Conclusions: Patients treated in the CORRECT study in the US appear similar to the overall cohort and results are generally consistent with the overall findings of the trial. Clinical trial information: NCT01103323.

scholarly journals Family perspective on home visiting program

2015 ◽  
Vol 12 (2) ◽  
pp. 477
Author(s):  
Sebahattin Ziyanak ◽  
Hakan Yagci
Keyword(s):  
Low Income ◽  
Home Visiting ◽  
Small Sample Size ◽  
The United States ◽  
Small Sample ◽  
Major City ◽  
Factor Solution ◽  
Family Perspective ◽  
The Family ◽  
Home Visiting Program

<p>This study focused on a lately constructed survey instrument that was intended to test the family perspective on a home visiting program and school. The four areas investigated were parent-teacher communications, student-teacher interactions, the parent’s perception of the school and the parents’ understanding of the home visiting program. The participants were selected from parents/guardians of 7th, 8th, 9th and 10th grade students at a Charter school in a southwestern major city in Texas, the United States of America. Twenty-two questions were asked to evaluate parent’s viewpoint with the four designated areas of interaction and communication of among school-parent-teacher. The findings showed that 73.5% of the students’ families living were in low income. The outcomes for reliability were promising (a = .909). Yet, the factor analysis outcomes of a rotated four-factor solution were insufficient to assess validity. This might be related to a small sample size (n = 45).</p>

scholarly journals Head-Down Tilt Bed Rest Studies as a Terrestrial Analog for Spaceflight Associated Neuro-Ocular Syndrome

2021 ◽  
Vol 12 ◽  
Author(s):  
Joshua Ong ◽  
Andrew G. Lee ◽  
Heather E. Moss
Keyword(s):  
United States ◽  
Experimental Model ◽  
Space Flight ◽  
Visual Loss ◽  
Small Sample Size ◽  
Bed Rest ◽  
The United States ◽  
Small Sample ◽  
Preventative Measures ◽  
Ocular Changes

Astronauts who undergo prolonged periods of spaceflight may develop a unique constellation of neuro-ocular findings termed Spaceflight Associated Neuro-Ocular Syndrome (SANS). SANS is a disorder that is unique to spaceflight and has no terrestrial equivalent. The prevalence of SANS increases with increasing spaceflight duration and although there have been residual, structural, ocular changes noted, no irreversible or permanent visual loss has occurred after SANS, with the longest spaceflight to date being 14 months. These microgravity-induced findings are being actively investigated by the United States' National Aeronautics Space Administration (NASA) and SANS is a potential obstacle to future longer duration, manned, deep space flight missions. The pathophysiology of SANS remains incompletely understood but continues to be a subject of intense study by NASA and others. The study of SANS is of course partially limited by the small sample size of humans undergoing spaceflight. Therefore, identifying a terrestrial experimental model of SANS is imperative to facilitate its study and for testing of preventative measures and treatments. Head-down tilt bed rest (HDTBR) on Earth has emerged as one promising possibility. In this paper, we review the HDTBR as an analog for SANS pathogenesis; the clinical and imaging overlap between SANS and HDTBR studies; and potential SANS countermeasures that have been or could be tested with HDTBR.

Real-World Treatment Patterns and Outcomes of Proteasome Inhibitor (PI: Bortezomib [V], Carfilzomib [K], or Ixazomib [I])-Lenalidomide/Dexamethasone (Rd)-Triplets By Prior Lenalidomide-Exposure in Patients with Relapsed/Refractory Multiple Myeloma (RRMM) Engaged in Routine Care in the United States (US)

Blood ◽  
2020 ◽  
Vol 136 (Supplement 1) ◽  
pp. 47-48
Author(s):  
Larysa Sanchez ◽  
Dasha Cherepanov ◽  
Dorothy Romanus ◽  
Aditya Raju ◽  
Marlo Blazer ◽  
...  
Keyword(s):  
High Risk ◽  
Real World ◽  
Research Funding ◽  
Small Sample Size ◽  
The United States ◽  
Treatment Patterns ◽  
Small Sample ◽  
Prior Exposure ◽  
Bone Lesions ◽  
Front Line

BACKGROUND: PIs combined with an Rd backbone are the most commonly used triplet combination regimens in patients (pts) with RRMM in the US. The hallmark trials supporting the efficacy of these regimens were predominantly in pts without prior exposure to lenalidomide (R).1,2 Real-world analyses have shown that R-based regimens are increasingly used in the front-line setting.3-5 Thus, real-world treatment patterns in pts with prior R exposure and the real-world comparative effectiveness of PI-Rd triplets in this population with RRMM needs further elucidation. METHODS: A retrospective cohort of RRMM pts initiating IRd, KRd, or VRd in line of therapy (LOT) ≥2 were followed between 7/2007-9/2018 in Optum's deidentified national electronic health records database. RRMM pts were defined as those initiating LOT ≥2 between 1/2014 and 9/2018 and were categorized as having or not having prior exposure to R (R-exposed; no-prior-R) in any prior LOT. Index regimen was the first use of I-/K-/or V-Rd. LOTs were defined via an algorithm developed with MM specialists to proxy the definition of a LOT in RCTs & in accordance with NCCN MM Guidelines.6 Baseline data included: CRAB (hyperCalcemia, Renal insufficiency, Anemia, and Bone lesions); high risk cytogenetics (defined as del[17p], 1q21 gain, t[4;14], or t[14;16]); Charlson Comorbidity Index (CCI) score; and modified frailty score using age and CCI score. Median duration of therapy (DOT) and time-to-next-treatment (TTNT) (a proxy for PFS; defined as time from index regimen start to subsequent LOT or death) were estimated using Kaplan-Meier methods and compared using covariate-adjusted Cox proportional hazard models (FIGURE). Observations were censored at time of loss to follow-up (f/u)/end of study period (9/30/2018). RESULTS: Of 650 pts included, 397 were R-exposed (IRd, n=112; KRd, n=115; VRd, n=170); 253 had no-prior-R (IRd, n=29; KRd, n=62; VRd, n=162). R-exposed pts, overall, were treated in later LOTs (LOT2: 55% v 78%) and had a longer median time from diagnosis to index LOT (26.7 v 13.4 months) than no-prior-R pts; this differed between treatment cohorts (TABLE). In R-exposed pts, more pts with symptomatic relapse (≥1 CRAB symptom, 87%) or high-risk cytogenetics (30%) received KRd than IRd (75% & 23%) or VRd (74% & 16%) (TABLE). More pts treated with IRd were ≥75 years old: 42% (IRd) v 36% (VRd) / 21% (KRd). In R-exposed pts, 35.3% of those receiving VRd in LOT ≥2 had prior V-IMID-based and 53.5% had IMID-based therapy (ie, IMID with no PI nor monoclonal antibody) in LOT1; &gt;98% of LOT1 IMID use was R, across groups. In R-exposed pts, 56.5% of those receiving KRd had prior V-IMID-based and 16.5% had IMID-based therapy in LOT1; in IRd pts in LOT ≥2, 29.5% and 43.8% had prior V-IMID-based and IMID-based therapy in LOT1. In unadjusted analysis, at a median f/u of 11, 11.9, and 14.8 months for I-, K-, and V-Rd, median TTNT for R-exposed pts: 12.3 months (IRd), 7.8 months (KRd), and 13.9 months (VRd) (P=0.50); HRs for TTNTLOT stratified: 0.84 (IRd v KRd), 0.96 (IRd v VRd), 1.15 (KRd v VRd), and median regimen DOTs: 8.4 months (IRd), 7.5 months (KRd), and 9.5 months (VRd) (P=0.75). In no-prior-R pts, HRs for TTNTLOT stratified were significant for IRd v KRd (HR=0.33) and KRd v VRd (HR=1.62) (P&lt;0.01, both); IRd v VRd (HR=0.53; P=0.11). In adjusted analysis, there were no significant differences for R-exposed pts by PI-Rd regimens for TTNT (FIGURE), nor for regimen DOT. For no-prior-R pts, adjusted HR for TTNT was significant for I- v K-Rd (HR=0.36; P=0.03) and for regimen DOT was significant for I- v V-Rd (HR=0.34; P=0.03). CONCLUSIONS: In this real-world study, the majority of pts received a PI-Rd combination after prior VRd or Rd in front-line. After controlling for baseline characteristics, including prior PI-exposure, PI-Rd triplets were comparable in TTNT in R-exposed pts treated in LOTs ≥2. TTNT was significantly longer for I- v K-Rd in pts with no-prior-R, although this is limited by small sample size. Published studies indicate that individualized treatment recommendations may improve real-world outcomes, such as IRd v KRd in frail pts which was associated with significantly longer TTNT.6 Prior-R exposure, in our analysis, does not appear to influence the relative PI-triplet regimen effectiveness in LOTs ≥2. With increasing use of R in earlier LOTs, understanding real-world treatment patterns and subsequent PI-Rd effectiveness in consequent LOTs is key for optimizing RRMM pt management. Disclosures Cherepanov: Millennium Pharmaceuticals, Inc., a wholly owned subsidiary of Takeda Pharmaceutical Company Limited: Current Employment. Romanus:Takeda: Current Employment. Raju:Xcenda: Current Employment, Other: Xcenda received research funding from Takeda. Blazer:Xcenda: Current Employment, Other: Xcenda received research funding from Takeda. Farrelly:Xcenda: Current Employment, Other: Xcenda received research funding from Takeda. Stull:Takeda: Current Employment. Ailawadhi:Phosplatin: Research Funding; Celgene: Honoraria; Amgen: Research Funding; Takeda: Honoraria; Janssen: Research Funding; Pharmacyclics: Research Funding; Cellectar: Research Funding; BMS: Research Funding; Medimmune: Research Funding.

Industrial and Agricultural Chemicals

PEDIATRICS ◽  
1974 ◽  
Vol 53 (5) ◽  
pp. 843-844
Author(s):  
S. Hope Sandifer
Keyword(s):  
South Carolina ◽  
Environmental Protection Agency ◽  
Small Sample Size ◽  
The United States ◽  
Small Sample ◽  
Adult Males ◽  
Community Studies ◽  
Water Supplies ◽  
Intermittent Exposure ◽  
High Concentrations

The alert practitioner should know the types of pollution created by agriculture and industry in his area. In agriculture, two important pollutants are nitrates and pesticides (which include insecticides, herbicides, fungicides, rodenticides, and defoliants). Pediatricians are well aware of methemoglobmnemia due to excessive nitrates in water. Nitrates in water supplies are of increasing concern because of runoff from feed lots and incremental use of fertilizers. Tolerance levels of nitrate in municipal water supplies are established, and pediatricians should insist that these standards be enforced in their community. With regard to pesticides, the Environmental Protection Agency has funded 13 community studies throughout the United States. The purpose is to monitor the health of pesticide workers compared with suitable controls. To date no significant health effects have been demonstrated. Most studies have been made on adult males because of their occupational exposure to pesticides. The groups under surveillance include workers who manufacture pesticides, pest-control operators who spray daily, and farmers who have intermittent exposure to high concentrations of pesticides. We are seeking the effects, if any, in the most heavily exposed persons before trying to determine the effects of smaller doses. This approach suffers the problem of small sample size (several thousand instead of hundreds of thousands of exposed persons). Our studies and those of others have shown that DDT in the sera of blacks is about two to three times that of whites.1-3 We had assumed that this difference was due to environmental exposure, but recent studies in Charleston, South Carolina, have suggested a genetic factor.

Abstract P113: Lipid-related Genetic Variants and Lipid Outcomes in a Cohort of Chilean Children

Circulation ◽  
2017 ◽  
Vol 135 (suppl_1) ◽  
Author(s):  
Ann Von Holle ◽  
Anne Justice ◽  
Kari E North ◽  
Bárbara Angel ◽  
Estela Blanco ◽  
...  
Keyword(s):  
Genetic Variants ◽  
Genetic Model ◽  
Small Sample Size ◽  
A Priori ◽  
Density Lipoprotein ◽  
The United States ◽  
Small Sample ◽  
Lipoprotein Cholesterol ◽  
Risk Scores ◽  
Lipid Levels

Dyslipidemia is an important risk factor for chronic cardiometabolic diseases. Lipid traits are highly heritable and there are currently >185 established loci influencing lipid levels in adults. Recent studies have confirmed that variants associated with lipids influence lipid levels across the lifecourse, and in ancestrally diverse populations. Given that Hispanic/Latinos (HL) shoulder much of the cardiometabolic burden in the United States, it is important to identify genetic variants that contribute the greatest risk for elevated lipid levels across life stages. Thus, our primary aim is to examine the association of known lipid variants with lipid traits identified in large study of adult participants from a Chilean infancy cohort of primarily European-descent. The sample assessed from 2008 to 2013 (n=546) had genotyping and well-measured lipid phenotypes (median age: 16.8 years, interquartile range: 16.6, 16.9). We assessed single variant associations using linear regression for high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C) and triglycerides (TG), assuming an additive genetic model, adjusted for sex. Additionally, we regressed phenotypes onto weighted trait-specific polygenic risk scores (PRS). Only six variants from the Chilean sample met the a priori threshold of power > 0.8. We found statistically significant effect sizes (mmol/l (se)) for four of the six variants: rs3764261 (0.16 (0.04)) and rs1532085 (0.05 (0.04)) for HDL and rs1260326 (0.34 (0.15)) and rs964184 (0.33 (0.15)) for TG. For each significant variant, direction of effect matched the multiethnic adult GWAS from which SNPs were selected. We compared our findings to a previous study in Finnish children at age 18 years (n=1,216) and found an opposite direction of effect for our significant HDL variants. Likewise, when comparing coefficients for the PRS between the Chilean and Finnish youth sample we found the association to be stronger in the Chilean sample for every trait and gender group with the exception of LDL for males. The lipid loci explained the least amount of total variance for LDL (males=4% and females=5%) and the most amount of variance for HDL (males=20% and females=14%). In conclusion, there is evidence that lipid loci from a HL sample of adolescents contain similar associations as those from European children and adults. Despite the small sample size and possibility for bias with different ancestral groups we found meaningful and statistically significant associations relating lipid loci in a HL cohort of Chilean adolescents with those found in European ancestral groups. These associations emphasize the importance of adolescence as a time for disease prevention given studies demonstrating both the persistence of associations between PRS and lipids over the life course and the increasing role PRS plays in predicting disease.

Sign in / Sign up

Export Citation Format

Share Document