Heat Dose Based Large Tumor Treatment with Multiple Site Injections of Heat-generating Nanoparticles Dispersible within Tumor Tissue

Laser thermotherapy is a technique used for tumor treatment. It generates a local heating, causes thermal coagulation of living tissue and eliminates the tumor. Precise heating of tumor tissue with healthy minimum thermal injury to adjacent tissue is essential to thermotherapy. Understanding of heat transfer and optical-thermal interaction is important for control of temperature and design of thermotherapy. This study applies the Arrhenius damage model to describe the heat-induced change of optical properties. It calculates the distribution temperature, damage and optical-thermal response of bio-tissue during the laser treatment, and shows how these factors affect the effectiveness of laser thermotherapy. Similar research has been performed by Kim and coworkers [1996], Iizuka and coworkers [2000], and Whelan and coworkers [2000]. This study relaxes some conditions in previous investigations. It reveals the importance and the effect of size of the laser head.

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Application of Gold-Based Nanomaterials in Tumor Photothermal Therapy and Chemotherapy

Journal of Biomedical Nanotechnology ◽

10.1166/jbn.2020.2938 ◽

2020 ◽

Vol 16 (6) ◽

pp. 739-762

Author(s):

Minyu Zhou ◽

Yunfei Zhou ◽

Yixin Cheng ◽

Yanqi Wu ◽

Jun Yang ◽

...

Keyword(s):

Photothermal Therapy ◽

Tumor Targeting ◽

Tumor Tissue ◽

Treatment Method ◽

Tumor Treatment ◽

Targeting Therapy ◽

Photothermal Conversion ◽

Gold Nanomaterials ◽

Development Prospects ◽

Therapy Treatment

Photothermal therapy (PTT) is a minimally invasive tumor treatment method in which photothermal conversion agents (PTAs) can be enriched in tumor tissue by external light stimulation to convert photon energy into thermal energy to induce the temperature of tumor tissue higher than normal physiological, and can effectively kill tumor cells and tissues while avoiding damage to healthy tissue. As a well-known biocompatible nanomaterial, gold-based nanomaterials have high photothermal conversion efficiency and cross section, which can be used in tumor targeting therapy treatment as a potential photothermal conversion agent. Combining PTT and chemotherapy can be achieved by loading a chemotherapeutic drug modified on the surface of a gold nanomaterials. Therefore, this paper first reviews the preparation and surface functionalization of Au-based nanomaterials, such as Au nanorods, Au nanostars, Au nanoshells, and so on. Second, we have also introduced the application of Au-based nanomaterials in PTT, chemotherapy, and combination therapy. Finally, the limitations and challenges of Au-based photothermal conversion agents are summarized and the development prospects in this field are prospected.

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NIMG-16. EXPLORATORY EVALUATION OF Q-SPACE TRAJECTORY IMAGING PARAMETERS AS NOVEL IMAGING BIOMARKERS FOR GLIOMAS

Neuro-Oncology ◽

10.1093/neuonc/noaa215.629 ◽

2020 ◽

Vol 22 (Supplement_2) ◽

pp. ii150-ii150

Author(s):

Parikshit Juvekar ◽

Filip Szczepankiewicz ◽

Thomas Noh ◽

Carl-Fredrik Westin ◽

Alexandra Golby

Keyword(s):

Diffusion Mri ◽

Tumor Tissue ◽

De Novo ◽

Tumor Grade ◽

Imaging Biomarkers ◽

Tumor Treatment ◽

Tissue Microstructure ◽

Non Invasive ◽

Recurrent Tumors ◽

Diffusion Parameters

Abstract Neuroimaging offers a non-invasive means to probe tumor tissue in order to inform decision making at all phases of brain tumor treatment. Diffusion MRI is particularly sensitive to tumor tissue microstructure, with greater heterogeneity being reflected as a larger diffusional kurtosis. Q-Space Trajectory Imaging (QTI) uses tensor-valued diffusion encoding (encoding along multiple directions per shot) to disentangle Isotropic Mean Kurtosis (MKi) from Anisotropic Mean Kurtosis (MKa), which are otherwise conflated in the Total Mean Kurtosis (MKt). To test whether disentangling MKi and MKa facilitates a more specific probe of tumor tissue heterogeneity and malignancy, we investigated if QTI parameters could distinguish low- from high-grade gliomas and enhancing from non-enhancing regions using pre-operative QTI imaging of 13 W.H.O. grade I-II and 18 grade III-IV glioma patients. We also analyzed these features separately for de novo and recurrent tumors. Regions of Interest (ROIs) were drawn on QTI maps, with support from T1 and T2-weighted images, for enhancing region, non-enhancing region, necrotic cavity, cyst, edema and resection cavity. ROC was used to gauge QTI parameter performance in classifying tumor characteristics. MKi was found to be the strongest predictor of tumor grade (AUC = 0.74, p = 0.019). MKi and MKt separated de novo from recurrent tumors (AUC = 0.80 and 0.76, p < 0.05). MKt separated enhancing regions from non-enhancing regions with an AUC of 0.88 in all tumors and 0.97 in de novo tumors. Our preliminary results highlight that tensor-valued diffusion MRI and QTI analysis have the potential to non-invasively characterize tumor grade. Further, MKt accurately differentiated enhancing from non-enhancing tumors and could potentially substitute for gadolinium injection in some situations thereby decreasing risk, time, and cost. Our ongoing studies in larger groups aim to further correlate molecular tumor markers (eg. IDH1 status) with these diffusion parameters.

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Conformal Tumor Treatment by the Combined Cryosurgical and Hyperthermic System: Optimal Configuration of the Multiple Probes

Volume 2: Biomedical and Biotechnology Engineering ◽

10.1115/imece2007-43920 ◽

2007 ◽

Cited By ~ 1

Author(s):

Zhong-Shan Deng ◽

Jing Liu

Keyword(s):

Tumor Tissue ◽

Three Dimensional ◽

Optimal Configuration ◽

Tumor Treatment ◽

Hyperthermia Treatment ◽

Combined System ◽

Hyperthermic Treatment ◽

System Optimal ◽

Probe System ◽

Optimal Configurations

Recently, a minimally invasive probe system capable of performing both cryosurgery and hyperthermia treatment for deep tumor was developed. With the increasing applications of such combined system, it becomes apparent that without optimal configuration of the multiple probes during multiple freeze/heat cycles, it is difficult produce a conformal lesion in the tumor tissue, which may lead to either insufficient or excessive freezing/heating and consequently, to tumor recurrence or to destruction of healthy tissue. In this study, a comprehensive three-dimensional numerical investigation is performed to design optimal configurations of the multiple probes used in the combined cryosurgical and hyperthermic treatment. The results presented in this study will be useful for treatment planning of the combined cryosurgical and hyperthermic treatment.

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Gemcitabine Peptide-Based Conjugates and Their Application in Targeted Tumor Therapy

Molecules ◽

10.3390/molecules26020364 ◽

2021 ◽

Vol 26 (2) ◽

pp. 364

Author(s):

Aleksandra Hawryłkiewicz ◽

Natalia Ptaszyńska

Keyword(s):

Therapeutic Agent ◽

Tumor Tissue ◽

Tumor Therapy ◽

Therapeutic Index ◽

Tumor Treatment ◽

First Line ◽

Conventional Chemotherapy ◽

Wide Range ◽

Direct Targeting ◽

Adverse Influence

A major obstacle in tumor treatment is associated with the poor penetration of a therapeutic agent into the tumor tissue and with their adverse influence on healthy cells, which limits the dose of drug that can be safely administered to cancer patients. Gemcitabine is an anticancer drug used to treat a wide range of solid tumors and is a first-line treatment for pancreatic cancer. The effect of gemcitabine is significantly weakened by its rapid plasma degradation. In addition, the systemic toxicity and drug resistance significantly reduce its chemotherapeutic efficacy. Up to now, many approaches have been made to improve the therapeutic index of gemcitabine. One of the recently developed approaches to improve conventional chemotherapy is based on the direct targeting of chemotherapeutics to cancer cells using the drug-peptide conjugates. In this work, we summarize recently published gemcitabine peptide-based conjugates and their efficacy in anticancer therapy.

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A Robotic System for Overlapping Radiofrequency Ablation in Large Tumor Treatment

IEEE/ASME Transactions on Mechatronics ◽

10.1109/tmech.2010.2078827 ◽

2010 ◽

Vol 15 (6) ◽

pp. 887-897 ◽

Cited By ~ 27

Author(s):

Liangjing Yang ◽

Rong Wen ◽

Jing Qin ◽

Chee-Kong Chui ◽

Kah-Bin Lim ◽

...

Keyword(s):

Radiofrequency Ablation ◽

Robotic System ◽

Tumor Treatment ◽

Large Tumor

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Localization of Gallium-67 in Peritoneal Cells by Electron Microscopic Autoradiography

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100072460 ◽

1973 ◽

Vol 31 ◽

pp. 404-405

Author(s):

D. C. Swartzendruber ◽

Norma L. Idoyaga-Vargas

Keyword(s):

Clinical Trials ◽

Soft Tissue ◽

Tumor Tissue ◽

Soft Tissue Tumors ◽

Clinical Usefulness ◽

Electron Microscopic ◽

Normal Cells ◽

Electron Microscopic Autoradiography ◽

Peritoneal Cells ◽

Gallium 67

The radionuclide gallium-67 (67Ga) localizes preferentially but not specifically in many human and experimental soft-tissue tumors. Because of this localization, 67Ga is used in clinical trials to detect humar. cancers by external scintiscanning methods. However, the fact that 67Ga does not localize specifically in tumors requires for its eventual clinical usefulness a fuller understanding of the mechanisms that control its deposition in both malignant and normal cells. We have previously reported that 67Ga localizes in lysosomal-like bodies, notably, although not exclusively, in macrophages of the spocytaneous AKR thymoma. Further studies on the uptake of 67Ga by macrophages are needed to determine whether there are factors related to malignancy that might alter the localization of 67Ga in these cells and thus provide clues to discovering the mechanism of 67Ga localization in tumor tissue.

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