Factors of cardiovascular risk and intervisit arterial pressure variability

The aim: To determine the relationship between modified, unmodified cardiovascular risk factors (CRF) and intervisit arterial pressure variability (IAPW) in men of working age with arterial hypertension (AH).Material and methods. We examined 160 men with uncomplicated AH, among them, 82 patients had high IAPW, and 78 patients – low IAPW. The average age in patients with high and low IAPW did not differ and was 50.65 ± 6.14 and 50.26 ± 6.27 years, respectively (p = 0.689). Indices of IAPW were calculated based on the standard deviation (SD) of measurements of office blood pressure during 4 visits to the clinic. The criterion for high IAPW was the value of systolic arterial pressor (AP) – 15 / 15 mm Hg (day / night), for diastolic AP – 14/12 mm Hg (day / night). The analysis was carried out using standard statistical methods for parametric and non-parametric parameters. Results. It has been established, that the frequency of both modified and unmodified risk factors is greater in patients with hypertension and high IAPW, than in patients with low IAPW. The presence of obesity (36 of 82 versus 7 of 78; р ≤ 0.0001), family anamnesis (71 of 82 versus 52 of 78; p = 0.004), smoking episodes (62 of 82 versus 12 of 78; р ≤ 0.0001) and alcohol use (24 of 82 versus 2 of 78; p ≤ 0.0001) is significantly more common in patients with high IAPW, than in patients with low level of IAPW. There was a direct correlation between the MBA value and the percentage of 10-year risk of cardiovascular death on the SCORE scale (r = 0.47; p ≤ 0.0001) іn patients with hypertension.Conclusion. The results of the study confirm the hypothesis that, it is expedient to determine IAPW in patients with AH, as an independent prognostic risk factor for cardiovascular complications.

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Haematocrit: Relationships with Blood Lipids, Blood Pressure and other Cardiovascular Risk Factors

Thrombosis and Haemostasis ◽

10.1055/s-0038-1648811 ◽

1994 ◽

Vol 72 (01) ◽

pp. 058-064 ◽

Cited By ~ 14

Author(s):

Goya Wannamethee ◽

A Gerald Shaper

Keyword(s):

Physical Activity ◽

Risk Factors ◽

Blood Pressure ◽

Body Mass Index ◽

Cardiovascular Risk ◽

Cardiovascular Risk Factors ◽

Alcohol Intake ◽

Blood Lipids ◽

The Other ◽

The Relationship

SummaryThe relationship between haematocrit and cardiovascular risk factors, particularly blood pressure and blood lipids, has been examined in detail in a large prospective study of 7735 middle-aged men drawn from general practices in 24 British towns. The analyses are restricted to the 5494 men free of any evidence of ischaemic heart disease at screening.Smoking, body mass index, physical activity, alcohol intake and lung function (FEV1) were factors strongly associated with haematocrit levels independent of each other. Age showed a significant but small independent association with haematocrit. Non-manual workers had slightly higher haematocrit levels than manual workers; this difference increased considerably and became significant after adjustment for the other risk factors. Diabetics showed significantly lower levels of haematocrit than non-diabetics. In the univariate analysis, haematocrit was significantly associated with total serum protein (r = 0*18), cholesterol (r = 0.16), triglyceride (r = 0.15), diastolic blood pressure (r = 0.17) and heart rate (r = 0.14); all at p <0.0001. A weaker but significant association was seen with systolic blood pressure (r = 0.09, p <0.001). These relationships remained significant even after adjustment for age, smoking, body mass index, physical activity, alcohol intake, lung function, presence of diabetes, social class and for each of the other biological variables; the relationship with systolic blood pressure was considerably weakened. No association was seen with blood glucose and HDL-cholesterol. This study has shown significant associations between several lifestyle characteristics and the haematocrit and supports the findings of a significant relationship between the haematocrit and blood lipids and blood pressure. It emphasises the role of the haematocrit in assessing the risk of ischaemic heart disease and stroke in individuals, and the need to take haematocrit levels into account in determining the importance of other cardiovascular risk factors.

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The impact of obesity on cardiovascular disease risk factor

Asian Journal of Medical Sciences ◽

10.3126/ajms.v10i1.21294 ◽

2018 ◽

Vol 10 (1) ◽

pp. 1-12 ◽

Cited By ~ 1

Author(s):

Arun Kumar

Keyword(s):

Risk Factors ◽

Insulin Resistance ◽

Blood Pressure ◽

Cardiovascular Disease ◽

Risk Factor ◽

Cardiovascular Risk ◽

Sodium Intake ◽

Action Plan ◽

Saturated Fat ◽

The World

Obesity has emerged as the most potential cardiovascular risk factor and has raised concern among public and their health related issues not only in developed but also in developing countries. The Worldwide obesity occurrence has almost has gone three times since 1975. Research suggests there are about 775 million obese people in the World including adult, children, and adolescents. Nearly 50% of the children who are obese and overweight in Asia in are below 5 years. There is a steep incline of childhood obesity when compared to 1971 which is not only in developed countries but also in developing countries. A considerable amount of weight gain occurs during the transition phase from adolescence to young adulthood. It is also suggested that those adultswho were obese in childhood also remained obese in their adulthood with a higher metabolic risk than those who became obese in their adulthood. In India, the urban Indian female in the age group of 30-45 years have emerged as an 〝at risk population” for cardiovascular diseases. To understand how obesity can influence cardiovascular function, it becomes immense important to understand the changes which can take place in adipose tissue due to obesity. There are two proposed concepts explaining the inflammatory status of macrophage. The predominant cause of insulin resistance is obesity. Epidemiological and research studies have indicated that the pathogenesis of obesity-related metabolic dysfunction involves the development of a systemic, low-grade inflammatory state. It is becoming clear that targeting the pro-inflammatory pathwaymay provide a novel therapeutic approach to prevent insulin resistance, particularly in obesity inducedinsulin resistance. Some cost effective interventions that are feasible by all and can be implemented even in low-resource settings includes - population-wide and individual, which are recommended to be used in combination to reduce the greatest cardiovascular disease burden. The sixth target in the Global NCD action plan is to reduce the prevalence of hypertension by 25%. Reducing the incidence of hypertension by implementing population-wide policies to educe behavioral risk factors. Reducing cigarette smoking, body weight, blood pressure, blood cholesterol, and blood glucose all have a beneficial impact on major biological cardiovascular risk factors. A variety of lifestyle modifications have been shown, in clinical trials, to lower bloodpressure, includes weight loss, physical activity, moderation of alcohol intake, increased fresh fruit and vegetables and reduced saturated fat in the diet, reduction of dietary sodium intake, andincreased potassium intake. Also, trials of reduction of saturated fat and its partial replacement by unsaturated fats have improved dyslipidaemia and lowered risk of cardiovascular events. This initiative driven by the Ministry of Health and Family Welfare, State Governments, Indian Council of Medical Research and the World Health Organization are remarkable. The Government of India has adopted a national action plan for the prevention and control of non-communicable diseases (NCDs) with specific targets to be achieved by 2025, including a 25% reduction inoverall mortality from cardiovascular diseases, a 25% relative reduction in the prevalence of raised blood pressure and a 30% reduction in salt/sodium intake. In a nutshell increased BMI values can predict the nature of obesity and its aftermaths in terms inflammation and other disease associated with obesity. It’s high time; we must realize it and keep an eye on health status in order to live long and healthy life.

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Abstract P011: Cardiovascular Risk Factors and Longevity

Circulation ◽

10.1161/circ.137.suppl_1.p011 ◽

2018 ◽

Vol 137 (suppl_1) ◽

Author(s):

Michelle C Odden ◽

Andreea Rawlings ◽

Alice Arnold ◽

Mary Cushman ◽

Mary Lou Biggs ◽

...

Keyword(s):

Risk Factors ◽

Blood Pressure ◽

Risk Factor ◽

Cardiovascular Risk ◽

Systolic Blood Pressure ◽

Cardiovascular Risk Factors ◽

Old Age ◽

Repeated Measures ◽

Ldl Cholesterol ◽

Low Cardiovascular Risk

Introduction: Cardiovascular disease is the leading cause of mortality in old age, yet there is limited research on the patterns of cardiovascular risk factors that predict survival to 90 years. Hypothesis: The patterns of cardiovascular risk factors that portend longevity will differ from those that confer low cardiovascular risk. Methods: We examined repeated measures of blood pressure, LDL-cholesterol, and BMI from age 67 and survival to 90 years in the Cardiovascular Health Study (CHS). CHS is a prospective study of 5,888 black and white adults in two waves (1989-90 and 1992-93) from Medicare eligibility lists in four counties in the U.S. We restricted to participants aged 67 to 75 years at baseline to control for birth cohort effects and examined repeated measures of cardiovascular risk factors throughout the late-life course. We fit logistic regression models to predict survival to age 90 using generalized estimating equations, and modeled the risk factors as linear, a linear spline, and clinically relevant categories. Models were adjusted for demographics and medication use, and we also examined whether the association of each risk factor with longevity varied by the age of risk factor measurement. Best fit models are presented. Results: Among 3,645 participants in the birth cohort, 1,160 (31.8%) survived to 90 by June 16 th , 2015. Higher systolic blood pressure in early old age was associated with reduced odds for longevity, but there was an interaction with age such that the association crossed the null at 80 years. (Table) Among those with LDL-cholesterol <130 mg/dL, higher LDL-cholesterol was associated with greater longevity; at levels above 130 mg/dL there was no association between LDL-cholesterol and longevity. BMI had a u-shaped association with longevity. Conclusions: In summary, the patterns of risk factors that predict longevity differ from that considered to predict low cardiovascular risk. The risk of high systolic blood pressure appears to depend on the age of blood pressure measurement.

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Recommended Intake of Key Food Groups and Cardiovascular Risk Factors in Australian Older, Rural-Dwelling Adults

Nutrients ◽

10.3390/nu12030860 ◽

2020 ◽

Vol 12 (3) ◽

pp. 860 ◽

Cited By ~ 2

Author(s):

Alice J. Owen ◽

Michael J. Abramson ◽

Jill F. Ikin ◽

Tracy A. McCaffrey ◽

Sylvia Pomeroy ◽

...

Keyword(s):

Risk Factors ◽

Risk Factor ◽

Cardiovascular Risk ◽

Diet Quality ◽

Cardiometabolic Risk ◽

Soft Drink ◽

Cardiometabolic Risk Factors ◽

Processed Meat ◽

Cardiometabolic Risk Factor ◽

The Relationship

This study examined the relationship between diet quality scores and cardiometabolic risk factors in regionally-dwelling older Australian adults with increased cardiovascular risk. This study was a cross-sectional analysis of demographic, anthropometric, and cardiometabolic risk factor data from 458 participants of the Cardiovascular Stream of the Hazelwood Health Study. Participants completed a 120 item semi-quantitative food frequency questionnaire. Multivariable linear regression adjusting for age, sex, smoking, physical activity, education, diabetes, and body mass index was used to examine the relationship between diet and cardiometabolic risk factors. Mean (SD) age of participants was 71 (8) years, and 55% were male. More than half of men and women did not meet recommended intakes of fibre, while 60% of men and 42% of women exceeded recommended dietary sodium intakes. Higher diet quality in terms of intake of vegetables, grains, and non-processed meat, as well as intake of non-fried fish, was associated with more favourable cardiometabolic risk profiles, while sugar-sweetened soft drink intake was strongly associated with adverse cardiometabolic risk factor levels. In older, regionally-dwelling adults, dietary public health strategies that address whole grain products, vegetable and fish consumption, and sugar-sweetened soft-drink intake may be of benefit in reducing cardiometabolic risk.

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Cardiovascular risk factor control: is it possible with a home-based cardiac rehabilitation program?

European Journal of Preventive Cardiology ◽

10.1093/eurjpc/zwab061.257 ◽

2021 ◽

Vol 28 (Supplement_1) ◽

Author(s):

NPD Cunha ◽

I Aguiar-Ricardo ◽

T Rodrigues ◽

S Couto Pereira ◽

P Silverio Antonio ◽

...

Keyword(s):

Risk Factors ◽

Blood Pressure ◽

Risk Factor ◽

Cardiovascular Risk ◽

Cardiac Rehabilitation ◽

Cardiovascular Risk Factors ◽

Rehabilitation Program ◽

Cardiac Rehabilitation Program ◽

Face To Face ◽

Home Based

Abstract Funding Acknowledgements Type of funding sources: None. Introduction Cardiovascular risk factors (CVRF) control, needing different strategies, through patient education, lifestyle changes and therapeutic optimization is a central core of cardiac rehabilitation. However, further studies are needed to demonstrate effectiveness of home-based Cardiac Rehabilitation (CR-HB) programs in controlling CVRF. Purpose To evaluate the effectiveness of a CR-HB program in controlling cardiovascular risk factors. Methods Prospective cohort study including patients who were previously participating in a centre-based CR program and accepted to participate in a CR-HB program due to forced closure of the centre-based CR program for COVID-19 pandemic. The CR-HB consisted of a multidisciplinary digital CR program, including patient regular assessment, exercise, educational, and psychological and relaxation sessions. A structured online educational program for patients and family members/caregivers was provided including educational videos, and powerpoints and webinars. A real time Webinar regarding "nutritional myths and facts" was organized with the duration of 90 minutes as a substitution of the regular face-to-face regular workshop provided at our centre-based CR program. Also, self-control of blood pressure and heart rate and of glycemia in diabetics were promoted, as well as smoking cessation. To assess the impact of the CR-HB on risk factors control, all the patients were submitted to a clinical and analytical evaluation before and after the end of this at distance program. Results 116 cardiovascular disease patients (62.6 ± 8.9 years, 95 males) who were attending a face-to-face CR program were included in a CR-HB program. Almost 90% (n = 103) of the participants had coronary artery disease. Regarding risk factors, obesity was the most prevalent risk factor (74.7 %) followed by hypertension (59.6%), family history (41.8%), dyslipidaemia (37.9%), diabetes (18.1%), and smoking (12.9%). Regarding the blood pressure control, 80% of the patients stated that almost daily they measured blood pressure at home; baseline systolic pressure decreased from 117 ± 13 to 113 ±12mmHg, p = 0.007, while there was no significant change in diastolic pressure. The majority (76%) of diabetic patients said they controlled blood glucose; HbA1c decreased from 6.1 ± 1.1 to 5.9 ± 0.9mg/dL (p = 0.047). Considering the lipid profile, LDL decreased (from 75 ± 30 to 65 ± 26mg/dL, p = 0.012). The Nt-proBNP also decreased (818 ± 1332 vs 414pg/ml ± 591, p = 0.042). There were no other statistically significant differences concerning risk factors modification. Conclusions Our study showed that a Home-based Cardiac Rehabilitation program can improve or maintain cardiovascular risk factors control, which has important prognostic implications and is frequently a difficult task to achieve.

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P824 Impact of cardiovascular risk factors and treatment strategies on the presence of intramyocardial hemorrhage visualized by magnetic resonance in patients with reperfused infarction

European Heart Journal - Cardiovascular Imaging ◽

10.1093/ehjci/jez319.475 ◽

2020 ◽

Vol 21 (Supplement_1) ◽

Author(s):

B Igual Munoz ◽

E S L C Elena Sanchez Lacuesta ◽

J L D G Jose Luis Diez Gil ◽

M F V Maria Ferre Valverdu ◽

F T M Francisco Ten Morro ◽

...

Keyword(s):

Risk Factors ◽

Blood Pressure ◽

Risk Factor ◽

Cardiovascular Risk ◽

Magnetic Resonance ◽

Protective Effect ◽

Cardiovascular Risk Factors ◽

Independent Risk Factor ◽

Treatment Strategies ◽

Lv Mass

Abstract Intramyocardial hemorrhage (IMH) is considered a marker of tissue damage severity in patients with reperfused ST-segment elevation myocardial infarction (STEMI) and has been associated with a poor prognosis despite successful revascularization of the culprit artery . We aim to study the impact of cardiovascular risk factors and treatment strategies on the presence of IMH studied with T2* -w cardiovascular magnetic resonance (CMR) in this clinical setting METHODS A prospective observational study including patients with repefused STEMI who underwent an MRI during the first week post-revascularization were conducted . The presence of IMH was analyzed in ECG triggered T2 * w sequences as presence of hipointensity area . Clinical data including cardiovascular risk factors and treatment strategies at cath lab were studied. RESULTS 94 patients with reperfused STEMI were included. Demographic data are shown at the the table. No significant association was observed between the presence of IMH and the different treatment strategies used. All data were introduced in a multivariate model including presence of thrombus, total ischemia time and culprit coronary artery. The analysis showed previous infarction as an independent risk factor (OR: 6 p = 0.03, CI: 1.1-29) while history of hypertension (OR: 0.9, p = 0.04, CI: 0.1- 0.9) and systolic blood pressure showed independent protective effect (OR: 0.3 p = 0.02 IC: 0.9-0.99.) CONCLUSIONS. 1. Previous infarction was shown to be an independent risk factor for IMH . 2. Arterial hypertension and systolic blood pressure showed a protective effect. Age (years) 62 ±13 Male sex 72 (77) Diabetes mellitus 32 (34) Hypertension 53 (56) Hyperlipidaemia 52 (55) Current or prior smoking 55 (58) Time to reperfusion 203 (142-300) Infarct-related artery LAD 38 (41) RCA 49 (52) Cx 7 (7) Infarct size (% LV mass) 18 ± 11 MO (% LV mass) 3.15 (1.44-5.48) Abstract P824 Figure. Intramyocardial hemorraghe T2* sequences

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The challenge of multiple cardiovascular risk factor control outside Western Europe: Findings from the International ChoLesterol management Practice Study

European Journal of Preventive Cardiology ◽

10.1177/2047487319871735 ◽

2019 ◽

Vol 27 (13) ◽

pp. 1403-1411 ◽

Cited By ~ 3

Author(s):

Dirk J Blom ◽

Raul D Santos ◽

Veronique Daclin ◽

Florence Mercier ◽

Alvaro J Ruiz ◽

...

Keyword(s):

Risk Factors ◽

Blood Pressure ◽

Risk Factor ◽

Cardiovascular Risk ◽

Cardiovascular Risk Factors ◽

Western Europe ◽

Management Practice ◽

Risk Factor Control ◽

Practice Study ◽

Cholesterol Management

Background Comprehensive control of multiple cardiovascular risk factors reduces cardiovascular risk but is difficult to achieve. Design A multinational, cross-sectional, observational study. Methods The International ChoLesterol management Practice Study (ICLPS) investigated achievement of European Society of Cardiology (ESC)/European Atherosclerosis Society (EAS) guideline low-density lipoprotein cholesterol (LDL-C) targets in patients receiving lipid-modifying therapy in countries outside Western Europe. We examined the rate of, and association between, control of multiple risk factors in ICLPS participants with dyslipidaemia, diabetes and hypertension (N = 2377). Results Mean (standard deviation) age of patients was 61.4 (10.4) years; 51.3% were male. Type 2 diabetes was the most common form of diabetes (prevalence, 96.9%). The prevalence of metabolic syndrome was 67.8%, obesity 40.4%, atherosclerotic disease 39.6% and coronary artery disease 33.5%. All patients were at high (38.2%) or very high (61.8%) cardiovascular risk according to ESC/EAS guidelines. Body mass index (BMI) was <25 kg/m2 in 20.3% of patients, 62.8% had never smoked and 25.2% were former smokers. Overall, 12.2% achieved simultaneous control of LDL-C, diabetes and blood pressure. Risk factor control was similar across all participating countries. The proportion of patients achieving individual guideline-specified treatment targets was 43.9% for LDL-C, 55.5% for blood pressure and 39.3% for diabetes. Multiple correspondence analysis indicated that control of LDL-C, control of blood pressure, control of diabetes, BMI and smoking were associated. Conclusion Comprehensive control of multiple cardiovascular risk factors in high-risk patients is suboptimal worldwide. Failure to control one risk factor is associated with poor control of other risk factors.

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Distribution and risk profile of atrial fibrillation patterns among women and men from the general population

European Heart Journal ◽

10.1093/eurheartj/ehab724.2415 ◽

2021 ◽

Vol 42 (Supplement_1) ◽

Author(s):

M J Tilly ◽

Z Lu ◽

S Geurts ◽

M A Ikram ◽

M P M De Maat ◽

...

Keyword(s):

Risk Factors ◽

Atrial Fibrillation ◽

Blood Pressure ◽

Risk Factor ◽

Cardiovascular Risk ◽

General Population ◽

Population Based ◽

Mixed Effect ◽

Duration Of Symptoms ◽

Men And Women

Abstract Background In a clinical setting, atrial fibrillation (AF) subgroups are defined, including paroxysmal, persistent, and permanent AF. These subgroups differ in terms of clinical characteristics, management strategy, and long-term outcomes. Application of clinical classifications in population-based settings is challenging as they are based on the duration of symptoms, recurrence, and treatment. Purpose We aim to develop an objective and standardized classification for AF patterns in the general population and examine the associated cardiovascular risk profiles and outcomes for the identified AF patterns. Methods Participants with only one reported AF episode were categorized as single-documented AF, if at least two separate AF episodes were reported as multiple-documented AF and as longstanding persistent AF if at least two consecutive ECG's at the research center showed AF, not followed by an ECG showing sinus rhythm. We fitted mixed effect models with age as time scale to characterize sex-specific cardiovascular risk factor trajectories preceding each AF pattern. We further used Cox proportional hazard modelling to describe the risk of coronary heart disease (CHD), heart failure (HF), stroke, and all-cause mortality following AF. Results We included 14,620 men and women aged ≥45 years. 1137 participants were categorized as single-documented AF, 208 as multiple-documented AF, and 57 as longstanding persistent AF. We identified significant differences in the preceding trajectories of weight, body mass index, systolic blood pressure, diastolic blood pressure, waist circumference, hip circumference, and waist-hip ratio with various AF patterns. In general, both men and women with persistent-elevated levels of these risk factors were prone to longstanding persistent AF. AF was associated with a large risk for subsequent CHD, HF, stroke, and mortality in the general population. Among the different AF patterns, single-documented AF conferred the largest risk of CHD [hazard ratio, 95% confidence interval: 1.92 (1.19–3.03)] and mortality [1.70 (1.41–2.07)] as compared to multiple-documented AF, and as compared to longstanding persistent AF [1.45 (0.72–2.90) and 3.66 (2.25–5.95), respectively]. Conclusion We developed a classification for AF patterns within a general population. We identified differences in risk factor trajectories preceding each AF pattern, which implies differences in pathophysiological mechanisms underlying AF. Participants with single-documented AF showed worse prognosis than those with multiple AF episodes. This might be due to the subgroup definition, since participants should live for a longer period of time to be categorized in the multiple-documented AF and longstanding persistent AF groups. This can also imply that participants suffering from multiple AF episodes are more frequently monitored, and treated for other risk factors. However, this could also suggest that singular AF episodes are not as innocent as commonly thought. FUNDunding Acknowledgement Type of funding sources: Public hospital(s). Main funding source(s): - Erasmus MC Mrace grant. - Netherlands Organization for the Health Research and Development (ZonMw) Figure 1 Figure 2. Progosis of various AF patterns

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Blood Pressure

PEDIATRICS ◽

10.1542/peds.80.5.784 ◽

1987 ◽

Vol 80 (5) ◽

pp. 784-788

Author(s):

Gregory L. Burke ◽

Antonie W. Voors ◽

Charles L. Shear ◽

Larry S. Webber ◽

Carey G. Smoak ◽

...

Keyword(s):

Blood Pressure ◽

Risk Factor ◽

Cardiovascular Risk ◽

Body Size ◽

Cardiovascular Risk Factor ◽

Early Life ◽

White Children ◽

Before And After ◽

Factor Measurement ◽

The Relationship

BP was measured in 440 children followed longitudinally from birth to 7 years of age in Bogalusa, LA. Levels, trends, and determinants of BP were evaluated in this newborn cohort. Both systolic and diastolic BP levels remained relatively constant between the ages of 6 months and 7 years. BP levels varied between the different instruments, and differences were also noted between measures obtained using the same instrument before and after venipuncture. White children were noted to have slightly higher levels of systolic and diastolic BP pressure at 6 months and 1 year of age, even after adjustment for body size. Significant prediction of year 7 BP rank occurred as early as 6 months of age for systolic and at 1 year of age for diastolic BP levels. Body size was inconsistently related to BP levels from ages 6 months through 4 years, but the relationship was stronger and more consistent with changes in body size. Of interest is the relatively constant levels of indirect BP during this period of rapid growth, as measured by currently available instruments. These data emphasize the importance of cardiovascular risk factor measurement during early life and of the need to improve methods of indirect BP measurement in infancy.

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BLOOD PRESSURE, HYPOCHONDRIA AND DEPRESSION: MATHEMATICAL MODELS OF RELATIONSHIP

International Medical Journal ◽

10.37436/2308-5274-2020-4-2 ◽

2020 ◽

pp. 12-20

Author(s):

M. O. Pavlovska

Keyword(s):

Risk Factors ◽

Blood Pressure ◽

Information Technology ◽

Cardiovascular Risk ◽

Left Ventricular Hypertrophy ◽

Arterial Pressure ◽

Arterial Hypertension ◽

Diastolic Dysfunction ◽

Ventricular Hypertrophy ◽

Left Ventricular

Modern clinical diagnostics has standards and medical systems for the diagnosis of hypertension, advanced information technology. Mathematical models of the relationship between systolic blood pressure and psychological indices of hypochondria and depression have been described. Methods of mathematical statistics were applied as follows: factor, cluster, discriminant, regression analyzes, Markov chains, polynomial splines and neural networks, they were implemented in software products, such as NeuroModelDBPM, "Monitoring", VerMed. The presented model of interaction of systolic arterial pressure, Hs−hypochondria, D−depression confirms an importance of these states at an initial stage of arterial hypertension and allows the allocation of four options of psychosomatic relations in patients: organ and system somatic defeats of psychosomatic character, somaticized psychiatric reactions, reactions of exogenous type. It has been shown that disharmonious personality traits, risk factors, disorder of chronobiological structure of blood pressure, left ventricular hypertrophy and its diastolic dysfunction contribute to the formation of nosogeny in hypertension. Their development is hindered by harmonious personality traits, keeping a healthy lifestyle, minimal changes in the chronobiological structure of blood pressure, a slight degree of left ventricular hypertrophy and its diastolic dysfunction. The leading cardiovascular risk factors in patients with hypertension are stress, burdened heredity, low physical activity, carbohydrate abuse, higher education and high socioeconomic status. Nosogeny in hypertension should also be considered as a risk factor, as well as should be taken into account in the stratification of the overall cardiovascular risk and accomplishing a proper adjustments. Key words: arterial hypertension, mathematical statistics, arterial pressure, hypochondria, depression, information technology.

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