Morphological Index of Sassone for Predicting Serous Type of Epithelial Ovarium Cancer

Objective: To obtain whether there was a correlation between the Sassone morphological index and CA 125 tumour markers for suspecting epithelial ovarian cancer with serous types.Methods: This research was analysis correlation and diagnostic test using cross-sectional design. This study was conducted in Dr. Zainoel Abidin Hospital, from November 2018 until April 2019. Results: There were 30 samples of patients with suspected malignant ovarian tumours. The Mann-Whitney test has been performed and the results show no relationship between the Sassone morphological index and epithelial ovarian cancer with serous type (p-value 0.627) and there was no correlation between CA 125 tumour marker and epithelial ovarian cancer with serous types (p-value 0.251). The diagnostic test was performed to examine the sensitivity and specificity for the Sassone morphological index in epithelial ovarian cancer with serous type, resulting in 60% and 28%, respectively. In this study, the sensitivity and specificity for CA 125 tumour marker in epithelial ovarian cancer with serous type were 80% and 40%, respectively. Conclusion: There was no correlation between the Sassone morphological index and CA 125 tumour marker for suspecting epithelial ovarian cancer with serous types. Keywords: CA 125 tumour marker, 0 epithelial ovarian cancer with serous types, morphological index of Sassone. Abstrak Tujuan: Untuk mengetahui adakah korelasi antara indeks morfologi Sassone dan penanda tumor CA 125 dalam memprediksi kanker ovarium epitelial tipe serous. Metode: Penelitian ini menggunakan rancangan potong lintang dengan melakukan uji korelasi dan diagnostik.Penelitian dilakukandi RSUD Dr. Zainoel abidin, dalam kurun waktu November 2018 sampai dengan April 2019.Hasil : Selama penelitian didapatkan 30 sampel penderita tumor ovarium suspek ganas. Dilakukan analisis dengan uji Mann-Whitney, didapatkan tidak terdapat hubungan antara indeks morfologi Sassone terhadap kanker ovarium epitelial tipe serous (p-value 0,627) dan tidak terdapat hubungan antara penanda tumor CA 125 terhadap kanker ovarium epitelial tipe serous (p-value 0,251). Kemudian dilakukan uji diagnostik dimana didapatkan nilai sensitivitas, spesifisitas dari indeks morfologi Sassone pada kanker ovarium epitelial tipe serous adalah 60% dan 28%. Sedangkan nilai sensitivitas dan spesifisitas penada tumor CA 125 pada kanker ovarium epitelial tipe serous pada penelitian ini didapatkan 80% dan 40%.Kesimpulan: Tidak ada hubungan antara indeks morfologi Sassone dan penanda tumor CA 125 dalam memprediksi kanker ovarium epitelial tipe serous.Kata kunci: indeks morfologi Sassone, kanker ovarium epitelial tipe serous, penanda tumor CA 125

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Correlation of Tumor Marker Cancer Antigen (CA-125) against Hemoglobin, Leucocytes, and Platelet Lymphocyte Ratio in Ovarian Cancer Patients at RSUD ULIN Banjarmasin

Jurnal Ilmiah Kedokteran Wijaya Kusuma ◽

10.30742/jikw.v7i1.328 ◽

2018 ◽

Vol 7 (1) ◽

pp. 93

Author(s):

Hermin Sabarudin

Keyword(s):

Ovarian Cancer ◽

Tumor Marker ◽

Cancer Patients ◽

Negative Relationship ◽

Sampling Technique ◽

Ca 125 ◽

P Value ◽

Cross Sectional ◽

Normality Test ◽

Limitation Method

CA-125 is the most commonly used tumor marker in ovarian cancer, its known as the "Gold Standard" for the diagnosis of ovarian cancer. CA-125 allegely related to the inflammatory mechanisms which associated with leukocytes and lymphocytes, as well as Lymphocyte Platelet Ratio. This study is to prove above hypothesis. The objective is to investigate CA-125 correlation as tumor marker of inflammatory hematology examination which consisting of Hemoglobin, leucocytes and PLR as indicator of inflammatory examination in ovarian cancer patient. The method is an observational analytic study with cross sectional retrospective descriptive. The sample is 42 patients medical record who are treated in Oncology Polyclinic RSUD ULIN in October 2014 - October 2017 period. Samples selected by time limitation method. Sampling technique using nonpropability method followed by purposive sampling method. After the data is taken and selected then processed into SPSS for normality test and continued by multiple linear regression test. The results showed that correlation analysis of CA-125 tumor marker on Hb, leukocyte and PLR levels was P = 858b; P value <0.05. The CA-125 relationship to Hb, leucocytes and PLR is a negative relationship (r Hb = -3,463, r leukocytes = -6,117, r PLR = -2.281), which means that more high the Hb, leukocyte and PLR value, conversely CA125 value become more low. The conclusions of this study is there no correlation of CA125 tumor marker against Hb, leucocytes and PLR in ovarian cancer patients. The results of this study indicate that the increasing of CA125 value is negative correlation because it is not followed by decreasing of Hb, increasing of leukocyte and PLR.

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The Combination of Serum Biomarker (CA-125, FASN, and GLS) as a Predictor Suboptimal Cytoreduction in Epithelial Ovarian Cancer

10.21203/rs.2.21972/v1 ◽

2020 ◽

Author(s):

Gatot Nyarumenteng Adhipurnawan Winarno ◽

Yudi Mulyana Hidayat ◽

Setiawan Soetopo ◽

Sofie Rifayani Krisnadi ◽

Maringan Diapari Lumban Tobing ◽

...

Keyword(s):

Ovarian Cancer ◽

Epithelial Ovarian Cancer ◽

Cytoreductive Surgery ◽

Cross Sectional Study ◽

Ca 125 ◽

Cross Sectional ◽

Average Value ◽

Preoperative Serum ◽

Serum Ca125 ◽

Sensitivity Specificity

Abstract Purpose. Cytoreduction has an important role in improving the survival rate of epithelial ovarian cancer (EOC) patients. The use of preoperative CA-125 as an optimal predictor cytoreduction in patients with ovarian cancer is still controversial. This study aimed to assess the ability of preoperative serum CA125, FASN and GLS as a predictor of cytoreductive surgery in epithelial ovarian cancer (EOC). This observational-analytic cross-sectional study included 109 women diagnosed with epithelial ovarian cancer (EOC) between 2017-2019, who had serum CA-125, GLS, FASN measured preoperatively and underwent cytoreductive surgery. Result. The average value of serum CA-125, FASN, and GLS in the suboptimal cytoreduction were higher than the optimal cytoreduction group. The cut off point (COP) of CA-125 was 248.55 (p=0.0001) with 73.2% sensitivity and 73.6% specificity, FASN was 0.445 (p=0.017) with 62.5% sensitivity and 60.4% specificity, and GLS was 22.895 (p=0.0001) with 73.2% sensitivity and 75.5% specificity. The COP value of CA-125 and GLS combined was 29.16 (p=0.0001) with sensitivity 82.1% and spesificity 73.6%, while the COP of CA-125, GLS, and FASN combined was 0.83 (p=0.0001) with 87.5% sensitivity and 73.6% specificity. If the value of biomarker serum more than COP will more likely have suboptimal cytoreductive surgery. Conclusion. The role of CA125, FASN and GLS levels in predicting suboptimal cytoreductive surgery for patients with ovarian cancer seems questionable. However, the combination of CA-125 and GLS or CA-125, FASN and GLS are able to increase the sensitivity, specificity, and accuracy classification to predict suboptimal cytoreductive surgery.

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The Ability Pre-operative Serum (Cancer Antigen-125, Fatty Acid Synthase, and Glucose Transporter) to Predict Primary Suboptimal Cytoreduction in Epithelial Ovarian Cancer

Open Access Macedonian Journal of Medical Sciences ◽

10.3889/oamjms.2020.4817 ◽

2020 ◽

Vol 8 (A) ◽

pp. 858-865

Author(s):

Gatot Nyarumenteng Adhipurnawan Winarno ◽

Yudi Mulyana Hidayat ◽

Setiawan Soetopo ◽

Sofie Rifayani Krisnadi ◽

Maringan Diapari Lumban Tobing ◽

...

Keyword(s):

Ovarian Cancer ◽

Fatty Acid ◽

Epithelial Ovarian Cancer ◽

Fatty Acid Synthase ◽

Glucose Transporter ◽

Ca 125 ◽

Cancer Antigen 125 ◽

Cancer Antigen ◽

Cross Sectional ◽

Auc Value

BACKGROUND: The incidence of ovarian cancer ranks 8th in the world, with 295,414 cases and 184,799 death in 2018. Management in ovarian cancer is surgery and chemotherapy. Some studies state that patients who underwent optimal cytoreduction surgery have better survival rates than suboptimal cytoreduction surgery. The pre-operative serum assessed in this study was Cancer Antigen-125 (CA-125), Fatty Acid Synthase (FASN), and Glucose Transporter (GLUT) to predict suboptimal cytoreduction in epithelial ovarian cancer (EOC). AIM: We aimed to use FASN and GLUT1 as other biomarkers, besides CA-125, to predict suboptimal cytoreduction surgery in epithelial ovarian cancer. METHODS: This observational-analytic cross-sectional study included 109 women diagnosed with epithelial ovarian cancer (EOC) between 2017 and 2019, who had serum CA-125, FASN, and GLUT measured preoperatively and underwent cytoreductive surgery. RESULTS: The results of the statistical analysis test in this study obtained p values at CA-125 (p = 0.0001), FASN (p = 0.017), and at GLUT (p = 0.013). While the cutoff point (COP) on CA-125 was 248.55, FASN was 0.445, and GLUT was 0.1980. The value of area under curve (AUC) obtained by the ROC method at CA-125 76.7%, FASN 65.3%, and GLUT 63.8%. The combination of CA-125 and FASN shows AUC value 76.9%, the combination of CA-125 and GLUT shows AUC value 72.2%, and the combination of the three shows AUC value 75.2%. CONCLUSION: The use of CA-125 as a predictor of cytoreduction surgery is still considered to be the best predictor compared to serum biomarkers in this study.

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CA 125 as a tumour marker in epithelial ovarian cancer

Irish Journal of Medical Science (1971 -) ◽

10.1007/bf02942008 ◽

1989 ◽

Vol 158 (1) ◽

pp. 10-13

Author(s):

J. D. Sheehan ◽

M. J. Duffy ◽

M. A. Allen ◽

J. J. Fennelly

Keyword(s):

Ovarian Cancer ◽

Epithelial Ovarian Cancer ◽

Tumour Marker ◽

Ca 125

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Uterine involvement in epithelial ovarian cancer and its risk factors

Journal of Ovarian Research ◽

10.1186/s13048-021-00925-7 ◽

2021 ◽

Vol 14 (1) ◽

Author(s):

Narges Zamani ◽

Azam Sadat Mousavi ◽

Setare Akhavan ◽

Shahrzad Sheikhhasani ◽

Somayeh Nikfar ◽

...

Keyword(s):

Risk Factors ◽

Ovarian Cancer ◽

Epithelial Ovarian Cancer ◽

Uterine Cancer ◽

Histological Type ◽

The Other ◽

Ca 125 ◽

Study Patient ◽

P Value ◽

Ovary Tumor

Abstract Background Epithelial ovarian cancer (EOC) is an extremely aggressive and lethal carcinoma. Specific data that identify high-risk groups with uterine involvement are not available. Thus, this study aimed to evaluate a gross number of women with EOC to obtain the frequency of uterine involvement and its risk factors. Methods This retrospective observational study was conducted on 1900 histologically confirmed EOC women, diagnosed and treated in our tertiary hospital from March 2009 to September 2020. Data including their demographic, medical and pathological findings were collected. Results From 1900 histologically confirmed EOC women, 347 patients were eligible for participations. The mean age of study patients was 51.31 ± 11.37 years with the age range of 25 to 87 years. Uterine involvement was detected in 49.6% (173) of the patients either macroscopic (47.4%) or microscopic (52.6%) types. Uterine involvement was significantly associated with having AUB (P-value = 0.002), histological type of ovary tumor (P-value < 0.001), ovarian cancer stage (P-value < 0.001), and abnormal CA-125 concentration (P-value = 0.004). Compared to the other study patient, the patients with metastatic uterine involvement had significantly higher stage (p-value< 0.001), higher grade of ovary tumor (p-value = 0.008), serous histological type (p-value< 0.001), and a higher level of CA-125 concentration (p-value< 0.001). on the other hand, the patients with synchronous uterine cancer were significantly younger (p-value = 0.013), nulliparous (p-value< 0.001), suffered from AUB symptoms (p-value< 0.001) and had endometroid histological type (p-value = 0.010) of ovary cancer in comparison to other study patients. Conclusion Considering the high prevalence of uterine involvement in EOC patients, ultrasound evaluation and/or endometrium biopsy assessment should be done before planning any treatment.

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HUBUNGAN LAMA WAKTU MENDERITA STROKE DENGAN TINGKAT KEMANDIRIAN KLIEN DALAM MELAKUKAN AKTIVITAS PEMENUHAN KEBUTUHAN SEHARI-HARI

Jurnal Kesehatan Saelmakers PERDANA ◽

10.32524/jksp.v1i2.382 ◽

2018 ◽

Vol 1 (2) ◽

pp. 58

Author(s):

Setia Budi ◽

Ria Dila Syahfitri

Keyword(s):

Data Analysis ◽

Univariate Analysis ◽

Sampling Technique ◽

P Value ◽

Cross Sectional ◽

Stroke Incidence ◽

Bivariate Data ◽

Cross Sectional Design ◽

Interviewing Techniques ◽

Need For Rehabilitation

The rate of stroke incidence is about 200 per 100,000 people throughout the world. This study aims to determine the Relation Suffer Stroke With Independence Level In Neurology Polyclinic TK II DR Ak Gani Palembang Year Hospital 2017. The research method used is descriptive quantitative with cross sectional design that is done by interviewing techniques with questionnaires on 42 respondents with Accidental sampling technique. This research was conducted in August 2017. Data analysis used is univariate data analysis and bivariate data analysis with one way anova test result. The results of univariate analysis showed that the duration of the respondents suffering from stroke was between 2.10 years to 3.38 years. Also found that most respondents were at the level of independence f; independent, except bathing, dressing, moving, and one other function with a total of 12 respondents. The results showed that there was a significant relationship between the long suffering stroke with the level of independence with the value of p value 0.025. For that the need for rehabilitation to patients and families of patients in order to help improve the independence of stroke patients in doing their daily activities. Keywords : Long Suffer Stroke, Level of Independence

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HUBUNGAN INTELEGENSI DENGAN PERILAKU NERS TINGKAT II STIKES SANTA ELISABETH MEDAN

Elisabeth Health Jurnal ◽

10.52317/ehj.v1i1.185 ◽

2016 ◽

Vol 1 (1) ◽

pp. 21-30

Author(s):

Imelda Derang

Keyword(s):

Student Nurses ◽

Sampling Technique ◽

P Value ◽

Test Results ◽

Cross Sectional ◽

Intelligence Level ◽

Level Ii ◽

Study Population ◽

Cross Sectional Design ◽

The Relationship

Intelligence is the ability to apply the knowledge and experiences that have been gained into the effort tasks are challenging and flexible book. Behaviour is an action that involves aspects of affective, cognitive, and psychomotor. Goal: This study aims to determine the relationship between the behavior of student nurses intelligence level II STIKes Santa Elisabeth Medan. Method: This study uses correlation with cross sectional design. The study population was all students / i Ners Level II STIKes Santa Elisabeth Medan as 65. The samples used were 65 respondents, the sampling technique in this research is using purposive sampling. The instrument of this study using questionnaire and observation sheets by using product moment test person. Result: Intelligence students as many as 30 people (46.2%) classified as having an average level of intelligence. A total of 32 people (49.2%) classified as well-behaved students. Person product moment test results obtained p value = 0.172 where a significant level of p> 0.05 so that this value proves that the absence of a relationship between the behavior of student nurses intelligence level II STIKes Santa Elisabeth Medan. Conclusion: Recommended for institutions, motivating students in balancing the behavior and intelligence.

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FAKTOR-FAKTOR YANG BERHUBUNGAN DENGAN PERNIKAHAN DINI DI DUSUN I DESA BARU KEC PANCUR BATU DELI SERDANG SUMATERA UTARA TAHUN 2017

Elisabeth Health Jurnal ◽

10.52317/ehj.v4i1.257 ◽

2019 ◽

Vol 4 (1) ◽

pp. 41-49

Author(s):

Meriati Bunga Arta Purba

Keyword(s):

Divorce Rate ◽

Drop Out ◽

Early Marriage ◽

P Value ◽

Cross Sectional ◽

Birth Complication ◽

Sexuality And Gender ◽

Analytical Research ◽

Cross Sectional Design ◽

And Gender

Based on the research by the Sexuality and Gender Study Center of University of Indonesia, the rate of early marriage in Indonesia is the second highest in Southeast Asian in which 2 million out of 7.3 million women below 15 years old are married and drop out from school. Early marriage hinders them from going to school, causes pregnancy and birth complication, impedes the achievement of KB (Family Planning) Program and increases divorce rate. Goals : The objective of the research was to discover the correlation of value of virginity, knowledge and trust with early marriage at Dusun I Desa Baru. Methods: This is an observational analytical research with cross sectional design. It was done at Dusun I Desa Baru, Pancur Batu Subdistrict from November, 2017 until February, 2018. The population covered the teenagers below 20 years old which was all taken as the research samples i.e. 139 people. The dependent variable was early marriage, while the independent variables were parent income, trust, knowledge and value of virginity. The data were collected through questionnaires. Multiple logistic regression testing was employed to analyze the data. Result : The research results demonstrated that the variable with the most dominant influence was parent income at p-value = 0.006 (p<0.05) and Exp. β value = 3.675, followed by the variable of trust at p-value = 0.027 (p<0.05) and Exp. β value = 2.368, the variable of knowledge at p-value = 0.003 (p<0.05) and Exp. β value 6.064, and the variable of virginity at p-value = 0.003 (p<0.05) and Exp. Β value = 6.064. Based on these results, it was concluded that f(y) was 97%. It indicated that the probability of the variables of parent income, trust, knowledge and virginity influenced early marriage of 97.7%. Conclusion: It is recommended that the local government cooperate with local Puskesmas, Religious Figures, and Parents to conduct counseling to improve people’s knowledge of the ideal age to get married, so that they can prevent from possible problems due to early marriage and provide their children parent income at early age the importance of protecting their virginity until they get married.

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