scholarly journals Infrared spectroscopy in detection of brain tumor of different morphological structure

2021 ◽  
Vol 22 (1) ◽  
pp. 218-226
Author(s):  
I.A. IMedyanik ◽  
A.S. Gordetsov ◽  
O.V. Krasnikova ◽  
A.R. Kondratyeva1 ◽  
S.K. Badu ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Infrared Spectroscopy ◽  
Brain Tumors ◽  
Blood Serum ◽  
Healthy Volunteers ◽  
Morphological Structure ◽  
Brain Lesions ◽  
Absorption Bands ◽  
Cerebrovascular Accidents ◽  
Diagnosis Method

The study considers the results of application of blood serum infrared spectroscopy as a diagnosis method of brain tumors with various morphological structure. The study involves 99 patients with brain tumors (glioblastomas were diagnosed in 22 patients, astrocytomas – in 21, neuromas – in 13, meningiomas – in 12, ependymomas – in 11, oligodendroastrocytomas – in 10, hypophyseal adenomas – in 10 patients), 16 patients with acute cerebrovascular accidents of ischemic type, 24 patients with severe traumatic brain injury and 20 healthy volunteers. In each studied case, 13 ratios of peak heights of blood serum infrared spectrum absorption bands were studied applying infrared spectroscopy (IRS). The results of morphological and immunohistochemical examinations were compared with the results of blood serum IRS data of patients with brain tumors. There were statistically significant correlations between the histological nature of brain tumors and IRS values. Statistically significant differences between the blood serum IRS of patients with tumor, non-tumor brain lesions and healthy volunteers were also found.

Iron concentration in the blood serum of patients with mild and moderate craniocerebral trauma in acute and intermediate periods

2014 ◽  
Vol 18 (4 (72)) ◽  
Author(s):  
M. G. Semchyshyn ◽  
B. V. Zadorozhna
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Blood Serum ◽  
Healthy Volunteers ◽  
Clinical Features ◽  
Clinical Symptoms ◽  
Iron Concentration ◽  
Craniocerebral Trauma ◽  
Control Group ◽  
Iron Deficit

Clinical features and dynamics of changing the iron concentration in the serum of blood of patients with a traumatic brain injury have been studied.Methods. Complex clinical and para-clinical examination of 283 patients with mild and moderate traumatic braininjury in acute and intermediate periods, 20 almost healthy volunteers (control group).Results. The concentration of iron tends to decrease in the serum of blood in patients with mild and moderate braininjury in acute and intermediate periods.Area of results application. Neurology.Conclusion. The connection between iron deficit and the development of basic clinical symptoms of craniocerebraltrauma is obvious.

scholarly journals BIOMARKERS FOR EARLY DIAGNOSTICS OF BRAIN TUMORS

2021 ◽  
Vol 22 (1) ◽  
pp. 86-96
Author(s):  
I.A. Medyanik ◽  
A.S. Gordetsov ◽  
K.S. Yashin ◽  
O.V. Krasnikova ◽  
Frayerman ◽  
...  
Keyword(s):  
Infrared Spectroscopy ◽  
Brain Tumors ◽  
Blood Serum ◽  
Early Stage ◽  
Combined Therapy ◽  
Research Direction ◽  
Ct Scans ◽  
Early Diagnostics ◽  
Prospective Research

Early diagnostics of brain tumors – is an important component of combined therapy for treatment neoplasms. Searching markers of glioma allowing to diagnose tumors at an early stage (before appearance of some changes on MRI and CT scans), to predict their course and to estimate the effectiveness of the performed therapy is a prospective research direction. Now-a-days the properties of microRNK and infrared spectroscopy of blood serum is being studied actively. This review covers results of the performed studies, confirming the possibility of application of such methods as biomarkers of glioma.

First Nano-Infrared Spectroscopy and Imaging Measurements of Single Phospholipid Bilayers

2018 ◽  
Author(s):  
Adrian Cernescu ◽  
Michał Szuwarzyński ◽  
Urszula Kwolek ◽  
Karol Wolski ◽  
Paweł Wydro ◽  
...  
Keyword(s):  
Infrared Spectroscopy ◽  
Ir Spectroscopy ◽  
Absorption Band ◽  
Spectral Region ◽  
Near Field ◽  
Phospholipid Bilayers ◽  
Model Systems ◽  
Absorption Bands ◽  
Protein Complement ◽  
20 Nm

<div><div>Scattering-mode Scanning Near-Field Optical Microscopy (sSNOM) allows one to obtain absorption spectra in the mid-IR region for samples as small as 20 nm in size. This configuration has made it possible to measure FTIR spectra of the protein complement of membranes. (Amenabar 2013) We now show that mid-IR sSNOM has the sensitivity required to measure spectra of phospholipids in individual bilayers in the spectral range 800 cm<sup>-1</sup>–1400 cm<sup>-1</sup>. We have observed the main absorption bands of the dipalmitoylphosphatidylcholine headgroups in this spectral region above noise level. We have also mapped the phosphate absorption band at 1070 cm<sup>-1</sup> simultaneously with the AFM topography. We have shown that we could achieve sufficient contrast to discriminate between single and multiple phospholipid bilayers and other structures, such as liposomes. This work opens the way to further research that uses nano-IR spectroscopy to describe the biochemistry of cell membranes and model systems.</div></div><div></div>

CNTM-03. Functional connectivity networks in patients with brain tumors and vascular lesions in the occipital cortex

2021 ◽  
Vol 23 (Supplement_6) ◽  
pp. vi224-vi225
Author(s):  
Katharina Rosengarth ◽  
Katharina Hense ◽  
Tina Plank ◽  
Mark Greenlee ◽  
Christina Wendl ◽  
...  
Keyword(s):  
Functional Connectivity ◽  
Brain Tumors ◽  
Visual Processing ◽  
Network Connectivity ◽  
Occipital Cortex ◽  
Brain Lesions ◽  
Vascular Lesions ◽  
Surrounding Tissue ◽  
Tumor Patients ◽  
Default Mode

Abstract OBJECTIVE Space-occupying brain lesions as brain tumors in the occipital lobe have only been sparsely investigated so far, as this localization is extremely rare with only 1% of cases. It is still unclear how this affects the overall organization of the visual system. We investigated functional connectivity of functional networks associated with higher visual processing between patients with occipital space-occupying lesion in the occipital cortex and healthy controls. METHODS 12 patients with brain tumors, 7 patients with vascular lesions in the occipital cortex and 19 healthy subjects matched for age and sex were included. During functional MRI patients and subjects performed a visual excentricity mapping task. Data analysis was done using CONN toolbox based on Matlab. See-to-ROI connectivities of 23 Regions of Interest (ROIs) implemented in the CONN toolbox which were assigned to the Default Mode, Visual, Salience, Dorsal Attention, and Frontoparietal network were assessed. For each subject, connectivity was calculated using Fischer transformed pairwise correlations. These correlations were first considered separately for each group in one-sample analyses and then compared between the groups. RESULTS Main results show, that compared to control subjects and vascular patients, tumor patients showed weaker intra-network connectivity of components of all networks except the default-network. Tumor patients showed even stronger between-network connectivity in the default-mode network compared to the other groups. Weaker connectivity was observed within the salience network in both patient groups compared to controls. CONCLUSION The results indicate that in the course of the disease, compensatory countermeasures take place in the brain against a brain tumor or a space-occupying brain lesion with the aim of maintaining the performance level and cognitive processes for as long as possible. However, more research is needed in this area to understand the mechanisms and effects of brain tumors and space-consuming brain lesions on surrounding tissue.

scholarly journals Forensic Examination of Inks Extracted from Printed Documents using Fourier Transform Infrared Spectroscopy

2018 ◽  
pp. 10-17
Author(s):  
Paul Ocheje Ameh ◽  
Musa Suud Ozovehe
Keyword(s):  
Fourier Transform ◽  
Infrared Spectroscopy ◽  
Fourier Transform Infrared Spectroscopy ◽  
Alkyd Resin ◽  
Epoxy Resins ◽  
Ftir Spectra ◽  
Absorption Bands ◽  
Triarylmethane Dyes ◽  
Infra Red ◽  
Aliphatic Ester

Yellow, cyan, magenta and black inks were extracted from documents printed using two common brands of printing cartridge in Nigerian market and analyzed to identify / compare the functional groups present using Fourier Transform Infra-red Spectroscopy (FTIR). The FTIR spectra obtained were found to show highly characteristic absorption bands depending on the composition of the printer inks. Also, the results indicated the presence of triarylmethane dyes, epoxy resins, alkyd resin and esters in all the inks as they are peaks assigned to the vibration of aliphatic ester, asymmetrical and symmetrical stretching. The pure ink and its extract from the same band were also found to exhibit similar FTIR spectra while inks extract from different brands exhibits marked difference in absorption bands. This research can provide valuable information if an admitted sample is provided for comparing with the suspect printed document.

scholarly journals Analysis of infrared spectra of blood serum of patients with multiple myeloma

2021 ◽  
Vol 2103 (1) ◽  
pp. 012052
Author(s):  
D A Chernyshev ◽  
E S Mikhailets ◽  
E A Telnaya ◽  
L V Plotnikova ◽  
A D Garifullin ◽  
...  
Keyword(s):  
Multiple Myeloma ◽  
Principal Component Analysis ◽  
Infrared Spectroscopy ◽  
Blood Serum ◽  
Infrared Spectra ◽  
Early Stage ◽  
Principal Component ◽  
Healthy Donors ◽  
Components Analysis ◽  
Serious Disease

Abstract Multiple myeloma (MM) is a serious disease that is difficult to diagnose especially at early stage. Infrared spectroscopy is a promising approach for diagnosing MM. The principal component analysis (PCA) allows us to reduce the dimension of the data and keep only the important variables. In this study, we apply principal components analysis to infrared (IR) spectra of blood serum from healthy donors and multiple myeloma patients. As a result of the analysis by PCA, it was possible to visualize the separation of patient’s and donor’s samples into two clusters. The result indicates that this method is potentially applicable for diagnosis of multiple myeloma.

Passivation of N-Type Silicon by Hydrogen

1987 ◽  
Vol 104 ◽  
Author(s):  
K. Bergman ◽  
Michael Stavola ◽  
S. J. Pearton ◽  
J. Lopata
Keyword(s):  
Infrared Spectroscopy ◽  
Complex Formation ◽  
Heat Treatments ◽  
Hydrogen Passivation ◽  
Absorption Bands ◽  
Type Silicon

ABSTRACTInfrared spectroscopy has been used to study hydrogen passivation of P, As, and Sb donors in Si. The spectra show several new absorption bands due to donor-H complexes. By comparing spectra after different heat treatments it is shown directly that the passivation is due to complex formation.

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