scholarly journals Decreased Heart Rate Variability in COVID-19

2021 ◽  
pp. 1-6
Author(s):  
Lei Xu ◽  
Chengfen Yin ◽  
Jianguo Li ◽  
Zhiyong Wang ◽  
Yongle Zhi ◽  
...  
Keyword(s):  
Heart Rate ◽  
Heart Rate Variability ◽  
Sinus Node ◽  
Antiviral Drugs ◽  
Alveolar Epithelial Cells ◽  
World Health ◽  
Alveolar Epithelial ◽  
Preclinical Phase ◽  
Cardiac Autonomic Dysfunction ◽  
Health Organization

On March 12, 2020, the World Health Organization (WHO) announced that the coronavirus disease 2019 (COVID-19) outbreak had become a pandemic. COVID-19 is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which primarily infects the lower airways and binds to Angiotensin-Converting Enzyme 2 (ACE2) on alveolar epithelial cells. ACE2 is widely expressed, not only in the lungs but also in the cardiovascular system. Therefore, SARS-CoV-2 can also damage the myocardium. We analysed three COVID-19 cases that resulted in death and found that either COVID-19 or antiviral drugs could affect the coupling between the autonomic nervous system and the sinus node, thus affecting heart rate variability and preventing the heart rate from rising in response to the increase in body temperature. Early detection of the preclinical phase of cardiac autonomic dysfunction may help determine patients in need of aggressive treatment and control of cardiovascular risk factors. Antiviral drugs should be used with caution in patients with heart injury.

scholarly journals Optimal Length of Heart Rate Variability Data and Forecasting Time for Ventricular Fibrillation Prediction Using Machine Learning

2021 ◽  
Vol 2021 ◽  
pp. 1-5
Author(s):  
Da Un Jeong ◽  
Getu Tadele Taye ◽  
Han-Jeong Hwang ◽  
Ki Moo Lim
Keyword(s):  
Heart Rate ◽  
Heart Rate Variability ◽  
Ventricular Fibrillation ◽  
World Health ◽  
Artificial Neural Network Classifier ◽  
Life Threatening ◽  
Causes Of Mortality ◽  
Health Organization ◽  
Forecast Time ◽  
Data Length

Ventricular fibrillation (VF) is a cardiovascular disease that is one of the major causes of mortality worldwide, according to the World Health Organization. Heart rate variability (HRV) is a biomarker that is used for detecting and predicting life-threatening arrhythmias. Predicting the occurrence of VF in advance is important for saving patients from sudden death. We extracted features from seven HRV data lengths to predict the onset of VF before nine different forecast times and observed the prediction accuracies. By using only five features, an artificial neural network classifier was trained and validated based on 10-fold cross-validation. Maximum prediction accuracies of 88.18% and 88.64% were observed at HRV data lengths of 10 and 20 s, respectively, at a forecast time of 0 s. The worst prediction accuracy was recorded at an HRV data length of 70 s and a forecast time of 80 s. Our results showed that features extracted from HRV signals near the VF onset could yield relatively high VF prediction accuracies.

scholarly journals Endothelial dysfunction and reduced heart rate variability in patients with metabolic syndrome

2018 ◽  
Vol 12 (1) ◽  
pp. 51
Author(s):  
Elena Nikolaevna Smirnova ◽  
Evgeniya Alexandrovna Loran ◽  
Sofia Grigorievna Shulkina ◽  
Sergey Yurievich Podtaev ◽  
Maxim Victorovich Trushin
Keyword(s):  
Metabolic Syndrome ◽  
Heart Rate ◽  
Heart Rate Variability ◽  
Endothelial Dysfunction ◽  
Heart Rhythm ◽  
Developed Countries ◽  
Cold Test ◽  
World Health ◽  
Complex Investigation ◽  
Health Organization

According to experts of the World Health Organization (WHO), metabolic syndrome (MS) can be considered as pandemy of the XXI century, because its prevalence among the population of developed countries is about 25-35%. In this study with the purpose of complex investigation of the autonomic nervous system and endothelial function we included 66 patients with MS between the ages of 25 and 61 (46.9±9.9 years). A comparison group of apparently healthy individuals (16 individuals, average age of 45.3±2.3 years; P>0.05) was studied. To evaluate the response of microvascular tone, we used the method of wavelet analysis of skin temperature oscillations during cooling of the limb. All patients underwent the study of heart rate variability. The levels of insulin, endothelin-1, and vascular endothelial growth factor were determined using enzyme immunoassay. Patients with MS had significant differences in all metabolic parameters. Our study showed that in the group of MS there is a decrease of the variability of heart rhythm compared with the healthy group. Conducting cold test revealed signs of endothelial dysfunction in the MS group, which was manifested by the decrease of the index of vasodilation in the endothelial and neurogenic frequency range. In the study group we determined the increase in biochemical markers of endothelial dysfunction, which correlated with parameters of vasodilation. Also, the presence of endothelial dysfunction significantly correlated with signs of reduction of the variability of the heart rhythm.

scholarly journals Personal exposure to particulate matter and heart rate variability among informal electronic waste workers at Agbogbloshie: a longitudinal study

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Afua A. Amoabeng Nti ◽  
Thomas G. Robins ◽  
John Arko Mensah ◽  
Duah Dwomoh ◽  
Lawrencia Kwarteng ◽  
...  
Keyword(s):  
Heart Rate ◽  
Heart Rate Variability ◽  
Particulate Matter ◽  
Electronic Waste ◽  
Ambient Air ◽  
Repeated Measurements ◽  
Ambient Air Pollution ◽  
Continuous Exposure ◽  
Cardiac Autonomic Dysfunction ◽  
Increased Risk

Abstract Background Informal electronic waste recycling activities are major contributors to ambient air pollution, yet studies assessing the effects or relationship between direct/continuous exposure of informal e-waste workers to particulate matter and cardiovascular function are rare. Methods Repeated measurements of fractions of PM2.5, PM10–2.5, and PM10 in personal air of informal e-waste workers, (n = 142) and a comparable group (n = 65) were taken over a period of 20 months (March 2017 to November, 2018). Concurrently, 5-min resting electrocardiogram was performed on each participant to assess resting heart rate variability indices. Linear mixed-effects models were used to assess the association between PM fractions and cardiac function. Results SDNN, RMSSD, LF, HF and LH/HF ratio were all associated with PM. Significant associations were observed for PM2.5 and Mean NN (p = 0.039), PM10 and SDNN (p = 0.035) and PM 10–2.5 and LH/HF (p = 0.039). A 10 μg/m3 increase in the concentrations of PM 2.5, PM10–2.5, and PM10 in personal air was associated with reduced HRV indices and increased resting HR. A 10 μg/m3 per interquartile (IQR) increase in PM10–2.5 and PM10, decreased SDNN by 11% [(95% CI: − 0.002- 0.000); (p = 0.187)] and 34% [(95% CI: − 0.002-0.001); (p = 0.035)] respectively. However, PM2.5 increased SDNN by 34% (95% CI: − 1.32-0.64); (p = 0.493). Also, 10 μg/m3 increase in PM2.5, PM10–2.5 and PM10 decreased RMSSD by 27% [(− 1.34–0.79); (p = 0.620)], 11% [(− 1.73, 0.95); (p = 0.846)] and 0.57% [(− 1.56–0.46); (p = 0.255%)]. Conclusion Informal e-waste workers are at increased risk of developing cardiovascular disease from cardiac autonomic dysfunction as seen in reduced HRV and increased heart rate.

Impaired parasympathetic heart rate control in mice with a reduction of functional G protein βγ-subunits

2002 ◽  
Vol 282 (2) ◽  
pp. H445-H456 ◽  
Author(s):  
Josef Gehrmann ◽  
Michael Meister ◽  
Colin T. Maguire ◽  
Donna C. Martins ◽  
Peter E. Hammer ◽  
...  
Keyword(s):  
Heart Rate ◽  
Heart Rate Variability ◽  
Transgenic Mice ◽  
G Protein ◽  
Rate Control ◽  
Sinus Node ◽  
Physiological Role ◽  
Heart Rate Control ◽  
Electrophysiological Studies

Acetylcholine released on parasympathetic stimulation slows heart rate through activation of muscarinic receptors on the sinus nodal cells and subsequent opening of the atrial muscarinic potassium channel (KACh). KACh is directly activated by G protein βγ-subunits. To elucidate the physiological role of Gβγ for the regulation of heart rate and electrophysiological function in vivo, we created transgenic mice with a reduced amount of membrane-bound Gβ protein by overexpressing nonprenylated Gγ2-subunits in their hearts using the α-myosin heavy chain promoter. At baseline and after muscarinic stimulation with carbachol, heart rate and heart rate variability were determined with electrocardiogram telemetry in conscious mice and in vivo intracardiac electrophysiological studies in anesthetized mice. Reduction of the amount of functional Gβγ protein by >50% caused a pronounced blunting of the carbachol-induced bradycardia as well as the increases in time- and frequency-domain indexes of heart rate variability and baroreflex sensitivity that were observed in wild types. In addition, sinus node recovery time and inducibility of atrial arrhythmias were reduced in transgenic mice. Our data demonstrate in vivo that Gβγ plays a crucial role for parasympathetic heart rate control, sinus node automaticity, and atrial arrhythmia vulnerability.

scholarly journals Heart Rate Variability in Children and Adolescents with Cerebral Palsy—A Systematic Literature Review

2020 ◽  
Vol 9 (4) ◽  
pp. 1141 ◽  
Author(s):  
Jakub S. Gąsior ◽  
Antonio Roberto Zamunér ◽  
Luiz Eduardo Virgilio Silva ◽  
Craig A. Williams ◽  
Rafał Baranowski ◽  
...  
Keyword(s):  
Heart Rate ◽  
Heart Rate Variability ◽  
Cerebral Palsy ◽  
English Language ◽  
Pediatric Patients ◽  
Medical Subject Headings ◽  
Mesh Terms ◽  
Cardiac Autonomic Dysfunction ◽  
Guidelines And Recommendations ◽  
Methodological Guidelines

Cardiac autonomic dysfunction has been reported in patients with cerebral palsy (CP). The aim of this study was to assess the existing literature on heart rate variability (HRV) in pediatric patients with CP and a special attention was paid to the compliance of the studies with the current HRV assessment and interpretation guidelines. A systematic review was performed in PubMed, Web of Science, and Cumulative Index to Nursing and Allied Health Literature (CINAHL) databases searched for English language publications from 1996 to 2019 using Medical Subject Headings (MeSH) terms “heart rate variability” and “cerebral palsy” in conjunction with additional inclusion criteria: studies limited to humans in the age range of 0–18 years and empirical investigations. Out of 47 studies, 12 were included in the review. Pediatric patients with CP presented a significantly higher resting heart rate and reduced HRV, different autonomic responses to movement stimuli compared to children with normal development, but also reduced HRV parameters in the children dependent on adult assistance for mobility compared to those generally independent. None of the included studies contained the necessary details concerning RR intervals acquisition and HRV measurements as recommended by the guidelines. Authors of HRV studies should follow the methodological guidelines and recommendations on HRV measurement, because such an approach may allow a direct comparison of their results.

scholarly journals Heart rate variability: Measurement and emerging use in critical care medicine

2019 ◽  
Vol 21 (2) ◽  
pp. 148-157 ◽  
Author(s):  
Brian W Johnston ◽  
Richard Barrett-Jolley ◽  
Anton Krige ◽  
Ingeborg D Welters
Keyword(s):  
Heart Rate ◽  
Heart Rate Variability ◽  
Intensive Care ◽  
Sinus Node ◽  
Heart Rate Variability Analysis ◽  
Time Interval ◽  
Physiological Basis ◽  
Disease States ◽  
Organ Systems ◽  
Heart Rate Variability Measurement

Variation in the time interval between consecutive R wave peaks of the QRS complex has long been recognised. Measurement of this RR interval is used to derive heart rate variability. Heart rate variability is thought to reflect modulation of automaticity of the sinus node by the sympathetic and parasympathetic components of the autonomic nervous system. The clinical application of heart rate variability in determining prognosis post myocardial infarction and the risk of sudden cardiac death is well recognised. More recently, analysis of heart rate variability has found utility in predicting foetal deterioration, deterioration due to sepsis and impending multiorgan dysfunction syndrome in critically unwell adults. Moreover, reductions in heart rate variability have been associated with increased mortality in patients admitted to the intensive care unit. It is hypothesised that heart rate variability reflects and quantifies the neural regulation of organ systems such as the cardiovascular and respiratory systems. In disease states, it is thought that there is an ‘uncoupling’ of organ systems, leading to alterations in ‘inter-organ communication’ and a clinically detectable reduction in heart rate variability. Despite the increasing evidence of the utility of measuring heart rate variability, there remains debate as to the methodology that best represents clinically relevant outcomes. With continuing advances in technology, our understanding of the physiology responsible for heart rate variability evolves. In this article, we review the current understanding of the physiological basis of heart rate variability and the methods available for its measurement. Finally, we review the emerging use of heart rate variability analysis in intensive care medicine and conditions in which heart rate variability has shown promise as a potential physiomarker of disease.

A135 SINUS NODE DYSFUNCTION AND HEART RATE VARIABILITY DURING ISOFLURANE AND DESFLURANE

1997 ◽  
Vol 87 (Supplement) ◽  
pp. 135A
Author(s):  
N. Nathan ◽  
J.P. Frat ◽  
M. Benrhaiem ◽  
P. Blanc ◽  
P. Feiss
Keyword(s):  
Heart Rate ◽  
Heart Rate Variability ◽  
Sinus Node ◽  
Sinus Node Dysfunction
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