TO STUDY CORRELATION OF SERUM VITAMIN D LEVEL WITH OSTEOARTICULAR INFECTION

Background: To study correlation of serum vitamin D level with osteoarticular infection Methods: All patients (5 to 65 years of age) were presented with pain and raised local temperature of osteoarticular joint or prosthetic joint in the Orthopaedic department of S.M.S. Medical college and attached hospitals, were included in the study. Results: The mean (SD) of S. Vitamin D (ng/mL) in the Osteoarticular Infection: Present group was 19.08 (8.41). The mean (SD) of S. Vitamin D (ng/mL) in the Osteoarticular Infection: Absent group was 18.53 (9.26). The median (IQR) of S. Vitamin D (ng/mL) in the Osteoarticular Infection: Present group was 17.7 (14.15-23.3). The median (IQR) of S. Vitamin D (ng/mL) in the Osteoarticular Infection: Absent group was 14.85 (11.6-23.3). The S. Vitamin D (ng/mL) in the Osteoarticular Infection: Present ranged from 8.2 -38. The S. Vitamin D (ng/mL) in the Osteoarticular Infection: Absent ranged from 9.2 - 46. Conclusion: Our study result were similar in respect to other authors but statistically not significant, therefore requires reopening of the debate on correlation of serum vitamin D with osteoarticular infections. Keywords: Osteoarticular Infection, Vitamin D, Joint

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Vitamin D levels in patients with bronchial asthma

International Journal of Research in Medical Sciences ◽

10.18203/2320-6012.ijrms20210070 ◽

2021 ◽

Vol 9 (2) ◽

pp. 375

Author(s):

Chandan Sharma

Keyword(s):

Vitamin D ◽

Bronchial Asthma ◽

Serum Vitamin ◽

Persistent Asthma ◽

Cross Sectional ◽

Medical College ◽

Serum Vitamin D ◽

Vitamin D Levels ◽

Asthma Patients ◽

The Mean

Background: Bronchial asthma is one of the most common chronic diseases. In India, bronchial asthma has 66% frequency of reported exacerbations. Vitamin D has action on pro-inflammatory mediators and smooth muscle function and proliferation, which has direct relevance for lung function in asthma.Methods: The cross sectional observational study was conducted in the Department of Medicine, Government Medical College Jammu for 10 months from January 2018-August 2018. 50 Patients of 18-60 years with diagnosis of bronchial asthma on the basis of clinical and radiological signs were included, while age matched 50 controls years free from any disease and morbidity were included and assessed for vitamin D levels.Results: The mean serum vitamin D level was significantly low at 26.13±4.91 ng/ml in patients, while 39.67±4.03 ng/ml was the mean vitamin D level of controls. The vitamin D levels of mild and moderate (persistent) asthma patients was seen lower than those of the controls.Conclusions: Vitamin D deficiency is highly prevalent in patients during exacerbations of bronchial asthma. It is also associated with lower lung functions and increased number of exacerbations. Thus improving vitamin D status may be effective in the prevention and treatment of bronchial asthma and exacerbations.

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No correlation was observed between vitamin D levels and disability of patients with multiple sclerosis between latitudes 18° and 30° South

Arquivos de Neuro-Psiquiatria ◽

10.1590/0004-282x20160173 ◽

2017 ◽

Vol 75 (1) ◽

pp. 3-8 ◽

Cited By ~ 4

Author(s):

Yara Dadalti Fragoso ◽

Tarso Adoni ◽

Soniza Vieira Alves-Leon ◽

Samira L. Apostolos-Pereira ◽

Walter Oleschko Arruda ◽

...

Keyword(s):

Multiple Sclerosis ◽

Vitamin D ◽

Large Population ◽

Serum Vitamin ◽

Serum Levels ◽

Serum Vitamin D ◽

Control Subjects ◽

Vitamin D Levels ◽

The Mean ◽

25 Oh Vitamin D

ABSTRACT Objective: Vitamin D has taken center stage in research and treatment of multiple sclerosis (MS). The objective of the present study was to assess the serum vitamin D levels of a large population of patients with MS and controls living in a restricted tropical area. Methods: Data from 535 patients with MS and 350 control subjects were obtained from 14 cities around the Tropic of Capricorn. Results: The mean serum 25-OH vitamin D level was 26.07 ± 10.27 ng/mL for the control subjects, and 28.03 ± 12.19 ng/mL for patients with MS. No correlation was observed between vitamin D levels and the disability of patients over the disease duration. Conclusion: At least for the region around the Tropic of Capricorn, serum levels of vitamin D typically are within the range of 20 to 30 ng/mL for controls and patients with MS.

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Oral Vitamin D3 Supplementation for Femtosecond LASIK–Associated Dry Eye

10.21203/rs.3.rs-517022/v1 ◽

2021 ◽

Author(s):

Ying Lin ◽

Huanjun Su ◽

Jianbin Wu ◽

Muzhi Yuan ◽

Yong Zhang

Keyword(s):

Vitamin D ◽

Dry Eye ◽

Vitamin D3 ◽

Serum Vitamin ◽

Control Group ◽

Oral Vitamin ◽

Serum Vitamin D ◽

The Mean ◽

Experimental Group ◽

Schirmer I Test

Abstract Purpose: To assess the effect of oral vitamin D3 supplementation in dry eye after femtosecond laser-assisted in situ keratomileusis (FS-LASIK).Setting: Liuzhou Worker’s Hospital.Design: This prospective study included 90 patients selected between January and December in 2019, who underwent fs-lasik operation in our hospital and had obvious symptoms indicating dry eyes one month after operation. The subjects were randomly divided into two groups: the experimental group (n = 45) received vitamin D3 2000 IU / D continuously for 12 weeks; the control group (n = 45) did not take vitamin D3 orally. Ocular surface disease index（OSDI）, tear breakup time（TBUT）and Schirmer’s Test I were evaluated pre-medication and 1,3,6 months after treatment. Serum vitamin D level, and the mean concentration of cytokine IL-6, IL-17, IL-23 in tears were also measured. Results: One month after treatment, the mean OSDI score of the experimental group (11.67 ± 8.53) was significantly lower than that of the control group (23.82 ± 13.22) (P = 0.007). TBUT (10.71±1.02s) and Schirmer I (9.36±0.40mm) of the experimental group were higher than those of the control group (7.49±1.29 s and 7.51±0.44 mm). The OSDI (10.25 ± 5.49), TBUT (10.75±1.09 seconds) and Schirmer I test value (11.34±0.39 mm) of the experimental group were significantly lower than those of the control group (20.22±6.23, 8.36±1.23， 8.12±0.50) at 3 months after treatment. There were significant differences in OSDI, TBUT (P ＜ 0.05) and Schirmer I test value between the two groups at 6 months after treatment. Serum vitamin D3 level was negatively correlated with OSDI score (r=-0.90；P=0.00), and positively correlated with Schirmer I test (r=0.88；P=0.00), TBUT score (r=0.89；P=0.00) and TMH (r=0.80；P=0.00). IL-17 level was shown to be significantly correlated with TBUT (r=-0.25, P=0.014) and Schirmer I test (r=-0.21, P=0.018). IL-6 level was significantly correlated with OSDI (R=0.18, P = 0.020) and TBUT (R=0.20, P = 0.019).

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A study on association between respiratory tract infection and serum 25 (OH) vitamin D level in children

International Journal of Contemporary Pediatrics ◽

10.18203/2349-3291.ijcp20204545 ◽

2020 ◽

Vol 7 (11) ◽

pp. 2198

Author(s):

Rajesh Kumar Sah ◽

Hemant Kumar

Keyword(s):

Vitamin D ◽

Tract Infection ◽

Respiratory Tract ◽

Respiratory Tract Infection ◽

Serum Vitamin ◽

Acute Respiratory Tract Infection ◽

Control Group ◽

Medical College ◽

Serum Vitamin D ◽

25 Oh Vitamin D

Background: Acute respiratory tract infection are a major cause of global morbidity and mortality. Observational studies report consistent independent association between low serum concentration of 25-hydroxy-vitamin D and susceptibility to acute respiratory tract infection. This study was done to assess serum vitamin D level in children and correlation with respiratory tract infection.Methods: The present study was undertaken in department of paediatrics medicine, Patna Medical College and Hospital in patients attending out-patients department (OPD) as well as admitted in in-patients department (IPD). Assessment of serum 25(OH) Vitamin D was done by the enzyme immunoassay kit at Patna Medical College and Hospital.Results: The mean serum vitamin D level in cases was (20.52±5.64 ng/ml) where as in control group was (26.46±4.52 ng/ml) with a statically significant p value of <0.0001, hence cases are associated with vitamin D deficiency.Conclusions: The finding in this study showed significantly decreased mean serum vitamin D level in cases than that of control which implies that vitamin D deficiency predisposes to respiratory tract infection in children.

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Vitamin D levels in children with COVID-19: a report from Turkey

Epidemiology and Infection ◽

10.1017/s0950268821001825 ◽

2021 ◽

Vol 149 ◽

Author(s):

Aysegul Alpcan ◽

Serkan Tursun ◽

Yaşar Kandur

Keyword(s):

Vitamin D ◽

Vitamin D Deficiency ◽

Statistical Significance ◽

Serum Vitamin ◽

University Hospital ◽

Control Group ◽

Serum Vitamin D ◽

Vitamin D Levels ◽

Normal Vitamin ◽

The Mean

Abstract Several studies have demonstrated that higher levels of vitamin D are associated with better prognosis and outcomes in infectious diseases. We aimed to compare the vitamin D levels of paediatric patients with mild/moderate coronavirus disease 2019 (COVID-19) disease and a healthy control group. We retrospectively reviewed the medical records of patients who were hospitalised at our university hospital with the diagnosis of COVID-19 during the period between 25 May 2020 and 24 December 2020. The mean age of the COVID-19 patients was 10.7 ± 5.5 years (range 1–18 years); 43 (57.3%) COVID-19 patients were male. The mean serum vitamin D level was significantly lower in the COVID-19 group than the control group (21.5 ± 10.0 vs. 28.0 ± 11.0 IU, P < 0.001). The proportion of patients with vitamin D deficiency was significantly higher in the COVID-19 group than the control group (44% vs. 17.5%, P < 0.001). Patients with low vitamin D levels were older than the patients with normal vitamin D levels (11.6 ± 4.9 vs. 6.2 ± 1.8 years, P = 0.016). There was a significant male preponderance in the normal vitamin D group compared with the low vitamin D group (91.7% vs. 50.8%, P = 0.03). C-reactive protein level was higher in the low vitamin D group, although the difference did not reach statistical significance (9.6 ± 2.2 vs. 4.5 ± 1.6 mg/l, P = 0.074). Our study provides an insight into the relationship between vitamin D deficiency and COVID-19 for future studies. Empiric intervention with vitamin D can be justified by low serum vitamin D levels.

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Vitamin D levels in children with otitis media with effusion

QJM ◽

10.1093/qjmed/hcab094.017 ◽

2021 ◽

Vol 114 (Supplement_1) ◽

Author(s):

Ahmed Adly Mohamed ◽

Marwa Mohamed EL-Begermy ◽

Ahmed Abdelmoneim Teaima ◽

Mohamed Ali Abdelghafar

Keyword(s):

Vitamin D ◽

Otitis Media ◽

Otitis Media With Effusion ◽

Serum Vitamin ◽

Control Group ◽

University Hospitals ◽

Serum Vitamin D ◽

Vitamin D Levels ◽

25 Hydroxy Vitamin D ◽

The Mean

Abstract Objective To investigate the relationship between otitis media with effusion (OME) and serum vitamin D level in children. Methods This prospective case control study was conducted at Ain Shams University Hospitals between February 2018 and May 2019. The study population included 50 children with OME confirmed by tympanometry type (B) who will undergo adenotonsillectomy and grommet tube insertion compared to 50 children without OME confirmed by tympanometry type (A) who will undergo adenotonsillectomy. Measurement of serum 25-hydroxy vitamin D using electrochemiluminescence technique from a blood sample (3cm) taken from them on the day of surgery. Results In this study, the mean age of the cases was 4.24 ± 0.80 and 5.34 ± 1.19 years for the controls besides 23 (46%) of the OME group were boys and 27 (54%) were girls, compared with 29 (58%) boys and 21 (42%) were girls in the control group. The mean levels of vitamin D in children with OME was 16.24 ± 7.14 ng/mL and in children in the control group was 15.89 ± 5.84 ng/mL (P = 0.815) and it was statistically non significant. Conclusion There was no significant relation between vitamin D serum level and the incidence of OME in children.

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Correlation between vitamin D and lipid profile in multiple sclerosis patients

QJM ◽

10.1093/qjmed/hcab102.013 ◽

2021 ◽

Vol 114 (Supplement_1) ◽

Author(s):

Azza AbdelNaser AbdelAziz ◽

Prof Dr. Rasha Mamdouh Saleh ◽

Mahmoud Saad Swelam ◽

Janet Masoud Ayad

Keyword(s):

Multiple Sclerosis ◽

Vitamin D ◽

Disease Activity ◽

Lipid Profile ◽

Serum Vitamin ◽

Density Lipoprotein ◽

P Value ◽

Serum Vitamin D ◽

The Mean ◽

Multiple Sclerosis Patients

Abstract Background Studies have suggested that vitamin D and lipid profile have been linked to the etiology of multiple sclerosis and have an impact on the activity and progression of the disease. Objectives The aim of the present study was to determine correlation between vitamin D level and lipid profile in multiple sclerosis (MS) patients and their effect on disease activity and progression for better management and control of risk factors. Patients and Methods It is a cross-sectional hospital based study carried on clinically definite 111 Relapsing Remitting MS (RRMS) patients according to McDonald criteria 2010 recruited from Multiple sclerosis unit at Ain Shams University Hospitals, both genders included and aged from 18 to 50 years old. All subjects were assessed regarding their basic demographic data, serum vitamin D level and lipid profile and correlated these data with their state of disease activity and degree of disability. Results The mean level of serum vitamin D was 18.93 ± 9.85 ng/mL. Serum vitamin D level was insufficient (< 30 ng/mL) in 81.08% of patients and sufficient (≥ 30 ng/mL) in 18.92% of patients. The mean level of total cholesterol (TC) was 204.9 ± 50.9 mg/dL, of tri-glycerides (TG) was 105.4 ± 44.6 mg/dL, of low density lipoprotein (LDL) was 122.2 ± 38.8 mg/dL and of high density lipoprotein (HDL) level was 56.2 ± 16.6 mg/dL. High relapse frequency was found to be significantly related to low serum vitamin D level with P-value 0.005. Near all lipid related variables were positively correlated to disease duration. TC and TG were positively related to EDSS while HDL was negatively related with it. Number of brain T2 lesions was significantly correlated with TC and TG levels with P-value 0.001 and 0.002 respectively. Fingolimod was found to be associated with dyslipidemia. We found that each 1 ng/mL increase in vitamin D was associated with decrease in TC of 1.48 mg/dL (95% CI: -2.42 to -0.54, P-value 0.002) and increase in HDL of 0.35 mg/dL (95% CI: 0.04 to -0.66, P-value 0.028). Conclusion Vitamin D deficiency is predominant among Egyptian MS patients. Patients with insufficient vitamin D were found to have higher annualized relapse rate (ARR). Patients with dyslipidemia found to have longer duration, more disability and higher brain T2 lesion load. Vitamin D was correlated positively with HDL and negatively with TC.

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Association of Serum Vitamin D Levels and Stress Fractures in Collegiate Athletes

Orthopaedic Journal of Sports Medicine ◽

10.1177/2325967120966967 ◽

2020 ◽

Vol 8 (12) ◽

pp. 232596712096696

Author(s):

David Millward ◽

Allison D. Root ◽

Jeremy Dubois ◽

Randall P. Cohen ◽

Luis Valdivia ◽

...

Keyword(s):

Vitamin D ◽

Stress Fracture ◽

Serum Vitamin ◽

Stress Fractures ◽

Serum Vitamin D ◽

Outdoor Sports ◽

Vitamin D Levels ◽

Study Results ◽

The Mean ◽

Indoor Sports

Background: Low vitamin D levels along with high-intensity athletic training may put an athlete at increased risk for a stress fracture. Purpose: To assess whether supplementation with vitamin D is associated with a reduced risk of stress fractures in college athletes. We also assessed differences in vitamin D levels among athletes participating in outdoor versus indoor sports. Study Design: Cohort study; Level of evidence, 2. Methods: The study participants included 802 National Collegiate Athletic Association Division I intercollegiate athletes (497 men and 305 women) on a sports team for at least 1 semester from 2012 to 2018. All athletes who had a baseline vitamin D level in their medical record were included. Athletes with vitamin D levels <40 ng/mL were given vitamin D supplements. We assessed differences in the rate of stress fracture among those who maintained or improved vitamin D levels to ≥40 ng/mL and those who did not, as well as differences in average baseline vitamin D levels by sport type (indoor vs outdoor). Results: The rate of stress fracture was 12% higher (95% CI, 6-19; P < .001) for those who remained low in vitamin D compared with those who were low at baseline but improved their vitamin D status to ≥40 ng/mL. The rate of stress fracture was also 12% higher (95% CI, 5-18; P < .001) for those who had low vitamin D levels compared with those who maintained normal levels. The mean baseline vitamin D values were significantly higher for men participating in outdoor sports versus indoor sports. For men, the mean vitamin D level was 5.7 ng/mL higher (95% CI, 0.9-10.5; P = .01) in outdoor athletes. For women, the mean vitamin D level was 3.7 ng/mL higher (95% CI, –0.58 to 8.03; P < .04) for outdoor versus indoor sports. Conclusion: Study results indicated that correcting low serum vitamin D levels reduces the risk of stress fracture. This study also presented evidence that athletes who participate in indoor sports may be at greater risk for vitamin D deficiency than those who compete in outdoor sports.

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Status of Vitamin D among Patients Visiting a Tertiary Care Centre in Rupandehi, Nepal

International Journal of Applied Sciences and Biotechnology ◽

10.3126/ijasbt.v9i4.40425 ◽

2021 ◽

Vol 9 (4) ◽

pp. 256-260

Author(s):

Tirtha Narayan Shah ◽

Amar Kumar Sinha ◽

Krishna Kumar Jha ◽

Ram Jiban Prasad

Keyword(s):

Vitamin D ◽

Tertiary Care ◽

Age Groups ◽

Serum Vitamin ◽

Hypovitaminosis D ◽

Target Population ◽

Tertiary Care Centre ◽

Medical College ◽

Serum Vitamin D ◽

High Level

Serum vitamin D is one of the fat-soluble vitamin which has the role in maintenance of calcium and phosphorus levels and ultimately proper bone health and various physiological processes. Although many studies prevail hypovitaminosis D, we focused to find out the pattern of elevated or decreased serum vitamin D level as its deficiency and surplus have adverse effects to our health.. For this, a retrospective study was done from the records present in a hospital laboratory of Devdaha Medical College and Research Institute (DMCRI), Rupandehi, Nepal from January 2018 to December 2020 where 201 participants with 70.1% male and 29.9% female with different age groups were present. From total participants, 14.9% had deficient, 42.8% had insufficient, 35.3% had sufficient and 7% had high level of serum vitamin D. Male had 2.9% deficient and 14,9% insufficient vitamin D whereas female had 11.9% deficient, 27.8% insufficient and 7.0% surplus vitamin D. The greater prevalence of hypovitaminosis D in the females than the males could be overcome by the necessary strategies in the form of further studies and judicious supplementation vitamin D in the target population by monitoring the level of serum vitamin D. Int. J. Appl. Sci. Biotechnol. Vol 9(4): 256-260.

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Vitamin D Insufficiency in Disease Severity and Prognosis of the Patients With SARS Corona Virus-2 Infection

ACTA MEDICA IRANICA ◽

10.18502/acta.v59i11.7779 ◽

2021 ◽

Author(s):

Ali Asgari ◽

Ebrahim Hazrati ◽

Saeed Soleiman-Meigooni ◽

Mohsen Rajaeinejad ◽

Sam Alahyari ◽

...

Keyword(s):

Vitamin D ◽

Disease Severity ◽

Odds Ratio ◽

Laboratory Data ◽

Serum Vitamin ◽

Serum Vitamin D ◽

Corona Virus ◽

Vitamin D Levels ◽

The Mean ◽

General Wards

The global crisis caused by the SARS Corona virus-2 infection is continuing through 2021, with more than 3.5 million deaths. Several risk factors for this virus’s severity and death were documented, including diabetes, hypertension, and ischemic heart disease. To evaluate the relation between serum vitamin D3 level, the disease severity, and prognosis of the patients with SARS Corona virus-2 infection. Patients with COVID-19 were evaluated for serum vitamin D levels and laboratory data. Correlation between vitamin D levels and laboratory data with disease severity and prognosis was assessed. Cox and logistic regression tests, as well as ROC curves, were used for data analysis. Ninety-eight patients with Corona virus-2 disease (COVID-19), which consisted of sixty patients with moderate COVID-19 in the general wards, and thirty-eight patients with severe COVID-19 in the intensive care unit (ICU), were evaluated. The mean age in the general wards was lower than in ICU (60.96±14.86 compared to 67.94±16.46, P=0.001), and the mean serum vitamin D level in the patients admitted in the general wards was higher than in the ICU (31 ng/mL compared to 20.57 ng/mL, P=0.003). Furthermore, vitamin D deficiency (25 (OH) D <25 ng/ml) significantly increased the risk of severe disease. (odds ratio=2.91, P=0.019) and mortality (odds ratio=3.64, P=0.026). Vitamin D deficiency is a risk factor for disease severity and poor prognosis in COVID-19. Vitamin D levels of 25 ng/mL can be used as a cut-off value for predicting severity and prognosis.

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