scholarly journals Functional foods’ bioactive components and their chemoprevention mechanism in cervical, breast, and liver cancers: A systematic review

2021 ◽  
Vol 11 (11) ◽  
pp. 559
Author(s):  
John Oluwafemi Teibo ◽  
Kehinde Sulaimon Ayinde ◽  
Olamide Tosin Olaoba ◽  
Temitope Isaac Adelusi ◽  
Titilade Kehinde Ayandeyi Teibo ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Systematic Review ◽  
Cervical Cancer ◽  
Drug Development ◽  
Functional Foods ◽  
Ros Generation ◽  
Bioactive Components ◽  
Incidence And Mortality ◽  
Liver Cancers ◽  
Anti Cancer

The invasiveness and low survivability on the part of patients associated with cancer continues to raise global concern. Different approaches have been used in the treatment and restoration of normalcy in cancer patients. However, most of the therapeutic strategies employed are challenged with high cost, low efficacy, high toxicity, and multiple side effects. In recent times, emergent studies have provided evidence that functional foods and their bioactive components serve roles as potential agents in the prevention and treatment of cancers. Moreover, global interest has focused on how this chemoprevention potential of functional foods can be explored as plant-based medicines for drug development. Although, the literature is replete with the mechanism of chemoprevention elicited by individual components of functional foods, there are limited reports on their overall anti-cancer mechanisms. Therefore, this systematic review aims to unify the anti-cancer mechanisms of functional foods in cervical, breast, and liver cancers which were selected due to their high incidence and mortality globally. We reviewed articles from NCBI/PUBMED from 2010 until February 2020. Three different search words used include “Functional food and cervical cancer”; “Functional foods and breast cancer”; “Functional foods and hepatocarcinoma”. Consequently, 434 scientific papers resulted from the three search words. However, after applying the inclusion/exclusion criteria, 37 articles were selected: 14 on cervical cancer, 10 on breast cancer, and 13 on hepatocellular carcinoma. We subsequently emphasize the anti-cancer mechanisms of various functional foods in the studies selected and these include induction of apoptosis, cell cycle arrest, disruption of microtubular network, downregulation of anti-apoptotic Bcl-2 family expression, induction of autophagy, modulation of signaling cascades, ROS generation, and suppression of specific genes. Therefore, functional foods possess effective chemoprevention mechanisms which can be explored in drug development. Keywords: Cervical cancer, Breast cancer, Liver cancer, Cancer prevention, Functional foods, Bioactive compounds

Prevascularized, Co-Culture Model for Breast Cancer Drug Development

2012 ◽  
Author(s):  
Lauren Marshall ◽  
Isabel Löwstedt ◽  
Paul Gatenholm ◽  
Joel Berry
Keyword(s):  
Breast Cancer ◽  
Drug Development ◽  
Three Dimensional ◽  
Human Tumor ◽  
3D Models ◽  
Cancer Drug ◽  
Cancer Therapies ◽  
Anti Cancer

The objective of this study was to create 3D engineered tissue models to accelerate identification of safe and efficacious breast cancer drug therapies. It is expected that this platform will dramatically reduce the time and costs associated with development and regulatory approval of anti-cancer therapies, currently a multi-billion dollar endeavor [1]. Existing two-dimensional (2D) in vitro and in vivo animal studies required for identification of effective cancer therapies account for much of the high costs of anti-cancer medications and health insurance premiums borne by patients, many of whom cannot afford it. An emerging paradigm in pharmaceutical drug development is the use of three-dimensional (3D) cell/biomaterial models that will accurately screen novel therapeutic compounds, repurpose existing compounds and terminate ineffective ones. In particular, identification of effective chemotherapies for breast cancer are anticipated to occur more quickly in 3D in vitro models than 2D in vitro environments and in vivo animal models, neither of which accurately mimic natural human tumor environments [2]. Moreover, these 3D models can be multi-cellular and designed with extracellular matrix (ECM) function and mechanical properties similar to that of natural in vivo cancer environments [3].

scholarly journals Association of TNF-α -308G>A Polymorphism with Susceptibility to Cervical Cancer and Breast Cancer – a Systematic Review and Meta-analysis

2019 ◽  
Vol 32 (3) ◽  
Author(s):  
Meraj Farbod ◽  
Mojgan Karimi-Zarchi ◽  
Naeimeh Heiranizadeh ◽  
Neda Seifi-Shalamzari ◽  
Mohammad Javad Akbarian-Bafghi ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Systematic Review ◽  
Cervical Cancer ◽  
Meta Analysis ◽  
Tnf Α

Breast cancer oral anti-cancer medication adherence: a systematic review of psychosocial motivators and barriers

2017 ◽  
Vol 165 (2) ◽  
pp. 247-260 ◽  
Author(s):  
Cheryl Lin ◽  
Rachel Clark ◽  
Pikuei Tu ◽  
Hayden B. Bosworth ◽  
Leah L. Zullig
Keyword(s):  
Breast Cancer ◽  
Systematic Review ◽  
Medication Adherence ◽  
Anti Cancer

scholarly journals A Systematic Review of Cervical Cancer Incidence and Mortality in the Pacific Region

2014 ◽  
Vol 15 (21) ◽  
pp. 9433-9437 ◽  
Author(s):  
J. Obel ◽  
Y. Souares ◽  
D. Hoy ◽  
W. Baravilala ◽  
S.M. Garland ◽  
...  
Keyword(s):  
Systematic Review ◽  
Cervical Cancer ◽  
Cancer Incidence ◽  
Pacific Region ◽  
Cervical Cancer Incidence ◽  
The Pacific ◽  
Incidence And Mortality

scholarly journals The Effectiveness of Cognitive Behavioral Therapy (CBT) To Decreased Depression in Woman Patients with Cancer included cervical cancer and breast cancer

2019 ◽  
Vol 6 (3) ◽  
pp. 27
Author(s):  
Dwi Fitriyanti ◽  
Mardiyono Mardiyono ◽  
Yuriz Bakhtiar
Keyword(s):  
Breast Cancer ◽  
Systematic Review ◽  
Cervical Cancer ◽  
Cognitive Behavioral Therapy ◽  
Cause Of Death ◽  
Behavioral Therapy ◽  
Cognitive Behavioral ◽  
Future Research ◽  
Newly Diagnosed ◽  
Patients With Cancer

<em>The highest cancers in Indonesia in women are breast cancer and cervical cancer. Both are the most common cancers in women and the highest cause of death in women. Some woman patients with newly diagnosed of breast cancer or cervical cancer will experience depression. most patients newly diagnosed with cancer, less than 6 months reported a feeling of depression of 91.4%. An effective intervention to reduce the level of depression is to provide cognitive behavioral therapy (CBT) interventions. CBT is a psychotherapy recommended for treating depression in patients with breast cancer and cervical cancer. The objective of this study to review the effects of CBT on decreasing depression in woman patients with cancer including cervical cancer and breast cancer. This study is a systematic review. We search articles from EBSCOhost, Google Scholar, Pubmed, and Science Direct database which published from 2008 till 2018. RCTs are included in this review. Four RCTs included in this study. CBT interventions are carried out differently for each article, in general, each session is given for 60-90 minutes with a different number of sessions. Outcome measured in 3 articles was more than one variable (not only depression) and one article only measured the level of depression. Cognitive behavioral therapy can be used for woman patients with breast cancer and cervical cancer who are depressed. Future research to the effectiveness of CBT in reducing depression in woman patients specifically in newly diagnosed with cervical cancer is needed to confirm the evidence</em>

scholarly journals Sri Lankan Patterns of Female Cancers: Incidence and Mortality Over 1995-2010

2021 ◽  
Vol 6 (1) ◽  
pp. 27-33
Author(s):  
Palatiyana V. S. C Vithana ◽  
Dompeyalage S. A.F Dheerasinghe ◽  
Hadagiripathira M. I Handagiripathira ◽  
Shreeni Alahapperuma ◽  
Irosha Nilaweera ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cervical Cancer ◽  
Sri Lanka ◽  
Cancer Incidence ◽  
Cancer Mortality ◽  
Uterine Cancer ◽  
World Health ◽  
Sri Lankan ◽  
Incidence And Mortality ◽  
Uterine Cancers

Background: Neoplasms are the second leading cause of deaths in Sri Lanka. Present study analysed the trends in incidence and mortality of all cancers, breast cancer, cervical, ovarian and uterine cancers among Sri Lankan females over 1995-2010. Methods: Cancer incidence was obtained from national hospital-based cancer registries. Cancer mortality was abstracted from World Health Organization database and Department of Census and Statistics Sri Lanka. Number of new cases and deaths were obtained by five-year age group for all cancers by sex and breast, cervical, ovarian and uterine cancers for females. Particular cancer specific incidence and mortality rates were directly age-standardised to the Segi-Doll world standard population. Age-standardised incidence and mortality for young adults (20-34 years), adults (35-64 years) and older adults (over 64 years) by the type of the female cancer over 1995-2010 were calculated. Results: Age-standardised rates for incidence for all cancers among females rose from 63.3 to 87.5 per 100 000 population during 1995-2010 and its morality increased from 44.5 to 53.5 per 100 000 population. In spite of having similar trends in both sexes, cancer incidence among females remained higher while mortality persisted lower than males. Breast cancer was the commonest cancer among females with its incidence and mortality increasing through-out. Cervical cancer incidence increased during 1995-2000, declined slightly in 2005 and remained stable over 2006-2010.Cervical cancer mortality remained stable over 1995-1999, declined in 1999-2003, increased slightly throughout 2003-2006 and remained stable during 2007-2010. Ovarian cancer incidence remained stable over 1995-2010. Its mortality remained stable over 1995-2000, declined slightly during 2000-2003 and increased in 2003-2010. Uterine cancer incidence and mortality increased steadily throughout 1995-2010. For all these cancers, incidence and mortalityin 0-34 years remained low.Conclusions: Increasing trend of cancer incidence and mortality among females over 1995-2010, directs the need of revisiting female cancer control programmes. 

scholarly journals Accuracy of Self-report for Cervical and Breast Cancer Screening: A Systematic Review and Meta-analysis

2019 ◽  
Author(s):  
Johanna Anderson ◽  
Donald S. Bourne ◽  
Kim A. Peterson ◽  
Katherine M. Mackey
Keyword(s):  
Breast Cancer ◽  
Systematic Review ◽  
Cervical Cancer ◽  
Cancer Screening ◽  
Breast Cancer Screening ◽  
Cervical Cancer Screening ◽  
Medical Records ◽  
Meta Analysis ◽  
Self Report ◽  
System Level

Abstract Background: Guideline-based breast and cervical cancer screenings are fundamental components of high-quality preventive women’s health care services. Accurate measurement of screening rates is vital to ensure all women are adequately screened. Our systematic review and meta-analysis aims to provide an updated synthesis of the evidence on the accuracy of self-reported measures of cervical and breast cancer screening compared to medical records. Methods: To identify studies, we searched MEDLINE®, Cochrane Database of Systematic Reviews, and other sources up to July 2019. Two reviewers sequentially selected studies, abstracted data, and assessed internal validity and strength of the evidence. Adjusted summary numbers for sensitivity and specificity were calculated using a bivariate random-effects meta-analysis. Results: Unscreened women tended to over-report screening among 39 included studies examining the accuracy of self-report for cervical and/or breast cancer screening. The specificity of self-report was 48% (95% CI 41 to 56) for cervical cancer screening and 61% (95% CI 53 to 69) for breast cancer screening while the sensitivity of self-report was much higher at 96% (95% CI 94 to 97) for cervical cancer screening and 96% (95% CI 95 to 98). We have moderate confidence in these findings, as they come from a large number of studies directly assessing the accuracy of self-report compared to medical records and are consistent with findings from a previous meta-analysis. Conclusions: Unscreened women tend to over-report cervical and breast cancer screening, while screened women more accurately report their screening. Future research should focus on assessing the impact of over-reporting on clinical and system-level outcomes.

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