scholarly journals Determination of the concentration of Fe, Se and Zn elements in nails of Vietnamese women with breast cancer using k0-INAA method

2020 ◽  
Vol 22 (4) ◽  
pp. 370-377
Author(s):  
Phuong Truc Huynh ◽  
Tran Pham Ngoc Trinh ◽  
Dinh Thanh Binh ◽  
Nguyen Thi Truc Linh ◽  
Truong Thi Hong Loan ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Trace Elements ◽  
Analytical Data ◽  
Correlation Coefficients ◽  
Breast Cancer Diagnosis ◽  
Healthy Women ◽  
Vietnamese Women ◽  
Significant Difference ◽  
The Difference

Introduction: Breast cancer is the most common type of cancer resulting in death. Trace elements of Fe, Se and Zn can play a key role in the onset and prevention of breast cancer. Trace elements in the fingernails may be used as bioindicators for breast cancer diagnosis. The purpose of this work is to determine the concentrations of Fe, Se, and Zn in the fingernails of women with breast cancer and healthy women, which used to find the difference and correlation of these elements in the fingernail. Methods: This research was approved by the Ethics Committee of Dong Nai General Hospital. The fingernail collected from 29 women with breast cancer and 30 healthy women, who are the same age and living in Dong Nai province, Vietnam. The concentrations of Fe, Se, and Zn in the fingernails were determined using the k0-INAA method. The analytical data were evaluated using some statistical analysis for the correlation of trace elements in the fingernails of both groups. Results: As a result, the mean concentrations of Fe, Se and Zn in fingernails of women with breast cancer were 102.87 ug/g, 0.75 ug/g and 65.49 ug/g, respectively, while those of healthy women were 69.74 ug/g, 0.78 ug/g and 107.75 ug/g. The assessment of these elements in fingernails for both two sample groups, including t-test and correlation coefficients, was also carried out in this study. As a result, the significant difference (p < 0.05) was found for the Fe and Zn in fingernails of women with breast cancer, while those of Se was not found. The correlation between Se and Zn was found in both groups. The correlation between Fe and Zn was found in fingernails of healthy women, but it disappears in the women with breast cancer. Conclusions: From our finding, it can be concluded that Fe and Zn significantly associated with the risk of breast cancer, while Se is not associated.  

Serum and Saliva Levels of Cancer Antigen 15-3, Carcinoembryonic Antigen, Estradiol, Vaspin, and Obestatin as Biomarkers for the Diagnosis of Breast Cancer in Postmenopausal Women

2020 ◽  
Vol 51 (6) ◽  
pp. 620-627
Author(s):  
Hyder Farahani ◽  
Jamal Amri ◽  
Mona Alaee ◽  
Fathollah Mohaghegh ◽  
Mohammad Rafiee
Keyword(s):  
Breast Cancer ◽  
Carcinoembryonic Antigen ◽  
Correlation Coefficients ◽  
Control Group ◽  
Case Group ◽  
Cancer Antigen ◽  
Healthy Women ◽  
Significant Difference ◽  
Serum Cea ◽  
Control Study

Abstract Objective To find suitable biomarkers for diagnosis of Breast cancer in serum and saliva; also, to examine the correlation between salivary and serum concentrations of suitable biomarkers. Methods This case-control study included 30 women with breast cancer as a case group and 30 healthy women as a matched control group. Blood and saliva specimens were collected from all participants. We evaluated serum and salivary cancer antigen 15-3 (CA15-3), carcinoembryonic antigen (CEA), estradiol, vaspin, and obestatin concentrations. Mann-Whitney U testing and Spearman correlation coefficients were used for statistical analysis. Results Serum and salivary concentrations of estradiol were significantly higher in patients with breast cancer (BC) than in healthy women (P &lt; .05). Also, serum CEA and salivary obestatin concentrations were significantly higher in BC patients than in the control group (P &lt; .05). However, there was no significant difference between other parameters in patients with BC and controls. We observed a positive correlation between serum and salivary concentrations of CA15-3, as well as a negative correlation between serum and salivary concentrations of vaspin and obestatin. Conclusion The results of this study demonstrated that concentrations of CEA and estradiol in serum, obestatin in serum and saliva, and estradiol in saliva were significantly different between the 2 groups.

scholarly journals Breast Cancer Survival Defined by Biological Receptor and Menopausal Status in Vietnamese Women

2019 ◽  
Vol 26 (1) ◽  
pp. 107327481986527 ◽  
Author(s):  
Thang Vu Hong ◽  
Duc Nguyen Ba ◽  
Lambert Skoog ◽  
Van Ta Thanh ◽  
Edneia Tani
Keyword(s):  
Breast Cancer ◽  
Prognostic Factors ◽  
Survival Rate ◽  
Progesterone Receptor ◽  
Cox Model ◽  
Menopausal Status ◽  
Survival Rates ◽  
Factors Associated ◽  
Vietnamese Women ◽  
Significant Difference

Little is known about breast cancer in Vietnamese women. Previous studies have reported the frequencies of prognostic factors of breast cancer in this population. The aim of this study was to examine the prognostic factors associated with the survival rates of patients with breast cancer treated at the National Cancer Hospital, Hanoi, Vietnam. We recruited 248 women with operable breast cancer treated with surgery and adjuvant therapy. Tumor tissue samples were stained by many immunohistochemical approaches and analyzed for estrogen receptor, progesterone receptor, and HER2 gene amplification status. A Cox model was used to determine the relationship between survival and the prognostic factors. The disease-free survival rate, overall survival rate, and cancer-specific survival rate were 75.8%, 80.6%, and 86.4%, respectively, at 5 years and 62.3%, 68.1%, and 78.9%, respectively, at 10 years. The lung was the most common metastatic site. Women with factors associated with a poor prognosis (eg, advanced clinical stage, high tumor grade, progesterone receptor [PR] negativity, HER2 amplification) had significantly lower survival rates. Patients with PR-negative breast cancer had significantly worse survival rates compared to those who were PR positive, according to multivariate analysis (hazard ratio = 1.77, 95% confidence interval: 1.01-3.11, P = .045); however, there was only a statistically significant difference in postmenopausal patients. The PR was a prognostic factor in postmenopausal women with breast cancer, but not in premenopausal women.

scholarly journals Pengaruh Penerapan Model Pembelajaran Kooperatif Tipe Course Review Horay (CRH) Terhadap Keaktifan Belajar dan Hasil Belajar Ekonomi

2019 ◽  
Vol 1 (1) ◽  
pp. 1
Author(s):  
Aisyah Aisyah
Keyword(s):  
Learning Outcomes ◽  
Sampling Method ◽  
Learning Model ◽  
Positive Influence ◽  
Learning Activity ◽  
Economic Study ◽  
Purposive Sampling ◽  
Significant Difference ◽  
The Difference

This research is experimental research on students class XI of MIPA in SMA Negeri 3 Purwokerto. This research takes the title of "The Influence of the Application of the Cooperative Learning Model Type Course Review Horay (CRH) Against the Liveliness of learning and the Results of the Economic Study (study on the Grade XI MIPA in SMA Negeri 3 Purwokerto)". The purpose of this research is to know the difference in learning outcomes and learning activity between the learning model Course Review Horay (CRH) with conventional learning model, to know the influence of learning model Course Review Horay (CRH) against the learning outcomes and learning activity, as well as to know the influence of the liveliness of the learning results of learning. The population of this research is the grade XI MIPA in SMA Negeri 3 Purwokerto. The number of samples taken in this study is 72 i.e. 2 Class XI of MIPA which each class amounted to 36 students. Purposive Sampling Method used in the determination of the sample. Based on the results of the research and the anallisis data indicate that (1) there is a significant difference between the model of learning learning activeness cooperative Course Review Horay (CRH) and conventional learning model on economics. (2) there are significant differences between the learning outcomes learning model cooperative Course Review Horay (CRH) and conventional learning model on economi. (3) there is a positive influence learning model cooperative Course Review Horay (CRH) against the liveliness of the study on economic. (4) there is a positive influence learning model cooperative Course Review Horay (CRH) against the results of the study on economic. (5) there is no positive influence between the liveliness of student learning against the results of the study on economic. Penelitian ini adalah penelitian eksperimen pada siswa kelas XI MIPA di SMA Negeri 3 Purwokerto. Penelitian ini mengambil judul “Pengaruh Penerapan Model Pembelajaran Kooperatif Tipe Course Review Horay (CRH) terhadap Keaktifan Belajar dan Hasil Belajar Ekonomi (Studi pada Siswa Kelas XI MIPA di SMA Negeri 3 Purwokerto)”.        Tujuan dari penelitian ini adalah untuk mengetahui perbedaan keaktifan belajar dan hasil belajar antara model pembelajaran Course Review Horay (CRH) dengan model pembelajaran konvensional, untuk mengetahui pengaruh model pembelajaran Course Review Horay (CRH) terhadap keaktifan belajar dan hasil belajar, serta untuk mengetahui pengaruh keaktifan belajar terhadap hasil belajar. Populasi penelitian ini adalah siswa kelas XI MIPA di SMA Negeri 3 Purwokerto. Jumlah sample yang diambil dalam penelitian ini adalah 72 yaitu 2 kelas XI MIPA yang masing-masing kelas berjumlah 36 siswa. Purposive Sampling Method digunakan dalam penentuan sample. Berdasarkan hasil penelitian dan anallisis data menunjukkan bahwa (1) Terdapat perbedaan signifikan keaktifan belajar antara model pembelajaran kooperatif Course Review Horay (CRH) dengan model pembelajaran konvensional pada mata pelajaran ekonomi. (2) Terdapat perbedaan signifikan hasil belajar antara model pembelajaran kooperatif Course Review Horay (CRH)  dengan model pembelajaran konvensional pada mata pelajaran ekonomi. (3) Terdapat pengaruh positif model pembelajaran kooperatif Course Review Horay (CRH)  terhadap keaktifan belajar pada mata pelajaran ekonomi. (4) Terdapat pengaruh positif model pembelajaran kooperatif Course Review Horay (CRH)  terhadap hasil belajar pada mata pelajaran ekonomi. (5) Tidak terdapat pengaruh positif antara keaktifan belajar siswa terhadap hasil belajar pada mata pelajaran ekonomi.  

scholarly journals Study on the Distribution Characteristics and Influencing Factors of Homocysteine in the Physical Examination Population

2021 ◽  
Author(s):  
Fang Bao ◽  
Ming Cui ◽  
Xiuying Shi ◽  
Shaoqing Ju ◽  
Hui Cong
Keyword(s):  
Blood Pressure ◽  
Physical Examination ◽  
Large Scale ◽  
Kidney Injury ◽  
Scientific Basis ◽  
Cerebrovascular Diseases ◽  
Health Examination ◽  
Significant Difference ◽  
The Difference

Abstract Background: Homocysteine (Hcy) is considered to be an independent risk factor for cardiovascular and cerebrovascular diseases. No study has evaluated the distribution of Hcy on a large-scale health examination. Accordingly, this study aimed to investigate the level and distribution of Hcy in the healthy physical examination population and the correlation with other biomarkers, and analyzed for cardiovascular and other diseases. The prevention provides an important scientific basis.Methods: From February 2017 to April 2020, 8063 medical examination populations were selected for analysis. Determination of serum Hcy, TC, TG, LDL-c, HDL-c, ALT, ALP, γ-GT, TBIL, GLU, urea, Cr, UA and related metabolic risk factors. According to the multivariate regression model of age, gender, smoking, drinking, body mass index (BMI), systolic blood pressure (SBP) and diastolic blood pressure (DBP), the relationship between Hcy and other biochemical indicators was evaluated. Results: Among 8063 cases, the age, BMI, SBP and DBP of the high-Hcy group were higher than those of the low-Hcy group, the difference was statistically significant (P<0.05), and the proportion of males, smoking and drinking were higher than the low In the Hcy group, the difference was statistically significant (P<0.05); the ALT, ALP, γ-GT, TBIL, Urea, Cr, UA, and TG in the high Hcy group were higher than those in the low Hcy group, and the difference was statistically significant (P<0.05 ); HDL-c in the high-Hcy group was lower than that in the low-Hcy group, and the difference was statistically significant (P<0.05). There was no statistically significant difference in TC, LDL-c, and GLU between the high- and low-Hcy groups (P>0.05). In multivariate analysis, lnHDL-C was negatively correlated with lnHcy (β=-0.038, SE=0.016, P<0.05), lnCr was positively correlated with lnHcy (β=0.055, SE=0.016, P<0.05), lnUA and lnHcy were positive correlation (β=0.043, SE=0.019, P<0.05). Conclusion: Hcy is closely related to HDL-c, Cr and UA, which indicates that Hcy may affect the metabolism of HDL-c and UA, and can also be used as an auxiliary diagnostic index for kidney injury.

Pyridine Extraction Method for Determination of Bacitracin in Feeds: Collaborative Evaluation

1979 ◽  
Vol 62 (3) ◽  
pp. 662-670
Author(s):  
Hussein S Ragheb
Keyword(s):  
High Temperature ◽  
Extraction Method ◽  
Main Difficulty ◽  
Coefficients Of Variation ◽  
Significant Difference ◽  
The Difference ◽  
Zinc Bacitracin ◽  
Collaborative Evaluation

Abstract Seventeen laboratories evaluated the pyridine extraction method and neomycin-sensitized agar for the determination of zinc and MD bacitracin in swine and broiler rations at 10 and 100 g/ton. The method was also applied to the analysis of 2 premixes labeled 50 g/lb (MD bacitracin) and 40 g/lb (zinc bacitracin). Bacitracin activity was determined on each of 2 days with 2 dilutions on each day. No significant difference was found between dilutions within a day or between days for each sample. The type of bacitracin or type of feed did not significantly affect results. The difference in results between MD and zinc bacitracin in premixes approached significance. The large coefficients of variation for premixes (ca 13%) and complete feeds (ca 15–30%) indicate operational problems. The main difficulty was evaporation of pyridine. Some laboratories were not able to evaporate it completely, whereas others lost bacitracin activity, probably due to high temperature of drying. The pyridine extraction method as in 42.200 and 42.204 should be discontinued.

scholarly journals The effect of breast cancer on work participation in different sectors. A Danish registry based study

2019 ◽  
Vol 29 (Supplement_4) ◽  
Author(s):  
L Jensen ◽  
H Bøggild ◽  
C Overgaard ◽  
K Fonager
Keyword(s):  
Breast Cancer ◽  
Hospitality Industry ◽  
Work Force ◽  
Breast Cancer Diagnosis ◽  
Good Prognosis ◽  
Work Participation ◽  
Negative Effect ◽  
Cancer Tumor ◽  
Stage Ia ◽  
The Difference

Abstract Background A breast cancer diagnosis affects an individual’s affiliation to the labor market, but whether the effect of breast cancer variates in different sectors in a Danish setting has not been examined. The present study investigated the effect of stage IA breast cancer (tumor&lt;20 mm and no lymph nodes involved in six sectors among Danish women being part of the work force. Stage IA breast cancer has a good prognosis, and it would be assumed that the majority have returned to work after 1 year. Methods This registry-based cohort study was based on data from linked Danish nationwide registries. We identified 5,543 women (aged 25-63 years) diagnosed with breast cancer (BC) stage IA (exposed) and 65.889 women without breast cancer (unexposed) and included women from the different sectors. We calculated a yearly Work Participation Score (WPS), defined as the proportion of weeks being self-supported during a year. We compared the means of WPS for exposed and unexposed women in six different sectors: 1) teaching, 2) childcare, 3) eldercare, 4) cleaning, 5) administration and 6) hospitality industry. Results BC had a negative effect on being self-supporting for women in all six sectors in all three years, although the effect declined. In the first year, the difference in WPS varied between 0.38 and 0.54. During the second year all BC patients had still significantly lower WPS with the largest difference in hospitality industry (0.65 (95% CI 0.50-0.80) for exposed women and 0.86 (95% CI 0.83-0.88) for unexposed women). In the third year, the effect further declined although WPS was still significantly lower for most sectors with the biggest difference in the cleaning sector. Conclusions A stage IA BC diagnosis had a negative effect on being self-supportive after 2 and 3 years among women in all six sectors, although the difference was largest among cleaning workers. This may indicate, that individual follow-up in relation to work participation is necessary. Key messages Although breast cancer stage IA has a good prognosis, it still affects being self-supporting after three years. A diagnosis of breast cancer affects the affiliation to the labour market, but the effect differs according to different sectors.

scholarly journals EVALUATION OF CASPASE 3 AS AN INDICATOR FOR BREAST CANCER CHEMOTHERAPY RESPONSE

2018 ◽  
Vol 11 (8) ◽  
pp. 259
Author(s):  
Kamal Basri Siregar ◽  
Tjakra Wibawa Manuaba ◽  
Muhammad Najib Dahlan Lubis ◽  
Rosita Juwita Sembiring
Keyword(s):  
Breast Cancer ◽  
Clinical Response ◽  
Caspase 3 ◽  
Chemotherapy Response ◽  
Pathology Laboratory ◽  
Breast Cancer Chemotherapy ◽  
Breast Tumor Tissue ◽  
Significant Difference ◽  
The Difference ◽  
Tnbc Subtype

Objectives: This study aimed to assess the difference of postchemotherapy caspase 3 level between triple negative breast cancer (TNBC) subjects with and without clinical response.Methods: A total of 48 subjects with intraductal and 12 subjects with intralobular TNBC who were undergoing surgery at Adam Malik General Hospital were analyzed the response of neoadjuvant chemotherapy. Postsurgical breast tumor tissue was treated in pathology laboratory for caspase 3 analysis. The data were processed in SPSS 22 with significance limitation of 0.05.Results: Median levels of caspase 3 postchemotherapy were higher both in intraductal and intralobular TNBC subtype (6 vs. 4.5 and 5 vs. 3, respectively) responsive group, while no changes detected in the group without clinical response. In statistical analysis, there was a significant difference of caspase 3 level postchemotherapy only in group with clinical response (p=0.005 in intraductal carcinoma and p=0.0031 in intralobular carcinoma).Conclusion: Postchemotherapy caspase 3 level increased significantly in TNBC, either intraductal or intralobular subtype, subjects with clinical response, but not in subjects without clinical response. 

Electrochemical immunoplatform to improve the reliability of breast cancer diagnosis through the simultaneous determination of RANKL and TNF in serum

2020 ◽  
Vol 314 ◽  
pp. 128096 ◽  
Author(s):  
Alejandro Valverde ◽  
Verónica Serafín ◽  
Jesús Garoz ◽  
Ana Montero-Calle ◽  
Araceli González-Cortés ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Simultaneous Determination ◽  
Cancer Diagnosis ◽  
Breast Cancer Diagnosis

scholarly journals Accuracy of two hand-held electronic devices for determination of blood β-hydroxybutyrate in dairy cows

2017 ◽  
Vol 18 (3) ◽  
pp. 439-445 ◽  
Author(s):  
Eliana FIORENTIN ◽  
Anderson TIECHER ◽  
Cristina MENEGAT ◽  
Clarice SOARES ◽  
Adelina AIRES ◽  
...  
Keyword(s):  
Dairy Cows ◽  
Standard Method ◽  
Electronic Devices ◽  
Correlation Coefficients ◽  
Standard Technique ◽  
Portable Devices ◽  
Predictive Values ◽  
Subclinical Ketosis ◽  
Significant Difference

SUMMARY The cowside determination of blood β-hydroxybutyrate (BHB) is an important tool for diagnosing subclinical ketosis in dairy cattle. Portable methods to measure BHB have been introduced in the past years. This study evaluated the accuracy of two hand-held electronic devices for blood determination of BHB in dairy cows at early postpartum. A total of 98 blood samples were collected from dairy cows in the first month of lactation and tested with FreeStyle Optium (FSO, Abbott) and KetoVet (KVE, TaiDoc) portable devices according to the manufacturer instructions. Spectrophotometric BHB analysis (Ranbut, Randox) was used as standard method. The incidence of subclinical ketosis was 37.7 % determined by the standard method, 40.8 % determined by the FSO system and 42.8 % detected with the KVE system. The sensitivity and specificity indexes were 88.1% and 98.4% for FSO and 78.7% and 92.4% for KVE, respectively. The Pearson´s correlation coefficients comparing the portable devices to the standard technique were 0.96 for FSO and 0.93 for KVE. No significant difference in BHB values was found between the two portable tests and the standard method. Predictive values (PV) were better using FSO (positive PV 97.3 %, negative PV 92.4%) than using KVE (positive PV 88.1 %, negative PV 85.9 %). Passing-Bablok regressions revealed good agreement between methods. Though FSO system had a better performance than KVE system, the results suggest that the two portable systems have good accuracy and are reliable for measuring BHB.

scholarly journals A comparative study of selenium concentration and glutathione peroxidase activity in normal and breast cancer patients

2009 ◽  
Vol 12 (1) ◽  
pp. 59-63 ◽  
Author(s):  
Masoumeh Moradi ◽  
Mohammad Hassan Eftekhari ◽  
Abdolrasoul Talei ◽  
Abdolreza Rajaei Fard
Keyword(s):  
Breast Cancer ◽  
Glutathione Peroxidase ◽  
Cancer Patients ◽  
Selenium Concentration ◽  
Atomic Absorption Spectrophotometry ◽  
Breast Cancer Patients ◽  
Healthy Women ◽  
Significant Difference ◽  
Gpx Activity ◽  
Control Study

AbstractObjectiveThe present study was undertaken to compare plasma Se values and glutathione peroxidase (GPX) activity in normal and breast cancer patients.DesignIn a case–control study, forty-five breast cancer patients and the same number of healthy women were randomly selected from their population. Se was measured in plasma by atomic absorption spectrophotometry and GPX activity in erythrocytes was measured using a standard spectrophotometric method.ResultsPlasma Se concentration in healthy women and breast cancer patients was in the normal range, with no statistically significant difference observed between the two groups (138·40 (sd 40·36) μg/l v. 132·15 (sd 35·37) μg/l, respectively). Erythrocyte GPX activity was significantly (P<0·01) higher in breast cancer patients (24·81 (sd 11·66) U/g Hb) compared with healthy women (20·29 (sd 4·24) U/g Hb).ConclusionThe present study indicated that Se deficiency was not a problem in the participants, and sufficient quantity of this element could increase GPX activity to have a protective effect against oxidative damage.

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