scholarly journals A Smart Approach for Food Contaminants Risk Management, Complementary to Diet Nutritional Balance

2021 ◽  
pp. 1-7
Author(s):  
Monia Renzi ◽  
Cristiana Guerranti ◽  
Eleonora Bertacchini ◽  
Stefano Maccanico ◽  
Eleonora Grazioli ◽  
...  
Keyword(s):  
Heavy Metals ◽  
Mediterranean Diet ◽  
High Protein Diet ◽  
Important Food ◽  
Food Contaminants ◽  
Synthetic Compounds ◽  
Low Levels ◽  
The One ◽  
Personalized Risk Assessment ◽  
Personalized Risk

Food is usually the major source of human exposure to environmental contaminants like heavy metals and synthetic compounds. This study proposes a quick and simple approach to combine the estimate of the intake of certain pollutants with the diet, in combination with different nutritional plans (Mediterranean diet, weight loss and for athletes). The estimation of the intake of three heavy metals and two perfluoroalkyl substances was carried out by entering the type and quantity of the foods provided by each of the three selected dietary plans in the UltraBio® app. Recurring elements are high levels of Cd and Pb and very low levels of PFASs, for all the plans considered. The Mediterranean diet scheme was the one with the lowest intake of all contaminants, which, in any case, remains within the safety limits by a large margin. The high protein diet leads to exceeding the limits for two metals and critical values for the third. The advantages of this approach are mainly represented by the possibility of having a personalized risk assessment of the intake of important food contaminants for the prevention of exposures that, over time, could put health at risk.

scholarly journals Testing Todd: family types and development

2021 ◽  
pp. 1-18
Author(s):  
Jerg Gutmann ◽  
Stefan Voigt
Keyword(s):  
Rule Of Law ◽  
Civil Society Organizations ◽  
The Rule Of Law ◽  
State Fragility ◽  
Family Types ◽  
Low Levels ◽  
Parsimonious Model ◽  
The One ◽  
High Level

Abstract Many years ago, Emmanuel Todd came up with a classification of family types and argued that the historically prevalent family types in a society have important consequences for its economic, political, and social development. Here, we evaluate Todd's most important predictions empirically. Relying on a parsimonious model with exogenous covariates, we find mixed results. On the one hand, authoritarian family types are, in stark contrast to Todd's predictions, associated with increased levels of the rule of law and innovation. On the other hand, and in line with Todd's expectations, communitarian family types are linked to racism, low levels of the rule of law, and late industrialization. Countries in which endogamy is frequently practiced also display an expectedly high level of state fragility and weak civil society organizations.

INHERITED FACTOR-VII DEFECT IN A NEGRO FAMILY

PEDIATRICS ◽  
1961 ◽  
Vol 27 (2) ◽  
pp. 204-213
Author(s):  
Helen I. Glueck ◽  
James M. Sutherland
Keyword(s):  
Prothrombin Time ◽  
Factor Vii ◽  
Homozygous State ◽  
Control Value ◽  
One Stage ◽  
First Case ◽  
Severe Deficiency ◽  
Low Levels ◽  
The Difference ◽  
The One

A case of factor-VII deficiency of a congenital nature in a Negro male child has been reported. As far as can be determined, this is the first case reported in this race. The defect was detected at 6 hours of age. Prothrombin, as contrasted to factor VII, after initially low levels normally found in infants, rose to adult levels. The patient's one-stage prothrombin time has ranged between 25 to 35 second (normal 11 to 12 seconds). In spite of this, he has never shown any manifestations of hemorrhage. The patient's family was studied and the findings indicate that the patient's defect represented a homozygous state and that both parents with a less severe deficiency were heterozygous for the trait. The defect is an autosomal disorder directly inherited. It is clinically apparent and easily detected only in the homozygous state. The heterozygous state is characterized by a very slight prolongation of the one-stage prothrombin time, the difference from the control value being so minimal as to be overlooked. In one subject studied, an aunt of the propositus, the quantitative defect (42% of normal) could not be regularly detected by the usual methods. Only by using the plasma of the propositus as the test plasma, was the defect in her plasma detected, thus explaining the transmission of the trait to her offspring. These findings explain the difficulties previously encountered in understanding the inheritance of the disorder.

Abstract P016: Metabolites of Glutamate Metabolism are Associated with Incident Cardiovascular Events in the Predimed (“Prevencion Con Dieta Mediterranea”) Trial

Circulation ◽  
2016 ◽  
Vol 133 (suppl_1) ◽  
Author(s):  
Yan Zheng ◽  
Frank B Hu ◽  
Miguel Ruiz-Canela ◽  
Clary Clish ◽  
Courtney Dennis ◽  
...  
Keyword(s):  
Mediterranean Diet ◽  
Control Diet ◽  
Glutamate Metabolism ◽  
Limited Evidence ◽  
Cvd Risk ◽  
Increased Risk ◽  
Cardiometabolic Disorders ◽  
Low Levels ◽  
Fatal Myocardial Infarction

Background: Glutamate metabolism may play a role in the pathophysiology of cardiometabolic disorders. However, there is limited evidence on the association between glutamate-related metabolites and, moreover, changes in these metabolites, and risk of cardiovascular disease (CVD). Methods and Results: Plasma levels of glutamate and glutamine were measured at baseline and 1-year follow-up in a case-cohort study including 980 participants (mean age: 67 years; 46% male) from the PREDIMED randomized trial, which assessed a Mediterranean diet intervention in the primary prevention of CVD. During median 4.8 years of follow-up, there were 229 incident CVD events (non-fatal stroke, non-fatal myocardial infarction, or CVD death). In fully-adjusted models, per 1-SD, baseline glutamate was associated with 43% (95% CI: 16-76%) and 81% (39-137%) increased risk of composite CVD and stroke alone, respectively, and baseline glutamine-to-glutamate ratio with 25% (6-40%) and 44% (25-58%) decreased risk of composite CVD and stroke alone, respectively. Associations appeared linear for stroke (both Plinear trend≤0.005). Among participants with high baseline glutamate, the interventions lowered CVD risk by 37% compared to the control diet; the intervention effects were not significant when baseline glutamate was low (Pinteraction=0.02). No significant effect of the intervention on year-1 changes in metabolites was observed, and no effect of changes themselves on CVD risk was apparent. Conclusions: Baseline glutamate was associated with increased CVD risk, particularly stroke, and glutamine-to-glutamate ratio was associated with decreased risk. Participants with high glutamate levels may obtain greater benefits from the Mediterranean diet than those with low levels.

Does Lead at Low Dose Affect Intelligence in Children?

PEDIATRICS ◽  
1981 ◽  
Vol 68 (6) ◽  
pp. 894-896
Author(s):  
Herbert L. Needleman ◽  
David Bellinger ◽  
Alan Leviton
Keyword(s):  
Adverse Effects ◽  
Low Dose ◽  
Intelligence Test ◽  
Pediatric Clinic ◽  
Study Find ◽  
Group Data ◽  
Low Levels ◽  
The One ◽  
The Individual

Ernhart et al, on the basis of their own follow-up data and an incorrect critique of a single study, find reason to question the entire literature documenting the adverse effects of low levels of lead. They assert that, if effects exist, they are minimal. To reach this sweeping conclusion, they contradict or ignore the findings of the earlier study by Perino and Ernhart, misread a table from the one study they single out for criticism, and draw debatable conclusions from their own data. We conclude by calling the readers' attention to this sentence: "While the effects of subclinical lead intoxication may not be noted in the individual cases seen in a pediatric clinic, analysis of group data indicate quite clearly (emphasis added) that performance on an intelligence test is impaired."

scholarly journals Sleep deprivation undermines the link between identity and intergroup bias

SLEEP ◽  
2019 ◽  
Author(s):  
Jinxiao Zhang ◽  
Yang Yang ◽  
Ying-Yi Hong
Keyword(s):  
Sleep Deprivation ◽  
Sleep Time ◽  
Intergroup Bias ◽  
Sleep Study ◽  
Global Context ◽  
Low Levels ◽  
Common Identity ◽  
Common Ingroup Identity ◽  
The One ◽  
Ingroup Identity

Abstract This research seeks to bridge two findings—on the one hand, top-down controlled processes inhibit display of intergroup bias; on the other one hand, sleep deprivation impairs cognitive control processes. Connecting these two proven statements, begs the question: would sleep deprivation also influence intergroup bias? This intriguing link has hardly been explored in extant literature. To fill this gap, we theorize through the lens of social identity. Previous research has shown that individuals who share a common identity with an outgroup are more motivated to inhibit biases toward the outgroup than do their counterparts who do not endorse such common identity. We predicted that this motivated inhibition would be compromised by sleep deprivation. Across two studies, as predicted, we found that only when an individual has adequate sleep did common ingroup identity attenuate the display of intergroup bias, whereas individuals with short habitual sleep (study 1) or after one-night sleep deprivation (study 2) displayed equally high levels of intergroup bias regardless of their high or low levels of common ingroup identity. In the global context of incessant intergroup bias and diminishing sleep time, our findings offer new insights for understanding and handling intergroup bias.

Determination of Heavy Metals in Wheat and Barley Grains Using ICP-MS/MS

2020 ◽  
Vol 103 (5) ◽  
pp. 1277-1281
Author(s):  
Tamer M A M Thabit ◽  
Shokr Abdelsalam Shokr ◽  
Dalia I H Elgeddawy ◽  
Medhat A H El-Naggar
Keyword(s):  
Heavy Metals ◽  
Acid Digestion ◽  
Validation And Verification ◽  
European Origin ◽  
Three Samples ◽  
Icp Ms ◽  
Two Samples ◽  
Low Levels ◽  
Barley Grains

Abstract Wheat and barley grains are two of the most important nutritional grains for humans and animals and they play an essential role in the nutritional cycle by different ratios according to people's nutritional habits. This work aimed to monitor ten of the most important heavy metals in some European-origin wheat and barley grains during the season of 2018. The measured elements, Al, As, Cd, Co, Cr, Hg, Mo, Ni, Pb, and V, are of importance ecologically and biologically and may be involved in many health disorders affecting the human body. Moisture, protein, and specific grain weights were checked. Samples were digested using microwave acid digestion and the elements measured with ICP-MS/MS in He mode to increase sensitivity, lower the background, and avoid interference. Method validation and verification were carried out through spiking at two levels (2.0 and 10 ppb), then RSD, LOD, and LOQ were calculated. Recoveries were >97% for all elements at both levels with an RSD of <7.6%. Results revealed that As, Cd, Hg, and Pb were not detected in most wheat and barley samples, whereas Cd was detected in one sample of Ukrainian wheat and two samples of Estonian barley (but in very small traces). Pb was detected in three samples of Polish wheat (in very small traces). Al, Mo, and Ni were detected in some samples of wheat and barley of all origins, whereas other elements were at very low levels considered to be negligible concentrations.

Ancestry‐specific hereditary cancer panel yields: Moving toward more personalized risk assessment

2020 ◽  
Vol 29 (4) ◽  
pp. 598-606
Author(s):  
Maegan E. Roberts ◽  
Lisa R. Susswein ◽  
Wanchun Janice Cheng ◽  
Natalie J. Carter ◽  
Amber C. Carter ◽  
...  
Keyword(s):  
Risk Assessment ◽  
Hereditary Cancer ◽  
Personalized Risk Assessment ◽  
Personalized Risk ◽  
Cancer Panel

Environmental Disturbance and Life Histories: Principles and Examples

1979 ◽  
Vol 36 (3) ◽  
pp. 329-334 ◽  
Author(s):  
D. M. Lehmkuhl
Keyword(s):  
Heavy Metals ◽  
Life Histories ◽  
Life Cycles ◽  
Detectable Effect ◽  
Toxic Substances ◽  
Short Term ◽  
Environmental Disturbances ◽  
Temperature Changes ◽  
Low Levels ◽  
Available Information

While many environmental disturbances have no readily detectable effect on aquatic invertebrates in the short term, they may prevent normal reproduction and cause eventual local extinction of a species. Small temperature changes may interfere with diapause signals and prevent completion of the life cycle. Heavy metals and toxic substances may drastically reduce reproduction rates in species exposed to sublethal levels. Dissolved salts and pH affect organisms at abnormally high or low levels but most mechanisms are unknown. It is concluded that relatively little information is available on the effects of environmental disturbances on life cycles. Available information, however, is sufficient to provide evidence of many problems that require attention. Key words: life histories, benthos, environmental disturbances, toxic substances, diapause, temperature, heavy metals

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