scholarly journals The first report of direct skeletal attachment method applying for tibia prosthetic leg in a chicken by cortical screw

2019 ◽  
Vol 2 (3) ◽  
pp. 3-5
Author(s):  
Piyabongkarn Damrongdej
Keyword(s):  
Stainless Steel ◽  
Blood Loss ◽  
Endotracheal Tube ◽  
Surgical Procedure ◽  
Small Animal ◽  
Long Bone ◽  
Long Bones ◽  
First Report ◽  
Cortical Screw ◽  
Intramedullary Screw

This is the first report of successful method for direct skeletal attachment for invent tibia prosthetic leg in a chicken amputee by using 3.0 mm stainless steel cortical screw as an intramedullary bone stem for right tibia endoprosthesis leg part and using acrylic with some part of endotracheal tube as an exoprosthesis leg part. This surgery was performed in a chicken amputee without bone cement using. A chicken could stand and sometime walk after 15 days of surgery. No complication problem with a screw’s stump. This intramedullary bone stem technique by a screw can adapt using in other parts of long bone animal amputee. This technique can apply for invent endoprosthesis limb in other small animal amputees and can use intramedullary screw technique with other long bones such as femur, humerus, radius, and ulna because this technique uses only one stainless 316L screw so the surgery cost is not too much. The surgical procedure is not complicated and blood loss during surgery is not much so the risk for this technique is low.

scholarly journals Preoperative embolization in surgical treatment of long bone metastasis: a systematic literature review

2020 ◽  
Vol 5 (1) ◽  
pp. 17-25 ◽  
Author(s):  
Stijn E. W. Geraets ◽  
P. Koen Bos ◽  
Johan van der Stok
Keyword(s):  
Blood Transfusion ◽  
Blood Loss ◽  
Bone Metastases ◽  
Transfusion Requirement ◽  
Primary Tumour ◽  
Significant Risk ◽  
Long Bone ◽  
Preoperative Embolization ◽  
Long Bones ◽  
Perioperative Blood Loss

Surgery of long bone metastases is associated with a significant risk of perioperative blood loss, which may necessitate blood transfusion. Successful embolization (> 70% obliteration of vascularity) can be achieved in 36–75% of cases. The reported rate of embolization-related complications is 0–9%. Three out of six level III evidence studies showed a reduction in perioperative blood loss and/or blood transfusion requirement after preoperative embolization of renal cell carcinoma metastasis in long bones; three out of six studies did not. One level III evidence study did not show a reduction in perioperative blood loss and/or transfusion requirement after preoperative embolization of hepatocellular carcinoma metastases in long bones. There were no studies found that support preoperative embolization of thyroid metastases or other frequent long bone metastases (e.g. mamma carcinoma, lung carcinoma, or prostate carcinoma). The clinical level of evidence of the studies found is low and randomized studies taking into account primary tumour, location of metastases and type of surgery are therefore desired. Cite this article: EFORT Open Rev 2020;5:17-25. DOI: 10.1302/2058-5241.5.190013

scholarly journals Collagen heterogeneity within different growth regions of long bones of rachitic and nonrachitic chicks

1972 ◽  
Vol 127 (4) ◽  
pp. 715-720 ◽  
Author(s):  
Bryan P. Toole ◽  
Andrew H. Kang ◽  
Robert L. Trelstad ◽  
Jerome Gross
Keyword(s):  
Vitamin D ◽  
Amino Acid ◽  
Bone Matrix ◽  
Bone Collagen ◽  
Long Bone ◽  
Long Bones ◽  
Collagen Structure ◽  
Collagen Molecules ◽  
Relationship Of ◽  
Chain Type

The different anatomical regions involved in osteogenesis in the chick long bone have been examined for heterogeneities in collagen structure that might relate to the mechanism of ossification. Experimentally induced lathyrism was employed to enhance collagen solubility, and vitamin D deficiency to allow accumulation of osteoid, the precursor of bone matrix. The extractable lathyritic collagens of the cartilaginous and osseous regions of growing long bones from rachitic and non-rachitic chicks were examined for α-chain type and amino acid composition. In both groups of animals the growth plate and cartilaginous regions of the epiphysis gave collagen molecules of the constitution [α1(II)]3, whereas the ossifying regions contained [α1(I)]2 α2. The degree of hydroxylation of the lysine moieties was increased by approximately 50% in the α1(I)-chain and α2-chain of rachitic bone collagen. Since uncalcified osteoid is greatly enriched in rachitic bone, it is concluded that the collagen of osteoid has the configuration [α1(I)]2 α2, similar to that of bone matrix, but has an elevated hydroxylysine content. The possible relationship of this difference to the mechanism of calcification is discussed.

scholarly journals Comparison of Mechanical Stability of Elastic Titanium, Nickel-Titanium, and Stainless Steel Nails Used in the Fixation of Diaphyseal Long Bone Fractures

Materials ◽  
2018 ◽  
Vol 11 (11) ◽  
pp. 2159 ◽  
Author(s):  
Pei-Yuan Lee ◽  
Yen-Nien Chen ◽  
Jin-Jia Hu ◽  
Chih-Han Chang
Keyword(s):  
Stainless Steel ◽  
Mechanical Stability ◽  
Fe Simulation ◽  
Bone Fractures ◽  
Nickel Titanium ◽  
Long Bone ◽  
Bone Modeling ◽  
Long Bone Fractures ◽  
Elastic Nails ◽  
The Difference

Elastic nails made of the nickel-titanium shape memory alloy (Nitinol) have been reported to control bone modeling in animal studies. However, the mechanical stability of the Nitinol nail in the fixation of long bone fractures remains unclear. This study compared mechanical stability among nails made of three materials, namely Nitinol, titanium, and stainless steel, in the fixation of long bone fractures. These three materials had identical shapes (arc length: π/2 and radius: 260 mm). A cylindrical sawbone with a 10-mm gap and fixed with two C-shaped elastic nails was used to examine the stability of the nails. A finite element (FE) model was developed based on the sawbone model. The end cap for elastic nails was not used in the sawbone test but was considered based on a constraint equation in FE simulation. The results of stability tests appeared to depend on the presence or absence of the end cap. In the sawbone test, the titanium nail yielded a higher ultimate force against the applied load than did the stainless steel and Nitinol nails before the gap completely closed; the difference in linear stiffness between the nails was nonsignificant. In FE simulation, the titanium nail produced smaller gap shortening than did stainless steel and Nitinol nails without the end cap; the difference in gap shortening between the nails was minor with the end cap. The titanium elastic nail should be a better choice in managing diaphyseal long bone fractures when the end cap is not used. For Nitinol and stainless steel nails, the end cap should be used to stop the nail from dropping out and to stabilize the fractured bone.

Longitudinal bone growth in vitro: effects of insulin-like growth factor I and growth hormone

1991 ◽  
Vol 124 (5) ◽  
pp. 602-607 ◽  
Author(s):  
Ben A. A. Scheven ◽  
Nicola J. Hamilton
Keyword(s):  
Growth Hormone ◽  
Growth Factor ◽  
Bone Growth ◽  
Long Bone ◽  
Long Bones ◽  
Insulin Like Growth Factor ◽  
Serum Free ◽  
Factor I ◽  
Igf I

Abstract. Longitudinal growth was studied using an in vitro model system of intact rat long bones. Metatarsal bones from 18- and 19-day-old rat fetuses, entirely (18 days) or mainly (19 days) composed of chondrocytes, showed a steady rate of growth and radiolabelled thymidine incorporation for at least 7 days in serum-free media. Addition of recombinant human insulin-like growth factor-I to the culture media resulted in a direct stimulation of the longitudinal growth. Recombinant human growth hormone was also able to stimulate bone growth, although this was generally accomplished after a time lag of more than 2 days. A monoclonal antibody to IGF-I abolished both the IGF-I and GH-stimulated growth. However, the antibody had no effect on the growth of the bone explants in control, serum-free medium. Unlike the fetal long bones, bones from 2-day-old neonatal rats were arrested in their growth after 1-2 days in vitro. The neonatal bones responded to IGF-I and GH in a similar fashion as the fetal bones. Thus in this study in vitro evidence of a direct effect of GH on long bone growth via stimulating local production of IGF by the growth plate chondrocytes is presented. Furthermore, endogenous growth factors, others than IGFs, appear to play a crucial role in the regulation of fetal long bone growth.

scholarly journals Effect of premedication with oral clonidine on intraoperative blood loss during rhinoplasty surgery - A systematic review

2020 ◽  
Vol 11 (4) ◽  
pp. 5206-5213
Author(s):  
Sudarssan Subramaniam Gouthaman ◽  
Janani Kandamani ◽  
Divya Sanjeevi Ramakrishnan ◽  
P. U. Abdul Wahab
Keyword(s):  
Systematic Review ◽  
Blood Loss ◽  
Surgical Procedure ◽  
Intraoperative Blood Loss ◽  
Pertinent Literature ◽  
Intraoperative Bleeding ◽  
Oral Clonidine ◽  
Hypotensive Anaesthesia ◽  
The Past ◽  
Manual Search

Rhinoplasty is one frequent surgical procedure of many technical variations that only a few surgeons are considered to have mastered its broad scope. Operative site bleeding is considered to be an exasperating issue in the surgical procedure of rhinoplasty. Over the past few decades, the strategy of lowering patient's blood pressure during anaesthesia or "Hypotensive anaesthesia" has been practised to reduce the blood loss during surgeries. Clonidine is an antihypertensive drug and is suggested to have advantageous effects in controlling the intraoperative blood loss. The objective of this systematic review was to explore and study the existing literature and determine the efficacy of oral clonidine as a premedication in reducing the intraoperative blood loss in rhinoplasty surgeries. Data was gathered from electronic databases like PubMed, Medline and Cochrane central library. An additional manual search was performed with various journals to look for available articles to include in the systematic review. Only those studies which met the criteria for inclusion were selected. All studies and reports that evaluated oral clonidine with placebo in reducing bleeding during rhinoplasty surgery were included. Pertinent literature abstracts and full-text articles pertaining to the query were analysed. Two articles in total were taken in for qualitative analysis, both of which were randomised clinical trials. Oral clonidine shows significantly more efficient in reducing intraoperative bleeding than the placebo group. Premedication with oral clonidine is significantly effective in controlling blood loss during the surgical procedure of rhinoplasty.

scholarly journals Exposure to the RXR agonist SR11237 in early life causes disturbed skeletal morphogenesis in a rat model

2019 ◽  
Author(s):  
Holly Dupuis ◽  
Michael Andrew Pest ◽  
Ermina Hadzic ◽  
Thin Xuan Vo ◽  
Daniel B. Hardy ◽  
...  
Keyword(s):  
Growth Plate ◽  
Bone Growth ◽  
Long Bone ◽  
Tunel Staining ◽  
Long Bones ◽  
Micro Computed Tomography ◽  
Computed Tomography Scanning ◽  
Calcified Tissue ◽  
Trap Staining ◽  
Tomography Scanning

AbstractLongitudinal bone growth occurs through endochondral ossification (EO), controlled by various signaling molecules. Retinoid X Receptor (RXR) is a nuclear receptor with important roles in cell death, development, and metabolism. However, little is known about its role in EO. In this study, the agonist SR11237 was used to evaluate RXR activation on EO.Rats given SR11237 from post-natal day 5 to 15 were harvested for micro-computed tomography scanning and histology. In parallel, newborn CD1 mouse tibiae were cultured with increasing concentrations of SR11237 for histological and whole mount evaluation.RXR agonist-treated rats were smaller than controls, and developed dysmorphia of the growth plate. Cells invading the calcified and dysmorphic growth plate appeared pre-hypertrophic in size and shape corresponding with P57 immunostaining. Additionally, SOX9 positive cells were found surrounding the calcified tissue. The epiphysis of SR11237 treated bones showed increased TRAP staining, and additional TUNEL staining at the osteo-chondral junction. MicroCT revealed morphological disorganization in the long bones of treated animals. Isolated mouse long bones treated with SR11237 grew significantly less than their DMSO controls.This study demonstrates that stimulation of the RXR receptor causes irregular ossification, premature closure of the growth plate, and disrupted long bone growth in rodent models.

Classification of Fractures of Long Bones in the Dog and Cat: Introduction and Clinical Application

1990 ◽  
Vol 03 (02) ◽  
pp. 41-50 ◽  
Author(s):  
M. Unger ◽  
P. M. Montavon ◽  
U. F. A. Heim
Keyword(s):  
Bone Fractures ◽  
Reliable Data ◽  
Long Bone ◽  
Small Animals ◽  
Long Bones ◽  
Coding System ◽  
Fracture Classification ◽  
Fracture Criteria ◽  
Filing System

AbstractA computer filing system for the classification of fractured long bones in dogs and cats is described. It includes definitions of terms and a method of classification, based on fracture criteria seen on radiographs. This fracture classification was adapted from the AO/ASIF classification in man, to accomodate the special requirements of small animals. The localization and morphology of fractures were characterized with defined conventional terms, in order to assign an alpha-numeric code to each fracture. This coding system may also be used for computer filing of the data. With this classification system, the fractures are ranked in increasing severity and complexity for the various anatomical locations. This provides some prognostic and therapeutic informations. The system was used to code 1038 radiographically documented long bone fractures in dogs and cats. The distribution of fractures, with regard to their localization and morphology, was recorded. The system was easy to apply and proved to be able to supply valuable and reliable data.A computer filing system for the classification of fractured long bones in dogs and cats is described.

Modal Frequencies of Long Tibia Bones: Heterogeneous vs Homogeneous Material Considerations

2017 ◽  
Author(s):  
Reem A. Yassine ◽  
Mohammad Karim Elham ◽  
Samir Mustapha ◽  
Ramsey F. Hamade
Keyword(s):  
Heterogeneous Material ◽  
Approximate Solutions ◽  
3D Models ◽  
Long Bone ◽  
Homogeneous Material ◽  
Long Bones ◽  
Bone Properties ◽  
Stiffness Properties ◽  
Mode 2 ◽  
Experimental Values

Where heterogeneous material considerations may yield more accurate estimates of long bones’ modal characteristics, homogeneous description has the advantage for yielding faster approximate solutions. In this study, modal frequencies of (bovine) long tibia bones are numerically estimated using the finite element method (FEM) using ANSYS starting from anatomically accurate CT scans and 3D models. Whole long bones are segmented into their cortical and cancellous constituents based on Hounsfield (HU) values. Bones’ cortical and cancellous constituents are first treated as heterogeneous material. Relative to stiffness-density relations, stiffness values are assigned for each element yielding a stiffness-graded structure. Modal frequencies are generated and values compared to those measured from dynamic experiments. Analysis was repeated where bone properties are homogenized by averaging the stiffness properties of bone constituents. The resulting frequencies are compared with those of the heterogeneous stiffness-graded bones. As compared with measured experimental values of one control long bone, the heterogeneous material assumption returned good estimates of the frequency values in the CC plane with of +0.85 % for mode 1 and +10.66 % for mode 2. For homogeneous material assumption, underestimates were returned with error values of −13.25% and −0.13 % differences for mode 2. In the ML plane, heterogeneous material assumption returned good estimates of the frequency values with −8.89 % for mode 1 and + 1.01 % for mode 2. Homogeneous material assumption underestimated the frequency values with error of −20.52 % for mode 1 and −7.50 % for mode 2. Homogeneous simplifications yielded faster and more memory-efficient FEM runs with heterogeneous modal analysis requiring 1.5 more running time and twice the utilized memory.

Test Methods for Accurate and Robust Material Property Measurements of Rodent Cortical Bone

2008 ◽  
Author(s):  
Douglas J. Adams ◽  
Svetlana Lublinsky ◽  
Mauricio Barrero
Keyword(s):  
Cortical Bone ◽  
Material Property ◽  
Statistical Power ◽  
Test Methods ◽  
Standard Test ◽  
Long Bone ◽  
Long Bones ◽  
Tissue Properties ◽  
Serial Test ◽  
Direct Measurements

Direct measurements of cortical bone material properties are difficult to achieve in rodent long bones due to the inherently small dimensions and difficulties in machining standard test specimen geometries [1]. Bone tissue properties in nearly all rodent studies are thus limited to estimates from flexural tests of long bone diaphyses. In addition to the inaccuracies imposed by the bending stress state itself, these material property estimates are further confounded by the non-uniform geometry of long bones along the diaphyseal length. The goal of this work was to develop a series of techniques to improve the accuracy and precision of material property measurements in rodent long bones, with explicit mathematical correction for geometrical complexity and multiple measurements from individual bones. In combination, these techniques provide a pragmatic serial test routine for collecting multiple direct measurements of cortical tissue elastic modulus and strength, with a potential for improving sensitivity and statistical power in skeletal studies using rodents.

Superior supercapacitive performance of grass-like CuO thin films deposited by liquid phase deposition

2020 ◽  
Vol 44 (17) ◽  
pp. 6778-6790 ◽  
Author(s):  
Shreelekha N. Khatavkar ◽  
Shrikrishna D. Sartale
Keyword(s):  
Thin Films ◽  
Stainless Steel ◽  
Liquid Phase ◽  
Liquid Phase Deposition ◽  
Supercapacitive Performance ◽  
First Report

First report on deposition and supercapacitive performance of grass-like CuO thin films by liquid phase deposition on flat and mesh stainless steel (SS). The maximum specific capacitances on flat and mesh SS are 552 and 849 F g−1.

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