scholarly journals Antimicrobial Resistant Streptococcus pneumoniae

2010 ◽  
Vol 49 (179) ◽  
Author(s):  
B Khanal ◽  
A Acharya ◽  
R Amatya ◽  
R Gurung ◽  
N Paudyal ◽  
...  
Keyword(s):  
Streptococcus Pneumoniae ◽  
Antimicrobial Susceptibility ◽  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Care Hospital ◽  
Pneumococcal Infections ◽  
Intermediate Resistance ◽  
Resistance To Penicillin ◽  
Susceptibility Patterns

Introduction: Pneumococcal infections are important cause of morbidity and mortality. Knowledge of antimicrobial susceptibility patterns plays important role in the selection of appropriate therapy.  Present study was undertaken to analyze the susceptibility patterns of pneumococcal isolates against  commonly used antimicrobials with special reference to determination of minimum inhibitory  concentration (MIC) of penicillin in a tertiary care hospital in eastern Nepal. Methods: Twenty-six strains of S. pneumoniae isolated from various clinical specimens submitted to microbiology laboratory were evaluated. All isolates were tested for antimicrobial susceptibility by  disk diffusion method. MIC of penicillin was tested by broth dilution method. Results: Of the total isolates 19 (73%) were from invasive infections. Seven isolates were resistant to cotrimoxazole. No resistance to penicillin was seen in disk diffusion testing. Less susceptibility to penicillin (MIC 0.1-1.0 mg/L) was observed in five (17%) isolates. High level resistance to penicillin was not detected. One isolate was multidrug resistant. Conclusions: S. pneumoniaeisolates with intermediate resistance to penicillin prevail in Tertiary Care Hospital in eastern Nepal, causing invasive and noninvasive infections. As intermediate resistance is not detected in routine susceptibility testing, determination of MIC is important. It helps not only in the effective management of life threatening infections but is also essential in continuous monitoring and early detection of resistance. In addition, further study on pneumococcal infections, its antimicrobial resistance profile and correlation with clinical and epidemiological features including serotypes and group prevalence is recommended in future. Keywords: antimicrobial susceptibility pattern, penicillin, Streptococcus pneumoniae.

scholarly journals Increasing antimicrobial resistance is not inevitable: in reply to microbiological and antibiotic profile of osteomyelitis tertiary care hospital

2021 ◽  
Vol 8 (6) ◽  
pp. 1967
Author(s):  
Ruth A. Corrigan ◽  
Maria Dudareva ◽  
Martin McNally
Keyword(s):  
Antimicrobial Resistance ◽  
Antimicrobial Susceptibility ◽  
Chronic Osteomyelitis ◽  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Care Hospital ◽  
South West ◽  
Susceptibility Patterns

It was with interest and alarm that we read the report by Vijakumar et al regarding antimicrobial susceptibility patterns of pathogens isolated from patients with chronic osteomyelitis.1 The authors reviewed 132 isolates from 100 patients managed in Davangere, Karnataka, South West India between January 2017-December 2019.

Increase in Penicillin and multidrug resistance in Streptococcus pneumoniae (1993-2016): report from a tertiary care hospital laboratory, Pakistan

2022 ◽  
Vol 71 (12) ◽  
pp. 2726-2730
Author(s):  
Afia Zafar ◽  
Farida Khurram Lalani ◽  
Ahmer Arif Longi ◽  
Mohammad Raheel Jajja ◽  
Maera Haider ◽  
...  
Keyword(s):  
Streptococcus Pneumoniae ◽  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Significant Rise ◽  
Penicillin Resistance ◽  
Care Hospital ◽  
Resistance To Penicillin ◽  
Resistance Rates ◽  
The Impact ◽  
Second Period

Background: Streptococcus pneumoniae is a major cause of morbidity and mortality worldwide. With the emergence of penicillin-resistant S. pneumoniae (PRSP), treatment has become challenging. The Clinical and Laboratory Standards Institute (CLSI) in 2008 revised its guidelines for S. pneumoniae and recommended separate penicillin breakpoints for meningeal and non-meningeal strains. Similar to penicillin’s, resistance to other classes of antibiotics has emerged globally. Objective: The objective of this study is to determine the trend of resistance to antimicrobials in S. pneumoniae infections and the impact of new CLSI guidelines on penicillin susceptibility among meningeal isolates. Methodology: Twenty-four years (1993-2016) data from S. pneumoniae isolates and their antimicrobial susceptibility was retrieved from the computerized database. Data was divided into two groups for analysis, pre-2008 and post 2008. Results: Penicillin resistance remained unchanged in non-meningeal isolates during both study periods. A significant rise in penicillin resistance in meningeal isolates was observed in the second period 2008-2016 (2.9% vs 36.2%). High resistance rates were observed for co-trimoxazole, tetracycline and erythromycin. Increased trend of multi-drug resistant (MDR) strains were also noted, from 11% in 1999 to 36% in 2016.  Conclusion: The emergence of MDR strains is evident from our dataset. It seems like the rise in PRSP in meningeal isolates is due to revised CLSI guidelines. Overall low resistance to penicillin in non-meningeal isolates and no resistance to ceftriaxone is encouraging and will assist in drafting local guidelines. Cautious use of antimicrobials are essential to reduce further emergence of antimicrobial resistance in indigenous isolates.  

scholarly journals Antimicrobial Susceptibility Patterns for Recent Clinical Isolates of Anaerobic Bacteria in South Korea

2010 ◽  
Vol 54 (9) ◽  
pp. 3993-3997 ◽  
Author(s):  
Yangsoon Lee ◽  
Yongjung Park ◽  
Myung Sook Kim ◽  
Dongeun Yong ◽  
Seok Hoon Jeong ◽  
...  
Keyword(s):  
South Korea ◽  
Antimicrobial Susceptibility ◽  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Anaerobic Bacteria ◽  
Clinical Isolates ◽  
Care Hospital ◽  
Highly Active ◽  
Gram Positive Cocci ◽  
Susceptibility Patterns

ABSTRACT We determined the antimicrobial susceptibilities of 255 clinical isolates of anaerobic bacteria collected in 2007 and 2008 at a tertiary-care hospital in South Korea. Piperacillin-tazobactam, cefoxitin, imipenem, and meropenem were highly active β-lactam agents against most of the isolates tested. The rates of resistance of Bacteroides fragilis group organisms and anaerobic Gram-positive cocci to moxifloxacin were 11 to 18% and 0 to 27%, respectively.

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