scholarly journals Monitoring electric field induced changes in biological tissue by using ultrasound

2021 ◽  
Author(s):  
Ozkan Doganay

A new effect resulting from the application of an electric field to biomaterials was discovered by analyzing ultrasound echo signals. The new effect was observed in ex-vivo biological tissues such as porcine heart, muscle, fat, and liver and tissue mimicking phantoms for an electric field were on the order of a few Volt/cm. Changes in the arrival time of ultrasound echoes were processed using cross-correlation based algorithms. The gradient of shifting along the ultrasound axis showed a strain in the direction perpendicular to the applied electric field. The electric field also lead to changes in the ultrasound echo amplitude. The amount of the strain and the echo amplitude change depended on the history of the applied electric field. The new effect cannot be explained by resistive heating, piezoelectric effect, or electrostriction. It might be related to the electrokinetic effects.

2021 ◽  
Author(s):  
Ozkan Doganay

A new effect resulting from the application of an electric field to biomaterials was discovered by analyzing ultrasound echo signals. The new effect was observed in ex-vivo biological tissues such as porcine heart, muscle, fat, and liver and tissue mimicking phantoms for an electric field were on the order of a few Volt/cm. Changes in the arrival time of ultrasound echoes were processed using cross-correlation based algorithms. The gradient of shifting along the ultrasound axis showed a strain in the direction perpendicular to the applied electric field. The electric field also lead to changes in the ultrasound echo amplitude. The amount of the strain and the echo amplitude change depended on the history of the applied electric field. The new effect cannot be explained by resistive heating, piezoelectric effect, or electrostriction. It might be related to the electrokinetic effects.


Author(s):  
Baoyuan Sun ◽  
Yinhui Shi ◽  
Min Qian ◽  
Jun Zhang ◽  
Zhonghua Zhang

Based on the theory of classical piezoelectricity, the relationship between the generation of multiple piezoelectric effect under applied electric field and boundary conditions is analyzed. The generating process of multiple piezoelectric effect is elaborated and the formulas of secondary direct and tertiary converse piezoelectric effect are deduced. The displacement or voltage generated by primary converse, secondary direct and tertiary converse piezoelectric effect is calculated by using coupled-field analysis function in the Finite Element Analysis software-ANSYS. Experimental research of multiple piezoelectric effect under applied electric field is performed through PZT-5 stack. The experimental result verifies the existence of multiple piezoelectric effect. Experimental data shows that voltage and displacement generated by secondary direct and tertiary converse piezoelectric effect respectively are linear with the applied voltage. Both the simulation and experimental results prove that the theoretical analysis is accurate.


2000 ◽  
Vol 655 ◽  
Author(s):  
C. S. Ganpule ◽  
A. L. Roytburd ◽  
V. Nagarajan ◽  
A. Stanishevsky ◽  
J. Melngailis ◽  
...  

AbstractFocused ion beam milling was used to fabricate ferroelectric islands in Pb-Zr-Ti-O thin films. The islands ranged in size from 200μm×200μm to 0.3μm×0.3μm. The inverse piezoelectric effect was studied in these islands as a function of their size by tracking the surface displacement of the top electrode of the island (under an applied electric field) using an atomic force microscope (AFM). It was found that there was a substantial increase in the piezoresponse as the size of the island decreased below 100μm×100μm. This increase was attributed to the elastic deformation of the substrate.


1972 ◽  
Vol 33 (C1) ◽  
pp. C1-63-C1-67 ◽  
Author(s):  
M. BERTOLOTTI ◽  
B. DAINO ◽  
P. Di PORTO ◽  
F. SCUDIERI ◽  
D. SETTE

2012 ◽  
Vol 15 (2-3) ◽  
pp. 127-139
Author(s):  
Tung Tran Anh ◽  
Laurent Berquez ◽  
Laurent Boudou ◽  
Juan Martinez-Vega ◽  
Alain Lacarnoy

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Pranav Lanka ◽  
Kalloor Joseph Francis ◽  
Hindrik Kruit ◽  
Andrea Farina ◽  
Rinaldo Cubeddu ◽  
...  

AbstractAccurate monitoring of treatment is crucial in minimally-invasive radiofrequency ablation in oncology and cardiovascular disease. We investigated alterations in optical properties of ex-vivo bovine tissues of the liver, heart, muscle, and brain, undergoing the treatment. Time-domain diffuse optical spectroscopy was used, which enabled us to disentangle and quantify absorption and reduced scattering spectra. In addition to the well-known global (1) decrease in absorption, and (2) increase in reduced scattering, we uncovered new features based on sensitive detection of spectral changes. These absorption spectrum features are: (3) emergence of a peak around 840 nm, (4) redshift of the 760 nm deoxyhemoglobin peak, and (5) blueshift of the 970 nm water peak. Treatment temperatures above 100 °C led to (6) increased absorption at shorter wavelengths, and (7) further decrease in reduced scattering. This optical behavior provides new insights into tissue response to thermal treatment and sets the stage for optical monitoring of radiofrequency ablation.


2008 ◽  
Vol 75 (1) ◽  
Author(s):  
Q. Li ◽  
Y. H. Chen

A semi-permeable interface crack in infinite elastic dielectric/piezoelectric bimaterials under combined electric and mechanical loading is studied by using the Stroh complex variable theory. Attention is focused on the influence induced from the permittivity of the medium inside the crack gap on the near-tip singularity and on the energy release rate (ERR). Thirty five kinds of such bimaterials are considered, which are constructed by five kinds of elastic dielectrics and seven kinds of piezoelectrics, respectively. Numerical results for the interface crack tip singularities are calculated. We demonstrate that, whatever the dielectric phase is much softer or much harder than the piezoelectric phase, the structure of the singular field near the semi-permeable interface crack tip in such bimaterials always consists of the singularity r−1∕2 and a pair of oscillatory singularities r−1∕2±iε. Calculated values of the oscillatory index ε for the 35 kinds of bimaterials are presented in tables, which are always within the range between 0.046 and 0.088. Energy analyses for five kinds of such bimaterials constructed by PZT-4 and the five kinds of elastic dielectrics are studied in more detail under four different cases: (i) the crack is electrically conducting, (ii) the crack gap is filled with air/vacuum, (iii) the crack gap is filled with silicon oil, and (iv) the crack is electrically impermeable. Detailed comparisons on the variable tendencies of the crack tip ERR against the applied electric field are given under some practical electromechanical loading levels. We conclude that the different values of the permittivity have no influence on the crack tip singularity but have significant influences on the crack tip ERR. We also conclude that the previous investigations under the impermeable crack model are incorrect since the results of the ERR for the impermeable crack show significant discrepancies from those for the semi-permeable crack, whereas the previous investigations under the conducting crack model may be accepted in a tolerant way since the results of the ERR show very small discrepancies from those for the semi-permeable crack, especially when the crack gap is filled with silicon oil. In all cases under consideration the curves of the ERR for silicon oil are more likely tending to those for the conducting crack rather than to those for air or vacuum. Finally, we conclude that the variable tendencies of the ERR against the applied electric field have an interesting load-dependent feature when the applied mechanical loading increases. This feature is due to the nonlinear relation between the normal electric displacement component and the applied electromechanical loadings from a quadratic equation.


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