scholarly journals HIV Infection: What Should We Know?

2020 ◽  
Vol 2 (1) ◽  
pp. 01-16
Author(s):  
Ridwan Balatif
Keyword(s):  
Hiv Infection ◽  
Hiv Transmission ◽  
Opportunistic Infections ◽  
Antiretroviral Drugs ◽  
People Living With Hiv ◽  
Stigma And Discrimination ◽  
Acquired Immunodeficiency ◽  
To Come ◽  
Immunodeficiency Syndrome ◽  
Living With Hiv

Acquired Immunodeficiency Syndrome (AIDS) was first known in 1981 in homosexual groups who had opportunistic infections and malignancies. In Indonesia the first AIDS case was reported in 1987 to a Dutch citizen living in the province of Bali. Cases of HIV infection in Indonesia are reported to increase every year and most occur at the age of 25-49 years. HIV transmission is not easily transmitted, even when an HIV-infected person takes antiretroviral drugs can reduce the risk of transmission by up to 96%. But one of the biggest challenges in managing HIV infection is facing stigma and discrimination. As many as 1 in 5 people living with HIV are afraid to come to the clinic because they will experience discrimination and stigma from the community if this condition occurs will cause treatment delay until PLWHA (People living with HIV/AIDS) will fall to the AIDS stage and PLWHA will be susceptible to opportunistic infections. A clinic in Namibia, when stigma and discrimination were successfully overcome, there was a 20% reduction in mortality in PLWHA

Mechanisms of immune aging in HIV

2022 ◽  
Vol 136 (1) ◽  
pp. 61-80
Author(s):  
Manon Chauvin ◽  
Delphine Sauce
Keyword(s):  
Immune Activation ◽  
Opportunistic Infections ◽  
People Living With Hiv ◽  
Adaptive Immune ◽  
Hiv Progression ◽  
Immunodeficiency Virus ◽  
Acquired Immunodeficiency ◽  
Immunodeficiency Syndrome ◽  
Living With Hiv ◽  
Hiv 1

Abstract Massive CD4+ T-cell depletion as well as sustained immune activation and inflammation are hallmarks of Human Immunodeficiency Virus (HIV)-1 infection. In recent years, an emerging concept draws an intriguing parallel between HIV-1 infection and aging. Indeed, many of the alterations that affect innate and adaptive immune subsets in HIV-infected individuals are reminiscent of the process of immune aging, characteristic of old age. These changes, of which the presumed cause is the systemic immune activation established in patients, likely participate in the immuno-incompetence described with HIV progression. With the success of antiretroviral therapy (ART), HIV-seropositive patients can now live for many years despite chronic viral infection. However, acquired immunodeficiency syndrome (AIDS)-related opportunistic infections have given way to chronic diseases as the leading cause of death since HIV infection. Therefore, the comparison between HIV-1 infected patients and uninfected elderly individuals goes beyond the sole onset of immunosenescence and extends to the deterioration of several physiological functions related to inflammation and systemic aging. In light of this observation, it is interesting to understand the precise link between immune activation and aging in HIV-1 infection to figure out how to best care for people living with HIV (PLWH).

scholarly journals Reduction of CD4 count induces opportunistic infections in people living with HIV (PLHIV)

2014 ◽  
Vol 13 (3) ◽  
pp. 285-291 ◽  
Author(s):  
Rashed Noor ◽  
Md. Morsalin ◽  
Bidhan Chakraborty
Keyword(s):  
Opportunistic Infections ◽  
Medical Science ◽  
Skin Lesions ◽  
The Body ◽  
Cd4 Count ◽  
People Living With Hiv ◽  
Immunodeficiency Virus ◽  
Acquired Immunodeficiency ◽  
Immunodeficiency Syndrome ◽  
Living With Hiv

Objective: Human immunodeficiency virus (HIV), a lentivirus (member of the retrovirus family) causing acquired immunodeficiency syndrome (AIDS), weakens the immune system of the body and hence associates different opportunistic infections. Present study undertook a survey on opportunistic infections. Materials and Methods: Data were collected from both HIV carriers (CD4 count more than 250/mL of blood) and AIDS patients (CD4 count less than 250/mL of blood). Results: Analyses of the data revealed that diarrhoea, pulmonary tuberculosis, gland tuberculosis, skin lesions and fever were the common opportunistic infections. Conclusion: It can be summarized that HIV infected patients having a reduced CD4 count (<250/mL) encounter different opportunistic infections and some of these infections could be continual for long as well. DOI: http://dx.doi.org/10.3329/bjms.v13i3.19151 Bangladesh Journal of Medical Science Vol.13(3) 2014 p.285-291

Acquired immunodeficiency syndrome (AIDS)

2021 ◽  
pp. 197-212
Author(s):  
Quarraisha Abdool Karim ◽  
Urisha Singh ◽  
Cheryl Baxter ◽  
Salim S. Abdool Karim
Keyword(s):  
Acquired Immunodeficiency Syndrome ◽  
Sexual Transmission ◽  
Hiv Infections ◽  
Antiretroviral Drugs ◽  
People Living With Hiv ◽  
History Of ◽  
Acquired Immunodeficiency ◽  
Immunodeficiency Syndrome ◽  
Exposure Prophylaxis ◽  
Living With Hiv

This chapter traces the history of human immunodeficiency virus (HIV) from its origins, remarkable scientific advances, and unprecedented global responses through to the current state of the epidemic, progress towards ending acquired immunodeficiency syndrome (AIDS) and remaining challenges. It explains the origins of HIV-1 and HIV-2, the development of a surveillance system, and the viral structure. It outlines different antiretroviral drugs used in the treatment of HIV infections, and current drug research. The prevention of both mother-to-child transmission and sexual transmission is outlined, including pre-exposure prophylaxis (PrEP) use. The development of modern technologies and social media to help people living with HIV is covered. Programmes to modify behaviour and reduce risk from injecting drug use are explained.

scholarly journals Chronic Cystoisospora belli infection in a Colombian patient living with HIV and poor adherence to highly active antiretroviral therapy

Biomédica ◽  
2021 ◽  
Vol 41 (Supl. 1) ◽  
pp. 17-22
Author(s):  
Ana Luz Galván-Díaz ◽  
Juan Carlos Alzate ◽  
Esteban Villegas ◽  
Sofía Giraldo ◽  
Jorge Botero ◽  
...  
Keyword(s):  
Antiretroviral Therapy ◽  
Highly Active Antiretroviral Therapy ◽  
Diarrheal Disease ◽  
Opportunistic Infections ◽  
Poor Adherence ◽  
Highly Active ◽  
Immunodeficiency Virus ◽  
Acquired Immunodeficiency ◽  
Immunodeficiency Syndrome ◽  
Living With Hiv

Cystoisospora belli is an intestinal Apicomplexan parasite associated with diarrheal illness and disseminated infections in humans, mainly immunocompromised individuals such as those living with the human immunodeficiency virus (HIV) or acquired immunodeficiency syndrome (AIDS). An irregular administration of highly active antiretroviral therapy (HAART) in HIV patients may increase the risk of opportunistic infections like cystoisosporiasis.We describe here a case of C. belli infection in a Colombian HIV patient with chronic gastrointestinal syndrome and poor adherence to HAART. His clinical and parasitological cure was achieved with trimethoprim-sulfamethoxazole treatment. Although a reduction in the number of C. belli cases has been observed since the use of HAART, this parasite still has to be considered as a differential diagnosis of diarrheal disease in HIV/AIDS patients.Effective interventions enhancing adherence to HAART should be included in HIV patient care programs.

scholarly journals Trans cohort metabolic reprogramming towards glutaminolysis in long-term successfully treated HIV-infection

2022 ◽  
Vol 5 (1) ◽  
Author(s):  
Flora Mikaeloff ◽  
Sara Svensson Akusjärvi ◽  
George Mondinde Ikomey ◽  
Shuba Krishnan ◽  
Maike Sperk ◽  
...  
Keyword(s):  
Hiv Infection ◽  
Cell Model ◽  
Antiretroviral Drugs ◽  
Metabolic Reprogramming ◽  
System Level ◽  
People Living With Hiv ◽  
Low Grade ◽  
Middle Income ◽  
Living With Hiv

AbstractDespite successful combination antiretroviral therapy (cART), persistent low-grade immune activation together with inflammation and toxic antiretroviral drugs can lead to long-lasting metabolic flexibility and adaptation in people living with HIV (PLWH). Our study investigated alterations in the plasma metabolic profiles by comparing PLWH on long-term cART(>5 years) and matched HIV-negative controls (HC) in two cohorts from low- and middle-income countries (LMIC), Cameroon, and India, respectively, to understand the system-level dysregulation in HIV-infection. Using untargeted and targeted LC-MS/MS-based metabolic profiling and applying advanced system biology methods, an altered amino acid metabolism, more specifically to glutaminolysis in PLWH than HC were reported. A significantly lower level of neurosteroids was observed in both cohorts and could potentiate neurological impairments in PLWH. Further, modulation of cellular glutaminolysis promoted increased cell death and latency reversal in pre-monocytic HIV-1 latent cell model U1, which may be essential for the clearance of the inducible reservoir in HIV-integrated cells.

scholarly journals Features of choosing the tactics and method of treatment of external joint frequencies of long external bones in people living with HIV

2020 ◽  
Vol 12 (1) ◽  
pp. 65-72
Author(s):  
N. G. Doronin ◽  
S. N. Khoroshkov ◽  
S. L. Maksimov
Keyword(s):  
Hiv Infection ◽  
Infectious Complications ◽  
Antiretroviral Drugs ◽  
People Living With Hiv ◽  
Long Bones ◽  
Treatment Results ◽  
Improve Treatment ◽  
Articular Fractures ◽  
And Migration ◽  
Living With Hiv

Objective. Develop an algorithm for determining tactics and parameters of their treatment to improve treatment outcomes. Methodology. Material and research methods. A statistical analysis of the treatment results of 90 HIV-infected patients aged from 23 to 54 years with extra-articular fractures of long bones of the extremities was carried out. When determining the tactics and method of treatment, the peculiarities of the effect of HIV infection, antiretroviral drugs, and opportunistic diseases on the patient’s body were not taken into account. Results. Non-infectious complications are characteristic of HIV-infected patients: sides of the postoperative wound (seromas, hematomas, discrepancy of wound edges, delayed crushing), aseptic loosening and migration of fixatives, delayed consolidation of fractures. The presence of a statistically significant relationship between the objective factors characterizing the course of HIV infection: the stage of the disease, the number of CD lymphocytes, the ratio of CD4 / CD8 lymphocytes, viral load and the risk of postoperative complications was revealed.Conclusion. The application of the developed algorithm allows you to objectify the procedure and provide an individual approach in determining the tactics and method of treatment for HIV-infected patients with extraarticular fractures of long bones of the extremities

scholarly journals Discrimination of people living with hiv/aids: a survey with dentists in Abidjan, Côte d’Ivoire

2019 ◽  
Vol 29 (Supplement_4) ◽  
Author(s):  
J C Guinan ◽  
G D Meless ◽  
A D Sangaré ◽  
V Danho-Da ◽  
B S Kouassi ◽  
...  
Keyword(s):  
Hiv Infection ◽  
Continuing Education ◽  
Cote D'ivoire ◽  
Côte D’Ivoire ◽  
Hiv Transmission ◽  
People Living With Hiv ◽  
Cote D’Ivoire ◽  
Côte D'ivoire ◽  
Living With Hiv ◽  
Lack Of Knowledge

Abstract Background Despite several decades of fighting HIV infection, discrimination against people living with this infection persists, even among health professionals. Understanding the determinants of discriminatory attitudes of dentists is a first step towards access to oral health care and improved care for people living with HIV (PLHIV). Objectives To analyse the determinants of discriminatory attitudes towards people living with HIV among dentists in Côte d’Ivoire. Methods A cross-sectional survey was conducted among dentists in Abidjan in 2016. In addition to socio-professional characteristics, a questionnaire collected information on their knowledge about HIV (transmission, hiv-related oral diseases) and their individual perception (fear of being contaminated, cross-contamination...). The chi2 test for independent sampling was used to identify factors associated with discriminatory attitudes (threshold α = 5%). Results A total of 120 dentists were interviewed: 61.3% from the public sector; 56.7% men; 54.2% in couple; 53.3% had participated in continuing education on HIV; 29.2% did not know HIV-related diseases and transmission modes and 69.2% reported fear of being infected during care; 44.2% reported informing staff of the patient’s HIV status. The proportion of dentists with discriminatory attitudes was estimated at 69.2%. The main associated factors were: female gender (p = 0.001), living in couple (p = 0.000), lack of knowledge of the risk of HIV transmission after a blood exposure accident (p = 0.000), the law protecting people living with HIV in Côte d’Ivoire (p = 0.009) and fear of being infected (p = 0.000). Conclusions The results of this study show that the determinants of discriminatory attitudes among dentists result from their lack of knowledge of the disease, justifying the need to strengthen their continuing education on HIV/AIDS infection. Key messages Dentists discrimination towards people living with HIV infection result from their lack of knowledge about the infection. It’s essential to strengthen their knowledge about HIV in order to improve access to care for people living with HIV.

Challenges in Providing Comprehensive and Coordinated Care to HIV/AIDS Patients: A Canadian Perspective

2000 ◽  
Vol 13 (1) ◽  
pp. 43-49 ◽  
Author(s):  
Peter Tsasis
Keyword(s):  
Chronic Illness ◽  
Hiv Infection ◽  
Chronic Conditions ◽  
Opportunistic Infections ◽  
Healthcare Delivery ◽  
Coordinated Care ◽  
Healthcare Delivery System ◽  
Canadian Perspective ◽  
Acquired Immunodeficiency ◽  
Immunodeficiency Syndrome

This article focuses our attention on the means by which healthcare is provided to HIV-infected patients who require comprehensive and coordinated care to address the variety of changing and challenging needs presented by the acquired immunodeficiency syndrome (AIDS). Improved clinical management of HIV infection over the past decade, with antiretroviral agents, protease inhibitors and prophylactic therapies against opportunistic infections has transformed HIV infection from an acute to a chronic illness. Many individuals with AIDS are now living longer with more chronic conditions. Concomitant with the transformation of HIV infection from an acute to a chronic illness comes the challenge to provide effective, humane and economical care to patients with chronic conditions that continue to reside in the community, within a healthcare delivery system that has evolved to treat patients with acute diseases.

scholarly journals HIV/AIDS SEBAGAI “RUANG” PELAYANAN PASTORAL GEREJA

2020 ◽  
Vol 3 (1) ◽  
pp. 37-46
Author(s):  
Robinson Simanungkalit
Keyword(s):  
Hiv And Aids ◽  
People Living With Hiv ◽  
Proper Understanding ◽  
Immunodeficiency Virus ◽  
History Of ◽  
Acquired Immunodeficiency ◽  
Immunodeficiency Syndrome ◽  
Living With Hiv ◽  
The Church ◽  
Hiv Aids

It is important to explain some important things on Human Immunodeficiency Virus (HIV) or Acquired Immunodeficiency Syndrome (AIDS). This study was aimed to to provide a proper understanding on the HIV/AIDS. Consequently, this study described what the HIV/AIDS is, the history of the emergence of HIV/AIDS, the transmission of HIV/AIDS, and the effects of HIV/AIDS on infected human. People infected with HIV and AIDS are referred to as PLWHA (People living with HIV and AIDS). They may be church citizens. Therefore, the church must not "turn a blind eye", but is required to be proactive in responding to people who have infected with HIV/AIDS.BAHASA INDONESIA ABSTRACT: Sangatlah penting untuk menjelaskan beberapa hal penting tentang HIV/AIDS guna memberikan pemahaman yang benar tentang HIV/AIDS. Dibutuhkan penjelasan tentang apa itu HIV/AIDS, Sejarah munculnya HIV/AIDS, Penularan HIV/AIDS dan dampak yang ditimbulkan oleh HIV/AIDS terhadap orang- orang yang terinfeksi. Orang yang terinfeksi HIV dan AIDS itu disebut sebagai ODHA (Orang yang hidup dengan HIV dan AIDS). Mungkin saja mereka adalah warga gereja dan karena itu gereja tidak boleh “menutup mata” tetapi dituntut untuk proaktif dalam menyikapi keberadaan warganya yang terinfeksi HIV/AIDS.Keywords: HIV/AIDS, ODHA

scholarly journals CLINICAL AND IMMUNOLOGICAL CHARACTERISTICS OF HIV-INFECTION IN DYNAMICS AGAINST THE BACKGROUND OF ANTIRETROVIRAL THERAPY AMONG PATIENTS IN POLTAVA REGION

2019 ◽  
Vol 23 (5-6) ◽  
pp. 20-24
Author(s):  
O.H. Marchenko ◽  
T.I. Koval ◽  
L.M. Syzova ◽  
S.S. Rudenko ◽  
N.P. Lymarenko
Keyword(s):  
T Lymphocytes ◽  
Hiv Infection ◽  
Opportunistic Infections ◽  
Initial Level ◽  
People Living With Hiv ◽  
Clinical Progression ◽  
Relevant Issue ◽  
Control Center ◽  
Living With Hiv ◽  
And Control

HIV-infection is a relevant issue of the modern healthcare system due to socio-medical and demographic significance. The problem of correlation between clinico-laboratory characteristics and immunological indexes in people living with HIV-infection and obtain ART remains relevant, and the solution may help to expand the knowledge about predictors of the disease in the future. The aim of our research was to analyze the clinical and immunological characteristics of HIV-infection in dynamics against the background of ART considering the initial level of CD4+ T-lymphocytes. Patients and methods. We conducted a cohort study of 181 people living with HIV-infection – 127 male and 54 female patients, aged from 21 to 55 years (the average age 34.6±0.6 years), who underwent dispensary observation at Poltava Regional HIV/AIDS Prevention and Control Center during 2003-2017, for the purpose of evaluation of clinical and immunological characteristics of HIV-infection in dynamics against the background of ART. Results of the research and their discussion. We found that among people living with HIV, young people (90.0%) predominated; among them – males (70.2%); patients who injected drugs at the time of referral to medical care (49.2%); with bad habits (smoking – 49.2%, alcohol abuse – 14.4%) and had experience of incarceration (26.5%). They were diagnosed with opportunistic infections inherent to III and IV clinical stages of HIV-infection, including bacterial (37.0%), fungal (44.2%), viral (35.4%) and parasitic (6.6%) infections. Moreover, 24 (13.3%) patients developed the CD4+ T lymphocytes level ≥350 cells/µl. Examination of HIV-infected patients in dynamics showed that there was a clinical progression of HIV-infection against the background of ART background in 72 (39.8%) out of 181 patients, 21 of them (30%) with CD4+ T lymphocytes ≥350 cells/μl.

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