The impact of exogenous and endogenous factors on the stomach wall, macro-, microscopic anatomy of newborn white rats

2018 ◽  
Vol 22 (1) ◽  
pp. 1-20 ◽  
Author(s):  
Jose Antonio Belso-Martinez ◽  
Isabel Diez-Vial

Purpose This paper aims to explain how the evolution of knowledge networks and firms’ strategic choices affect innovation. Endogenous factors associated with a path-dependent evolution of the knowledge network are jointly considered with a firm’s development of international relationships and increasing internal absorptive capacity over time. Design/methodology/approach In a biotech cluster, the authors gathered data on the firms’ characteristics and network relationships by asking about the technological knowledge they received in the cluster in 2007 and 2012 – “roster-recall” method. Estimation results were obtained using moderated regression analysis. Findings Firms that increase their involvement in knowledge networks over time also tend to increase their innovative capacity. However, efforts devoted to building international links or absorptive capacity negatively moderate the impact of network growth on innovation. Practical implications Practitioners have two alternative ways of increasing innovation inside knowledge networks: they can increase their centrality by developing their knowledge network interactions or invest in developing their internal absorptive capacity and new international sources of knowledge. Investing in both of these simultaneously does not seem to improve a firm’s innovative capacity. Originality/value Coupling firms’ strategic options with knowledge network dynamics provide a more complete way of explaining how firms can improve their innovative capacity.


2021 ◽  
Author(s):  
James Lyons-Weiler

AbstractHuman evolution sits at several important thresholds. In organic evolution, interplay between exogenous environmental and genetic factors rendered new phenotypes at rates limited by genetic variation. The interplay took place on adaptive fitness landscapes determined by correspondence of genetic and environmental relationships. Human evolution involved important emergences that altered the adaptive landscape: language, writing, organized societies, science, and the internet. These endogenous factors ushered in transformative periods leading to more rapidly evolving emergences. I explore the impact of development of emerging biotransformative technologies capable of being applied to effect self-genetic modification and artificial intelligence-augmented cognition on the evolutionary landscape of phenotypes important to cognitive plasticity. Interaction effects will yield unanticipated emergences resulting in hyperrealm adaptive landscapes with more rapid evolutionary processes that feed back upon more fundamental levels while vastly outpacing organic evolution. Emerging technologies exist that are likely to impact the evolution of cognitive plasticity in humans in ways and at rates that will lead to societal upheaval. I show that the theoretical contribution of organic evolution in future human evolution is expected to become comparatively insignificant relative to that made by endogenous environmental factors such as external cognition aids and manipulation of the human genome. The results support the conclusion of a strong recommendation of a moratorium on the adoption of any technology capable of completely altering the course of human evolution.


2016 ◽  
Vol 23 (2) ◽  
pp. 403-428 ◽  
Author(s):  
Wai Hong Kan Tsui ◽  
Faruk Balli

An airport’s international passenger arrivals are susceptible to exogenous and endogenous factors (such as economic conditions, flight services, fluctuations and shocks). Accurate and reliable airport passenger demand forecasts are imperative for policymaking and planning by airport and airline management as well as by tourism authorities and operators. This article employs the Box–Jenkins SARIMA, SARIMAX and SARIMAX/EGARCH volatility models to forecast international passenger arrivals for the eight key Australian airports (Adelaide, Brisbane, Cairns, Darwin, Gold Coast, Melbourne, Perth and Sydney). Monthly international tourist arrivals between January 2006 and September 2012 are used for the empirical analysis. All the forecasting models are highly accurate with the lower values of mean absolute percentage error, mean absolute error and root mean squared error. The findings suggest that the international passenger arrivals of Australian airports are affected by positive and negative shocks and tourism marketing expenditure is also a significant factor influencing the majority of Australian airports’ international passenger arrivals.


Agriculture ◽  
2019 ◽  
Vol 9 (12) ◽  
pp. 264 ◽  
Author(s):  
Wojciech Sroka ◽  
Michał Dudek ◽  
Tomasz Wojewodzic ◽  
Karol Król

The increasing importance of large cities (metropolises) poses a range of challenges to the socio-economic functions of the rural and agricultural areas around them. One such challenge is pressure exerted on family-run farms to abandon agricultural activity and on people engaged in such activity to shift to other sectors. This may be a hindrance to successful succession on family farms. The aim of this paper is to present spatial variation in generational changes in farms located around large cities (metropolises) in Poland and to assess the factors affecting the scale of such changes. Special attention was paid to the importance of the location of farms relative to large cities. One innovative feature of the approach presented was to conduct an analysis of generational changes in the agricultural sector at the supra-local level along with an attempt to quantify the impact of large urban centers on that process. The empirical material based on which the conclusions were formulated included official statistics data and information made available by an institution engaged in the implementation of agricultural policy programs financed from European Union (EU) funds, i.e., young farmer payments (Common Agricultural Policy (CAP) pillar I) and measures “Setting up of young farmers” and “Early retirement” (CAP Pillar II). In the executed study, methods of descriptive and multivariate statistics, including regression trees, were used. It was found that socio-economic (exogenous) factors had a significant statistical impact on generational changes in farms. In areas with an attractive labor market and a high level of urbanization, a successful generational shift in farms occurred less often. Nonetheless, generational changes in the agriculture of the analyzed areas were relatively most strongly determined by endogenous factors linked with the economic potential of the farm. Farm characteristics (area of agricultural land and economic size) and the characteristics of managers, including in particular their education, were found to be more important than exogenous factors. In areas where large and economically strong farms dominated and the level of education among farmers was relatively high, generational changes were faster compared to other areas.


Botany ◽  
2016 ◽  
Vol 94 (3) ◽  
pp. 147-163 ◽  
Author(s):  
Anna Li-Mallet ◽  
Amélie Rabot ◽  
Laurence Geny

The grapevine (Vitis vinifera L.) is a widely cultivated species of major economic importance for wine production. The quality and quantity of grapes are criteria of prime importance to the wine industry, but they are highly variable from year to year. Unlike many perennial plants, cluster formation unfolds in two seasons: season 1 takes place in the bud until dormancy, and season 2 starts after budbreak in the following year. Season 1 corresponds to the initiation and differentiation of inflorescence primordia, controlled by many exogenous and endogenous factors, which explains up to 60% seasonal variation in yield. Season 2 consists of flowering and fruit development, which explains, respectively, 30% and 10% of seasonal variation in yield. It is therefore essential to understand the impact of these factors to better control the yield. This review aims to summarize past and present knowledge concerning the physiology of latent buds relating to their fruitfulness, and to assess the impact of environmental, hormonal, and regulation factors on the final yield. Avenues of further research to understand physiological, biochemical and molecular regulatory mechanisms of initiation and differentiation of clusters will be then proposed.


2016 ◽  
Vol 2016 ◽  
pp. 1-7 ◽  
Author(s):  
Victoria Senibi ◽  
Emmanuel Oduntan ◽  
Obinna Uzoma ◽  
Esther Senibi ◽  
Akinde Oluwaseun

Nigeria is confronted with the issue of limited capital and has to resort to foreign debt in order to augment domestic savings, balance of payment deficits, and shortfall in revenue which induce continuous raise in the debt stock at an alarming rate. In the light of this, this study assesses the impact of public debt on external reserve in Nigeria. The objectives of this study include the assessment of the trends and relationship between public debt and external reserve in Nigeria, using the Johansen cointegration and FMOLS technique on the secondary data from 1981 to 2013. The result revealed that public debt has a positive and significant effect on external reserve stock in the long run suggesting that the nation’s debt crisis can be attributed to both exogenous and endogenous factors such as the nature of the economy, economic policies, high dependence on oil, and swindling foreign exchange receipt. This study recommends that the federal government should employ more superior method to negotiate for fixed interest payment and varying amortization schemes, as well as seek multiyear rescheduling rather than year by year basis.


1961 ◽  
Vol 39 (6) ◽  
pp. 877-891 ◽  
Author(s):  
Gloria A. Webster ◽  
T. W. M. Cameron

Experimental infections in rodents with Echinococcus multilocularis sibiricensis, Echinococcus granulosus canadensis, and Echinococcus granulosus (Lebanon origin) both by ingestion of onchospheres and by parenteral injection are recorded. The microscopic anatomy of the larval parasite and of the host reaction are discussed and illustrated in detail. Voles and cotton rats display little resistance to the development of the cyst of E. m. sibiricensis and ultimately destroy the host, while collared lemmings and golden hamsters overcome the cyst and destroy it. Muskrats and certain white mice are intermediate in their effects. In all cases, however, some degree of degeneration of the parasite into the alveolar form is shown. White rats, guinea pigs, and rabbits could not be infected with this parasite. E. g. canadensis was developing in the lung of one AKR strain mouse while in the chinchilla the parasite commenced to develop in the lung but was overcome at an early stage. No development took place in the other species of hosts. E. granulosus (Lebanon) appeared to be developing successfully in some cotton rats and white mice fed on onchospheres.


Author(s):  
Leonard Ntakirutimana ◽  
Changbin Yin ◽  
Fuduo Li

The influence of instrumental variables on farmers ‘perceptions using rotation fallow as sustainable agriculture practices had been the aim of our research. By using simultaneous equations models, this study tried to understand the relationship between green manure farmer’s perceptions on using rotation-fallow and planting green manure in Guangxi Province, south of China. The results showed that subsidizing green manure farmers based on standard subsidy by the unit of green manure sown area; the training on the green manure planting technology or the demonstration preaching; the green manure farmers preference for the kinds of subsidy (funds, seeds, and mechanical services) were the mostly great drivers of the program of restoring planting green manure in the study area. These incentives measures must be enhanced as priority to restore definitely green manure planting. However, the findings of the study showed that the total income of the 2017 year, the area of an agricultural field of household and the household members (16–65 years old), providing labor in the agricultural field, have some influences on planting green manure and on  farmer’s perceptions on using rotation-fallow as sustainable agriculture practices. Brief, the unobserved factors which influenced the endogenous factors play an important role to enhance widely the impact of farmers’ perceptions on planting green manure.


Author(s):  
Alexey Chugunov

The subject of the study is theoretical and practical issues of the formation of budgets of local self-government in the system of social development of territorial communities. The purpose of the study is to reveal the priority tasks for improving the system of formation of budgets of local self-government. Research methods. The paper uses a set of scientific methods and approaches, including systematic, structural, comparative, factor methods, which allowed to realize the conceptual unity of the research. Results of work. The article reveals the role of local self-government budgets in the development of administrative-territorial units. A number of legislative and normative acts on regulation of the process of formation of budgets of local self-government are generalized. The priority tasks of the budget policy concerning support of territorial communities, strengthening of their tax capacity, increase of efficiency of coordination of activity of bodies of state power and local self-government are determined. The article is based on the establishment of an effective institutional framework for the formation of local self-government budgets in the system of social development of territorial communities. The field of application of results. System of state financial regulation, budgetary policy, budget system. Conclusions. The development of the budget system is possible by ensuring the sustainability of the formation of local government budgets in the system of social development of territorial communities, activating their innovation-investment component and strengthening the influence on the socio-economic development of administrative-territorial units. The importance of further enhancing the effectiveness and efficiency of the formation of local government budgets is conditioned by the need to increase the efficiency of the management of public financial resources in the conditions of their constraints, the development of a strategy for the development of local government budgets and the creation of institutional conditions for increasing their self-sufficiency, taking into account the cyclical nature of economic fluctuations and the impact of exogenous and endogenous factors in financially -budgetary environment. At this stage, the important task is to implement effective transformations of the system of forming local budgets by supporting voluntary associations of territorial communities, which necessitates the increase of efficiency and efficiency of administrative decisions of executive bodies and local governments in the field of strategic budget planning. It is advisable to improve the system of monitoring the socioeconomic efficiency of local government budget expenditures by using qualitative and quantitative indicators, introducing medium-term budget planning at the local level, adhering to the principle of transparency and accountability of local self-governance bodies to the public. Important tasks are improving the system of formation of local budgets taking into account application of modern financial-budget methods and tools; Creation of effective incentives to ensure the interest of local self-government bodies in the growth of their own income base and increase their level of responsibility for the use of budget resources; ensuring adequate revenues to local government budgets, and increasing the efficiency of the use of budget resources.


2021 ◽  
Vol 64 (4) ◽  
pp. 23-28
Author(s):  
Lilia Tacu ◽  
◽  
Valeriu Cobet ◽  

Background: The doxorubicin (Dx) cardiotoxicity is manifested by a marked heart failure evolution. The impact of Dx on lusitrop functions of the heart and the inherent diastolic disorders have a theoretical and practical value for the connection cardiology-oncology. Material and methods: Dx cardiotoxicity was reproduced by its administration i/p in white rats in cumulative dose 16 mg/kg (Dx group n=9). Control group (n=9) received only physiological solution. The study was performed in vitro by using models of isolated heart perfusion in either isovolumic or exterior working regimens. The assayed indices of diastole functioning were: left ventricle (LV) end-diastolic pressure (LVEDP), diastolic stiffness, isovolumic relaxation velocity (-dP/dTmax) and protodiastolic pressure of LV (LVPDP). Results: The indices of diastolic disorders induced by Dx were elevation of LVEDP, diastolic stiffness and LVPDP in a range of 97-168% comparing to control as well as diminution of -dP/dTmax in the physiological pattern of hemodynamics. LVEDP increased more in conditions of calcium overloading or endothelin-1 (ET-1) action that are involved in pathogenesis of diastolic rigidity. Dx action led to decrease of myocardium resistance to ischemiareperfusion action resulting in the LVEDP elevation by 53% comparing to control. Conclusions: 1. Diastolic disorders inherent to Dx cardiotoxicity are manifested by the increase of LVEDP and diastolic stiffness. 2. Diastolic disorders compromised the volume-pressure relationship of LV, the adaptation of the heart to effort with volume, being more pronounced during the action of calcium excess and ET-1


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