scholarly journals ROLE OF MALONDIALDEHYDE (MDA) IN PATIENTS WITH BREAST CANCER DISEASES

2020 ◽  
Vol 2 (2) ◽  
Author(s):  
Eti Yerizel ◽  
Niki Astria ◽  
Daan Khambri
Keyword(s):  
Breast Cancer ◽  
Cancer Patients ◽  
Gene Mutations ◽  
Observational Research ◽  
P Value ◽  
Breast Cancer Patients ◽  
Cross Sectional ◽  
The Many ◽  
Many Sources ◽  
And Control

Background: Breast cancer is one of the most common cancers as well as one of the leading causes of cancer mortality in women worldwide. Cancer risk potentially continues to increase because of the many sources of exposure to carcinogenic chemical compounds. Carcinogenic compounds can contribute to free radical formation which might further interact and damage biomolecules such as lipids. Lipid peroxidation will increase malondialdehyde (MDA) levels, triggering gene mutations that leads to cancer.  Objective: The purpose of this research was to measure and compare MDA levels between breast cancer patients and control.Methods: This research was observational research using a cross-sectional comparative design of 30 breast cancer patients and 30 healthy controls. The place of this research is in Ropanasuri specialized surgery hospital and biochemical laboratory,  Faculty of Medicine, Andalas University, Padang. This research was conducted from August to September 2019. The MDA was measured using a spectrophotometer and an independent T-test was done.Results: The result of this research showed the mean MDA level of breast cancer patients was 3.98 ± 0.35 nmol/ml, higher than controls was 3.04 ± 0.36 nmol/ml with p-value = 0.001.Conclusion: There were significant differences in MDA levels among breast cancer patients and control in Ropanasuri specialized surgery hospital, Padang. 

scholarly journals HUBUNGAN ANTARA NAFSU MAKAN DENGAN ASUPAN ENERGI DAN PROTEIN PADA PASIEN KANKER PAYUDARA POST KEMOTERAPI[Correlation between Appetite with Energy and Protein Intake of Post Chemotherapy Breast Cancer Patients]

2019 ◽  
Vol 14 (2) ◽  
pp. 170
Author(s):  
Silviana Putri ◽  
Merryana Adriani ◽  
Yayuk Estuningsih
Keyword(s):  
Breast Cancer ◽  
Cancer Patients ◽  
Side Effect ◽  
Protein Intake ◽  
Pearson Correlation ◽  
Observational Research ◽  
Breast Cancer Patients ◽  
Cross Sectional ◽  
Chemotherapy Drugs ◽  
Pearson Correlation Test

Chemotherapy drugs used to kill or inhibit proliferation of cancer cell that are cytotoxic and causing side effect for breast cancer patients. The side effect of chemotherapy drugs is decreasing the appetite which causing decrease in energy and protein intake, and could affect nutritional status. This study aim to determine the relationship between appetite with energy and protein intake of post chemotherapy breast cancer patients. This research was an analytic observational research using cross sectional design and purposive sampling conducted at Dr. Ramelan Navy Hospital Surabaya with a sample size of 50 patients. Correlation between appetite with energy and protein intake were analyzed using Pearson correlation. The average of energy and protein intake were 976.3±304.2 kcal and 29.4±12.9 g. Pearson correlation test showed signifi cant correlation between appetite as chemoteraphy side effect with energy intake (p=0.000; r=-0.558) and protein intake (p=0.000; r=-0.504). Decreasing of appetite due to chemoterapy reduce the energy and protein intake of breast cancer patient. Patient are suggest to consume foods in small portion but often to maintain adequate energy and protein intake.

scholarly journals Fatigue dan status nutrisi pada pasien dengan kanker payudara yang menjalani kemoterapi

2020 ◽  
Vol 13 (4) ◽  
pp. 278-283
Author(s):  
Sapti Ayubbana ◽  
Sari Narulita
Keyword(s):  
Breast Cancer ◽  
Side Effects ◽  
Nutritional Status ◽  
Cancer Patients ◽  
Nursing Intervention ◽  
P Value ◽  
Breast Cancer Patients ◽  
Chemotherapy Treatment ◽  
Cross Sectional ◽  
Breast Cancer Chemotherapy

Fatigue and nutritional status in patients with breast cancer undergoing chemotherapyBackground: Breast cancer is one type of cancer and is one of the leading causes of death in the world. Cancer patients who receive chemotherapy are at risk of impaired nutritional status due to the disease and its treatment. Chemotherapy treatment can have side effects on the gastrointestinal system such as nausea, vomiting, stomatitis, anorexia, changes in taste. These side effects can cause the patient's nutritional intake to decrease. Cancer and its treatment can cause fatigue complaints.Purpose: to identify the relationship between fatigue and nutritional status in patients with breast cancer patients undergoing chemotherapyMethods: The design of this study was quantitative using a cross sectional approach. The population in this study were patients with breast cancer undergoing chemotherapy. This research was conducted at Dr.H. Abdul Moeloek Hospital of Lampung Province with 42 respondents.Results: Spearman correlation test results found that nutritional status variables have a significant relationship with fatigue (p value = 0.031) with moderate correlation strength (r = 0.471).Conclusion: The nursing intervention on the side effects of chemotherapy treatment which has a positive effect on nutritional conditions in an effort to overcome nutritional disorders and complaints of fatigue in cancer patients.Keywords: Breast Cancer; Chemotherapy; Fatigue; Nutritional StatusPendahuluan: Kanker payudara merupakan salah satu jenis kanker dan menjadi salah satu penyebab kematian di dunia. Pasien kanker yang menerima kemoterapi memiliki resiko gangguan status nutrisi akibat penyakit dan pengobatannya. Pengobatan kemoterapi dapat memberikan efek samping terhadap sistem ganstrointestinal seperti mual, muntah, stomatitis, anoreksia, perubahan rasa. Efek samping tersebut dapat menyebabkan asupan nutrisi pasien dapat mengalami penurunan. Kanker dan pengobatannya dapat menyebabkan keluhan fatigue.Tujuan: Mengetahui adanya hubungan antara status nutrisi terhadap fatigue pada pasien kanker payudara yang menjalani kemoterapi.Metode: Desain penelitian ini adalah kuantitatif dengan menggunakan pendekatan cross sectional . Populasi pada penelitian ini adalah pasien dengan kanker payudara yang menjalani kemoterapi. Penelitian ini dilakukan di RSUD Dr.H. Abdul Moeloek Provinsi Lampung dengan 42 responden.Hasil: Pada uji korelasi spearman didapatkan bahwa variabel status nutrisi mempunyai hubungan yang bermakna dengan fatigue ( p value = 0,031) dengan kekuatan korelasi sedang (r = 0,471).Simpulan: Kesimpulan diperlukan intervensi keperawatan terhadap efek samping pengobatan kemoterapi yang berdapak terhadap kondisi nutrisi dalam upaya mengatasigangguan nutrisi dan keluhan fatigue pada pasien kanker 

scholarly journals Hubungan Dukungan Keluarga dengan Self Esteem pada Pasien Kanker Payudara di Poliklinik Bedah Onkologi RSUP Sanglah Denpasar

2020 ◽  
Vol 9 (2) ◽  
pp. 181
Author(s):  
Ni luh Putu Mahayani ◽  
Ni Komang Sukraandini ◽  
Ni Wayan Suniyadewi
Keyword(s):  
Breast Cancer ◽  
Family Support ◽  
Cancer Patients ◽  
Surgical Oncology ◽  
Self Esteem ◽  
P Value ◽  
Breast Cancer Patients ◽  
Cross Sectional ◽  
Cross Sectional Design ◽  
The Relationship

AbstractBreast cancer sufferers have a tendency to experience a decrease of self esteem that make  patients shall showing symptoms such as blaming themself for what they experienced. One way to increase self esteem in cancer patients is by increasing family participation through family support. The aim of this study is to determine the relationship between family support and self esteem in breast cancer patients. This study was using cross sectional design. The study was taken place at the Surgical Oncology Polyclinic, found samples of 188 respondents which was selected with a purposive sampling technique.The results showed that the majority of respondents were in the category of moderate self-esteem were 98 respondents (52.1%) and the category of moderate family support were 96 respondents (51.1%). The Rank Spearmen test results shows p value 0,000 (p <ɑ), means there is a relationship between self-esteem and family support in breast cancer patients with r value of 0.566 (positive relationship). It is expected that the family will always support the patient in every process of treatment, whether in the form of physical, psychological or financial support that could increase the patient's self esteem

scholarly journals LDL-c as a predictor of hormonal status and determining factor for therapy of breast cancer patients

2021 ◽  
Vol 2 (2) ◽  
pp. 023-031
Author(s):  
Reynard Budy Setiawan ◽  
Desak Gede Agung Suprabawati ◽  
Jusak Nugraha
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Cancer Patients ◽  
Density Lipoprotein ◽  
P Value ◽  
Hormonal Status ◽  
Breast Cancer Patients ◽  
Characteristic Analysis ◽  
Chi Square ◽  
Cross Sectional

Background: Immunohistochemical testing is important in determining clinical diagnosis and therapy, and is useful as a prognostic and predictive factor, but it is not easy to do and is not always available. Breast cancer patient with higher low-density-lipoprotein cholesterol [LDL-c]. level tends to have larger tumor size, higher grade, higher proliferation rate, positive Human Epidermal growth factor Receptor-2 (HER2-neu) and occasionally come at late stage. High LDL-c receptors are found on the surface of breast cancer cells, where cancer cells will take up cholesterol in serum, and a metabolite of 27-hydroxycholesterol cholesterol will affect Estrogen Receptor-α. Methods: Analytical observational study by cross sectional method, during July 2020 – November 2020, at Oncology Clinic Dr. Soetomo Hospital Surabaya with a total sample size of 42. The data obtained were analyzed using the SPSS version 23.0 program, regression test and Chi-Square were performed for characteristic analysis and Chi-Square Fischer’s Exact Test were performed for correlation test between lipid profiles with hormonal status. Results: The mean value of LDL-c was 117.88 ± 33.89 mg/dL. In the analysis of the correlation between LDL-c and hormonal status, it was found that the majority of patients who had positive hormonal status had LDL-c levels of ≤160 mg/dL with p value = 0.049. ROC analysis shown LDL-c cut-off point of 132 mg/dL, p value = 0.034 (OR 5.031, 95% CI 1.159-21.848), sensitivity 46.7% and specificity 83.35%. Conclusion: There is a statistically significant relationship between LDL-c levels and hormonal status with the cut-off point of 132 mg/dL. The increase in LDL-c in serum increases the tendency of negative hormonal status, therefore LDL-c levels can be considerate in determining the therapy for breast cancer patients.

scholarly journals Hubungan Usia Dengan Estrogen Receptor Pada Penderita Kanker Payudara di RSUD Dr. Pirngadi Medan Tahun 2018

2020 ◽  
Vol 6 (1) ◽  
pp. 1-4
Author(s):  
Jumikha Tamara Sahmaulyana Sidauruk
Keyword(s):  
Breast Cancer ◽  
Estrogen Receptor ◽  
Estrogen Receptors ◽  
Cancer Patients ◽  
Test Method ◽  
Bivariate Analysis ◽  
P Value ◽  
Breast Cancer Patients ◽  
Research Subjects ◽  
Cross Sectional

Background: Breast cancer is a malignancy in breast tissue that can be originated from ductal epithelium and lobules. It is the main cause of death from cancer suffered by women in the world. Age and hormonal are important risk factors for breast cancer where the longer a person is exposed to estrogen, the higher is the risk for breast cancer. The estrogen receptor is one of the main prognostic and predictive factors examined in breast cancer and can be determinant for hormonal therapy. Objectives: This study aimed to discover the relation between age and estrogen receptor in breast cancer patients of RSUD Dr.Pirngadi Medan in 2018. Methods: This research was an analytical study with a cross-sectional design. The research sample was 96 breast cancer patients by medical records of RSUD Dr.Pirngadi Medan in 2018 collected by a consecutive sampling method. Analysis of the data in this study was done by univariate to describe the characteristics of research subjects, while bivariate analysis used the chi-square test method to analyze the relationship between age and estrogen receptor. Results: The patients with breast cancer in RSUD Dr.Pirngadi Medan 2018 was mostly >40 years old (79.2%), with negative estrogen receptor hormonal status (53%), status was married (99%), and the highest level of education was high school (54.2%). The results of the study showed that there was a relationship between age and estrogen receptor in breast cancer patients with p-value =0.007 (p value<0,05). Conclusion: There was a significant relationship between age and estrogen receptors and estrogen receptors in breast cancer patients in RSUD Dr.Pirngadi Medan 2018.

scholarly journals Family Support and Quality of Life in Breast Cancer Patients

2020 ◽  
Vol 4 (3) ◽  
pp. 78-83
Author(s):  
Noorhidayah Noorhidayah ◽  
Hesti Prawita Widiastuti ◽  
Umi Kalsum
Keyword(s):  
Breast Cancer ◽  
Quality Of Life ◽  
Family Support ◽  
Cancer Patients ◽  
Total Sample ◽  
P Value ◽  
Life Questionnaire ◽  
Breast Cancer Patients ◽  
Cross Sectional

Introduction: In these days, one of the terrifying cancers for women throughout the world is breast cancer. The treatment of cancer should be holistic. Patients need family support to create a good quality of life. The purpose of this study was to determine the relationship between family support and quality of life in breast cancer patients at the Chemotherapy Unit of Abdul Wahab Sjahranie Hospital Samarinda. Methods: Quantitative research with analytical study and cross-sectional design. Sampling was done with a total sample of 76 respondents. The instruments used in this research were family support standards and the Quality of Life Questionnaire-Core 30 (EORTC QLQ-C30) for quality of life. The data were analyzed using the Chi-Square test. Results: The p-value was 0.003, OR = 4.090, indicating that there was a relationship between family support and quality of life in breast cancer patients. Conclusion: There is a relationship between family support and quality of life in breast cancer patients. It is expected that the hospital can proceed in providing health education and motivation to breast cancer patients and their families related to the importance of family support for the quality of life of breast cancer patients. Keywords: family support; breast cancer; quality of life

scholarly journals HUBUNGAN MEKANISME KOPING DENGAN KUALITAS HIDUP PADA PASIEN KANKER PAYUDARA

2018 ◽  
Vol 1 (1) ◽  
pp. 38
Author(s):  
Abdul Wakhid ◽  
Wiwik Nurhikmah ◽  
Rosalina Rosalina
Keyword(s):  
Breast Cancer ◽  
Quality Of Life ◽  
Cancer Patients ◽  
Sampling Technique ◽  
P Value ◽  
Coping Mechanism ◽  
Breast Cancer Patients ◽  
Chi Square ◽  
Cross Sectional

THE ROLE OF MENTAL HEALTH CADRES IN THE HANDLING OF MENTAL PATIENTS ABSTRACTPatients with cancer have a very significant increase including breast cancer that causes death. Breast cancer affects the greatest impact on the sufferer, thus affecting the quality of life. Decreased quality of life that is not resolved will inhibit treatment that will cause death. The purpose of this study was to determine the relationship between coping mechanism with quality of life in breast cancer patients. This research design is descriptive correlational with cross sectional approach. The population of this study was breast cancer patients with a sample of 55 respondents using accidental sampling technique and data collection tool using Cancer Coping Questionnaire 21 and WHOQoL-BREF. Data analysis used chi square test. The results showed that the mechanism of coping cancer patients 65.5% adaptive category, quality of life of breast cancer patients bad category 52,7%. There is a relationship of coping mechanism with quality of life in breast cancer patients who underwent chemotherapy with p value 0,048 (α = 0,05). Should the hospital facilitate interaction activities with fellow breast cancer patients in order to share experiences about improving the quality of life. Keywords: Mechanism of Coping, Quality of Life, Breast Cancer Patients

scholarly journals Hubungan Kesejahteraan Spiritual dengan Kualitas Hidup pada Pasien Kanker Payudara di Poli Bedah RSUP Dr. M. Djamil Padang

2020 ◽  
Vol 7 (2) ◽  
pp. 118
Author(s):  
Lola Despitasari ◽  
Lenni Sastra ◽  
Fitria Alisa ◽  
Letivia Azro
Keyword(s):  
Breast Cancer ◽  
Quality Of Life ◽  
Cancer Patients ◽  
General Hospital ◽  
Poor Quality ◽  
P Value ◽  
Breast Cancer Patients ◽  
Chi Square ◽  
Cross Sectional

Di Indonesia peningkatan jumlah kasus baru serta jumlah kematian akibat kanker payudara terus meningkat. Situasi yang dialami pasien kanker payudara menyebabkan permasalahan meliputi perubahan secara fisik, fungsi sosial, psikis maupun spiritual seseorang dan ini mempengaruhi kualitas hidup pasien kanker payudara. Salah satu faktor yang mempengaruhi kualitas hidup pasien kanker payudara adalah kesejahteraan spiritual. Tujuan penelitian untuk mengetahui hubungan kesejahteraan spiritual dengan kualitas hidup pada pasien kanker payudara di Poli Bedah RSUP Dr. M. Djamil Padang. Jenis penelitian analitik dengan desain cross sectional. Populasi pada semua wanita penderita kanker payudara yang datang ke poli bedah RSUP Dr.M.Djamil Padang sebanyak 509 orang dengan jumlah sampel sebanyak 83 orang.Teknik pengambilan sampel dengan accidental sampling. Data di analisa menggunakan uji Chi square. Hasil penelitian 44,6% pasien kanker payudara memiliki kualitas hidup buruk, 53% memiliki kesejahteraan spiritual yang buruk. Hasil uji statistik didapatkan p value 0,000(p ≤ 0,05), terdapat hubungan antara kesejahteraan spiritual dengan kualitas hidup pada pasien kanker payudara di Poli Bedah RSUP Dr.M.Djamil Padang. Disimpulkan bahwa pasien kanker payudara dengan kesejahteraan spiritual buruk cenderung memiliki kualitas hidup buruk. Diharapkan kepada tenaga kesehatan melakukan penyuluhan dan informasi yang edukatif tentang kualitas hidup kanker payudara sehingga meningkatkan kesejahteraan spiritual.Kata kunci : kanker payudara; kualitas hidup; kesejahteraan spiritual THE RELATIONSHIP OF SPIRITUAL WELFARE WITH QUALITY OF LIFE IN BREAST CANCER PATIENTS IN SURGERY POLYCLINIC AT Dr. M. DJAMIL PROVINCIAL GENERAL HOSPITAL OF PADANG ABSTRACTIn Indonesia the increase of new cases and the number of deaths from breast cancer continues to increase. The situation experienced by breast cancer patients cause problems include physical changes, social functions, psychic and spiritual of someone. The impact of these problems will affect the quality of life of breast cancer patients. One of the factors that affect the quality of life of breast cancer patients is spiritual welfare. The purpose of this study was to determine the relationship of spiritual welfare with quality of life in breast cancer patients in Surgery Policlinic at Dr. M. Djamil Provincial General Hospital of Padang. The type of research used was analytic survey, cross sectional study design. The population in this study were all women with breast cancer who came through surgery polyclinic at  Dr. M. Djamil Provincial General Hospital of Padang as many as 509 people with samples were 83 people taken by accidental sampling technique. Univaria data were analyzed using frequency table and bivariate used Chi square. The results showed almost half 44.6%, of breast cancer patients had poor quality of life, more than half 53%,  had poor spiritual welfare. Statistical test results obtained p value 0,000 (p ≤ 0.05) means there is a relationship between spiritual welfare with quality of life in breast cancer patients at surgery polyclinic at  Dr. M. Djamil Provincial General Hospital of Padang.The results of this study can be concluded that breast cancer patients with poor spiritual welfare have poor quality of life, while breast cancer patients with spiritual well-being have good quality of life. It is expected that health workers to educate and educational information about the quality of life of breast cancer.Keywords : breast cance; quality of life; spiritual welfare

BRCA gene mutations in Slovenian male breast cancer patients

2007 ◽  
Vol 4 (03) ◽  
Author(s):  
N Besic ◽  
B Cernivc ◽  
J De Greve ◽  
K Lokar ◽  
M Krajc ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Patients ◽  
Male Breast Cancer ◽  
Gene Mutations ◽  
Male Breast ◽  
Breast Cancer Patients ◽  
Brca Gene

Correlation of AGR2 expression with the incidence of metastasis in luminal breast cancer

2021 ◽  
pp. 1-5
Author(s):  
David Samuel Kereh ◽  
John Pieter ◽  
William Hamdani ◽  
Haryasena Haryasena ◽  
Daniel Sampepajung ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Patients ◽  
Mean Value ◽  
Rank Test ◽  
Luminal Breast Cancer ◽  
P Value ◽  
Strong Positive Correlation ◽  
Breast Cancer Patients ◽  
The Mean ◽  
Spearman Test

BACKGROUND: AGR2 expression is associated with luminal breast cancer. Overexpression of AGR2 is a predictor of poor prognosis. Several studies have found correlations between AGR2 in disseminated tumor cells (DTCs) in breast cancer patients. OBJECTIVE: This study aims to determine the correlation between anterior Gradient2 (AGR2) expression with the incidence of distant metastases in luminal breast cancer. METHODS: This study was an observational study using a cross-sectional method and was conducted at Wahidin Sudirohusodo Hospital and the network. ELISA methods examine AGR2 expression from blood serum of breast cancer patients. To compare the AGR2 expression in metastatic patients and the non-metastatic patient was tested with Mann Whitney test. The correlation of AGR2 expression and metastasis was tested with the Rank Spearman test. RESULTS: The mean value of AGR2 antibody expression on ELISA in this study was 2.90 ± 1.82 ng/dl, and its cut-off point was 2.1 ng/dl. Based on this cut-off point value, 14 subjects (66.7%) had overexpression of AGR2 serum ELISA, and 7 subjects (33.3%) had not. The mean value AGR2 was significantly higher in metastatic than not metastatic, 3.77 versus 1.76 (p < 0.01). The Spearman rank test obtained a p-value for the 2 tail test of 0.003 (p < 0.05), which showed a significant correlation of both, while the correlation coefficient of 0.612 showed a strong positive correlation of AGR2 overexpression and metastasis. CONCLUSIONS: AGR2 expression is correlated with metastasis in Luminal breast cancer.

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