Cardiological Biopharmaceuticals in the Conception of Drug Targeting Delivery: Practical Results and Research Perspectives

Acta Naturae ◽  
2012 ◽  
Vol 4 (3) ◽  
pp. 72-81 ◽  
Author(s):  
A. V. Maksimenko
Keyword(s):  
Cell Adhesion Molecules ◽  
Drug Targeting ◽  
Interventional Procedures ◽  
Target Localization ◽  
Clinical Use ◽  
Protein Conjugates ◽  
Research Perspectives ◽  
Significant Interest ◽  
Targeting Delivery ◽  
Molecular Sizes

The results of the clinical use of thrombolytic and antithrombotic preparations developed on the basis of protein conjugates obtained within the framework of the conception of drug targeting delivery in the organism are considered. A decrease has been noted in the number of biomedical projects focused on these derivatives as a result of various factors: the significant depletion of financial and organizational funds, the saturation of the pharmaceutical market with preparations of this kind, and the appearance of original means for interventional procedures. Factors that actively facilitate the conspicuous potentiation of the efficacy of bioconjugates were revealed: the biomedical testing of protein domains and their selected combinations, the optimization of molecular sizes for the bioconjugates obtained, the density of target localization, the application of cell adhesion molecules as targets, and the application of connected enzyme activities. Enzyme antioxidants and the opportunity for further elaboration of the drug delivery conception via the elucidation and formation of therapeutic targets for effective drug reactions by means of pharmacological pre- and postconditioning of myocardium arouse significant interest.

scholarly journals Strategic use of nanotechnology in drug targeting and its consequences on human health: A focused review

2019 ◽  
Vol 11 (1) ◽  
pp. 38-54 ◽  
Author(s):  
Anand Maurya ◽  
Anurag Kumar Singh ◽  
Gaurav Mishra ◽  
Komal Kumari ◽  
Arati Rai ◽  
...  
Keyword(s):  
Human Health ◽  
Surface Area ◽  
Medical Diagnosis ◽  
Drug Targeting ◽  
Pharmaceutical Market ◽  
Large Surface Area ◽  
Mass Ratio ◽  
Disease Therapy ◽  
Significant Interest ◽  
Medical Benefits

Since the development of first lipid-based nanocarrier system, about 15% of the present pharmaceutical market uses nanomedicines to achieve medical benefits. Nanotechnology is an advanced area to meliorate the delivery of compounds for improved medical diagnosis and curing disease. Nanomedicines are gaining significant interest due to the ultra small size and large surface area to mass ratio. In this review, we discuss the potential of nanotechnology in delivering of active moieties for the disease therapy including their toxicity evidences. This communication will help the formulation scientists in understanding and exploring the new aspects of nanotechnology in the field of nanomedicine.

scholarly journals The Social Robot in Rehabilitation and Assistance: What is the Future?

Healthcare ◽  
2021 ◽  
Vol 9 (3) ◽  
pp. 244
Author(s):  
Daniele Giansanti
Keyword(s):  
The Elderly ◽  
Social Robots ◽  
Social Robot ◽  
Clinical Use ◽  
Research Development ◽  
Future Directions ◽  
Collaborative Robotics ◽  
Research Perspectives ◽  
The Social ◽  
The Future

This commentary aims to address the field of social robots both in terms of the global situation and research perspectives. It has four polarities. First, it revisits the evolutions in robotics, which, starting from collaborative robotics, has led to the diffusion of social robots. Second, it illustrates the main fields in the employment of social robots in rehabilitation and assistance in the elderly and handicapped and in further emerging sectors. Third, it takes a look at the future directions of the research development both in terms of clinical and technological aspects. Fourth, it discusses the opportunities and limits, starting from the development and clinical use of social robots during the COVID-19 pandemic to the increase of ethical discussion on their use.

Characterization of Nanoparticle Distribution in Microcirculation Through a Microfluidics Device

2011 ◽  
Author(s):  
Antony Thomas ◽  
Jifu Tan ◽  
Susan Perry ◽  
Yaling Liu
Keyword(s):  
Drug Delivery ◽  
Drug Targeting ◽  
Volume Ratio ◽  
Target Cells ◽  
Nanoparticle Distribution ◽  
Nano Drug Delivery ◽  
Targeting Delivery ◽  
Drug Doses ◽  
Lower Drug

Various methods of targeted nano drug delivery have been developed in recent years to reduce side effects, toxicity, and lower drug doses [1]. The use of nanoparticles in drug delivery provides advantages in drug targeting, delivery and release along with serving in diagnosis and therapy [2]. Higher percentage of nanoparticle drug is uptaken by the target cells while larger drug particles are easily cleaned off by the human body. Nanoparticles also have large surface to volume ratio, which aids in attachment of many functional groups and thereby enhances targeting.

scholarly journals Metal Organic Frameworks as Drug Targeting Delivery Vehicles in the Treatment of Cancer

Pharmaceutics ◽  
2020 ◽  
Vol 12 (3) ◽  
pp. 232 ◽  
Author(s):  
Mengru Cai ◽  
Gongsen Chen ◽  
Liuying Qin ◽  
Changhai Qu ◽  
Xiaoxv Dong ◽  
...  
Keyword(s):  
Drug Targeting ◽  
Drug Loading ◽  
Metal Organic Frameworks ◽  
Zeolitic Imidazolate Frameworks ◽  
Passive Targeting ◽  
Normal Tissues ◽  
Excellent Research ◽  
Targeting Delivery ◽  
Metal Organic ◽  
University Of Oslo

In recent years, metal organic frameworks (MOFs) have been widely developed as vehicles for the effective delivery of drugs to tumor tissues. Due to the high loading capacity and excellent biocompatibility of MOFs, they provide an unprecedented opportunity for the treatment of cancer. However, drugs which are commonly used to treat cancer often cause side effects in normal tissue accumulation. Therefore, the strategy of drug targeting delivery based on MOFs has excellent research significance. Here, we introduce several intelligent targeted drug delivery systems based on MOFs and their characteristics as drug-loading systems, and the challenges of MOFs are discussed. This article covers the following types of MOFs: Isoreticular Metal Organic Frameworks (IRMOFs), Materials of Institute Lavoisier (MILs), Zeolitic Imidazolate Frameworks (ZIFs), University of Oslo (UiOs), and MOFs-based core-shell structures. Generally, MOFs can be reasonably controlled at the nanometer size to effectively achieve passive targeting. In addition, different ligands can be modified on MOFs for active or physicochemical targeting. On the one hand, the targeting strategy can improve the concentration of the drugs at the tumor site to improve the efficacy, on the other hand, it can avoid the release of the drugs in normal tissues to improve safety. Despite the challenges of clinical application of MOFs, MOFs have a number of advantages as a kind of smart delivery vehicle, which offer possibilities for clinical applications.

scholarly journals A hyaluronic acid–pentamidine bioconjugate as a macrophage mediated drug targeting delivery system for the treatment of leishmaniasis

RSC Advances ◽  
2015 ◽  
Vol 5 (116) ◽  
pp. 95545-95550 ◽  
Author(s):  
N. Micale ◽  
A. Piperno ◽  
N. Mahfoudh ◽  
U. Schurigt ◽  
M. Schultheis ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
Delivery System ◽  
Drug Targeting ◽  
Biological Recognition ◽  
Targeting Delivery

A new HA–Pent bioconjugate was synthetized and proposed as drug targeting delivery system for the treatment of leishmaniasis, exploiting the specific biological recognition of HA by the macrophage.

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