Parameters of cutaneous microvasculature in men of working age with newly diagnosed arterial hypertension

OBJECTIVE: To investigate structural and functional features of cutaneous microvasculature in men of working age with newly diagnosed arterial hypertension (AH). MATERIALS AND METHODS: The study included 161 apparently healthy men from 30 to 60 years, who underwent a comprehensive examination of cardiovascular system “from the heart to the capillaries”. Control group (CG) included 60 normotensive men. AH group included 101 men with elevated BP. RESULTS: There is no rarefaction of the capillary bed and latent fluid retention in the interstitial space in the skin in men with AH. No data were obtained for increased endothelial, neurogenic and myogenic tone of resistive cutaneous precapillary arterioles in AH group, but a decrease in the perfusion efficiency of the endothelial and myogenic mechanisms of tissue perfusion modulation was noted. CONCLUSION: Obtained results allow making the assumption that metabolic disorders at the level of capillaries that are of a systemic nature prevail in men with the onset of AH.

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The structural and functional features of the microcirculatory bed in patients with arterial hypertension and type 2 diabetes mellitus

Arterial’naya Gipertenziya (Arterial Hypertension) ◽

10.18705/1607-419x-2005-11-3-177-180 ◽

2005 ◽

Vol 11 (3) ◽

pp. 177-180 ◽

Cited By ~ 1

Author(s):

L. A. Lohankova ◽

Yu. V. Kotovskaya ◽

A. S. Milto ◽

Zh. D. Kobalava

Keyword(s):

Diabetes Mellitus ◽

Blood Flow ◽

Arterial Hypertension ◽

Control Group ◽

Microcirculatory Bed ◽

Type 2 Dm ◽

Group A ◽

Functional Features

The structural and functional features of the microcirculatory heel (MCB) were studied in patients with arterial hypertension (AH) in relation to the presence or absence of type 1 diabetes mellitus (DM). Two hundred and twelve patients were examined. These included 110 patients with grades 1 and 2 arterial hypertension (AH) and type 2 DM, 82 patients with AH without type 2 DM, and 20 apparently healthy individuals. Laser Doppler flowmetry (LDF) was used to estimate basal blood flow, the loading test parameters characterizing the structural and functional status of MCB, and the incidence of hemodynamic types of microcirculation. Patients with AH concurrent with type 1 DM were found to have the following microcirculatory features: an increase in perfusion blood flow (microcirculation index, 8,8±1,8 perf. units versus 4,9±0,8 perf, units in patients with AH without DM and 6,7±0,9 perf. units in the control group), a drastic reduction in myogenic activity to 13,2±5,7 % versus 16,7±6,8 and 25,2±6,4 %, respectively, a decrease in vascular resistance, impairment of autoregulation, and low reserve capacities (reserve capillary blood flow was 197,8±31,6 % versus 429,9±82,01 % in the group of AH without DM and 302,8±50,1 % in the control group), a predominance of the hyperemic hemodynamic type (58,8 % in patients with AH and DM, 20,9 % in those with AH without DM, and 20,0 % in the controls). The specific features of the altered microcirculatory bed in patients with AH concurrent with type 2 DM were ascertained. These included the predominance of hyperemic microcirculation, impaired autoregulation. diminished microvascular resistance, and the low reserve capacities of the microcirculatory bed.

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Prevalence of risk factors for arterial hypertension among draft age youth

Systemic Hypertension ◽

10.26442/2075082x.2021.2.200845 ◽

2021 ◽

Vol 18 (2) ◽

pp. 88-93

Author(s):

Basana V. Uvarovskaia ◽

Mariia V. Mel’nik ◽

Svetlana A. Kniazeva

Keyword(s):

Risk Factors ◽

Arterial Hypertension ◽

Quantitative Description ◽

Young Patients ◽

Adult Life ◽

Circulatory System ◽

Control Group ◽

Study Group ◽

Working Age ◽

Individual Program

Background. The currently observed diseases of the circulatory system getting younger, the increase in the incidence of arterial hypertension (AH) and the high mortality rate of men of working age in Russia are elements of one of the main medical and social problems. The identification of risk factors (RF) for the development of hypertension in young patients and the identification of the groups with the highest risk of cardiovascular events in their future adult life is aimed at preventing hypertension, early treatment initiation, increasing life expectancy and reducing mortality. Aim. To study the prevalence of the main modifiable RF associated with arterial hypertension among draft age youth. Materials and methods. The identification of RF, their qualitative, quantitative description, assessment and comparative analysis among men with normal and high blood pressure (BP) of varying degrees. Results. In the control group without hypertension, 37.1% of the subjects did not have any RF; 48.6% of the surveyed each had one RF; 14.3% were persons with two RFs. There were no people identified with three or more RFs. In the study group with AH, 27.0% of patients did not have any RF; 37.4% of patients had one RF; 22.6% of patients with two RFs; 9.5% of patients with three RFs and 2.6% of patients had four RFs. The occurrence of each RF in the control group without hypertension and in the study group with hypertension as a whole is presented as follows respectively: overweight/obesity 37.1 and 59.1%; smoking 34.3 and 38.3%; alcohol abuse 0 and 2.6%; physical inactivity 8.4 and 12.2%; hypercholesterolemia 2.9 and 20.9%; hypertriglyceridemia 5.7 and 16.5%; hyperglycemia 5.7 and 5.2%. Conclusion. RF is widespread in young men, regardless of BP level. More than 60% of draft age youth without hypertension have at least one RF. Among all modifiable RFs, the highest frequency of occurrence is associated with increased weight and smoking. Overweight or obesity is always found in individuals with two or more RFs. Among men with hypertension, people with obesity, low physical activity and impaired lipid metabolism are more common than among men without hypertension. Risk assessment in draft age youth presents certain difficulties. Identification and assessment of risk factors will make it possible to develop an individual program for their modification, prevention of the development of hypertension and detection of the disease in the early stages.

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Endothelial function in patients with asthma according to circadian blood pressure profile

Arterial’naya Gipertenziya (Arterial Hypertension) ◽

10.18705/1607-419x-2010-16-4-390-394 ◽

2010 ◽

Vol 16 (4) ◽

pp. 390-394

Author(s):

N. A. Karoli ◽

A. A. Roschina ◽

A. P. Rebrov

Keyword(s):

Blood Pressure ◽

Endothelial Dysfunction ◽

Endothelial Function ◽

Arterial Hypertension ◽

Bronchial Asthma ◽

Blood Pressure Monitoring ◽

Pressure Profile ◽

Control Group ◽

Essential Arterial Hypertension ◽

Functional Features

Objective. The aim of study is asses of the endothelial functional features in patient with bronchial asthma with different types of blood pressure (BP) circadial rhythm. Design and methods. 62 patients with bronchial asthma (from 25 to 60 years old) were included in our study. Control group was represented by 30 healthy people for examination of endothelial function and 77 patients with essential arterial hypertension for 24-h blood pressure rhythm analysis. We described 2 groups of patients («dippers» and «non-dippers») by ambulatory 24-h blood pressure monitoring. Results. «Non-dipper» type was significantly prevalent in patient with asthma in comparative with patients with essential arterial hypertension (51,6% opposite 33,7%). The flow-depended endothelial dysfunction is most common in patient with asthma (dippers and non-dippers) than in control group. Negative correlation between nitroglycerin-depended vasodilatation and night-depressing systolic and diastolic blood pressure degree was presented in the study. Conclusion. We founded associations between endothelial dysfunction and BP circadial rhythm in patients with bronchial asthma, especially in «non-dippers».

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IMMUNOREACTIVE GROWTH HORMONE IN PLASMA AND URINE IN JUVENILE DIABETICS BEFORE AND DURING INITIAL INSULIN TREATMENT

Acta Endocrinologica ◽

10.1530/acta.0.0750050 ◽

1974 ◽

Vol 75 (1) ◽

pp. 50-63 ◽

Cited By ~ 13

Author(s):

Kristian F. Hanssen

Keyword(s):

Growth Hormone ◽

Insulin Treatment ◽

Juvenile Diabetes ◽

Control Group ◽

List Type ◽

Newly Diagnosed ◽

Renal Tubular Reabsorption ◽

Juvenile Diabetics ◽

The Mean ◽

Renal Tubular

ABSTRACT Twenty newly diagnosed, but as yet untreated patients of both sexes with classical juvenile diabetes were investigated by determining the mean plasma immunoreactive growth hormone (IRHGH) and urinary IRHGH for a 24 hour period before and during initial insulin treatment. The plasma IRHGH was significantly higher (0.05 > P > 0.01) before than during initial insulin treatment. During initial insulin treatment, the mean plasma IRHGH was significantly higher (0.01 > P > 0.001) than in a control group. The urinary IRHGH was significantly higher (0.01 > P > 0.001) before than during insulin treatment. The increased urinary IRHGH observed before insulin treatment is thought to be partly due to a defective renal tubular reabsorption of growth hormone. No significant correlation was found between the mean blood sugar and plasma or urinary IRHGH either before or during insulin treatment.

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Diabetes-induced Alterations in HDL Subfractions Distribution

Current Pharmaceutical Design ◽

10.2174/1381612825666190227224246 ◽

2020 ◽

Vol 26 (27) ◽

pp. 3341-3348 ◽

Cited By ~ 1

Author(s):

Marek Femlak ◽

Anna Gluba-Brzozka ◽

Beata Franczyk ◽

Jacek Rysz

Keyword(s):

Diabetes Mellitus ◽

Cardiovascular Risk ◽

Public Health Problem ◽

Statin Treatment ◽

Oxidative Modification ◽

Control Group ◽

Newly Diagnosed ◽

Hdl Subfractions ◽

Patients With Diabetes ◽

Healthy Control

Introduction: Diabetes mellitus (DM) due to its increasing prevalence and associated morbidity and mortality has become a serious public health problem. In DM, HDL may lose its beneficial features and become proatherogenic due to its altered biological activity thus increasing cardiovascular risk. The aim of this study was to assess the influence of the presence of diabetes mellitus type 2 and its duration on the distribution of HDL subfractions. Moreover, the effect of statin treatment on HDL subfraction share was analysed in this study. Methods: The study group consisted of 50 patients with newly diagnosed DM and 50 persons with DM for longer than 10 years while the control group consisted of 50 healthy volunteers. HDL subfractions were analysed with the use of Lipoprint. Results: We demonstrated progressive worsening of heart functioning and impairment of its structure in the course of diabetes mellitus. Moreover, we observed that HDL-6 subfraction and intermediate HDL fraction are lowest in the group with advanced DMt2 compared to the group with newly diagnosed DM and a healthy control group. Finally, the results of our study indicated the effect of statin treatment on HDL subfractions that seems not to be advantageous. Conclusion: It seems that in patients with diabetes mellitus compromised antiatherogenic properties of HDL, as a result of oxidative modification and glycation of the HDL protein as well as the transformation of the HDL proteome into a proinflammatory protein, increase cardiovascular risk.

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Clinical effect of Suvarna Bindu Prashan

Journal of Ayurveda and Integrated Medical Sciences (JAIMS) ◽

10.21760/jaims.v2i3.8203 ◽

2017 ◽

Vol 2 (3) ◽

Cited By ~ 1

Author(s):

Patil Aniket ◽

Dindore Pallavi ◽

Arbar Aziz ◽

Kadam Avinash ◽

Saroch Vikas

Keyword(s):

Physical Health ◽

Eating Habits ◽

Control Group ◽

Inform Consent ◽

Significant Difference ◽

Group A ◽

Group B ◽

Immune Booster ◽

Mental And Physical Health ◽

Apparently Healthy

The quest for excellence in mental and physical health is not new. We find various references and formulations in Ayurvedic classics meant for promoting mental and physical health of a child. Suvarna Prashan is one of the formulations explained in age old Ayurvedic classic Kashyap Samhita. This formulation is very widely used now days as a memory and immune booster for children. But there is very little systematic documented study which can be used to evaluate the efficacy of the formulation. Suvarna Bhasma was prepared in Ayurved Rasayani Pharmacy, Pune. Madhu and Ghrita were collected from KLE Ayurveda Pharmacy, Belgaum. Suvarna Bindu Prashan was prepared in KLE Ayurved pharmacy, Belgaum. It contains Suvarna Bhasma, Ghrita and Madhu. Twenty apparently healthy male and female children with age group of three to four years were ready to sign inform consent form were selected into two groups each. Subjects in Group A received Suvarna Bindu Prashan where as Group B (Control group) did not receive any treatment. Both the groups were observed for six months. Children in Suvarna Bindu Prashan group showed significant reduction in the scores of eating habits, behavior, mood, temperament and scores of event of illness. However there was no significant difference in the score of sleeping habit. There was significant increase in IQ percentage.

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The Capabilities of Amlodipine/Lisinopril Single-Pill Combination in the Treatment of Newly Diagnosed Arterial Hypertension in a Middle-Aged Patient (Case Report)

Rational Pharmacotherapy in Cardiology ◽

10.20996/1819-6446-2020-03-03 ◽

2020 ◽

Vol 16 (2) ◽

pp. 221-230

Author(s):

A. I. Kochetkov ◽

M. V. Lopukhina ◽

E. A. Kotaeva ◽

A. A. Kirichenko ◽

O. D. Ostroumova

Keyword(s):

Blood Pressure ◽

Arterial Hypertension ◽

Left Ventricular ◽

Favorable Effect ◽

Newly Diagnosed ◽

Functional Changes ◽

Collagen Formation ◽

Cardiovascular Morbidity And Mortality ◽

Single Pill ◽

Left Atrial Stiffness

Arterial hypertension (AH) is one of the most significant modifiable risk factors that increase cardiovascular morbidity and mortality worldwide, including Russia. The complex of structural and functional changes in the heart that occurs during AH consists not only in the formation of left ventricular (LV) myocardial hypertrophy, but also in the myocardial stiffness increasing due to collagen formation and cardiomyocytes apoptosis. These abnormalities are substrate for diastolic function disturbances, electrical myocardial instability and ischemia. The article provides a clinical case of amlodipine/lisinopril single-pill combination (A/L SPC) use in real clinical practice in a patient with stage II grade 2 newly diagnosed AH and its effect on blood pressure and echocardiographic myocardial fibrosis markers, including speckle tracking parameters The high antihypertensive efficacy of A/L SPC, a favorable effect on blood pressure circadian rhythm, as well as pronounced target-organ protective properties, in particular the ability to reduce LV and left atrial stiffness, were demonstrated. So, we conclude that A/L SPC improve the elastic properties of the left heart.

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Near-infrared fluorescence imaging with indocyanine green for quantification of changes in tissue perfusion following revascularization

Vascular ◽

10.1177/17085381211032826 ◽

2021 ◽

pp. 170853812110328

Author(s):

Pim Van den Hoven ◽

Floris S Weller ◽

Merel Van De Bent ◽

Lauren N Goncalves ◽

Melissa Ruig ◽

...

Keyword(s):

Indocyanine Green ◽

Fluorescence Imaging ◽

Fluorescence Intensity ◽

Near Infrared ◽

Tissue Perfusion ◽

Control Group ◽

Maximum Slope ◽

Nir Fluorescence ◽

Significant Difference ◽

Revascularization Procedures

Objectives Current diagnostic modalities for patients with peripheral artery disease (PAD) mainly focus on the macrovascular level. For assessment of tissue perfusion, near-infrared (NIR) fluorescence imaging using indocyanine green (ICG) seems promising. In this prospective cohort study, ICG NIR fluorescence imaging was performed pre- and post-revascularization to assess changes in foot perfusion. Methods ICG NIR fluorescence imaging was performed in 36 patients with PAD pre- and post-intervention. After intravenous bolus injection of 0.1 mg/kg ICG, the camera registered the NIR fluorescence intensity over time on the dorsum of the feet for 15 min using the Quest Spectrum Platform®. Time-intensity curves were plotted for three regions of interest (ROI): (1) the dorsum of the foot, (2) the forefoot, and (3) the hallux. Time-intensity curves were normalized for maximum fluorescence intensity. Extracted parameters were the maximum slope, area under the curve (AUC) for the ingress, and the AUC for the egress. The non-treated contralateral leg was used as a control group. Results Successful revascularization was performed in 32 patients. There was a significant increase for the maximum slope and AUC egress in all three ROIs. The most significant difference was seen for the maximum slope in ROI 3 (3.7%/s to 6.6%/s, p < 0.001). In the control group, no significant differences were seen for the maximum slope and AUC egress in all ROIs. Conclusions This study shows the potential of ICG NIR fluorescence imaging in assessing the effect of revascularization procedures on foot perfusion. Future studies should focus on the use of this technique in predicting favorable outcome of revascularization procedures.

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The role of leukotriene modifying agent treatment in neuropsychiatric events of elderly asthma patients: a nested case control study

Asthma Research and Practice ◽

10.1186/s40733-021-00070-4 ◽

2021 ◽

Vol 7 (1) ◽

Author(s):

Sang Oh Kang ◽

Kyung Hyun Min ◽

Hyun Jeong Kim ◽

Tae Hyeok Kim ◽

Woorim Kim ◽

...

Keyword(s):

Case Control Study ◽

Case Control ◽

Boxed Warning ◽

Control Group ◽

Case Group ◽

Newly Diagnosed ◽

Crude Odds Ratio ◽

Asthma Patients ◽

Nested Case Control ◽

Control Study

Abstract Background In March 2020, the US Food and Drug Administration decided that the dangers related to neuropsychiatric events (NPEs) of montelukast, one of the leukotriene modifying agents (LTMAs), should be communicated through ‘boxed warning’. In case of NPEs, the prevalence has been the highest in elderly people. Because the characteristics of the elderly such as old age itself can act as risk factors. Therefore, an investigation on safety of LTMAs related to NPEs in elderly using LTMAs is needed. Method A nested case-control study using an elderly sample cohort from the Korean National Health Insurance Service database was used. The asthma cohort included asthma patients newly diagnosed between 2003 and 2013. Within the asthma cohort, the case group was defined as patients who were diagnosed with NPEs. Among patients who had never been diagnosed with NPEs, the control group was selected by matching 1:1 by propensity score. Patients who were prescribed LTMAs for 1 year prior to index date were defined as the exposure group. The logistic regression model was used to measure the effect of LTMAs on NPEs. Results We identified 141,165 patients with newly diagnosed asthma, and selected 31,992 patients per each case and control group. Exposure to LTMAs significantly increased the risk of overall NPEs about in comparison with the absence of exposure (crude odds ratio [OR] 1.58, 95% CI 1.50–1.68). After adjusting for confounding factors, the overall NPEs risk increased (adjusted OR, 1.67, 95% CI 1.58–1.78). Conclusion This study suggests that elderly asthma patients prescribed LTMAs had a higher risk of NPEs than patients who were not treated with LTMAs. Therefore, clinicians should be aware of the potential risks of LTMAs.

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