scholarly journals Chondroitin sulfate injection efficacy in the treatment of knee osteoarthritis

2021 ◽  
Vol 5 (5) ◽  
pp. 301-306
Author(s):  
S.A. Lapshina ◽  
◽  
G.F. Mingaleeva ◽  
Keyword(s):  
Knee Osteoarthritis ◽  
Chondroitin Sulfate ◽  
Matrix Protein ◽  
Life Quality ◽  
Pain Syndrome ◽  
Cartilage Degradation ◽  
Knee Joints ◽  
Standard Regimen ◽  
Reactive Protein ◽  
Keywords Osteoarthritis

Aim: to evaluate the efficacy of two-month therapy with chondroitin sulfate (CS) (Mucosat®) injections in patients with osteoarthritis and the drug potential in terms of structure-modifying action. Patients and Methods: an open prospective study with participation of 30 patients (mean age 52.5±11.7 years) with osteoarthritis, grade 2 gonarthrosis according to the Kellgren-Lawrence classification, and severe pain syndrome (more than 50 points according to VAS) was conducted. 76.7% of subjects had concomitant pathology. The drug was prescribed according to the standard regimen with a course of up to 25–30 injections. The examination included a clinical assessment of indicators of joint syndrome, life quality, joint function using WOMAC, Lekken, KOOS, EQ-5D scales, cartilage oligomeric matrix protein (COMP) and C-reactive protein (CRP), ultrasound of the knee joints. Results: after a two-month treatment course with Mucosat®, there was a significant (p<0.05) decrease in pain intensity by 1.8 times, the number of tender and swollen joints by 2 or more times, an improvement in indicators of functional activity and life quality of patients. Reactive synovitis of the knee joints, which was present at the beginning of the study in 53.3% of cases, was preserved clinically and according to ultrasound data only in 17% of subjects by the end of treatment. There was a tendency to decrease the levels of CRP and COMP. Ultrasound of the knee joints showed a significant (p=0.000) increase in the average thickness of articular cartilage from 1.55±0.26 mm initially to 1.67±0.27 mm after 2 months of treatment. More significant positive dynamics during therapy was observed in patients without arterial hypertension. In general, no adverse events were registered during treatment. Conclusion: in clinical practice, the use of the CS injections in patients with gonarthrosis is safe and effective. The tendency to decrease the cartilage degradation and increase its thickness suggests a positive effect of CS in the form of slowing the disease progression in the long-term period. KEYWORDS: osteoarthritis, cartilage degradation, synovitis, chondroitin sulfate, bioavailability, structure-modifying effect, Mucosat. FOR CITATION: Lapshina S.A., Mingaleeva G.F. Chondroitin sulfate injection efficacy in the treatment of knee osteoarthritis. Russian Medical Inquiry. 2021;5(5):301–306 (in Russ.). DOI: 10.32364/2587-6821-2021-5-5-301-306.

Experience of the Use of Chondroitin Sulfate in the Recovery Treatment of Posttraumatic Chondropathy of the Knee in Athletes Playing Sports

10.12737/7270 ◽  
2014 ◽  
Vol 21 (4) ◽  
pp. 61-67
Author(s):  
Сахарова ◽  
M. Sakharova ◽  
Капустина ◽  
N. Kapustina ◽  
Смоленский ◽  
...  
Keyword(s):  
Knee Joint ◽  
Chondroitin Sulfate ◽  
Pain Syndrome ◽  
Main Group ◽  
Knee Joints ◽  
Osteoarthritis Of The Knee ◽  
Isokinetic Testing ◽  
Deficit Reduction ◽  
Recovery Treatment ◽  
Angular Velocities

The article presents results of research on the effectiveness of comprehensive rehabilitation treatment of athletes with post-traumatic chondropathies of knee joints by means of chondro-protective therapy (chondroitin sulfate injections). The study involved 60 athletes playing sports. Athletes were examined through a survey questionnaire Knee injury and osteoarthritis outcome score - Scale Exodus of injury and osteoarthritis of the knee joint, as well as clinical examination, ultrasound examination of the knee joints, bilateral isokinetic testing of the muscles of the flexor-extensor of the knee joint. 2 groups of 30 athletes (the main group and the comparison group) had course of treatment: physical therapy by alternating magnetic field, therapeutic physical training, massage. Athletes of the main group was additionally applied intramuscularly drug chondroitin-sulfate (Astragal). The study showed greater efficacy of the treatment of athletes in the main group, this is confirmed by a significant decrease of pain syndrome, improving of functional status of the knee joints, increase sporting activity and improving the quality of life of athletes according to the survey; improving the biomechanical characteristics of the periarticular muscles and deficit reduction extensor tibiae between damaged and intact limb at angular velocities of 60 and 180 0/с, the positive dynamics of the ultrasonic examination of the knee joints.

scholarly journals Intra-articular hyaluronic acid: dependence of the effect on molecular weight

2021 ◽  
Vol 5 (3) ◽  
pp. 156-161
Author(s):  
Yu.S. Filatova ◽  
◽  
V.R. Gawert ◽  
Keyword(s):  
Molecular Weight ◽  
Hyaluronic Acid ◽  
Cartilage Degradation ◽  
Knee Joints ◽  
Keywords Osteoarthritis ◽  
Inflammatory Mechanism ◽  
Osteoarthritis Knee ◽  
Study Results ◽  
Intraarticular Administration ◽  
Acid Dependence

The article discusses the patient management with knee osteoarthritis according to the ESCEO 2019 algorithm. The focus is on the second stage in the persistence of osteoarthritis signs. The article pays attention to the means based on hyaluronic acid for intra-articular injection. It also provides the study analysis that proved the anti-inflammatory mechanism of action of hyaluronic acid-based drugs during intraarticular administration, as well as the study results in which histology data indicated that hyaluronic acid prevents cartilage degradation and can promote its regeneration. These researches show that repeated injections of hyaluronic acid are not only effective, but also safe. In the literature, there is evidence that during treatment, the time to endoprosthesis increases, as well as the need for taking NSAIDs and opioids decreases. The article discusses the molecular weight of hyaluronic acid, providing research data confirming the greatest efficacy of hyaluronic acid with medium and high molecular weight. KEYWORDS: osteoarthritis, knee joints, hyaluronic acid, intraarticular injection. FOR CITATION: Filatova Yu.S., Gawert V.R. Intra-articular hyaluronic acid: dependence of the effect on molecular weight. Russian Medical Inquiry. 2021;5(3):156–161. DOI: 10.32364/2587-6821-2021-5-3-156-161.

scholarly journals Chondroitin sulfate: treatment tactics in osteoarthritis

2021 ◽  
Vol 5 (2) ◽  
pp. 102-106
Author(s):  
A.V. Alabut ◽  
Keyword(s):  
Articular Cartilage ◽  
Chondroitin Sulfate ◽  
Structural Changes ◽  
Pain Syndrome ◽  
The Elderly ◽  
Medial Condyle ◽  
Positive Effects ◽  
Keywords Osteoarthritis ◽  
Dynamic Function ◽  
Meta Analyses

Osteoarthritis (OA) is the most common among all musculoskeletal disorders, becoming the main cause of chronic pain, impaired static and dynamic function and disability among the elderly, and represents the main burden for public health worldwide. Modern pharmacological treatment methods of OA are focused on reducing the disease symptoms and the pain syndrome intensity. One method in this direction is the use of symptom-modifying slow-acting drugs, which have shown promising positive effects on pain and other OA symptoms. The article presents an overview of the main experimental and clinical studies, and meta-analyses devoted to the evaluation of chondroitin sulfate (CS) efficacy and safety as one of the most commonly prescribed drugs for the treatment of OA. Some studies are devoted to the assessment of structural changes in articular cartilage during CS and placebo therapy, while others focus on the dynamics of pain syndrome and the degree of functional insufficiency, and on the assessment of the incidence and time of delayed knee replacement. The place of CS in the structure of EULAR and ESCEO recommendations is considered. KEYWORDS: osteoarthritis, chondroitin sulfate, symptom-modifying slow-acting drugs, medial condyle, articular cartilage thickness, articular replacement. FOR CITATION: Alabut A.V. Chondroitin sulfate: treatment tactics in osteoarthritis. Russian Medical Inquiry. 2021;5(2):102–106. DOI: 10.32364/2587-6821-2021-5-2-102-106.

scholarly journals Effect of Electro-acupuncture (EA) and Manual Acupuncture (MA) on Markers of Inflammation in knee osteoarthritis

2019 ◽  
Author(s):  
Guang-Xia Shi ◽  
Tian-Qi Wang ◽  
Jing-Wen Yang ◽  
Jian-Feng Tu ◽  
Li-Qiong Wang ◽  
...  
Keyword(s):  
Knee Osteoarthritis ◽  
Matrix Protein ◽  
Cartilage Degradation ◽  
Inflammatory Factors ◽  
Manual Acupuncture ◽  
Markers Of Inflammation ◽  
Tnf Α ◽  
Significant Difference ◽  
And Function ◽  
And Cartilage

Abstract Background Inflammation plays a significant role in the pathogenesis of knee osteoarthritis (KOA). Although both Electro-acupuncture (EA) and Manual Acupuncture (MA) are known to influence systemic inflammation, little is known about the potential changes in inflammation as a working mechanism of EA and MA in KOA.Methods Data from the Acupuncture for Knee Osteoarthritis Trial (ATKOA) were used. Serum concentrations of inflammatory factors (tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), IL-6, IL-8, IL-18, IL-4, IL-10,IL-13,IL-15, IL-17, monocyte chemotactic protein-1 (MCP-1), CC­chemokine ligand 5 (CCL5), and cartilage degradation biomarkers (matrix metalloproteinase-1 MMP-1, MMP-3, MMP-13 and cartilage oligomeric matrix protein COMP) were measured at baseline and after 8 weeks of treatment. Clinical outcomes were valid and reliable self-reported pain and function measures for osteoarthritis using the Western Ontario and McMasters osteoarthritis index questionnaire (WOMAC) and Visual Analogue Scale (VAS) at baseline and post-treatment.Results Both 8-weeks EA and MA significantly reduced pro-inflammatory cytokines (TNFα, IL-1β) and cartilage degradation biomarkers (MMP-3, MMP-13), significantly increased the anti-inflammatory cytokine IL-13 compared with pre-treatment (p<0.05). Further, the reduction of TNF-α were more significant in EA when compared to MA (p=0.046). While, there was no significant difference between groups in cytokines IL-1β (p=0.102), MMP-3(p=0.113), MMP-13(p=0.623) or IL-13(p=0.935). Moreover, in both EA and MA the effect of acupuncture on the VAS and WOMAC function scale after 8 weeks is clinically important, although no significant differences were found between groups.Conclusions 8 weeks of both EA and MA seem to provide improvement in pain relief and function among individuals with mild to moderate knee OA. This benefit is partly mediated by changes of major inflammatory factors TNF-α, IL-1β and IL-13.

scholarly journals Comparative analysis of the arthroscopy efficacy and complex therapy in the treatment of degenerative meniscal tears in patients with knee osteoarthritis

2021 ◽  
Vol 5 (2) ◽  
pp. 71-77
Author(s):  
M.S. Bessarab ◽  
◽  
G.O. Krasnov ◽  
A.M. Charchyan ◽  
S.N. Khoroshkov ◽  
...  
Keyword(s):  
Comparative Analysis ◽  
Conservative Treatment ◽  
Knee Osteoarthritis ◽  
Chondroitin Sulfate ◽  
Treatment Satisfaction ◽  
Combined Treatment ◽  
Life Quality ◽  
Glucosamine Sulfate ◽  
Meniscal Tears ◽  
Complex Therapy

Aim: to evaluate the efficacy of conservative treatment in patients with degenerative meniscal tear (DMT) in the setting of knee osteoarthritis (OA) as an alternative to combined treatment. Patients and Methods: a prospective comparative study included 236 patients aged 45–65 years with DMT in the setting of stage I–III OA according to the Kellgren-Lawrence classification (70 of them — men). Group 1 consisted of 122 patients (86 of them — women) who underwent combined treatment: arthroscopy for DMT of the knee joint and complex therapy in the postoperative period: NSAIDs (celecoxib), a combined drug from the group of symptom-modifying slow-acting drugs SYSADOA (chondroitin sulfate + glucosamine sulfate), exercise therapy, physiotherapy. Group 2 (n=114) received only complex therapy. Control tests (pain assessment on the visual analog scale (VAS), WOMAC scale, life quality assessment on the EQ-5D scale, treatment satisfaction) were performed 10 and 20 weeks after the therapy initiation. Results: there was a statistically significant (p<0.05) improvement in VAS and WOMAC indicators, which continued to decline by week 20 after 10 weeks of both combined and conservative treatment. Also, it did not depend on gender, age, concomitant pathology, but on the body mass index and OA stage according to the Kellgren-Lawrence classification, which was confirmed by the results of the correlation analysis. Patients’ treatment satisfaction and improvement in their life quality were noted in 50% of patients in both groups. Conclusion: arthroscopic meniscectomy should not be indicated as the first treatment stage in patients with DMT during OA. Complex therapy, including the use of drugs from the NSAID and SYSADOA groups at the recommended doses, has demonstrated high treatment efficacy and safety of patients with DMT during OA. KEYWORDS: knee arthritis, degenerative meniscus tear, arthroscopy, celecoxib, chondroitin sulfate, glucosamine sulfate, life quality. FOR CITATION: Bessarab M.S., Krasnov G.O., Charchyan A.M., Khoroshkov S.N. et al. Comparative analysis of the arthroscopy efficacy and complex therapy in the treatment of degenerative meniscal tears in patients with knee osteoarthritis. Russian Medical Inquiry. 2021;5(2):71–77. DOI: 10.32364/2587-6821-2021-5-2-71-77.

scholarly journals A Randomized, Placebo Controlled Clinical Trial to Evaluate the Efficacy and Safety of HFPM-01 in Improving Pain, Stiffness, and Inflammation in Patients Suffering from Knee Osteoarthritis

2021 ◽  
Vol 8 (4) ◽  
pp. 1-11
Author(s):  
Veena Deo ◽  
Bharatbhushan Shrikhande ◽  
Gayatri Ganu
Keyword(s):  
Knee Osteoarthritis ◽  
Muscle Tone ◽  
Womac Score ◽  
Joint Disease ◽  
Knee Joints ◽  
Controlled Clinical Trial ◽  
Keywords Osteoarthritis ◽  
Sf 36 ◽  
Gi Symptoms ◽  
Womac Questionnaire

Objective: Osteoarthritis is a common chronic joint condition which causes stiffness and difficulty in moving, loss of muscle tone, strength and stamina. All these difficulties affect daily activities and quality of life and may also have an impact of mental health. Globally over 9.6% men and 18.0% women aged over 60 years has symptomatic osteoarthritis worldwide. It is the second most common rheumatologic problem and it is the most frequent joint disease with a prevalence of 22% to 39% in India. Considering the increasing prevalence and limitations of the conventional treatment for the management of Osteoarthritis, the current research aims at systematic clinical validation of the HFPM-01 in subjects primarily suffering from knee osteoarthritis. Materials and Methods: 90 subjects were enrolled in the study and were randomized to one of the three treatment groups. Subjects were undergoing clinical examination. Vitals were recorded. Blood samples were collected for readings of CRP. Subjective questionnaire scores evaluation was performed like SF-36 health survey score, VAS scale, WOMAC questionnaire. Changes in symptoms severity were noted like morning stiffness, tiredness, tenderness, and muscle spasms along with assessment of GI symptoms. Results: The change in WOMAC score, the increase in SF-36 score, the decrease in VAS score, the decrease in CRP levels, and the reduction in GI symptoms were found to be 33%, 308%, 60.44%, 52%, 40% respectively. Swelling, inflammation and pain was reduced from moderated to mild and eventually to no symptoms. Conclusion: This explains that HFPM-01 tablet is significantly effective in improving SF36 score WOMAC and VAS scale score. It is effective in reducing pain, swelling, and stiffness of knee joints, also improves the mobility of knee joints, and provides gastro protection being effective in managing pain and stiffness. HFPM-01tablet is safe and effective in the management of Osteoarthritis. Keywords: Osteoarthritis, WOMAC, VAS, CRP, Gastro protective.

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