scholarly journals ANTIBIOTIC- ASSOCIATED RISK THE REDUCTION OF LACTOBACILLUS SPP. IN THE INTESTINAL MICROBIOTA IN PATIENTS WITH URINARY TRACT INFECTIONS

2017 ◽  
pp. 23-26
Author(s):  
N. Stepanova ◽  
N. Stashevska ◽  
L. Lebid ◽  
S. Savchenko ◽  
M. Kolesnyk
Keyword(s):  
Urinary Tract ◽  
Gut Microbiota ◽  
Medicinal Products ◽  
Colony Forming Units ◽  
Normal Composition ◽  
The Mean ◽  
Tract Infections ◽  
Urinary Oxalate Excretion ◽  
Lactobacillus Spp ◽  
Control Study

The aim of our study was to evaluate a risk reduction of indigenous gut microbiota in patients with urinary tract infection (UTI, associated with the intake of antibacterial medicinal products Materials and methods. To this retrospective cohort case-control study were involved 233 women with UTI. The mean age in the patient population was 36.7 ± 15.6 years. Cases were defined as reducing the number of Lactobacillus spp. < 10 million colony forming units in 1 g offeces (mln. CFU/g). We evaluated the daily urinary oxalate excretion and bacteriological seeding feces. Investigational antibiotics were medicines which are generally used to treat the outpatient with UTI. Results. The data analysis demonstrated an extremely high risk the reducing of Lactobacillus spp. colonization in the patient’s intestine. The use of ciprofloxacin was significantly associated with an availability of hyperoxaluria ( = 0.31, p = 0.008). Conclusions. Thus, the use of antibacterial medicinal products, even in prophylactic doses, by the patients with UTI leads to the destruction of the normal composition of gut microbiota, and, primarily, due to the fact that the content of Lactobacillus spp. is deceased.

scholarly journals Vitamin D Status and Its Role in First-Time and Recurrent Urinary Tract Infections in Children: A Case-Control Study

Children ◽  
2021 ◽  
Vol 8 (5) ◽  
pp. 419
Author(s):  
Carmen Muntean ◽  
Maria Săsăran
Keyword(s):  
Vitamin D ◽  
Urinary Tract ◽  
Case Control Study ◽  
Case Control ◽  
Study Group ◽  
Recurrent Utis ◽  
Vitamin D Levels ◽  
Tract Infections ◽  
First Time ◽  
Control Study

Vitamin D has emerged as a key factor in innate immunity. Its involvement in the pathogenesis of urinary tract infections (UTIs) has gained a lot of attention recently. The objective of this study is to investigate the association between serum 25-hydroxyvitamin D (25(OH)D) levels and first-time or recurrent UTIs in children. A prospective, case-control study was conducted on 101 pediatric patients, who were divided into two groups: 59 patients with UTIs and 42 age-matched healthy controls. Serum 25(OH)D was determined in each child and expressed in ng/mL. Vitamin D presented significantly lower values in study group subjects than in healthy controls (p < 0.01). Moreover, a significantly higher prevalence of vitamin D insufficiency and deficiency was found in children with UTIs (p < 0.01). Patients with recurrent UTIs presented significantly lower levels of vitamin D than those with first-time UTIs (p = 0.04). Urinary tract abnormalities did not seem to exercise an additional effect upon vitamin D levels within the study group. In conclusion, first-time and recurrent UTIs are associated with lower vitamin D levels. Further studies are necessary to validate our findings, as well as future longitudinal research regarding efficacy of vitamin D supplementation in children with UTIs.

scholarly journals Sexual Dysfunction in Young Women with Type 1 Diabetes

2020 ◽  
Vol 17 (12) ◽  
pp. 4468
Author(s):  
Edyta Cichocka ◽  
Michał Jagusiewicz ◽  
Janusz Gumprecht
Keyword(s):  
Type 1 Diabetes ◽  
Urinary Tract ◽  
Sexual Function ◽  
Urinary Tract Infections ◽  
Vascular Complications ◽  
Chronic Complications ◽  
Patients With Diabetes ◽  
The Mean ◽  
Tract Infections

Introduction: Sexual dysfunctions (SD) are chronic complications that can develop due to vascular complications or autonomic neuropathy. Additionally, such complications can be of hormonal, infectious or psychogenic etiology. Objectives: The aim of study was to assess the sexual function and acceptance of the chronic disease in young sexually active women with type 1 diabetes (T1DM). Materials and methods: A total of 169 female patients with T1DM completed two standardized questionnaires, the Female Sexual Function Index (FSFI) and the Acceptance of Illness Scale (AIS). Other medical data were collected from medical history. Results: The mean FSFI score was 27.96 ± 5.00, and the mean AIS score was 29.67 ± 8.28. The score < 26 points in FSFI was obtained by 28.7% of patients. Analysis of correlation between the FSFI and the AIS showed that the higher the score on the FSFI, the higher the score on the AIS. Patients who underwent regular physical activity (55%) had a significantly higher acceptance of the disease (p = 0.0026) and reported painful intercourse significantly less frequently (p = 0.01). The value of HbA1c in the study group was 7.31 ± 1.25%. Patients with poorer glycemic control (HbA1c > 8%) obtained significantly lower scores on the FSFI (p = 0.03), whereas no differences were found on the AIS. Diabetes-related complications were observed in 25.5% of patients. The presence of chronic complications did not affect the results of the FSFI or the AIS. Patients with diabetes and hypertension had poorer functioning in the sexual sphere and had significantly lower scores on the FSFI. Past or present history of depression was reported by 36% of patients and also negatively affected acceptance of diabetes (p = 0.0015). Patients who reported recurrent urinary tract infections (17%) achieved significantly lower scores on the FSFI (p = 0.03) and showed that sex-related pain was significantly more prevalent (p = 0.02). In the case of the statement related to the embarrassment of people around the patient due to diabetes, patients with lower scores complained of SD significantly more often (p = 0.0033). Past deliveries, the type of labor, the use of contraceptives or the number of sexual partners had no influence on the overall assessment in both scales. However, in terms of desire, women who had delivered obtained higher scores (p = 0.0021). Conclusion: SD in women with T1DM may result from diabetes-related complications, hormonal disorders or recurrent genital or urinary tract infections. However, they usually have a psychological basis due to the lack of acceptance of the problems related to the treatment of diabetes.

Urinary tract infections and risk of squamous cell carcinoma bladder cancer: A Danish nationwide case–control study

2020 ◽  
Vol 146 (7) ◽  
pp. 1930-1936 ◽  
Author(s):  
Anton Pottegård ◽  
Kasper B. Kristensen ◽  
Søren Friis ◽  
Jesper Hallas ◽  
Jørgen B. Jensen ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Bladder Cancer ◽  
Urinary Tract ◽  
Cell Carcinoma ◽  
Urinary Tract Infections ◽  
Squamous Cell ◽  
Case Control Study ◽  
Case Control ◽  
Tract Infections ◽  
Control Study

scholarly journals Six Out of Ten Women with Recurrent Urinary Tract Infections Complain of Distressful Sexual Dysfunction – A Case-Control Study

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Luca Boeri ◽  
Paolo Capogrosso ◽  
Eugenio Ventimiglia ◽  
Roberta Scano ◽  
Alessandra Graziottin ◽  
...  
Keyword(s):  
Urinary Tract ◽  
Sexual Dysfunction ◽  
Urinary Tract Infections ◽  
Case Control Study ◽  
Case Control ◽  
Recurrent Urinary Tract Infections ◽  
Tract Infections ◽  
Control Study

A Randomized, Double-Blind, Parallel-Group, Multicenter Clinical Study of Escherichia coli-Lyophilized Lysate for the Prophylaxis of Recurrent Uncomplicated Urinary Tract Infections

2015 ◽  
Vol 95 (2) ◽  
pp. 167-176 ◽  
Author(s):  
Florian M.E. Wagenlehner ◽  
Stefania Ballarini ◽  
Adrian Pilatz ◽  
Wolfgang Weidner ◽  
Lorenz Lehr ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Urinary Tract ◽  
Urinary Tract Infections ◽  
Double Blind ◽  
Period 2 ◽  
Parallel Group ◽  
The Mean ◽  
Tract Infections ◽  
Observation Period ◽  
Observation Results

Background: One strategy for managing recurrent uncomplicated urinary tract infections (UTIs) is prevention. This study tested OM-89S, a lyophilized lysate of 18 Escherichia coli strains manufactured using a modified lytic process. Methods: This was a randomized, double-blind trial in 451 female subjects with recurrent uncomplicated UTIs. Period 1 of the study tested 6 mg of OM-89S versus placebo (3 months), plus a 3-month observation. Period 2 of the study was a 3-month treatment period (each monthly cycle consisted of 6 mg of OM-89S daily for 10 days and placebo for 20 days, vs. 50 mg nitrofurantoin daily for 30 days), plus a 3-month observation. Results: There was no difference in the mean rate of UTI episodes between the OM-89S (0.66 ± 0.93) and placebo groups (0.63 ± 0.86; p = 0.95) in period 1. Similar findings were obtained for period 2. OM-89S was well-tolerated. Conclusions: Our results did not demonstrate a preventive effect of OM-89S compared to placebo. This may be due to the low number of UTIs that occurred during the study, the high number of protocol violations, and/or the modified manufacturing process used for OM-89S.

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