Neuropsychopharmacology: Changing the Face of Psychotropic Drug Discovery

CNS Spectrums ◽  
1997 ◽  
Vol 2 (9) ◽  
pp. 26-34
Author(s):  
B. E. Leonard
Keyword(s):  
Drug Discovery ◽  
Psychotropic Drug ◽  
Psychotropic Drugs ◽  
First Century ◽  
Central Nervous System Diseases ◽  
Trace Amine ◽  
Causative Agents ◽  
The Face ◽  
The Impact

AbstractThis review speculates on the changes currently taking place in psychopharmacology that will alter the course of psychotropic drug discovery and application in the coming millennium. The importance of endocoids as causative agents in central nervous system diseases; the role of neuropeptides and “trace” amine transmitters; the impact of imaging methods in elucidating the mechanism of action of psychotropic drugs; gene therapy; and the new role of psychoneuroimmunology in drug discovery are predicted to have a major impact in both the research and development of new psychotropic drugs in the twenty-first century.

Preserving Integrity in the Face of Performance Threat

2012 ◽  
Vol 23 (12) ◽  
pp. 1455-1460 ◽  
Author(s):  
Lisa Legault ◽  
Timour Al-Khindi ◽  
Michael Inzlicht
Keyword(s):  
Error Detection ◽  
Error Monitoring ◽  
Error Related Negativity ◽  
Threatening Information ◽  
Electrophysiological Responses ◽  
The Face ◽  
And Performance ◽  
The Impact ◽  
The Brain

Self-affirmation produces large effects: Even a simple reminder of one’s core values reduces defensiveness against threatening information. But how, exactly, does self-affirmation work? We explored this question by examining the impact of self-affirmation on neurophysiological responses to threatening events. We hypothesized that because self-affirmation increases openness to threat and enhances approachability of unfavorable feedback, it should augment attention and emotional receptivity to performance errors. We further hypothesized that this augmentation could be assessed directly, at the level of the brain. We measured self-affirmed and nonaffirmed participants’ electrophysiological responses to making errors on a task. As we anticipated, self-affirmation elicited greater error responsiveness than did nonaffirmation, as indexed by the error-related negativity, a neural signal of error monitoring. Self-affirmed participants also performed better on the task than did nonaffirmed participants. We offer novel brain evidence that self-affirmation increases openness to threat and discuss the role of error detection in the link between self-affirmation and performance.

Party-Political and Socio-Economic Сonsequences of Elections to the German Bundestag

2021 ◽  
pp. 24
Author(s):  
V.B. Belov
Keyword(s):  
Point Of View ◽  
The European Union ◽  
Social Democrats ◽  
The Social ◽  
Angela Merkel ◽  
The Face ◽  
German Bundestag ◽  
The Impact ◽  
Further Development

The article examines the results of the last Bundestag elections. They marked the end of the Angela Merkel era and reflected the continuation of difficult party-political and socio-economic processes in the informal leader of the European Union. The main attention of the research focuses on the peculiarities of the election campaign of the leading parties and of the search for ways of further development of Germany in the face of urgent economic and political challenges. These challenges include the impact of the coronavirus crisis, the impact of the energy and digital transition to a climate-neutral economy, and the complex international situation. Based on original sources, the author analyzes the causes of the SPD victory and the CDU/CSU bloc defeat, the results of the negotiations of the Social Democrats with the Greens and Liberals, the content of the coalition agreement from the point of view of the prospects for the development of domestic and foreign policy and the economy of Russia's main partner in the west of the Eurasian continent. The conclusion is made about the absence of breakthrough ideas, the consistent continuation of the course started by the previous government for a carbon-free economy and the strengthening of the role of Germany in Europe and the world. For this course, conflicts and problems in achieving the set goals will be immanent due to the compromising nature of the coalition agreements.

Transnationality in the XXI century. Concept and indicators

2021 ◽  
Vol ahead-of-print (ahead-of-print) ◽  
Author(s):  
Grazia Ietto-Gillies
Keyword(s):  
Structural Changes ◽  
Transnational Corporation ◽  
First Century ◽  
Future Research ◽  
Content Type ◽  
Low Degree ◽  
Fixed Assets ◽  
Inclusive Concept ◽  
The Impact

Purpose The purpose of this paper is to analyse the impact of major structural changes on the conceptualization of the transnational corporation (TNC) based on foreign direct investment (FDI) and on indicators of transnationality. Design/methodology/approach Analysis of three major structural changes which impact the current conception of transnationality. They are: the rise of digital companies; the increased role of finance in the economy; externalization of activities via non-equity modalities (NEMs) with an impact on FDI and on the labour market. Findings The paper finds that the current concept of transnationality needs widening to take account of companies with a low degree of fixed assets abroad such as the digital and the financial companies and those internationalizing via NEMs, as well as to take account of the evolving relationship between TNCs and labour. Research limitations/implications Future research along the lines proposed should consider: working explicitly with the new, inclusive concept of transnationality and arrive at an empirical estimate of the proposed indices of transnationality which modify and amplify the current United Nations Conference on Trade and Development indices. Social implications Useful for understanding the nature of transnationality in the twenty-first century and for developing policies. Originality/value The paper proposes a new concept of transnationality and of the TNC, one that allows for new ways of organizing direct business activities abroad. It also proposes broadening the list of indicators of transnationality.

scholarly journals ASYMMETRICAL THREATS AND THE IMPACT OF HYBRID WAR ON GLOBAL SECURITY AND ROLE OF NATO IN ENSURING PEACE

2019 ◽  
Author(s):  
Alika Guchua
Keyword(s):  
Cyber Attacks ◽  
First Century ◽  
Global Security ◽  
Security Issues ◽  
Asymmetric Warfare ◽  
Asymmetric Conflicts ◽  
New Type ◽  
Hybrid War ◽  
The Impact

Abstract: The article deals with new type of asymmetric warfare and hybrid war. The potential threats in international politics and global security issues, Euro-Atlantic Alliance policy of fighting against terrorism. A serious challenge to modern security creates many problems around the world. The beginning of the twenty-first century was marked by proliferation of hybrid wars, held between flexible and sophisticated adversaries engaged in asymmetric conflicts using various forms. The hybrid war is caused by a hybrid threat, a blend of military and non-military assets and operations, terrorism, guerrilla tactics, criminality and cyber attacks. The use of hybrid type tactics can ensure the achievement of the main objectives of an international actor, with a minimum of effort, usually without using the force, and can deny to the target/victim the possibility to take any defensive actions. The complexity, diversity, the nature and dynamics of contemporary conflicts represent challenges that should be widely studied. The war, be it ancient or modern, hybrid or not, is always complex and cannot be described by a single adjective. The work focuses on the role of NATO in ensuring peace worldwide in the context of new asymmetric threats. The aim of the research topic: analyzing global challenges, which pose a serious threat to international security.

scholarly journals Energy Saving as an Important Factor in Ensuring Product Competitiveness

2021 ◽  
Vol 2 (48) ◽  
pp. 120-125
Author(s):  
O. P. Vashkiv ◽  
◽  
S. B. Smereka ◽  
Keyword(s):  
Energy Saving ◽  
Specific Energy Consumption ◽  
Environmental Standards ◽  
Manufacturing Enterprise ◽  
Research Results ◽  
Industrial Enterprises ◽  
The Face ◽  
The One ◽  
The Impact

The article is aimed at studying the features of energy saving at a manufacturing enterprise and establishing a cause-and-effect relationship between energy saving and product competitiveness. Due to analyzing and generalizing the research results of domestic and foreign scientists the views of researchers on the process of energy saving at a manufacturing enterprise are systematized; the growing role of energy saving in ensuring energy efficiency and, consequently, product competitiveness is established. The research results show that energy saving at an enterprise is one of its most important assets, the impact of which on the level of product competitiveness is becoming increasingly important in the face of the exacerbating energy and environmental crises. Energy saving, basically focusing on the intensification of production processes and use of energy and energy resources, on the one hand, reduces the level of specific energy consumption and, consequently, the price of the released product while maintaining or increasing its quality; on the other hand, it reduces the carbon loading on the environment, thus contributes to the growth of the company's image among its consumers and partners. Both components are the most important factors in ensuring product competitiveness. The development and implementation of energy saving measures at industrial enterprises, with regard to the industry-specific character of economic entities, market conditions, and the requirements of environmental standards can serve as prospects for further research

Regulation

2020 ◽  
pp. 372-381
Author(s):  
Lawrence Gostin
Keyword(s):  
Public Health ◽  
International Law ◽  
Legal Change ◽  
The Face ◽  
Public Health Officials ◽  
The Law ◽  
The Impact

The objectives of this chapter are to help you understand: the impact of legislation, regulations, and litigation on the public’s health; the powers, duties, and restraints imposed by the law on public health officials; the potential of legal change to improve the public’s health; the role of international law and institutions in securing public health in the face of increasing globalization.

The impact of foreign direct investment on trade in Pakistan: the moderating role of terrorism

2020 ◽  
Vol 47 (5) ◽  
pp. 1137-1154
Author(s):  
Syed Hasanat Shah ◽  
Hafsa Hasnat ◽  
Delpachitra Sarath
Keyword(s):  
Foreign Direct Investment ◽  
Direct Investment ◽  
Trade Deficit ◽  
Method Of Moment ◽  
Content Type ◽  
The Face ◽  
External Sector ◽  
Generalized Method Of Moment ◽  
The Impact

PurposePakistan suffered with the menace of terrorism for long and become a front line state in the “War on Terror”. Terrorism shattered Pakistan economy and rendered her external sector vulnerable to instability and uncertainties.Design/methodology/approachTherefore, using system generalized method of moment (GMM), this paper investigates the impact of foreign direct investment (FDI) on exports, imports and trade deficit in the face of unabated terrorism in Pakistan.FindingsThe findings of the paper suggest that as terrorism in Pakistan increased, FDI contribution to Pakistan exports decreased while FDI contribution to Pakistan imports significantly increased. Terrorism also disrupted the chain of local production and increased Pakistan reliance on imports. Thus terrorism widened Pakistan trade deficit of Pakistan and expose Pakistan to external imbalances.Originality/valueDespite rise in organized acts of terrorism and its adverse impact on various departments of economy, hardly any study bothers to check its impact on trade and investment nexus. This is the first study of its nature that looks deep down to understand how terrorism affects the relation of major economic variables.

scholarly journals The impact of elite frames and motivated reasoning on beliefs in a global warming conspiracy: The promise and limits of trust

2017 ◽  
Vol 4 (3) ◽  
pp. 205316801771760 ◽  
Author(s):  
Kyle L Saunders
Keyword(s):  
Climate Change ◽  
Global Warming ◽  
Motivated Reasoning ◽  
Anthropogenic Global Warming ◽  
The Face ◽  
Conspiracy Beliefs ◽  
Original Question ◽  
Behavioral Impact ◽  
The Impact

Given the potential attitudinal and behavioral impact of Anthropogenic Global Warming (AGW) conspiracy beliefs, it is important to understand their causes and moderators. Here, two explanations for the variation in these beliefs are engaged: the first is the choice among elites to frame AGW using the phrase ‘global warming’ (GW) as opposed to ‘climate change’ (CC); the second is partisan motivated reasoning. A theory is then developed about the role of trust in moderating the impact of the two frames on AGW conspiracy beliefs. In the case of CC, which is perceived as less severe than GW (and is therefore less identity threatening among Republicans), it is hypothesized that trust will moderate hoax beliefs among Republicans. In the case of GW, where the implications of existence beliefs have policy consequences that are more unpleasant, motivated reasoning will ‘win out’, and trust will not moderate conspiracy endorsement among Republicans. The results from an original question framing experiment are consistent with the author’s hypotheses. Whilst trust is a welcome commodity to those looking to persuade citizens to support AGW-ameliorating policies, it is not a cure-all, especially in the face of elite partisan cues that edify pre-existing attitudes/identities and arouse a strong desire to engage in motivated reasoning.

scholarly journals STRATEGI ADAPTASI KEARIFAN LOKAL MASYARAKAT NELAYAN TERHADAP PERUBAHAN EKOSISTEM PESISIR ACEH

2018 ◽  
Vol 4 (1) ◽  
Author(s):  
Arfriani Maifizar
Keyword(s):  
Adaptation Strategies ◽  
Ecosystem Change ◽  
Fishing Communities ◽  
Group Discussions ◽  
Academic Knowledge ◽  
The Face ◽  
Ecosystem Changes ◽  
Taking Action ◽  
The Impact

This study includes the importance of maintaining local wisdom by fishing communities in the face of adaptation to the impact of ecosystem changes on Sabang Island. Through deepening of the literature review, in-depth interviews, observations, and focus group discussions were conducted with local fishing communities in the coastal area of Sabang Island, finally found some research results that made reference to the adaptation strategies that fishermen community carried to the impact of ecosystem changes through local wisdom. The results show that Sabang Island fishermen communities who have felt the impact of ecosystem changes such as mangrove damage, coral reefs due to exploitation of coastal resources and natural disasters can achieve the success of solving the problem in several ways either through knowledge about adaptation made by fishing communities obtained from academic knowledge, or through knowledge that has been entrusted in a downward manner known as local wisdom. Therefore, fisherman adaptation strategies in addressing the impacts of ecosystem change follow a pattern of reactive adaptation, they tend to use capabilities from within the community. This adaptation pattern is carried out by developing job diversification, modifying the fleet of boats and taking action with the community in rehabilitating damaged ecosystems and the role of commander laot to the fishermen in arranging the time of catching with the natural sign through the knowledge of inheritance as local wisdom that needs to be maintained all the time. Keyword: Fisherman Society, Adaptation, ecosystem change, local wisdom.

scholarly journals The Role of Responsive Leadership in Meeting Customers' Needs during Crises

2022 ◽  
Vol 13 (1) ◽  
pp. 0-0
Keyword(s):  
Large Scale ◽  
Education Institution ◽  
Face To Face ◽  
Leadership Attributes ◽  
Leadership Support ◽  
The Face ◽  
Quantitative Results ◽  
The Impact

This case study conducted to investigate the impact of a responsive leadership approach in meeting customers' needs in a higher education institution in the UAE during the COVID-19 pandemic. For this purpose, a mixed-method model has been used. The data has been collected from a convenient sample working and studying at Al Qasimia University Language Center, in fall 2020. This result indicates that the provided responsive leadership support during COVID-19 was effective and helped in motivating learners and customers to keep learning and making progress greater than what was shown before COVID-19, during the face-to-face teaching and physical assessment. Although the qualitative and quantitative results in this case study revealed a significant impact of responsive leadership approach on customers’ progress, there is still a need to conduct other researches to develop and validate a responsive leadership inventory to facilitate measuring of responsive leadership attributes in a large scale sample and/or population.

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